JP6470178B2 - 卵子の受精可能性の検査のためのバイオマーカーおよびそれを用いた判定 - Google Patents
卵子の受精可能性の検査のためのバイオマーカーおよびそれを用いた判定 Download PDFInfo
- Publication number
- JP6470178B2 JP6470178B2 JP2015529492A JP2015529492A JP6470178B2 JP 6470178 B2 JP6470178 B2 JP 6470178B2 JP 2015529492 A JP2015529492 A JP 2015529492A JP 2015529492 A JP2015529492 A JP 2015529492A JP 6470178 B2 JP6470178 B2 JP 6470178B2
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- amino acid
- acid sequence
- seq
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000004720 fertilization Effects 0.000 title claims description 51
- 238000012360 testing method Methods 0.000 title claims description 26
- 239000000090 biomarker Substances 0.000 title claims description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 141
- 238000000034 method Methods 0.000 claims description 47
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 44
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 31
- 210000001733 follicular fluid Anatomy 0.000 claims description 25
- 239000013068 control sample Substances 0.000 claims description 19
- 210000004681 ovum Anatomy 0.000 claims description 19
- 238000004949 mass spectrometry Methods 0.000 claims description 18
- 238000005259 measurement Methods 0.000 claims description 18
- 102000002322 Egg Proteins Human genes 0.000 claims description 17
- 108010000912 Egg Proteins Proteins 0.000 claims description 17
- 230000035558 fertility Effects 0.000 claims description 12
- 210000000287 oocyte Anatomy 0.000 claims description 3
- 235000013601 eggs Nutrition 0.000 description 39
- 239000000523 sample Substances 0.000 description 24
- 238000000338 in vitro Methods 0.000 description 13
- 230000035945 sensitivity Effects 0.000 description 12
- 239000000427 antigen Substances 0.000 description 10
- 238000010586 diagram Methods 0.000 description 10
- 102000036639 antigens Human genes 0.000 description 9
- 108091007433 antigens Proteins 0.000 description 9
- 239000003550 marker Substances 0.000 description 9
- 235000018102 proteins Nutrition 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 239000012634 fragment Substances 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 238000001514 detection method Methods 0.000 description 7
- 235000001014 amino acid Nutrition 0.000 description 5
- 239000012472 biological sample Substances 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000003018 immunoassay Methods 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- 102000008100 Human Serum Albumin Human genes 0.000 description 4
- 108091006905 Human Serum Albumin Proteins 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 235000018417 cysteine Nutrition 0.000 description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 4
- 238000001962 electrophoresis Methods 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 210000004408 hybridoma Anatomy 0.000 description 4
- 238000003317 immunochromatography Methods 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000000691 measurement method Methods 0.000 description 4
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 101710176384 Peptide 1 Proteins 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000011241 immuno-mass spectrometry Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 2
- 101001060288 Homo sapiens Alpha-2-HS-glycoprotein Proteins 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000012228 culture supernatant Substances 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 102000055634 human AHSG Human genes 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000101 novel biomarker Substances 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- JPOKAKNGULMYHZ-UILVTTEASA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]-3-(4-hydroxyp Chemical compound C([C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCN=C(N)N)C1=CC=C(O)C=C1 JPOKAKNGULMYHZ-UILVTTEASA-N 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229910005540 GaP Inorganic materials 0.000 description 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 description 1
- 208000035752 Live birth Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 229910004541 SiN Inorganic materials 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 238000003163 cell fusion method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229920001940 conductive polymer Polymers 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000010265 fast atom bombardment Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000010365 information processing Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000009027 insemination Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 238000001906 matrix-assisted laser desorption--ionisation mass spectrometry Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000002394 ovarian follicle Anatomy 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 238000007694 polyacrylamide gel isoelectric focusing Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 238000001269 time-of-flight mass spectrometry Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013156672 | 2013-07-29 | ||
| JP2013156672 | 2013-07-29 | ||
| PCT/JP2014/068506 WO2015016036A1 (ja) | 2013-07-29 | 2014-07-10 | 卵子の受精可能性の検査のためのバイオマーカーおよびそれを用いた判定 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018153454A Division JP6553264B2 (ja) | 2013-07-29 | 2018-08-17 | 卵子の受精可能性の検査のためのバイオマーカーおよびそれを用いた判定 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2015016036A1 JPWO2015016036A1 (ja) | 2017-03-02 |
| JP6470178B2 true JP6470178B2 (ja) | 2019-02-13 |
Family
ID=52431576
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529492A Expired - Fee Related JP6470178B2 (ja) | 2013-07-29 | 2014-07-10 | 卵子の受精可能性の検査のためのバイオマーカーおよびそれを用いた判定 |
| JP2018153454A Expired - Fee Related JP6553264B2 (ja) | 2013-07-29 | 2018-08-17 | 卵子の受精可能性の検査のためのバイオマーカーおよびそれを用いた判定 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018153454A Expired - Fee Related JP6553264B2 (ja) | 2013-07-29 | 2018-08-17 | 卵子の受精可能性の検査のためのバイオマーカーおよびそれを用いた判定 |
Country Status (2)
| Country | Link |
|---|---|
| JP (2) | JP6470178B2 (https=) |
| WO (1) | WO2015016036A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7032764B2 (ja) * | 2019-04-03 | 2022-03-09 | 京都府公立大学法人 | 大腸がんの検出方法 |
| JP7300660B2 (ja) * | 2019-04-03 | 2023-06-30 | 京都府公立大学法人 | 大腸がんの検出方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0214969A4 (en) * | 1984-04-19 | 1987-12-17 | Univ Queensland | CONTRACEPTIVE METHODS AND DISTRIBUTION SYSTEMS THEREFOR. |
| US6011005A (en) * | 1997-09-18 | 2000-01-04 | The Picower Institute For Medical Research | Prevention of pregnancy miscarriages |
| ATE455526T1 (de) * | 2000-08-24 | 2010-02-15 | Sidney Lerner | Nicht-hormonales vaginales verhütungsmittel |
| US8263342B2 (en) * | 2005-10-27 | 2012-09-11 | Yale University | Urinary proteomic biomarker patterns in preeclampsia |
| MY150687A (en) * | 2006-07-21 | 2014-02-28 | Femalon S P R L | Assay and kit for predicting implantation success in assisted fertilisation |
| WO2009075862A1 (en) * | 2007-12-11 | 2009-06-18 | New York University School Of Medicine | Method of assessing viability of embryos in vitro |
| JP5714285B2 (ja) * | 2010-09-29 | 2015-05-07 | 株式会社プロトセラ | 妊娠高血圧症候群マーカーおよびそれを用いた診断 |
| WO2013099376A1 (ja) * | 2011-12-26 | 2013-07-04 | 国立大学法人福井大学 | 体外受精における成熟卵子マーカー及びその使用 |
-
2014
- 2014-07-10 JP JP2015529492A patent/JP6470178B2/ja not_active Expired - Fee Related
- 2014-07-10 WO PCT/JP2014/068506 patent/WO2015016036A1/ja not_active Ceased
-
2018
- 2018-08-17 JP JP2018153454A patent/JP6553264B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015016036A1 (ja) | 2015-02-05 |
| JP2019007971A (ja) | 2019-01-17 |
| JPWO2015016036A1 (ja) | 2017-03-02 |
| JP6553264B2 (ja) | 2019-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6096813B2 (ja) | 乳癌診断用マルチバイオマーカーセット、その検出方法、及びそれに対する抗体を含む乳癌診断キット | |
| JPWO2008072676A1 (ja) | 新規疾患マーカーおよびそれを用いた診断 | |
| JPWO2017150681A1 (ja) | シグナルペプチドを指標にした筋萎縮性側索硬化症の診断方法 | |
| JP5363481B2 (ja) | 早産の危険性を評価するためのバイオマーカーの同定および定量化 | |
| JP2008175814A (ja) | 尿中タンパク質分子の検出・定量による糖尿病性腎症の検査方法及びそれに使用するキット | |
| JP5714285B2 (ja) | 妊娠高血圧症候群マーカーおよびそれを用いた診断 | |
| JP6553264B2 (ja) | 卵子の受精可能性の検査のためのバイオマーカーおよびそれを用いた判定 | |
| JPWO2009088022A1 (ja) | 新規癌マーカーおよびそれを用いた診断 | |
| JP2009168646A (ja) | 子宮内膜症に特異的なバイオマーカー | |
| JP2010071953A (ja) | 乳癌マーカーおよびそれを用いた診断 | |
| JP2013245960A (ja) | 乳がん患者手術治療後の予後判定方法 | |
| JP2020064051A (ja) | 神経変性疾患の診断用ペプチドマーカー | |
| JP2014020941A (ja) | 大腸癌のマーカーおよびそれを用いた診断 | |
| KR101431067B1 (ko) | 유방암 진단용 단백질 마커 아포리포단백질 (a), 이의 검출 방법 및 이에 대한 항체를 포함하는 유방암 진단키트 | |
| JP2015108515A (ja) | 大腸癌の診断のための検査方法 | |
| JP7336097B2 (ja) | 乳がんに関するペプチドマーカー | |
| JP2014025868A (ja) | がん転移マーカーおよびそれを用いた診断 | |
| JP7300660B2 (ja) | 大腸がんの検出方法 | |
| KR101819939B1 (ko) | 유방암 진단용 단백질 마커 베타-투 마이크로글로불린 및 이를 검출하는 방법 | |
| WO2009096502A1 (ja) | うつ病およびうつ状態のマーカーおよびそれを用いた検出・診断 | |
| JP7032764B2 (ja) | 大腸がんの検出方法 | |
| JP2024117521A (ja) | 膵臓がんの検出方法 | |
| JP2011080775A (ja) | 妊娠高血圧症候群マーカーおよびそれを用いた診断 | |
| JP2014181967A (ja) | 中枢神経ループス(npsle)診断用バイオマーカー | |
| JP6521306B2 (ja) | 飲酒に伴う高血圧発症の予測用ペプチドおよびそれを用いた飲酒に伴う高血圧発症の予測方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170526 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20170526 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180522 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20180719 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20180815 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180817 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20180815 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20181219 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190117 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6470178 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |