JP6476110B2 - Ｌ−リジン水酸化酵素およびそれを利用したヒドロキシ−ｌ−リジンの製造法およびヒドロキシ−ｌ−ピペコリン酸の製造法 - Google Patents

Ｌ−リジン水酸化酵素およびそれを利用したヒドロキシ−ｌ−リジンの製造法およびヒドロキシ−ｌ−ピペコリン酸の製造法 Download PDF

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JP6476110B2
JP6476110B2 JP2015501458A JP2015501458A JP6476110B2 JP 6476110 B2 JP6476110 B2 JP 6476110B2 JP 2015501458 A JP2015501458 A JP 2015501458A JP 2015501458 A JP2015501458 A JP 2015501458A JP 6476110 B2 JP6476110 B2 JP 6476110B2
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lysine
amino acid
hydroxy
seq
dependent
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JPWO2014129459A1 (ja
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木野　邦器
邦器 木野
良太郎 原
良太郎 原
良磨 三宅
良磨 三宅
潤 川端
潤 川端
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API Corp
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API Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11004—Procollagen-lysine 5-dioxygenase (1.14.11.4), i.e. lysine-hydroxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2015501458A 2013-02-19 2014-02-18 Ｌ−リジン水酸化酵素およびそれを利用したヒドロキシ−ｌ−リジンの製造法およびヒドロキシ−ｌ−ピペコリン酸の製造法 Active JP6476110B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013030311 2013-02-19
JP2013030311 2013-02-19
PCT/JP2014/053774 WO2014129459A1 (ja) 2013-02-19 2014-02-18 Ｌ－リジン水酸化酵素およびそれを利用したヒドロキシ－ｌ－リジンの製造法およびヒドロキシ－ｌ－ピペコリン酸の製造法

Related Child Applications (1)

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JP2019017912A Division JP2019062927A (ja) 2013-02-19 2019-02-04 Ｌ−リジン水酸化酵素およびそれを利用したヒドロキシ−ｌ−リジンの製造法およびヒドロキシ−ｌ−ピペコリン酸の製造法

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JPWO2014129459A1 JPWO2014129459A1 (ja) 2017-02-02
JP6476110B2 true JP6476110B2 (ja) 2019-02-27

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JP2015501458A Active JP6476110B2 (ja) 2013-02-19 2014-02-18 Ｌ−リジン水酸化酵素およびそれを利用したヒドロキシ−ｌ−リジンの製造法およびヒドロキシ−ｌ−ピペコリン酸の製造法
JP2019017912A Pending JP2019062927A (ja) 2013-02-19 2019-02-04 Ｌ−リジン水酸化酵素およびそれを利用したヒドロキシ−ｌ−リジンの製造法およびヒドロキシ−ｌ−ピペコリン酸の製造法

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US (1) US9512452B2 (OSRAM)
EP (1) EP2889378B1 (OSRAM)
JP (2) JP6476110B2 (OSRAM)
CN (1) CN104685061B (OSRAM)
IN (1) IN2015DN02381A (OSRAM)
WO (1) WO2014129459A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020213731A1 (ja) 2019-04-19 2020-10-22 株式会社エーピーアイ コーポレーション （１ｒ，３ｒ）－３－（トリフルオロメチル）シクロヘキサン－１－オール及びその中間体の製造法

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CN104685061B (zh) * 2013-02-19 2018-05-01 株式会社Api L-赖氨酸羟化酶和利用了该l-赖氨酸羟化酶的羟基-l-赖氨酸的制造法及羟基-l-2-哌啶酸的制造法
EP2876156A1 (en) * 2013-11-26 2015-05-27 Commissariat A L'energie Atomique Et Aux Energies Alternatives New enzymes and method for preparing hydroxylated L-lysine or L-ornithine and analogs thereof
US10954539B2 (en) 2015-10-02 2021-03-23 Api Corporation Method for producing hydroxy-L-pipecolic acid
CN107287255A (zh) * 2016-03-31 2017-10-24 南京诺云生物科技有限公司 Pseudomonas veronii CIP104663蛋白的新用途
CN107630049B (zh) * 2017-04-01 2018-09-21 武汉茵茂特生物技术有限公司 麻黄碱的生物制备方法
WO2020059891A1 (ja) 2018-09-21 2020-03-26 株式会社エーピーアイ コーポレーション アミノ酸誘導体の製造方法
CN113473863B (zh) 2019-02-03 2023-10-03 特尔维瓦股份有限公司 使用水黄皮油及其制剂控制香蕉中的黑叶斑病的方法
JP7386616B2 (ja) * 2019-04-25 2023-11-27 株式会社エーピーアイ コーポレーション Ｌ体環状アミノ酸の製造方法
WO2025142009A1 (ja) * 2023-12-25 2025-07-03 国立大学法人東京大学 Ｌ－リジン５位水酸化酵素及びそれを利用した５－ヒドロキシ－ｌ－リジンの製造方法

Family Cites Families (11)

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JPS57183799A (en) 1981-04-17 1982-11-12 Kyowa Hakko Kogyo Co Ltd Novel plasmid
ATE423205T1 (de) 1999-12-28 2009-03-15 Mercian Corp Verfahren zur biologischen herstellung von l- pipekolinsäure
FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2825717B1 (fr) * 2001-06-08 2005-02-18 Rhodia Chimie Sa Preparation stereoselective de l-acides amines cycliques
JP4590981B2 (ja) * 2003-08-26 2010-12-01 三菱化学株式会社 光学活性環状アミノ酸の製造方法
JP5395395B2 (ja) * 2008-10-10 2014-01-22 北興化学工業株式会社 微生物による環状アミノ酸の製造法
US9029107B2 (en) 2010-08-31 2015-05-12 Api Corporation Hydrolase protein
ES2693568T3 (es) 2012-12-20 2018-12-12 Api Corporation Método para producir un derivado de ácido cis-5-hidroxi-2-piperidincarboxílico, y método para purificar ácido cis-5-hidroxi-2-piperidincarboxílico
CN104685061B (zh) * 2013-02-19 2018-05-01 株式会社Api L-赖氨酸羟化酶和利用了该l-赖氨酸羟化酶的羟基-l-赖氨酸的制造法及羟基-l-2-哌啶酸的制造法
EP2876156A1 (en) 2013-11-26 2015-05-27 Commissariat A L'energie Atomique Et Aux Energies Alternatives New enzymes and method for preparing hydroxylated L-lysine or L-ornithine and analogs thereof
WO2015098774A1 (ja) 2013-12-26 2015-07-02 株式会社カネカ 光学活性環状イミノ酸の製造方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020213731A1 (ja) 2019-04-19 2020-10-22 株式会社エーピーアイ コーポレーション （１ｒ，３ｒ）－３－（トリフルオロメチル）シクロヘキサン－１－オール及びその中間体の製造法

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Publication number Publication date
EP2889378A1 (en) 2015-07-01
EP2889378B1 (en) 2018-01-10
WO2014129459A1 (ja) 2014-08-28
JPWO2014129459A1 (ja) 2017-02-02
IN2015DN02381A (OSRAM) 2015-09-04
US20150259715A1 (en) 2015-09-17
CN104685061B (zh) 2018-05-01
EP2889378A4 (en) 2016-03-09
US9512452B2 (en) 2016-12-06
JP2019062927A (ja) 2019-04-25
CN104685061A (zh) 2015-06-03

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