JP6457522B2 - グリコールのアシル化における向上した位置選択性 - Google Patents
グリコールのアシル化における向上した位置選択性 Download PDFInfo
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- JP6457522B2 JP6457522B2 JP2016535727A JP2016535727A JP6457522B2 JP 6457522 B2 JP6457522 B2 JP 6457522B2 JP 2016535727 A JP2016535727 A JP 2016535727A JP 2016535727 A JP2016535727 A JP 2016535727A JP 6457522 B2 JP6457522 B2 JP 6457522B2
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/06—Halogens; Compounds thereof
- B01J27/08—Halides
- B01J27/10—Chlorides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0201—Oxygen-containing compounds
- B01J31/0211—Oxygen-containing compounds with a metal-oxygen link
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0215—Sulfur-containing compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0255—Phosphorus containing compounds
- B01J31/0257—Phosphorus acids or phosphorus acid esters
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Description
本出願は、2013年12月19日に出願された米国仮特許出願第61/918,144号の優先権の利益を主張するものであり、その内容を参照によって本明細書に組み込む。
本開示は、ポリマー合成においてモノマーとして有用な特定の環式二官能性材料ならびに中間体化学的化合物に関する。特に、本発明は、1,4:3,6−ジアンヒドロヘキシトールのエステルおよびその調製のための方法に関する。
再生不能な石油化学製品の代用品として大きな可能性をもたらすバイオマス由来の化合物として、1,4:3,6−ジアンヒドロヘキシトールは再生可能な分子実体として高く評価される二環式フラノジオールのクラスである。(便宜上、1,4:3,6−ジアンヒドロヘキシトールは、本明細書において以下「イソヘキシド」と呼ぶ。)上述のとおり、イソヘキシドは、固有のキラル二官能基のため、最近、関心を得ている優れた化学的プラットフォームであり、合成できる既存および新規の両方の誘導体化合物の大幅な拡大を可能にする可能性がある。
Claims (13)
- イソソルビドの酸触媒アシル化のための方法であって、ルイス酸触媒の存在下において反応温度で、対応するモノエステル生成物を少なくとも3.4:1のエキソ/エンド位置選択性比で生成するのに十分な時間、イソソルビドを過剰なカルボン酸と接触させる工程を含み、
前記ルイス酸は、2−エチルヘキサン酸スズ(II)、ジブチル−スズ(II)クロリド、塩化スズ(II)、塩化ハフニウム、ジブチルスズマレアート、塩化チタン(IV)、塩化ジルコニウム(IV)、塩化ビスマス、ランタン(III)トリフラート、酸化ジブチルスズ(IV)、鉄(III)トリフラート、塩化アルミニウム、ビスマストリフラート、ガリウムトリフラート、スカンジウムトリフラートまたはそれらの組み合わせからなる群から選択される、
方法。 - 前記反応温度は150℃〜250℃である、請求項1に記載の方法。
- 前記反応温度は170℃〜220℃である、請求項2に記載の方法。
- 前記反応温度は175℃〜205℃である、請求項3に記載の方法。
- 前記反応時間は24時間未満である、請求項1に記載の方法。
- 前記反応時間は5〜12時間である、請求項5に記載の方法。
- 前記カルボン酸は、C2〜C26に及ぶ炭素鎖長を有するアルカン酸、アルケン酸、アルキン酸および芳香族酸から選択される、請求項1に記載の方法。
- 前記カルボン酸は、前記イソソルビドに対して2倍〜10倍モル過剰で存在する、請求項1に記載の方法。
- 前記カルボン酸は、前記イソソルビドに対して3倍モル過剰で存在する、請求項8に記載の方法。
- 前記エキソ/エンド位置選択性比は、前記ルイス酸触媒に対して3.5:1から3.9:1までの範囲である、請求項1に記載の方法。
- 前記ルイス酸は塩化ジルコニウム(IV)である、請求項1に記載の方法。
- 前記ルイス酸は、前記イソソルビド含有量に対して0.0001重量%から10重量%までの範囲の触媒添加量で存在する、請求項1に記載の方法。
- 前記ルイス酸は、前記イソソルビド含有量に対して3〜8重量%の触媒添加量で存在する、請求項12に記載の方法。
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PCT/US2014/069698 WO2015094894A1 (en) | 2013-12-19 | 2014-12-11 | Enhanced regio-selectivity in glycol acylation |
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DE3028873C2 (de) * | 1980-07-30 | 1983-10-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Herstellung von 1,4 zu 3,6-Dianhydro-D-glucit-5-nitrat (Isosorbid-5-nitrat) |
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US6608167B1 (en) * | 2002-03-26 | 2003-08-19 | E. I. Du Pont De Nemours And Company | Bis(2-hydroxyethyl isosorbide); preparation, polymers derived therefrom, and enduses thereby |
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US8367171B2 (en) * | 2008-11-26 | 2013-02-05 | Valspar Sourcing, Inc. | Polymer having polycyclic groups and coating compositions thereof |
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MX2016007946A (es) | 2016-09-09 |
EP3083636A4 (en) | 2017-05-10 |
BR112016014032A2 (pt) | 2018-01-16 |
AU2014366353A1 (en) | 2016-06-16 |
CA2932296C (en) | 2019-12-17 |
EP3083636A1 (en) | 2016-10-26 |
EP3083636B1 (en) | 2018-09-05 |
US10023586B2 (en) | 2018-07-17 |
CA2932296A1 (en) | 2015-06-25 |
KR20160098488A (ko) | 2016-08-18 |
AU2014366353B2 (en) | 2018-09-20 |
CN106061979B (zh) | 2018-09-28 |
WO2015094894A1 (en) | 2015-06-25 |
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