JP6461901B2 - ネコ科苦味受容体及び方法 - Google Patents

ネコ科苦味受容体及び方法 Download PDF

Info

Publication number
JP6461901B2
JP6461901B2 JP2016500723A JP2016500723A JP6461901B2 JP 6461901 B2 JP6461901 B2 JP 6461901B2 JP 2016500723 A JP2016500723 A JP 2016500723A JP 2016500723 A JP2016500723 A JP 2016500723A JP 6461901 B2 JP6461901 B2 JP 6461901B2
Authority
JP
Japan
Prior art keywords
seq
polypeptide
tas2r
receptor
feline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016500723A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016519649A (ja
JP2016519649A5 (https=
Inventor
エム． サンダウ、ミシェル
エム． サンダウ、ミシェル
イー． ローソン、ナンシー
イー． ローソン、ナンシー
Original Assignee
アプライド フード バイオテクノロジー インコーポレーテッド
アプライド フード バイオテクノロジー インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アプライド フード バイオテクノロジー インコーポレーテッド, アプライド フード バイオテクノロジー インコーポレーテッド filed Critical アプライド フード バイオテクノロジー インコーポレーテッド
Publication of JP2016519649A publication Critical patent/JP2016519649A/ja
Publication of JP2016519649A5 publication Critical patent/JP2016519649A5/ja
Application granted granted Critical
Publication of JP6461901B2 publication Critical patent/JP6461901B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/86—Addition of bitterness inhibitors
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Birds (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
JP2016500723A 2013-03-15 2014-03-06 ネコ科苦味受容体及び方法 Active JP6461901B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361788528P 2013-03-15 2013-03-15
US61/788,528 2013-03-15
US201461945500P 2014-02-27 2014-02-27
US61/945,500 2014-02-27
PCT/US2014/021110 WO2014149829A1 (en) 2013-03-15 2014-03-06 Feline bitter taste receptors and methods

Publications (3)

Publication Number Publication Date
JP2016519649A JP2016519649A (ja) 2016-07-07
JP2016519649A5 JP2016519649A5 (https=) 2017-04-06
JP6461901B2 true JP6461901B2 (ja) 2019-01-30

Family

ID=50391437

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016500723A Active JP6461901B2 (ja) 2013-03-15 2014-03-06 ネコ科苦味受容体及び方法

Country Status (9)

Country Link
US (2) US9603379B2 (https=)
EP (1) EP2983507B1 (https=)
JP (1) JP6461901B2 (https=)
AU (1) AU2014237801B2 (https=)
BR (1) BR112015023737A2 (https=)
CA (1) CA2903208C (https=)
ES (1) ES2797547T3 (https=)
MX (1) MX2015013013A (https=)
WO (1) WO2014149829A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169311B2 (en) 2013-03-15 2015-10-27 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
WO2022224061A1 (en) * 2021-04-21 2022-10-27 Societe Des Produits Nestle Sa Methods of identifying modulators of receptors over-expressed in circumvallate taste papillae in animals such as cats, methods of using such modulators in food, and foods made by such methods

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5825980B2 (ja) 1976-02-12 1983-05-31 ヤマサ醤油株式会社 サイクリックヌクレオチドの定量法
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
EP1214343A2 (en) 1999-09-10 2002-06-19 The Regents Of The University Of California T2r taste receptor family
US6558910B2 (en) * 1999-09-10 2003-05-06 The Regents Of The University Of California SF, a novel family of taste receptors
AU5125801A (en) 2000-04-07 2001-10-23 Senomyx Inc T2r taste receptors and genes encoding same
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
EP2272957A3 (en) 2002-09-25 2011-08-03 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Bitter taste receptors
AU2003286069A1 (en) 2002-12-18 2004-07-09 Givaudan Sa Chimeric alpha q-gustducin g-proteins
DK2311848T3 (da) 2002-12-23 2013-10-14 Vical Inc Kodon-optimerede polynukleotidbaserede vacciner mod human cytomegalovirus-infektion
WO2004069191A2 (en) 2003-02-03 2004-08-19 Senomyx Inc. Identification of t1r and t2r modulators
US7579453B2 (en) 2003-06-19 2009-08-25 The United States Of America As Represented By The Secretary Of The Dapartment Of Health And Human Services Variants of human taste receptor genes
US7527944B2 (en) 2003-06-27 2009-05-05 Monell Chemical Senses Center Taste receptors of the T1R family from domestic cat
AR046078A1 (es) 2003-08-06 2005-11-23 Senomyx Inc Nuevos sabores, modificadores de sabores, sustancias gustativas, mejoradores de gusto, sustancias gustativas y/o mejoradoras del gusto umani o dulce y uso de los mismos.
US7541158B2 (en) 2004-04-14 2009-06-02 Monell Chemical Senses Center Taste receptors of the T1R family from domestic dog
WO2006053771A2 (en) 2004-11-18 2006-05-26 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Stiftung Des Öffentlichen Rechts Agonists of bitter taste receptors and uses thereof
JP2008537473A (ja) 2005-02-08 2008-09-18 セノミクス・インコーポレーテッド アセトアミノフェン、ラニチジン、ストリキニーネおよびデナトニウムのｐヒトＴ２Ｒ受容体、ならびにヒト苦味調節剤を同定するための関連アッセイ
EP1975611A1 (en) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonists of bitter taste receptors and uses thereof
EP2137322B1 (en) 2007-03-30 2013-02-27 Givaudan SA Methods to identify tas2r modulators
EP1983342A1 (en) 2007-04-18 2008-10-22 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Antogonists of bitter taste receptors and uses thereof
US7932058B2 (en) 2007-06-08 2011-04-26 Senomyx, Inc. Rationale, methods, and assays for identifying human and non-human primate taste specific genes and use thereof in taste modulator and therapeutic screening assays
US8546085B2 (en) 2008-06-13 2013-10-01 Givaudan Sa Methods of identifying modulators of the bitter taste receptor TAS2R44
EP2924112A1 (en) 2009-02-02 2015-09-30 Chromocell Corporation Novel cell lines and methods
US8709745B2 (en) * 2009-07-28 2014-04-29 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Methods for isolating ligands of the human bitter taste receptor TAS2R49
US8673578B2 (en) * 2009-10-27 2014-03-18 Deutsches Institut für Ernahrungsforschung Potsdam-Rehbrücke Methods of identifying antagonists of the hTAS2R46 bitter taste receptor
WO2012013480A1 (en) 2010-07-27 2012-02-02 Specialites Pet Food Methods and compositions for stimulating a felidae t1r receptor.
US9169311B2 (en) 2013-03-15 2015-10-27 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods

Also Published As

Publication number Publication date
EP2983507A1 (en) 2016-02-17
ES2797547T3 (es) 2020-12-02
JP2016519649A (ja) 2016-07-07
US20160015062A1 (en) 2016-01-21
CA2903208A1 (en) 2014-09-25
CA2903208C (en) 2021-05-18
US9603379B2 (en) 2017-03-28
US10174096B2 (en) 2019-01-08
AU2014237801A1 (en) 2015-08-27
AU2014237801B2 (en) 2017-08-10
MX2015013013A (es) 2015-12-01
US20170198022A1 (en) 2017-07-13
BR112015023737A2 (pt) 2017-10-24
WO2014149829A1 (en) 2014-09-25
EP2983507B1 (en) 2020-04-22

Similar Documents

Publication Publication Date Title
JP4339542B2 (ja) Ｔ２ｒ、すなわち味覚受容体の新規ファミリー
RU2146132C1 (ru) Фармацевтическая композиция, активная в отношении рецептора кальция, способ лечения пациента, способ анализа соединения оказывать влияние на активность рецептора неорганического иона, нуклеиновая кислота, кодирующая рецептор, рецептор кальция
JP2009145349A (ja) 新規な苦味受容体ｔ２ｒ７６の同定
TW200904981A (en) Identification of TRPML3 (mcoln3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release
JP2001514879A (ja) カプサイシン受容体およびカプサイシン受容体関連ポリペプチドをコードする核酸配列ならびにその使用
US20090226403A1 (en) Olfactory and pheromones G-protein coupled receptors
RU2712515C2 (ru) Способы
JP6461901B2 (ja) ネコ科苦味受容体及び方法
KR20070053659A (ko) 쓴맛 수용체의 작용제 및 그의 용도
US10295529B2 (en) Feline bitter taste receptors and methods
Pernollet et al. Structural Recognition Between Odorants, Olfactory‐Binding Proteins and Olfactory Receptors‐First Events in Odour Coding
CN101998989A (zh) Trpml3(mcoln3)作为咸味受体的鉴定及在用于鉴定调控钠转运、吸收或排泄和/或醛固酮和/或血管加压素的产生或释放的味觉(咸味)调节剂和/或治疗剂的测定中的用途
CA2406481A1 (en) Trp8, a transient receptor potential channel expressed in taste receptor cells
US20070059688A1 (en) Gastrointestinal chemosensory receptors
AU2017250779B2 (en) Methods for identifying modulators of GPR92
JP2003528634A (ja) 単離ヒトｇタンパク質共役受容体、ヒトｇｐｃｒタンパク質をコード化している核酸分子、及びそれらの使用
Gibbs Bitter taste receptors in the domestic dog (Canis familiaris)
KR20070018987A (ko) 수용체 ｇｐｒ86의 용도
JP2003530834A (ja) 単離した癌原遺伝子サブファミリーに属するヒトｇタンパク質共役受容体、ヒトｇｐｃｒタンパク質をコード化している核酸分子、及びそれらの使用
Deng Department of Cell Physiology
Bredendiek Analysis of the gustatory receptor-mediated signaling cascade in Drosophila

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170303

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170303

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180306

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180606

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180730

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20181204

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20181226

R150 Certificate of patent or registration of utility model

Ref document number: 6461901

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250