JP6463328B2 - 眼内生理センサ - Google Patents
眼内生理センサ Download PDFInfo
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- JP6463328B2 JP6463328B2 JP2016501089A JP2016501089A JP6463328B2 JP 6463328 B2 JP6463328 B2 JP 6463328B2 JP 2016501089 A JP2016501089 A JP 2016501089A JP 2016501089 A JP2016501089 A JP 2016501089A JP 6463328 B2 JP6463328 B2 JP 6463328B2
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- sensor
- module
- measurement device
- intraocular
- physiological
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- ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N verteporfin Chemical compound C=1C([C@@]2([C@H](C(=O)OC)C(=CC=C22)C(=O)OC)C)=NC2=CC(C(=C2C=C)C)=NC2=CC(C(=C2CCC(O)=O)C)=NC2=CC2=NC=1C(C)=C2CCC(=O)OC ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N 0.000 description 1
- 229960003636 vidarabine Drugs 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
- 229960004740 voriconazole Drugs 0.000 description 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
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- ZXIBCJHYVWYIKI-PZJWPPBQSA-N ximelagatran Chemical compound C1([C@@H](NCC(=O)OCC)C(=O)N2[C@@H](CC2)C(=O)NCC=2C=CC(=CC=2)C(\N)=N\O)CCCCC1 ZXIBCJHYVWYIKI-PZJWPPBQSA-N 0.000 description 1
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- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 description 1
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Description
Claims (21)
- 一つ以上の電気構成要素を収めるように構成された管状メインボディと、
防湿バリアシールを用いて前記管状メインボディの第一端に挿入されるように構成されたセンサキャップであって、生物の生理特性を測定するように構成された検知モジュールを含むセンサキャップと、
を含む埋込可能な眼内生理測定デバイスであって、
前記一つ以上の電気構成要素は、前記眼内生理測定デバイスを制御するように構成されたコントローラモジュール、前記生理特性の測定値を伝送するように構成された伝送器モジュール、または前記生理特性の前記測定値を格納するように構成された測定結果記憶モジュールを含む、眼内生理測定デバイス。 - 防湿バリアシールを用いて前記管状メインボディの第二端に挿入されるように構成された先端キャップをさらに含む請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記防湿バリアシールは、前記管状メインボディと前記センサキャップとの間の内部接合部の一つ以上のOリングを含む請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記防湿バリアシールは、前記管状メインボディと前記センサキャップとの間の外部接合部に施された材料を含む請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記検知モジュールは、眼圧検知モジュールを含む請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記眼圧検知モジュールは、微小電気機械システム(MEMS)可変コンデンサを含む請求項5に記載の埋込可能な眼内生理測定デバイス。
- 前記管状メインボディ内の前記一つ以上の電気構成要素は、キャリア部材上に装着される請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記センサキャップは、前記キャリア部材と物理的に嵌合するように構成され、前記センサキャップは、嵌合時に前記キャリア部材に電気的に接続するように構成される請求項7に記載の埋込可能な眼内生理測定デバイス。
- 前記センサキャップは、前記キャリア部材を受け取るように構成されたカットアウトを含む請求項8に記載の埋込可能な眼内生理測定デバイス。
- 前記センサキャップは、前記検知モジュールから前記センサキャップが前記管状メインボディに挿入されたときに前記検知モジュールが前記電気構成要素のうちの少なくとも一つに電気的に接続される接合部まで前記センサキャップの前記ボディを通って延在する一つ以上のフィードスルー導体を含む請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記センサキャップは、前記管状メインボディに挿入されるように構成されたプラグ部と、前記センサキャップが前記管状メインボディに挿入されたときに前記管状メインボディから延在するヘッド部とを含む請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記センサキャップは、前記センサキャップが前記管状メインボディに挿入されたときに、前記管状メインボディ内に完全に凹設される請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記管状メインボディは、前記一つ以上の電気構成要素の保護のための防湿バリアを提供するために、セラミックで形成される請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記管状メインボディの内径のまわりで螺旋を描くアンテナをさらに含む請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記アンテナは、前記一つ以上の電気構成要素を取り巻く請求項14に記載の埋込可能な眼内生理測定デバイス。
- 前記アンテナは、外部デバイスへ前記測定値をワイヤレスで伝送し、前記外部デバイスからバッテリモジュールを充電するための電力をワイヤレスで受け取るように構成される請求項14に記載の埋込可能な眼内生理測定デバイス。
- 前記コントローラモジュールは、一定の間隔で前記検知モジュールを用いて前記測定値を取得するように構成される請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記測定値は、前記測定結果記憶モジュールに格納される前にデータ圧縮アルゴリズムを用いて圧縮される請求項17に記載の埋込可能な眼内生理測定デバイス。
- 前記センサキャップは、ガラスで形成される請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記一つ以上の電気構成要素に電力を供給するように構成されたバッテリモジュールをさらに含み、前記バッテリモジュールは、前記眼内生理測定デバイスに少なくとも約90日間電力を供給するのに十分なエネルギーを含む請求項1に記載の埋込可能な眼内生理測定デバイス。
- 前記デバイスは、人間の眼の毛様体上/脈絡膜上スペースに埋め込まれるように構成される請求項1に記載の埋込可能な眼内生理測定デバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/802,313 US9730638B2 (en) | 2013-03-13 | 2013-03-13 | Intraocular physiological sensor |
US13/802,313 | 2013-03-13 | ||
PCT/US2014/022851 WO2014164569A1 (en) | 2013-03-13 | 2014-03-10 | Intraocular physiological sensor |
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JP2018246350A Division JP6751839B2 (ja) | 2013-03-13 | 2018-12-28 | 眼内生理センサ |
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JP2016511107A JP2016511107A (ja) | 2016-04-14 |
JP6463328B2 true JP6463328B2 (ja) | 2019-02-06 |
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JP2016501089A Active JP6463328B2 (ja) | 2013-03-13 | 2014-03-10 | 眼内生理センサ |
JP2018246350A Active JP6751839B2 (ja) | 2013-03-13 | 2018-12-28 | 眼内生理センサ |
JP2020116837A Active JP6946523B2 (ja) | 2013-03-13 | 2020-07-07 | 眼内生理センサ |
JP2021149948A Active JP7254134B2 (ja) | 2013-03-13 | 2021-09-15 | 眼内生理センサ |
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JP2018246350A Active JP6751839B2 (ja) | 2013-03-13 | 2018-12-28 | 眼内生理センサ |
JP2020116837A Active JP6946523B2 (ja) | 2013-03-13 | 2020-07-07 | 眼内生理センサ |
JP2021149948A Active JP7254134B2 (ja) | 2013-03-13 | 2021-09-15 | 眼内生理センサ |
Country Status (6)
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US (3) | US9730638B2 (ja) |
EP (1) | EP2967326B1 (ja) |
JP (4) | JP6463328B2 (ja) |
AU (2) | AU2014249259B2 (ja) |
CA (1) | CA2904642A1 (ja) |
WO (1) | WO2014164569A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6638239B1 (en) | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
US8721702B2 (en) | 2010-11-15 | 2014-05-13 | Aquesys, Inc. | Intraocular shunt deployment devices |
US8663303B2 (en) | 2010-11-15 | 2014-03-04 | Aquesys, Inc. | Methods for deploying an intraocular shunt from a deployment device and into an eye |
US10085884B2 (en) | 2006-06-30 | 2018-10-02 | Aquesys, Inc. | Intraocular devices |
US8852256B2 (en) | 2010-11-15 | 2014-10-07 | Aquesys, Inc. | Methods for intraocular shunt placement |
US20120123316A1 (en) | 2010-11-15 | 2012-05-17 | Aquesys, Inc. | Intraocular shunts for placement in the intra-tenon's space |
US8308701B2 (en) | 2010-11-15 | 2012-11-13 | Aquesys, Inc. | Methods for deploying intraocular shunts |
US20170360609A9 (en) | 2007-09-24 | 2017-12-21 | Ivantis, Inc. | Methods and devices for increasing aqueous humor outflow |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
US10278810B2 (en) | 2010-04-29 | 2019-05-07 | Ojo, Llc | Injectable physiologically adaptive intraocular lenses (IOL's) |
US10842671B2 (en) | 2010-11-15 | 2020-11-24 | Aquesys, Inc. | Intraocular shunt placement in the suprachoroidal space |
WO2013040079A1 (en) | 2011-09-13 | 2013-03-21 | Dose Medical Corporation | Intraocular physiological sensor |
US8852136B2 (en) | 2011-12-08 | 2014-10-07 | Aquesys, Inc. | Methods for placing a shunt into the intra-scleral space |
US9808373B2 (en) | 2013-06-28 | 2017-11-07 | Aquesys, Inc. | Intraocular shunt implantation |
US8765210B2 (en) | 2011-12-08 | 2014-07-01 | Aquesys, Inc. | Systems and methods for making gelatin shunts |
US9610195B2 (en) | 2013-02-27 | 2017-04-04 | Aquesys, Inc. | Intraocular shunt implantation methods and devices |
US10080682B2 (en) | 2011-12-08 | 2018-09-25 | Aquesys, Inc. | Intrascleral shunt placement |
WO2013148275A2 (en) | 2012-03-26 | 2013-10-03 | Glaukos Corporation | System and method for delivering multiple ocular implants |
US9119699B2 (en) | 2012-10-22 | 2015-09-01 | Alcon Research, Ltd. | Pressure control in phacoemulsification system |
US9119701B2 (en) | 2012-10-22 | 2015-09-01 | Alcon Research, Ltd. | Pressure control in phacoemulsification system |
US10617558B2 (en) | 2012-11-28 | 2020-04-14 | Ivantis, Inc. | Apparatus for delivering ocular implants into an anterior chamber of the eye |
US10159600B2 (en) | 2013-02-19 | 2018-12-25 | Aquesys, Inc. | Adjustable intraocular flow regulation |
US9125723B2 (en) | 2013-02-19 | 2015-09-08 | Aquesys, Inc. | Adjustable glaucoma implant |
US9730638B2 (en) * | 2013-03-13 | 2017-08-15 | Glaukos Corporation | Intraocular physiological sensor |
US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
US9592151B2 (en) | 2013-03-15 | 2017-03-14 | Glaukos Corporation | Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye |
US8922366B1 (en) * | 2013-06-28 | 2014-12-30 | Google Inc. | Reader communication with contact lens sensors and display device |
US20150057524A1 (en) * | 2013-08-22 | 2015-02-26 | Alcon Research, Ltd | Systems and methods for intra-operative eye biometry or refractive measurement |
US9585790B2 (en) | 2013-11-14 | 2017-03-07 | Aquesys, Inc. | Intraocular shunt inserter |
US9452260B2 (en) * | 2013-11-22 | 2016-09-27 | Verily Life Sciences Llc | Closed loop control system based on a non-invasive continuous sensor |
DE102014212457A1 (de) * | 2014-06-27 | 2015-12-31 | Implandata Ophthalmic Products Gmbh | Implantat zur Bestimmung des Augeninnendrucks |
CN106714665A (zh) | 2014-07-01 | 2017-05-24 | 注射感知股份有限公司 | 用于植入眼内压传感器的方法和装置 |
US10973425B2 (en) | 2014-07-01 | 2021-04-13 | Injectsense, Inc. | Hermetically sealed implant sensors with vertical stacking architecture |
JP2017520337A (ja) * | 2014-07-01 | 2017-07-27 | インジェクトセンス, インコーポレイテッド | 患者を監視するための、無線インターフェイスを備える超低電力充電式植え込みセンサ |
US10709547B2 (en) | 2014-07-14 | 2020-07-14 | Ivantis, Inc. | Ocular implant delivery system and method |
CA2980289A1 (en) | 2015-03-20 | 2016-09-29 | Glaukos Corporation | Gonioscopic devices |
BR112017025859A2 (pt) | 2015-06-03 | 2018-08-14 | Aquesys, Inc. | colocação de shunt intraocular ab externo |
CN106645018A (zh) * | 2015-08-11 | 2017-05-10 | 南京理工大学 | 建立人眼房水葡萄糖含量近红外光谱预测数学模型的方法 |
EP3334329B1 (en) * | 2015-08-14 | 2023-09-13 | Alcon Inc. | Ocular implant with pressure sensor |
WO2017040853A1 (en) | 2015-09-02 | 2017-03-09 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
AU2016353229B2 (en) * | 2015-11-11 | 2021-05-06 | Innomedex Llc | Aqueous humor monitoring devices and methods |
WO2017106517A1 (en) | 2015-12-15 | 2017-06-22 | Ivantis, Inc. | Ocular implant and delivery system |
WO2017184881A1 (en) | 2016-04-20 | 2017-10-26 | Harold Alexander Heitzmann | Bioresorbable ocular drug delivery device |
CN114532976A (zh) | 2016-05-31 | 2022-05-27 | 酷拉公司 | 可植入眼压传感器和使用方法 |
JP2019517366A (ja) | 2016-06-02 | 2019-06-24 | アクシス、インコーポレイテッド | 眼内薬物送達 |
US20170358942A1 (en) * | 2016-06-13 | 2017-12-14 | Johnson & Johnson Vision Care, Inc. | Methods and apparatus for wireless biomedical device charging |
US10285590B2 (en) * | 2016-06-14 | 2019-05-14 | The Regents Of The University Of Michigan | Intraocular pressure sensor with improved voltage reference circuit |
US10674906B2 (en) | 2017-02-24 | 2020-06-09 | Glaukos Corporation | Gonioscopes |
WO2018204515A1 (en) * | 2017-05-02 | 2018-11-08 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
WO2018228690A1 (en) * | 2017-06-14 | 2018-12-20 | Sensimed Sa | Device and methods for monitoring a visual field progression of a user |
US11116625B2 (en) | 2017-09-28 | 2021-09-14 | Glaukos Corporation | Apparatus and method for controlling placement of intraocular implants |
WO2019068026A1 (en) * | 2017-09-29 | 2019-04-04 | Glaukos Corporation | INTRAOCULAR PHYSIOLOGICAL SENSOR |
EP3691586A2 (en) | 2017-10-06 | 2020-08-12 | Glaukos Corporation | Systems and methods for delivering multiple ocular implants |
USD846738S1 (en) | 2017-10-27 | 2019-04-23 | Glaukos Corporation | Implant delivery apparatus |
US11246753B2 (en) | 2017-11-08 | 2022-02-15 | Aquesys, Inc. | Manually adjustable intraocular flow regulation |
US11412929B2 (en) * | 2017-11-17 | 2022-08-16 | David A Wallace | System and method enabling affordable measurement, monitoring and reporting of intra-ocular pressure, combined with system for topical medication delivery, appropriate for office or home-based use |
EP3724650A4 (en) * | 2017-12-11 | 2021-09-08 | Microoptx Inc. | IMPLANTABLE EYEPIECE GLUCOSE SENSORS AND PROCEDURES |
WO2019118740A1 (en) * | 2017-12-13 | 2019-06-20 | The Regents Of The University Of Michigan | Intraocular pressure sensor |
US11135089B2 (en) | 2018-03-09 | 2021-10-05 | Aquesys, Inc. | Intraocular shunt inserter |
US10952898B2 (en) | 2018-03-09 | 2021-03-23 | Aquesys, Inc. | Intraocular shunt inserter |
CN111936853A (zh) * | 2018-03-13 | 2020-11-13 | 目立康株式会社 | 确定系统、计算装置、确定方法及程序 |
WO2019219193A1 (de) * | 2018-05-16 | 2019-11-21 | Implandata Ophthalmic Products Gmbh | Teilflexible vorrichtung zur bestimmung des augeninnendrucks zur implantation in den menschlichen körper |
CN113164043A (zh) | 2018-09-21 | 2021-07-23 | 奥夫博医疗创新有限公司 | 用于青光眼的组合物和方法 |
WO2020160262A1 (en) * | 2019-01-30 | 2020-08-06 | Qura, Inc. | Implantable intraocular pressure sensors and calibration |
US20220249284A1 (en) * | 2019-05-13 | 2022-08-11 | Verily Life Sciences Llc | Biofluid shunt valve with sheath and monitoring device |
US20220338976A1 (en) * | 2019-09-23 | 2022-10-27 | Adaptilens, Llc | Injectable physiologically adaptive intraocular lens |
DE102019126959A1 (de) * | 2019-10-08 | 2021-04-08 | Implandata Ophthalmic Products Gmbh | Anordnung zur in vivo Veränderung eines Augeninnendrucks |
JP2022552284A (ja) | 2019-10-10 | 2022-12-15 | シファメド・ホールディングス・エルエルシー | 流量調整可能な緑内障用シャントならびに関連システム及び方法 |
US11298063B2 (en) * | 2019-10-20 | 2022-04-12 | Bao Q Tran | Hydrogen powered device |
WO2021151007A1 (en) | 2020-01-23 | 2021-07-29 | Shifamed Holdings, Llc | Adjustable flow glaucoma shunts and associated systems and methods |
EP4103117A4 (en) | 2020-02-14 | 2024-03-20 | Shifamed Holdings Llc | MARGINING SYSTEMS WITH ROTATION-BASED FLOW CONTROL DEVICES AND ASSOCIATED SYSTEMS AND METHODS |
EP4106695A4 (en) | 2020-02-18 | 2024-03-20 | Shifamed Holdings Llc | ADJUSTABLE FLOW GLAUCOMA SHUNTS WITH NON-LINEAR FLOW CONTROL ELEMENTS AND ASSOCIATED SYSTEMS AND METHODS |
EP4120978A4 (en) | 2020-03-19 | 2024-04-17 | Shifamed Holdings Llc | INTRAOCULAR LEADS WITH TRAIL-FLAT ACTUATION ELEMENTS AND ASSOCIATED SYSTEMS AND METHODS |
CN115867237A (zh) | 2020-04-16 | 2023-03-28 | 施菲姆德控股有限责任公司 | 可调节青光眼治疗装置及相关联系统和方法 |
CN111714133A (zh) * | 2020-04-30 | 2020-09-29 | 苏州无双医疗设备有限公司 | 具有葡萄糖生物燃料电池的植入式医疗设备 |
US20220054309A1 (en) * | 2020-08-22 | 2022-02-24 | Jaie Chia-Hsin Kuo | Glaucoma treatment methods |
AU2022205382A1 (en) | 2021-01-11 | 2023-06-22 | Alcon Inc. | Systems and methods for viscoelastic delivery |
EP4281144A1 (en) | 2021-01-22 | 2023-11-29 | Shifamed Holdings, LLC | Adjustable shunting systems with plate assemblies, and associated systems and methods |
WO2023002287A1 (en) * | 2021-07-20 | 2023-01-26 | Alcon Inc. | Infusion cannula |
WO2023076582A1 (en) * | 2021-10-29 | 2023-05-04 | Murata Manufacturing Co., Ltd. | Implantable device |
TWI820842B (zh) * | 2022-08-03 | 2023-11-01 | 正修學校財團法人正修科技大學 | 動態眼壓偵測方法及其系統 |
Family Cites Families (393)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2031754A (en) | 1932-11-04 | 1936-02-25 | Ernest J Sweetland | Extensible coupling |
US3788327A (en) | 1971-03-30 | 1974-01-29 | H Donowitz | Surgical implant device |
CH546406A (de) | 1972-01-03 | 1974-02-28 | Siemens Ag | Geraet zum messen der zuckerkonzentration. |
US3837339A (en) | 1972-02-03 | 1974-09-24 | Whittaker Corp | Blood glucose level monitoring-alarm system and method therefor |
US4037604A (en) | 1976-01-05 | 1977-07-26 | Newkirk John B | Artifical biological drainage device |
US4168697A (en) | 1977-01-17 | 1979-09-25 | Cantekin Erdem I | Middle ear ventilating tube and method |
US4113088A (en) | 1977-06-06 | 1978-09-12 | Binkhorst Richard D | Sterile package |
US4175563A (en) | 1977-10-05 | 1979-11-27 | Arenberg Irving K | Biological drainage shunt |
US4402681A (en) | 1980-08-23 | 1983-09-06 | Haas Joseph S | Artificial implant valve for the regulation of intraocular pressure |
US4366582A (en) | 1980-12-01 | 1983-01-04 | Faulkner Gerald D | Posterior chamber intraocular lens |
NO147900C (no) | 1981-03-12 | 1983-07-06 | Finn Skjaerpe | Mikrokirurgisk instrument. |
US4428746A (en) | 1981-07-29 | 1984-01-31 | Antonio Mendez | Glaucoma treatment device |
US4468216A (en) | 1982-05-20 | 1984-08-28 | Rudolph Muto | Irrigation suction catheter |
US4554918A (en) | 1982-07-28 | 1985-11-26 | White Thomas C | Ocular pressure relief device |
JPS5985153A (ja) | 1982-11-08 | 1984-05-17 | Hitachi Ltd | 冗長化制御装置 |
US4521210A (en) | 1982-12-27 | 1985-06-04 | Wong Vernon G | Eye implant for relieving glaucoma, and device and method for use therewith |
US4560383A (en) | 1983-10-27 | 1985-12-24 | Leiske Larry G | Anterior chamber intraocular lens |
US4787885A (en) | 1984-04-06 | 1988-11-29 | Binder Perry S | Hydrogel seton |
US4634418A (en) | 1984-04-06 | 1987-01-06 | Binder Perry S | Hydrogel seton |
US4604087A (en) | 1985-02-26 | 1986-08-05 | Joseph Neil H | Aqueous humor drainage device |
US4820626A (en) | 1985-06-06 | 1989-04-11 | Thomas Jefferson University | Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself |
US4718907A (en) | 1985-06-20 | 1988-01-12 | Atrium Medical Corporation | Vascular prosthesis having fluorinated coating with varying F/C ratio |
US4632842A (en) | 1985-06-20 | 1986-12-30 | Atrium Medical Corporation | Glow discharge process for producing implantable devices |
US4883864A (en) | 1985-09-06 | 1989-11-28 | Minnesota Mining And Manufacturing Company | Modified collagen compound and method of preparation |
US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
NZ215409A (en) | 1986-03-07 | 1989-02-24 | Anthony Christopher Be Molteno | Implant for drainage of aqueous humour in glaucoma |
CH670760A5 (ja) | 1986-06-02 | 1989-07-14 | Sulzer Ag | |
US4722724A (en) | 1986-06-23 | 1988-02-02 | Stanley Schocket | Anterior chamber tube shunt to an encircling band, and related surgical procedure |
US4863457A (en) | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
US4846793A (en) | 1987-03-18 | 1989-07-11 | Endocon, Inc. | Injector for implanting multiple pellet medicaments |
US4846172A (en) | 1987-05-26 | 1989-07-11 | Berlin Michael S | Laser-delivery eye-treatment method |
US5113868A (en) | 1987-06-01 | 1992-05-19 | The Regents Of The University Of Michigan | Ultraminiature pressure sensor with addressable read-out circuit |
US4815472A (en) | 1987-06-01 | 1989-03-28 | The Regents Of The University Of Michigan | Multipoint pressure-sensing catheter system |
US4881410A (en) | 1987-06-01 | 1989-11-21 | The Regents Of The University Of Michigan | Ultraminiature pressure sensor and method of making same |
US5013396A (en) | 1987-06-01 | 1991-05-07 | The Regents Of The University Of Michigan | Method of making an ultraminiature pressure sensor |
US4900300A (en) | 1987-07-06 | 1990-02-13 | Lee David A | Surgical instrument |
AU2308988A (en) | 1987-08-06 | 1989-03-01 | Thomas C. White | Glaucoma drainage in the lacrimal system |
US4886488A (en) | 1987-08-06 | 1989-12-12 | White Thomas C | Glaucoma drainage the lacrimal system and method |
US4870953A (en) | 1987-11-13 | 1989-10-03 | Donmicheal T Anthony | Intravascular ultrasonic catheter/probe and method for treating intravascular blockage |
US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
US4816031A (en) | 1988-01-29 | 1989-03-28 | Pfoff David S | Intraocular lens system |
US4936825A (en) | 1988-04-11 | 1990-06-26 | Ungerleider Bruce A | Method for reducing intraocular pressure caused by glaucoma |
CA1334168C (en) | 1988-04-26 | 1995-01-31 | Louis M. De Santis | Antiglaucoma compositions containing combinations of .alpha.-2 agonists and .beta. blockers |
US5005577A (en) | 1988-08-23 | 1991-04-09 | Frenkel Ronald E P | Intraocular lens pressure monitoring device |
US5785674A (en) | 1988-10-07 | 1998-07-28 | Mateen; Ahmed Abdul | Device and method for treating glaucoma |
US5681275A (en) | 1988-10-07 | 1997-10-28 | Ahmed; Abdul Mateen | Ophthalmological device with adaptable multiple distribution plates |
US5098443A (en) | 1989-03-23 | 1992-03-24 | University Of Miami | Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents |
US5177105A (en) | 1989-05-22 | 1993-01-05 | Alcon Laboratories, Inc. | Methods for controlling intraocular pressure with transition metal complexes |
FR2651668B1 (fr) | 1989-09-12 | 1991-12-27 | Leon Claude | Ensemble microscope-endoscope utile notamment en chirurgie. |
US4946436A (en) | 1989-11-17 | 1990-08-07 | Smith Stewart G | Pressure-relieving device and process for implanting |
USRE35390E (en) | 1989-11-17 | 1996-12-03 | Smith; Stewart G. | Pressure relieving device and process for implanting |
US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
US5092837A (en) | 1989-12-20 | 1992-03-03 | Robert Ritch | Method for the treatment of glaucoma |
US4968296A (en) | 1989-12-20 | 1990-11-06 | Robert Ritch | Transscleral drainage implant device for the treatment of glaucoma |
US5073163A (en) | 1990-01-29 | 1991-12-17 | Lippman Myron E | Apparatus for treating glaucoma |
US5180362A (en) | 1990-04-03 | 1993-01-19 | Worst J G F | Gonio seton |
US5378703A (en) | 1990-04-09 | 1995-01-03 | Alcon Laboratories, Inc. | Sulfonamides useful as carbonic anhydrase inhibitors |
US5153192A (en) | 1990-04-09 | 1992-10-06 | Alcon Laboratories, Inc. | Thiophene sulfonamides useful as carbonic anhydrase inhibitors |
US5129895A (en) | 1990-05-16 | 1992-07-14 | Sunrise Technologies, Inc. | Laser sclerostomy procedure |
US5041081A (en) | 1990-05-18 | 1991-08-20 | Odrich Ronald B | Ocular implant for controlling glaucoma |
US5127901A (en) | 1990-05-18 | 1992-07-07 | Odrich Ronald B | Implant with subconjunctival arch |
US5178604A (en) | 1990-05-31 | 1993-01-12 | Iovision, Inc. | Glaucoma implant |
US5476445A (en) | 1990-05-31 | 1995-12-19 | Iovision, Inc. | Glaucoma implant with a temporary flow restricting seal |
US5397300A (en) | 1990-05-31 | 1995-03-14 | Iovision, Inc. | Glaucoma implant |
US5725529A (en) | 1990-09-25 | 1998-03-10 | Innovasive Devices, Inc. | Bone fastener |
US5454796A (en) | 1991-04-09 | 1995-10-03 | Hood Laboratories | Device and method for controlling intraocular fluid pressure |
US5312394A (en) | 1991-04-29 | 1994-05-17 | Hugh Beckman | Apparatus and method for surgically performing a filtering operation on an eye for glaucoma |
US5246451A (en) | 1991-04-30 | 1993-09-21 | Medtronic, Inc. | Vascular prosthesis and method |
US6007511A (en) | 1991-05-08 | 1999-12-28 | Prywes; Arnold S. | Shunt valve and therapeutic delivery system for treatment of glaucoma and methods and apparatus for its installation |
US5300020A (en) | 1991-05-31 | 1994-04-05 | Medflex Corporation | Surgically implantable device for glaucoma relief |
US5171213A (en) | 1991-08-14 | 1992-12-15 | Price Jr Francis W | Technique for fistulization of the eye and an eye filtration prosthesis useful therefor |
EP0601055B1 (en) | 1991-08-16 | 2000-06-07 | GALIN, Miles A. | Medicament coated refractive anterior chamber ocular implant |
US5500013A (en) | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
GB2260585A (en) | 1991-10-09 | 1993-04-21 | Avdel Systems Ltd | Self-plugging blind rivet |
US5360399A (en) | 1992-01-10 | 1994-11-01 | Robert Stegmann | Method and apparatus for maintaining the normal intraocular pressure |
US5207685A (en) | 1992-02-11 | 1993-05-04 | Cinberg James Z | Tympanic ventilation tube and related technique |
US5334137A (en) | 1992-02-21 | 1994-08-02 | Eagle Vision, Inc. | Lacrimal fluid control device |
US5346464A (en) | 1992-03-10 | 1994-09-13 | Camras Carl B | Method and apparatus for reducing intraocular pressure |
DE69326610T2 (de) | 1992-05-22 | 2000-06-08 | Senju Pharma Co | Arzneimittel gegen glaukom |
US5370641A (en) | 1992-05-22 | 1994-12-06 | O'donnell, Jr.; Francis E. | Laser trabeculodissection |
US5629008A (en) | 1992-06-02 | 1997-05-13 | C.R. Bard, Inc. | Method and device for long-term delivery of drugs |
DE4219299C2 (de) | 1992-06-12 | 1994-03-24 | Leica Mikroskopie & Syst | Mikroskop |
US5377524A (en) | 1992-06-22 | 1995-01-03 | The Regents Of The University Of Michigan | Self-testing capacitive pressure transducer and method |
US5767079A (en) | 1992-07-08 | 1998-06-16 | Celtrix Pharmaceuticals, Inc. | Method of treating ophthalmic disorders using TGF -β |
US6197056B1 (en) | 1992-07-15 | 2001-03-06 | Ras Holding Corp. | Segmented scleral band for treatment of presbyopia and other eye disorders |
US5290295A (en) | 1992-07-15 | 1994-03-01 | Querals & Fine, Inc. | Insertion tool for an intraluminal graft procedure |
US5318513A (en) | 1992-09-24 | 1994-06-07 | Leib Martin L | Canalicular balloon fixation stent |
US5370607A (en) | 1992-10-28 | 1994-12-06 | Annuit Coeptis, Inc. | Glaucoma implant device and method for implanting same |
WO1994013234A1 (en) | 1992-12-17 | 1994-06-23 | Michael Andrew Coote | Implant device and method for treatment of glaucoma |
US5338291A (en) | 1993-02-03 | 1994-08-16 | Pudenz-Schulte Medical Research Corporation | Glaucoma shunt and method for draining aqueous humor |
NZ256280A (en) | 1993-03-16 | 1997-05-26 | Photogenesis Inc | Eye graft; method and surgical instrument for forming a volute from donor eye tissue and inserting it into a host eye |
US5342370A (en) | 1993-03-19 | 1994-08-30 | University Of Miami | Method and apparatus for implanting an artifical meshwork in glaucoma surgery |
IL105828A (en) | 1993-05-28 | 1999-06-20 | Medinol Ltd | Medical stent |
US5731294A (en) | 1993-07-27 | 1998-03-24 | Hybridon, Inc. | Inhibition of neovasularization using VEGF-specific oligonucleotides |
US6184250B1 (en) | 1993-08-03 | 2001-02-06 | Alcon Laboratories, Inc. | Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension |
US5735892A (en) | 1993-08-18 | 1998-04-07 | W. L. Gore & Associates, Inc. | Intraluminal stent graft |
FR2710269A1 (fr) | 1993-09-22 | 1995-03-31 | Voir Vivre | Dispositif implantable pour le traitement des Óoedèmes . |
FI934513A (fi) | 1993-10-13 | 1995-04-14 | Leiras Oy | Anordning foer injektion av implantat |
US5639278A (en) | 1993-10-21 | 1997-06-17 | Corvita Corporation | Expandable supportive bifurcated endoluminal grafts |
US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US5743868A (en) | 1994-02-14 | 1998-04-28 | Brown; Reay H. | Corneal pressure-regulating implant device |
US5516522A (en) | 1994-03-14 | 1996-05-14 | Board Of Supervisors Of Louisiana State University | Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same |
US6165210A (en) | 1994-04-01 | 2000-12-26 | Gore Enterprise Holdings, Inc. | Self-expandable helical intravascular stent and stent-graft |
EP0754046A1 (en) | 1994-04-04 | 1997-01-22 | FREEMAN, William R. | Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure |
US5716394A (en) | 1994-04-29 | 1998-02-10 | W. L. Gore & Associates, Inc. | Blood contact surfaces using extracellular matrix synthesized in vitro |
IL109499A (en) | 1994-05-02 | 1998-01-04 | Univ Ramot | Implant device for draining excess intraocular fluid |
FR2721499B1 (fr) | 1994-06-22 | 1997-01-03 | Opsia | Implant de trabéculectomie. |
US6177427B1 (en) | 1994-06-28 | 2001-01-23 | Alcon Laboratories, Inc. | Treatment of glaucoma and ocular hypertension |
US5704907A (en) | 1994-07-22 | 1998-01-06 | Wound Healing Of Oklahoma | Method and apparatus for lowering the intraocular pressure of an eye |
US6102045A (en) | 1994-07-22 | 2000-08-15 | Premier Laser Systems, Inc. | Method and apparatus for lowering the intraocular pressure of an eye |
US5520631A (en) | 1994-07-22 | 1996-05-28 | Wound Healing Of Oklahoma | Method and apparatus for lowering the intraocular pressure of an eye |
US5599534A (en) | 1994-08-09 | 1997-02-04 | University Of Nebraska | Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use |
US5665114A (en) | 1994-08-12 | 1997-09-09 | Meadox Medicals, Inc. | Tubular expanded polytetrafluoroethylene implantable prostheses |
SE9402816D0 (sv) | 1994-08-24 | 1994-08-24 | Pharmacia Ab | Method and meams for drug administration |
DE4433104C1 (de) | 1994-09-16 | 1996-05-02 | Fraunhofer Ges Forschung | Einrichtung zur Messung mechanischer Eigenschaften von biologischem Gewebe |
US5702419A (en) | 1994-09-21 | 1997-12-30 | Wake Forest University | Expandable, intraluminal stents |
US6063396A (en) | 1994-10-26 | 2000-05-16 | Houston Biotechnology Incorporated | Methods and compositions for the modulation of cell proliferation and wound healing |
US6063116A (en) | 1994-10-26 | 2000-05-16 | Medarex, Inc. | Modulation of cell proliferation and wound healing |
US5643321A (en) | 1994-11-10 | 1997-07-01 | Innovasive Devices | Suture anchor assembly and methods |
JP3642812B2 (ja) | 1994-11-17 | 2005-04-27 | 株式会社町田製作所 | 医療用観察装置 |
US5601094A (en) | 1994-11-22 | 1997-02-11 | Reiss; George R. | Ophthalmic shunt |
US5602143A (en) | 1994-12-08 | 1997-02-11 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors |
US6228873B1 (en) | 1994-12-09 | 2001-05-08 | The Regents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
US5725493A (en) | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
US5433701A (en) | 1994-12-21 | 1995-07-18 | Rubinstein; Mark H. | Apparatus for reducing ocular pressure |
US5891084A (en) | 1994-12-27 | 1999-04-06 | Lee; Vincent W. | Multiple chamber catheter delivery system |
US5558630A (en) | 1994-12-30 | 1996-09-24 | Fisher; Bret L. | Intrascleral implant and method for the regulation of intraocular pressure |
GB2296663A (en) | 1995-01-03 | 1996-07-10 | Ahmed Salih Mahmud | Drainage device for alleviating excess ophthalmic fluid pressure |
WO1996020742A1 (en) | 1995-01-06 | 1996-07-11 | Wong Vernon G | Improve eye implant for relief of glaucoma |
EP0808160A1 (en) | 1995-02-10 | 1997-11-26 | The University Of Toronto Innovations Foundation | Deprenyl compounds for treatment of glaucoma |
US6231600B1 (en) | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
US6059772A (en) | 1995-03-10 | 2000-05-09 | Candela Corporation | Apparatus and method for treating glaucoma using a gonioscopic laser trabecular ablation procedure |
BE1009278A3 (fr) | 1995-04-12 | 1997-01-07 | Corvita Europ | Tuteur auto-expansible pour dispositif medical a introduire dans une cavite d'un corps, et dispositif medical muni d'un tel tuteur. |
US5626558A (en) | 1995-05-05 | 1997-05-06 | Suson; John | Adjustable flow rate glaucoma shunt and method of using same |
US5968058A (en) | 1996-03-27 | 1999-10-19 | Optonol Ltd. | Device for and method of implanting an intraocular implant |
IL113723A (en) | 1995-05-14 | 2002-11-10 | Optonol Ltd | Intraocular implant |
WO1996036377A1 (en) | 1995-05-14 | 1996-11-21 | Optonol Ltd. | Intraocular implant, delivery device, and method of implantation |
WO1996037167A1 (en) | 1995-05-25 | 1996-11-28 | Raychem Corporation | Stent assembly |
US5723005A (en) | 1995-06-07 | 1998-03-03 | Herrick Family Limited Partnership | Punctum plug having a collapsible flared section and method |
AU5675196A (en) | 1995-06-08 | 1997-01-09 | Bard Galway Limited | Endovascular stent |
US6194415B1 (en) | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
US5934285A (en) | 1995-07-27 | 1999-08-10 | Michiel S. Kritzinger | Method for reducing irregular astigmatism and debris/epithelium in the interface during lamellar corneal flap/cap surgery |
US5766243A (en) | 1995-08-21 | 1998-06-16 | Oasis Medical, Inc. | Abrasive polished canalicular implant |
US6099558A (en) | 1995-10-10 | 2000-08-08 | Edwards Lifesciences Corp. | Intraluminal grafting of a bifuricated artery |
US5547993A (en) | 1995-10-24 | 1996-08-20 | Mitsubishi Chemical Corporation | Therapeutic agent for glaucoma |
US5836939A (en) | 1995-10-25 | 1998-11-17 | Plc Medical Systems, Inc. | Surgical laser handpiece |
US5651783A (en) | 1995-12-20 | 1997-07-29 | Reynard; Michael | Fiber optic sleeve for surgical instruments |
AU1201297A (en) | 1995-12-21 | 1997-07-17 | Pharmacia & Upjohn Ab | Ophthalmic treatment |
US5798380A (en) | 1996-02-21 | 1998-08-25 | Wisconsin Alumni Research Foundation | Cytoskeletal active agents for glaucoma therapy |
US6299895B1 (en) | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
US5807302A (en) | 1996-04-01 | 1998-09-15 | Wandel; Thaddeus | Treatment of glaucoma |
US6629981B2 (en) | 2000-07-06 | 2003-10-07 | Endocare, Inc. | Stent delivery system |
US5830179A (en) | 1996-04-09 | 1998-11-03 | Endocare, Inc. | Urological stent therapy system and method |
US5865831A (en) | 1996-04-17 | 1999-02-02 | Premier Laser Systems, Inc. | Laser surgical procedures for treatment of glaucoma |
US5932299A (en) | 1996-04-23 | 1999-08-03 | Katoot; Mohammad W. | Method for modifying the surface of an object |
US5932229A (en) | 1996-04-25 | 1999-08-03 | Avon Products, Inc. | Oxa diacids and related compounds for treating skin conditions |
US6530896B1 (en) | 1996-05-13 | 2003-03-11 | James B. Elliott | Apparatus and method for introducing an implant |
US5670161A (en) | 1996-05-28 | 1997-09-23 | Healy; Kevin E. | Biodegradable stent |
US5681323A (en) | 1996-07-15 | 1997-10-28 | Arick; Daniel S. | Emergency cricothyrotomy tube insertion |
US5830139A (en) | 1996-09-04 | 1998-11-03 | Abreu; Marcio M. | Tonometer system for measuring intraocular pressure by applanation and/or indentation |
US6120460A (en) | 1996-09-04 | 2000-09-19 | Abreu; Marcio Marc | Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions |
US6544193B2 (en) | 1996-09-04 | 2003-04-08 | Marcio Marc Abreu | Noninvasive measurement of chemical substances |
US5886822A (en) | 1996-10-08 | 1999-03-23 | The Microoptical Corporation | Image combining system for eyeglasses and face masks |
US6007510A (en) | 1996-10-25 | 1999-12-28 | Anamed, Inc. | Implantable devices and methods for controlling the flow of fluids within the body |
US5925342A (en) | 1996-11-13 | 1999-07-20 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of potassium channel blockers |
AUPO394496A0 (en) | 1996-11-29 | 1997-01-02 | Lions Eye Institute | Biological microfistula tube and implantation method and apparatus |
US6261256B1 (en) | 1996-12-20 | 2001-07-17 | Abdul Mateen Ahmed | Pocket medical valve & method |
US5713844A (en) | 1997-01-10 | 1998-02-03 | Peyman; Gholam A. | Device and method for regulating intraocular pressure |
GB9700390D0 (en) | 1997-01-10 | 1997-02-26 | Biocompatibles Ltd | Device for use in the eye |
US6780165B2 (en) | 1997-01-22 | 2004-08-24 | Advanced Medical Optics | Micro-burst ultrasonic power delivery |
DE19705815C2 (de) | 1997-02-15 | 1999-02-11 | Heidelberg Engineering Optisch | Medizinisches Gerät zur Mikrochirurgie am Auge |
FR2759577B1 (fr) | 1997-02-17 | 1999-08-06 | Corneal Ind | Implant de sclerectomie profonde |
US6071286A (en) | 1997-02-19 | 2000-06-06 | Mawad; Michel E. | Combination angioplasty balloon/stent deployment device |
US5893837A (en) | 1997-02-28 | 1999-04-13 | Staar Surgical Company, Inc. | Glaucoma drain implanting device and method |
US6035856A (en) | 1997-03-06 | 2000-03-14 | Scimed Life Systems | Percutaneous bypass with branching vessel |
US6059812A (en) | 1997-03-21 | 2000-05-09 | Schneider (Usa) Inc. | Self-expanding medical device for centering radioactive treatment sources in body vessels |
JP3827429B2 (ja) | 1997-04-03 | 2006-09-27 | オリンパス株式会社 | 手術用顕微鏡 |
US5882327A (en) | 1997-04-17 | 1999-03-16 | Jacob; Jean T. | Long-term glaucoma drainage implant |
US6033418A (en) | 1997-04-25 | 2000-03-07 | New Jersey Institute Of Technology | Method and device for corneal shaping and refractive correction |
US6050970A (en) | 1997-05-08 | 2000-04-18 | Pharmacia & Upjohn Company | Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye |
DE19728069C1 (de) | 1997-07-01 | 1999-02-11 | Acritec Gmbh | Vorrichtung zur Messung des Augeninnendrucks |
US5752928A (en) | 1997-07-14 | 1998-05-19 | Rdo Medical, Inc. | Glaucoma pressure regulator |
US5980928A (en) | 1997-07-29 | 1999-11-09 | Terry; Paul B. | Implant for preventing conjunctivitis in cattle |
US5830171A (en) | 1997-08-12 | 1998-11-03 | Odyssey Medical, Inc. | Punctal occluder |
EP0898947A3 (de) | 1997-08-15 | 1999-09-08 | GRIESHABER & CO. AG SCHAFFHAUSEN | Verfahren und Vorrichtung zum Verbessern des Kammerwasserabflusses in einem Auge |
US6004302A (en) | 1997-08-28 | 1999-12-21 | Brierley; Lawrence A. | Cannula |
US6274138B1 (en) | 1997-09-03 | 2001-08-14 | Incyte Genomics, Inc. | Human mitochondrial malate dehydrogenase |
US6159458A (en) | 1997-11-04 | 2000-12-12 | Insite Vision | Sustained release ophthalmic compositions containing water soluble medicaments |
US6203513B1 (en) | 1997-11-20 | 2001-03-20 | Optonol Ltd. | Flow regulating implant, method of manufacture, and delivery device |
US8313454B2 (en) | 1997-11-20 | 2012-11-20 | Optonol Ltd. | Fluid drainage device, delivery device, and associated methods of use and manufacture |
JP2002508209A (ja) | 1997-12-15 | 2002-03-19 | プロリフィックス メディカル, インコーポレイテッド | 再狭窄の低減のための血管ステント |
US6050999A (en) | 1997-12-18 | 2000-04-18 | Keravision, Inc. | Corneal implant introducer and method of use |
US20020188207A1 (en) * | 1998-01-08 | 2002-12-12 | Jacob Richter | Anchor for sensor implanted in a bodily lumen |
US6589198B1 (en) | 1998-01-29 | 2003-07-08 | David Soltanpour | Implantable micro-pump assembly |
US6168575B1 (en) | 1998-01-29 | 2001-01-02 | David Pyam Soltanpour | Method and apparatus for controlling intraocular pressure |
US6268398B1 (en) | 1998-04-24 | 2001-07-31 | Mitokor | Compounds and methods for treating mitochondria-associated diseases |
US6231853B1 (en) | 1998-06-01 | 2001-05-15 | Incyte Pharmaceuticals, Inc. | Human glutathione peroxidase-6 |
US6109113A (en) | 1998-06-11 | 2000-08-29 | Delco Electronics Corp. | Silicon micromachined capacitive pressure sensor and method of manufacture |
US6077299A (en) | 1998-06-22 | 2000-06-20 | Eyetronic, Llc | Non-invasively adjustable valve implant for the drainage of aqueous humor in glaucoma |
US6378526B1 (en) | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
DE19840047B4 (de) | 1998-09-02 | 2004-07-08 | Neuhann, Thomas, Prof.Dr.med. | Vorrichtung zur gezielten Verbesserung und/oder dauerhaften Gewährleistung des Durchlässigkeitsvermögens für Augenkammerwasser durch das Trabekelwerk in den Schlemmschen Kanal |
KR100300527B1 (ko) | 1998-09-03 | 2001-10-27 | 윤덕용 | 밀봉형무선압력측정소자및그제조방법 |
EP1669042A3 (en) | 1998-09-10 | 2006-06-28 | Percardia, Inc. | TMR shunt |
US6241721B1 (en) | 1998-10-09 | 2001-06-05 | Colette Cozean | Laser surgical procedures for treatment of glaucoma |
US6254612B1 (en) | 1998-10-22 | 2001-07-03 | Cordis Neurovascular, Inc. | Hydraulic stent deployment system |
US6232150B1 (en) | 1998-12-03 | 2001-05-15 | The Regents Of The University Of Michigan | Process for making microstructures and microstructures made thereby |
US6348042B1 (en) | 1999-02-02 | 2002-02-19 | W. Lee Warren, Jr. | Bioactive shunt |
JP3382172B2 (ja) | 1999-02-04 | 2003-03-04 | 株式会社日立製作所 | 横型絶縁ゲートバイポーラトランジスタ |
US6193656B1 (en) | 1999-02-08 | 2001-02-27 | Robert E. Jeffries | Intraocular pressure monitoring/measuring apparatus and method |
US6231597B1 (en) | 1999-02-16 | 2001-05-15 | Mark E. Deem | Apparatus and methods for selectively stenting a portion of a vessel wall |
US6217895B1 (en) | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
US20050119601A9 (en) | 1999-04-26 | 2005-06-02 | Lynch Mary G. | Shunt device and method for treating glaucoma |
ES2609594T3 (es) | 1999-04-26 | 2017-04-21 | Glaukos Corporation | Dispositivo de drenaje para tratar el glaucoma |
US6342058B1 (en) | 1999-05-14 | 2002-01-29 | Valdemar Portney | Iris fixated intraocular lens and instrument for attaching same to an iris |
US6558342B1 (en) | 1999-06-02 | 2003-05-06 | Optonol Ltd. | Flow control device, introducer and method of implanting |
US6306120B1 (en) | 1999-06-07 | 2001-10-23 | Ben Gee Tan | Applicator and method for delivery of mitomycin to eye tissues during glaucoma filtering surgery |
US6201001B1 (en) | 1999-08-02 | 2001-03-13 | Abbott Laboratories | Imidazole antiproliferative agents |
US7033603B2 (en) | 1999-08-06 | 2006-04-25 | Board Of Regents The University Of Texas | Drug releasing biodegradable fiber for delivery of therapeutics |
US6596296B1 (en) | 1999-08-06 | 2003-07-22 | Board Of Regents, The University Of Texas System | Drug releasing biodegradable fiber implant |
US20020007113A1 (en) | 1999-08-26 | 2002-01-17 | March Wayne Front | Ocular analyte sensor |
CN1196436C (zh) | 1999-08-26 | 2005-04-13 | 诺瓦提斯公司 | 眼分析物传感器 |
US6187016B1 (en) | 1999-09-14 | 2001-02-13 | Daniel G. Hedges | Stent retrieval device |
DE19945879C2 (de) | 1999-09-24 | 2002-01-03 | Acritec Gmbh | Vorrichtung zum Messen des Augeninnendruckes mit einem faltbaren Implantat |
US6416777B1 (en) | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
BR0014929B1 (pt) | 1999-10-21 | 2009-01-13 | dispositivo para distribuiÇço de medicamento oftÁlmico. | |
US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
US6579235B1 (en) | 1999-11-01 | 2003-06-17 | The Johns Hopkins University | Method for monitoring intraocular pressure using a passive intraocular pressure sensor and patient worn monitoring recorder |
US6287313B1 (en) | 1999-11-23 | 2001-09-11 | Sdgi Holdings, Inc. | Screw delivery system and method |
DE29920949U1 (de) | 1999-11-29 | 2000-04-27 | Bugge Mogens | Saugrohr für chirurgische Zwecke |
KR100769224B1 (ko) | 1999-12-10 | 2007-10-22 | 아이싸이언스 인터벤셔날 코포레이션 | 안 질환의 치료방법 |
US6939299B1 (en) | 1999-12-13 | 2005-09-06 | Kurt Petersen | Implantable continuous intraocular pressure sensor |
US6713828B1 (en) | 1999-12-17 | 2004-03-30 | Delphi Technologies, Inc. | Monolithic fully-integrated vacuum sealed BiCMOS pressure sensor |
US6450937B1 (en) | 1999-12-17 | 2002-09-17 | C. R. Bard, Inc. | Needle for implanting brachytherapy seeds |
US6726676B2 (en) | 2000-01-05 | 2004-04-27 | Grieshaber & Co. Ag Schaffhausen | Method of and device for improving the flow of aqueous humor within the eye |
US7998412B2 (en) | 2000-01-07 | 2011-08-16 | Smart Holograms Limited | Ophthalmic device comprising a holographic sensor |
CN100408118C (zh) | 2000-01-12 | 2008-08-06 | 贝克顿迪肯森公司 | 降低眼内压力的系统和方法 |
US20050119737A1 (en) | 2000-01-12 | 2005-06-02 | Bene Eric A. | Ocular implant and methods for making and using same |
US6589203B1 (en) | 2000-01-26 | 2003-07-08 | Peter Mitrev | Glaucoma drainage device implant |
US6375642B1 (en) | 2000-02-15 | 2002-04-23 | Grieshaber & Co. Ag Schaffhausen | Method of and device for improving a drainage of aqueous humor within the eye |
US6471666B1 (en) | 2000-02-24 | 2002-10-29 | Steven A. Odrich | Injectable glaucoma device |
JP4700209B2 (ja) * | 2000-03-21 | 2011-06-15 | ラディ・メディカル・システムズ・アクチェボラーグ | 受動バイオテレメトリ |
US20050049578A1 (en) | 2000-04-14 | 2005-03-03 | Hosheng Tu | Implantable ocular pump to reduce intraocular pressure |
US20030060752A1 (en) | 2000-04-14 | 2003-03-27 | Olav Bergheim | Glaucoma device and methods thereof |
US20040111050A1 (en) | 2000-04-14 | 2004-06-10 | Gregory Smedley | Implantable ocular pump to reduce intraocular pressure |
US20020143284A1 (en) | 2001-04-03 | 2002-10-03 | Hosheng Tu | Drug-releasing trabecular implant for glaucoma treatment |
US6638239B1 (en) | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
US7708711B2 (en) | 2000-04-14 | 2010-05-04 | Glaukos Corporation | Ocular implant with therapeutic agents and methods thereof |
US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
US6533768B1 (en) | 2000-04-14 | 2003-03-18 | The Regents Of The University Of California | Device for glaucoma treatment and methods thereof |
WO2001079506A2 (en) | 2000-04-17 | 2001-10-25 | Children's Hospital Research Foundation | Treatment of ocular neovascularization and related diseases |
US6582453B1 (en) | 2000-07-14 | 2003-06-24 | Opus Medical, Inc. | Method and apparatus for attaching connective tissues to bone using a suture anchoring device |
US6749568B2 (en) | 2000-08-21 | 2004-06-15 | Cleveland Clinic Foundation | Intraocular pressure measurement system including a sensor mounted in a contact lens |
US6994672B2 (en) * | 2000-08-21 | 2006-02-07 | Cleveland Clinic Foundation | Apparatus and method for measuring intraocular pressure |
US6699211B2 (en) | 2000-08-22 | 2004-03-02 | James A. Savage | Method and apparatus for treatment of glaucoma |
US6428501B1 (en) | 2000-09-19 | 2002-08-06 | K2 Limited Partnership U/A/D | Surgical instrument sleeve |
US6730056B1 (en) | 2000-09-21 | 2004-05-04 | Motorola, Inc. | Eye implant for treating glaucoma and method for manufacturing same |
FR2817912B1 (fr) | 2000-12-07 | 2003-01-17 | Hispano Suiza Sa | Reducteur reprenant les efforts axiaux generes par la soufflante d'un turboreacteur |
US6595945B2 (en) | 2001-01-09 | 2003-07-22 | J. David Brown | Glaucoma treatment device and method |
WO2002056758A1 (de) * | 2001-01-17 | 2002-07-25 | Humanoptics Ag | Implantat zur bestimmung des augeninnendrucks |
US6968743B2 (en) | 2001-01-22 | 2005-11-29 | Integrated Sensing Systems, Inc. | Implantable sensing device for physiologic parameter measurement |
WO2002074052A2 (en) | 2001-03-16 | 2002-09-26 | Glaukos Corporation | Applicator and methods for placing a trabecular shunt for glaucoma treatment |
US7488303B1 (en) | 2002-09-21 | 2009-02-10 | Glaukos Corporation | Ocular implant with anchor and multiple openings |
US6981958B1 (en) | 2001-05-02 | 2006-01-03 | Glaukos Corporation | Implant with pressure sensor for glaucoma treatment |
EP1418868B1 (en) | 2001-04-07 | 2008-03-26 | Glaukos Corporation | Glaucoma stent for glaucoma treatment |
US6666841B2 (en) | 2001-05-02 | 2003-12-23 | Glaukos Corporation | Bifurcatable trabecular shunt for glaucoma treatment |
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
GB2374925A (en) | 2001-04-24 | 2002-10-30 | Anant Sharma | Pressure detectors |
US20040152963A1 (en) | 2001-04-27 | 2004-08-05 | March Wayne Front | Apparatus for measuring blood glucose concentrations |
US7678065B2 (en) | 2001-05-02 | 2010-03-16 | Glaukos Corporation | Implant with intraocular pressure sensor for glaucoma treatment |
US7094225B2 (en) | 2001-05-03 | 2006-08-22 | Glaukos Corporation | Medical device and methods of use of glaucoma treatment |
MXPA04001330A (es) | 2001-08-16 | 2004-05-05 | Gmp Vision Solutions Inc | DISPOSITIVO DE DERIVACION MEJORADO Y MeTODO PARA EL TRATAMIENTO DEL GLAUCOMA. |
US7331984B2 (en) | 2001-08-28 | 2008-02-19 | Glaukos Corporation | Glaucoma stent for treating glaucoma and methods of use |
IL145182A (en) | 2001-08-29 | 2005-11-20 | Yissum Res Dev Co | Self-powered biosensor |
US20050137480A1 (en) | 2001-10-01 | 2005-06-23 | Eckhard Alt | Remote control of implantable device through medical implant communication service band |
US20030097151A1 (en) | 2001-10-25 | 2003-05-22 | Smedley Gregory T. | Apparatus and mitochondrial treatment for glaucoma |
US7004015B2 (en) | 2001-10-25 | 2006-02-28 | The Regents Of The University Of Michigan | Method and system for locally sealing a vacuum microcavity, methods and systems for monitoring and controlling pressure and method and system for trimming resonant frequency of a microstructure therein |
US7163543B2 (en) | 2001-11-08 | 2007-01-16 | Glaukos Corporation | Combined treatment for cataract and glaucoma treatment |
US20030093084A1 (en) | 2001-11-13 | 2003-05-15 | Optonol Ltd. | Delivery devices for flow regulating implants |
AU2003207446A1 (en) | 2002-01-04 | 2003-07-24 | Kuchta, John | Diagnostic algorithms for a csf physiologic controller |
US6893885B2 (en) | 2002-01-18 | 2005-05-17 | The Regents Of The University Of Michigan | Method for electrically and mechanically connecting microstructures using solder |
WO2003073968A2 (en) | 2002-02-28 | 2003-09-12 | Gmp Vision Solutions, Inc. | Device and method for monitoring aqueous flow within the eye |
US7186232B1 (en) | 2002-03-07 | 2007-03-06 | Glaukoa Corporation | Fluid infusion methods for glaucoma treatment |
US20030229303A1 (en) | 2002-03-22 | 2003-12-11 | Haffner David S. | Expandable glaucoma implant and methods of use |
US20040024345A1 (en) | 2002-04-19 | 2004-02-05 | Morteza Gharib | Glaucoma implant with valveless flow bias |
US20050159660A1 (en) | 2002-05-31 | 2005-07-21 | Valentino Montegrande | Intraocular pressure sensor |
US20070123767A1 (en) | 2002-05-31 | 2007-05-31 | Valentino Montegrande | Intraocular pressure sensor and method of use |
US20030236483A1 (en) | 2002-06-25 | 2003-12-25 | Ren David H | Dual drainage ocular shunt for glaucoma |
ES2320121T3 (es) | 2002-07-19 | 2009-05-19 | Yale University | Dispositivo de drenaje uveoescleral. |
US6890300B2 (en) | 2002-08-27 | 2005-05-10 | Board Of Trustees Of Michigan State University | Implantable microscale pressure sensor system for pressure monitoring and management |
US7615010B1 (en) | 2002-10-03 | 2009-11-10 | Integrated Sensing Systems, Inc. | System for monitoring the physiologic parameters of patients with congestive heart failure |
US7131945B2 (en) | 2002-10-16 | 2006-11-07 | California Institute Of Technology | Optically powered and optically data-transmitting wireless intraocular pressure sensor device |
US7452334B2 (en) | 2002-12-16 | 2008-11-18 | The Regents Of The University Of Michigan | Antenna stent device for wireless, intraluminal monitoring |
EP1589866A2 (en) | 2003-01-09 | 2005-11-02 | The Regents of the University of California | Implantable devices and methods for measuring intraocular, subconjunctival or subdermal pressure and/or analyte concentration |
USD490152S1 (en) | 2003-02-28 | 2004-05-18 | Glaukos Corporation | Surgical handpiece |
US20040225250A1 (en) | 2003-05-05 | 2004-11-11 | Michael Yablonski | Internal shunt and method for treating glaucoma |
US20080009687A1 (en) | 2003-06-06 | 2008-01-10 | Smith Joseph T | Coiled circuit bio-sensor |
US20060069340A1 (en) | 2003-06-16 | 2006-03-30 | Solx, Inc. | Shunt for the treatment of glaucoma |
WO2004110391A2 (en) | 2003-06-16 | 2004-12-23 | Solx, Inc. | Shunt for the treatment of glaucoma |
DE10329159A1 (de) | 2003-06-27 | 2005-01-27 | Bytec Hard- Und Softwareentwicklungen Gmbh | Verfahren zur Bestimmung des Drucks in einem potenziell mit Eiweißstoffen kontaminierten Fluid, Einweg-Messdose und Umsetzer |
DE202004020869U1 (de) | 2003-06-27 | 2006-03-23 | Bytec Medizintechnik Gmbh | Einweg-Messdose und Umsetzer |
US7927519B2 (en) | 2003-07-30 | 2011-04-19 | Eyesense Ag | Reflection hologram sensor in contact lens |
US8131333B2 (en) | 2003-08-07 | 2012-03-06 | Eyesense Ag | Ophthalmic sensor |
WO2005020972A2 (en) | 2003-08-27 | 2005-03-10 | (Osi) Eyetech, Inc. | Combination therapy for the treatment of ocular neovascular disorders |
US7291125B2 (en) | 2003-11-14 | 2007-11-06 | Transcend Medical, Inc. | Ocular pressure regulation |
EP1687041A2 (en) | 2003-11-20 | 2006-08-09 | Angiotech International AG | Soft tissue implants and anti-scarring agents |
US20080058704A1 (en) | 2004-04-29 | 2008-03-06 | Michael Hee | Apparatus and Method for Ocular Treatment |
BRPI0510433A (pt) | 2004-04-29 | 2007-10-30 | Iscience Surgical Corp | aparelho para formar um trato de tecido de dentro de uma primeira passagem de um olho conectando a uma segunda passagem no olho, implante para colocação em um trato de tecido formado cirurgicamente, e, método para criar um caminho para fluido, para humor aquoso de um olho |
US20100173866A1 (en) | 2004-04-29 | 2010-07-08 | Iscience Interventional Corporation | Apparatus and method for ocular treatment |
GB0412654D0 (en) | 2004-06-07 | 2004-07-07 | Univ Cambridge Tech | Method of detection |
US7252006B2 (en) | 2004-06-07 | 2007-08-07 | California Institute Of Technology | Implantable mechanical pressure sensor and method of manufacturing the same |
US7713228B2 (en) | 2005-01-28 | 2010-05-11 | Alcon, Inc. | Surgical method |
US20060183986A1 (en) | 2005-02-11 | 2006-08-17 | Rice Mark J | Intraocular lens measurement of blood glucose |
WO2006128028A2 (en) | 2005-05-25 | 2006-11-30 | The Regents Of The University Of Michigan Office Of Technology Transfer | Wafer-level, polymer-based encapsulation for microstructure devices |
US20060281986A1 (en) * | 2005-06-09 | 2006-12-14 | Allergan, Inc. | Apparatus and methods useful for monitoring intraocular pressure |
EP3338743A1 (en) | 2006-01-17 | 2018-06-27 | Novartis Ag | Drug delivery treatment device |
EP3632385A1 (en) | 2006-01-17 | 2020-04-08 | Novartis AG | Glaucoma treatment device |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
US20100305420A1 (en) | 2006-02-27 | 2010-12-02 | Edwards Lifesciences Corporation | Flexible circuit and method for forming the same |
US20070236213A1 (en) | 2006-03-30 | 2007-10-11 | Paden Bradley E | Telemetry method and apparatus using magnetically-driven mems resonant structure |
US20080027304A1 (en) | 2006-04-18 | 2008-01-31 | Pardo Geoffrey B | Intraocular pressure attenuation device |
ES2396088T3 (es) * | 2006-04-26 | 2013-02-19 | Eastern Virginia Medical School | Sistemas para monitorizar y controlar la presión interna de un ojo o una parte del cuerpo |
US8090426B2 (en) | 2006-10-27 | 2012-01-03 | Felder Robin A | Microelectronic biosensor plug |
WO2008121972A2 (en) | 2007-03-30 | 2008-10-09 | The Regents Of The University Of Michigan | Deposited microarchitectured battery and manufacturing method |
US8267863B2 (en) * | 2007-04-30 | 2012-09-18 | Integrated Sensing Systems, Inc. | Procedure and system for monitoring a physiological parameter within an internal organ of a living body |
US8322346B2 (en) | 2007-06-28 | 2012-12-04 | Integrated Sensing Systems, Inc. | Minimally-invasive procedure for monitoring a physiological parameter within an internal organ |
US20080306429A1 (en) | 2007-06-07 | 2008-12-11 | Shields Milton B | Uveoscleral drainage device |
US8672870B2 (en) | 2007-07-17 | 2014-03-18 | Transcend Medical, Inc. | Ocular implant with hydrogel expansion capabilities |
US8475374B2 (en) * | 2007-08-23 | 2013-07-02 | Purdue Research Foundation | Intra-occular pressure sensor |
US20090085768A1 (en) | 2007-10-02 | 2009-04-02 | Medtronic Minimed, Inc. | Glucose sensor transceiver |
BRPI0722001B8 (pt) | 2007-10-19 | 2021-06-22 | Sensimed Ag | dispositivo de monitoramento de pressão intraocular |
CN102202708B (zh) | 2008-05-08 | 2015-01-21 | 迷你泵有限责任公司 | 药物输送泵及其制造方法 |
US20100152565A1 (en) | 2008-07-15 | 2010-06-17 | Thomas Gordon A | Non-invasive tonometer |
US20100016704A1 (en) | 2008-07-16 | 2010-01-21 | Naber John F | Method and system for monitoring a condition of an eye |
EP2361033A4 (en) | 2008-12-22 | 2012-09-12 | Integrated Sensing Systems Inc | WIRELESS DYNAMIC POWER CONTROL OF AN IMPLANTABLE SENSOR DEVICE AND METHODS |
US20100213057A1 (en) | 2009-02-26 | 2010-08-26 | Benjamin Feldman | Self-Powered Analyte Sensor |
US8182435B2 (en) | 2009-05-04 | 2012-05-22 | Alcon Research, Ltd. | Intraocular pressure sensor |
US8123687B2 (en) | 2009-05-07 | 2012-02-28 | Alcon Research, Ltd. | Intraocular pressure sensor |
CN102655823B (zh) | 2009-05-18 | 2016-04-20 | 多斯医学公司 | 药物洗脱眼植入物 |
US8527055B2 (en) | 2009-07-23 | 2013-09-03 | Alcon Research, Ltd. | Application of an electrical field in the vicinity of the trabecular meshwork to treat glaucoma |
IN2012DN03211A (ja) * | 2009-09-18 | 2015-10-23 | Orthomems Inc | |
EP2477534A1 (en) | 2009-09-18 | 2012-07-25 | Orthomems, Inc. | Implantable mems intraocular pressure sensor devices and methods for glaucoma monitoring |
US8545431B2 (en) | 2009-09-21 | 2013-10-01 | Alcon Research, Ltd. | Lumen clearing valve for glaucoma drainage device |
US8721580B2 (en) | 2009-09-21 | 2014-05-13 | Alcon Research, Ltd. | Power saving glaucoma drainage device |
US8419673B2 (en) | 2009-09-21 | 2013-04-16 | Alcon Research, Ltd. | Glaucoma drainage device with pump |
US8257295B2 (en) | 2009-09-21 | 2012-09-04 | Alcon Research, Ltd. | Intraocular pressure sensor with external pressure compensation |
US20110071454A1 (en) | 2009-09-21 | 2011-03-24 | Alcon Research, Ltd. | Power Generator For Glaucoma Drainage Device |
US8707734B2 (en) | 2009-10-19 | 2014-04-29 | The Regents Of The University Of Michigan | Method of embedding material in a glass substrate |
US20110160609A1 (en) * | 2009-12-29 | 2011-06-30 | Stone Robert T | Method and system for monitoring pressure in a body cavity |
EP2521482B1 (en) | 2010-01-05 | 2013-08-07 | Sensimed SA | Intraocular pressure monitoring device |
CN101766473B (zh) * | 2010-02-09 | 2011-09-07 | 北京大学人民医院 | 眼压监测系统 |
US9314175B2 (en) * | 2010-07-08 | 2016-04-19 | TCI3—Pressure Applications, LLC | Compartment syndrome monitoring systems and methods |
DE102010035294A1 (de) | 2010-08-25 | 2011-12-22 | Implandata Ophthalmic Products Gmbh | Sklera-Sensor |
EP2517619B1 (en) | 2011-04-27 | 2013-05-22 | Istar Medical | Improvements in or relating to glaucoma management and treatment |
WO2013040079A1 (en) | 2011-09-13 | 2013-03-21 | Dose Medical Corporation | Intraocular physiological sensor |
US9072588B2 (en) | 2011-10-03 | 2015-07-07 | Alcon Research, Ltd. | Selectable varied control valve systems for IOP control systems |
US9271677B2 (en) | 2011-10-05 | 2016-03-01 | Sensimed Sa | Intraocular pressure measuring and/or monitoring device |
US9596988B2 (en) * | 2011-10-12 | 2017-03-21 | Purdue Research Foundation | Pressure sensors for small-scale applications and related methods |
US8585631B2 (en) | 2011-10-18 | 2013-11-19 | Alcon Research, Ltd. | Active bimodal valve system for real-time IOP control |
US8753305B2 (en) | 2011-12-06 | 2014-06-17 | Alcon Research, Ltd. | Bubble-driven IOP control system |
US8771220B2 (en) | 2011-12-07 | 2014-07-08 | Alcon Research, Ltd. | Glaucoma active pressure regulation shunt |
US8840578B2 (en) | 2011-12-09 | 2014-09-23 | Alcon Research, Ltd. | Multilayer membrane actuators |
US8579848B2 (en) | 2011-12-09 | 2013-11-12 | Alcon Research, Ltd. | Active drainage systems with pressure-driven valves and electronically-driven pump |
US20130150777A1 (en) | 2011-12-12 | 2013-06-13 | Sebastian Böhm | Glaucoma Drainage Devices Including Vario-Stable Valves and Associated Systems and Methods |
US8585664B2 (en) | 2011-12-12 | 2013-11-19 | Alcon Research, Ltd | System and method for powering ocular implants |
US8603024B2 (en) | 2011-12-12 | 2013-12-10 | Alcon Research, Ltd. | Glaucoma drainage devices including vario-stable valves and associated systems and methods |
US9125721B2 (en) | 2011-12-13 | 2015-09-08 | Alcon Research, Ltd. | Active drainage systems with dual-input pressure-driven valves |
US9339187B2 (en) | 2011-12-15 | 2016-05-17 | Alcon Research, Ltd. | External pressure measurement system and method for an intraocular implant |
DE102012200574A1 (de) | 2012-01-17 | 2013-07-18 | Robert Bosch Gmbh | Implantatvorrichtung, Sensormodul, Einweginjektor mit einer Implantatvorrichtung und Verfahren zum Herstellen einer Implantatvorrichtung |
DE102012100441A1 (de) | 2012-01-19 | 2013-07-25 | Implandata Ophthalmic Products Gmbh | Verfahren und Vorrichtung zur kontinuierlichen Messung von Intraokulardrücken |
US8986240B2 (en) | 2012-02-14 | 2015-03-24 | Alcon Research, Ltd. | Corrugated membrane actuators |
US9155653B2 (en) | 2012-02-14 | 2015-10-13 | Alcon Research, Ltd. | Pressure-driven membrane valve for pressure control system |
US8998838B2 (en) | 2012-03-29 | 2015-04-07 | Alcon Research, Ltd. | Adjustable valve for IOP control with reed valve |
PL2852318T3 (pl) | 2012-05-21 | 2017-07-31 | Sensimed Sa | Układ do mierzenia i/albo monitorowania ciśnienia wewnątrzgałkowego z czujnikiem bezwładnościowym i/albo środowiskowym |
US8858491B2 (en) | 2012-05-23 | 2014-10-14 | Alcon Research, Ltd. | Pre-biased membrane valve |
US8864701B2 (en) | 2012-08-13 | 2014-10-21 | Alcon Research, Ltd. | Implantable MEMS device and method |
US8956320B2 (en) | 2012-08-28 | 2015-02-17 | Alcon Research, Ltd. | Capillary valve |
US9307905B2 (en) | 2012-09-14 | 2016-04-12 | University Of Washington | Intraocular pressure sensing devices and associated systems and methods |
US9132034B2 (en) | 2012-10-01 | 2015-09-15 | Alcon Research, Ltd. | Valve position sensor |
US9295389B2 (en) | 2012-12-17 | 2016-03-29 | Novartis Ag | Systems and methods for priming an intraocular pressure sensor in an intraocular implant |
US8874182B2 (en) * | 2013-01-15 | 2014-10-28 | Google Inc. | Encapsulated electronics |
US9730638B2 (en) * | 2013-03-13 | 2017-08-15 | Glaukos Corporation | Intraocular physiological sensor |
US20150057523A1 (en) | 2013-08-21 | 2015-02-26 | Alcon Research, Ltd. | Systems and methods for priming an intraocular pressure sensor chamber |
US20150057524A1 (en) | 2013-08-22 | 2015-02-26 | Alcon Research, Ltd | Systems and methods for intra-operative eye biometry or refractive measurement |
US9226851B2 (en) | 2013-08-24 | 2016-01-05 | Novartis Ag | MEMS check valve chip and methods |
US9289324B2 (en) | 2013-08-26 | 2016-03-22 | Novartis Ag | Externally adjustable passive drainage device |
US9283115B2 (en) | 2013-08-26 | 2016-03-15 | Novartis Ag | Passive to active staged drainage device |
US9375348B2 (en) | 2014-02-17 | 2016-06-28 | Novartis Ag | Systems and methods for a membrane-free electrolysis pump for an intraocular implant |
DE102014212457A1 (de) | 2014-06-27 | 2015-12-31 | Implandata Ophthalmic Products Gmbh | Implantat zur Bestimmung des Augeninnendrucks |
JP2017520337A (ja) | 2014-07-01 | 2017-07-27 | インジェクトセンス, インコーポレイテッド | 患者を監視するための、無線インターフェイスを備える超低電力充電式植え込みセンサ |
CN106714665A (zh) | 2014-07-01 | 2017-05-24 | 注射感知股份有限公司 | 用于植入眼内压传感器的方法和装置 |
US10973425B2 (en) | 2014-07-01 | 2021-04-13 | Injectsense, Inc. | Hermetically sealed implant sensors with vertical stacking architecture |
DE102014221373A1 (de) | 2014-10-21 | 2016-04-21 | Implandata Ophthalmic Products Gmbh | Kombiniertes Augenimplantat |
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