JP6457386B2 - 抗−ｄｒ５ファミリー抗体、二重特異性又は多価の抗−ｄｒ５ファミリー抗体及びそれらの使用方法 - Google Patents

抗−ｄｒ５ファミリー抗体、二重特異性又は多価の抗−ｄｒ５ファミリー抗体及びそれらの使用方法 Download PDF

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JP6457386B2
JP6457386B2 JP2015520954A JP2015520954A JP6457386B2 JP 6457386 B2 JP6457386 B2 JP 6457386B2 JP 2015520954 A JP2015520954 A JP 2015520954A JP 2015520954 A JP2015520954 A JP 2015520954A JP 6457386 B2 JP6457386 B2 JP 6457386B2
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seq
sequence
polypeptide
antibody
cdr1
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JP2015527992A (ja
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ブリジット フェルナンド ベルモ−デスロシェ クローディーヌ
ブリジット フェルナンド ベルモ−デスロシェ クローディーヌ
フレデリック スビジェル オリビエ
フレデリック スビジェル オリビエ
フランソワーズ ジャンヌ−マリー ブルダン ローレンス
フランソワーズ ジャンヌ−マリー ブルダン ローレンス
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ゲンマブ ホールディング ベスローテン フェンノートシャップ
ゲンマブ ホールディング ベスローテン フェンノートシャップ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2015520954A 2012-07-09 2013-07-09 抗−ｄｒ５ファミリー抗体、二重特異性又は多価の抗−ｄｒ５ファミリー抗体及びそれらの使用方法 Active JP6457386B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12305821.6A EP2684896A1 (en) 2012-07-09 2012-07-09 Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof
EP12305821.6 2012-07-09
US201261669866P 2012-07-10 2012-07-10
US61/669866 2012-07-10
PCT/EP2013/064466 WO2014009358A1 (en) 2012-07-09 2013-07-09 Anti-dr5 family antibodies, bispecific or multivalent anti-dr5 family antibodies and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2015527992A JP2015527992A (ja) 2015-09-24
JP6457386B2 true JP6457386B2 (ja) 2019-01-23

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JP2015520954A Active JP6457386B2 (ja) 2012-07-09 2013-07-09 抗−ｄｒ５ファミリー抗体、二重特異性又は多価の抗−ｄｒ５ファミリー抗体及びそれらの使用方法

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US (4) US9611327B2 (enExample)
EP (3) EP2684896A1 (enExample)
JP (1) JP6457386B2 (enExample)
CN (1) CN104619725B (enExample)
BR (1) BR112015000449B1 (enExample)
CA (1) CA2878790C (enExample)
DK (1) DK2877491T3 (enExample)
ES (1) ES2727486T3 (enExample)
IL (2) IL236651B (enExample)
IN (1) IN2015DN00143A (enExample)
PL (1) PL2877491T3 (enExample)
PT (1) PT2877491T (enExample)
SG (2) SG11201500177PA (enExample)
SI (1) SI2877491T1 (enExample)
WO (1) WO2014009358A1 (enExample)

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HK1247215A1 (zh) 2015-01-26 2018-09-21 Macrogenics, Inc. 包含dr5-结合结构域的多价分子
EP3112381A1 (en) * 2015-07-01 2017-01-04 FONDAZIONE IRCCS Istituto Nazionale dei Tumori Bispecific antibodies for use in cancer immunotherapy
AU2016291701B2 (en) * 2015-07-16 2022-09-29 Inhibrx Biosciences, Inc. Multivalent and multispecific DR5-binding fusion proteins
US20190202926A1 (en) * 2015-12-01 2019-07-04 Genmab B.V. Anti-death receptor antibodies and methods of use thereof
CN106397594B (zh) * 2016-10-25 2019-06-04 中国药科大学 一种全人源的抗人死亡受体5的激动剂单链抗体及应用
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EP3360898A1 (en) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
MA47449A (fr) 2017-02-10 2019-12-18 Genmab Bv Variants polypeptidiques et ses utilisations
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MA49259A (fr) 2017-06-07 2020-04-15 Genmab Bv Anticorps thérapeutiques à base d'hexamères d'igg mutées
EP3743440A1 (en) 2018-01-24 2020-12-02 Genmab B.V. Polypeptide variants and uses thereof
AU2019224136A1 (en) * 2018-02-26 2020-09-10 Igm Biosciences, Inc. Use of a multimeric anti-DR5 binding molecule in combination with a chemotherapeutic agent for treating cancer
US12338289B2 (en) 2018-05-03 2025-06-24 Genmab B.V. Antibody variant combinations and uses thereof
US12247075B2 (en) * 2018-12-26 2025-03-11 Imcheck Therapeutics Sas BTN3A binding proteins and uses thereof
MA55881A (fr) 2019-05-09 2022-03-16 Genmab Bv Schémas posologiques pour une combinaison d'anticorps anti-dr5 destinés à être utilisés dans le traitement du cancer
EP4055046A1 (en) 2019-11-06 2022-09-14 Genmab B.V. Antibody variant combinations and uses thereof
JP2023534726A (ja) 2020-07-23 2023-08-10 ジェンマブ ビー．ブイ． 多発性骨髄腫の治療に使用するための抗ｄｒ５抗体と免疫調節イミド薬との併用
US20250215104A1 (en) * 2022-03-02 2025-07-03 Walden Biosciences, Inc. Novel soluble urokinase plasminogen activator receptor (supar) binding molecules and uses thereof

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Publication number Publication date
CN104619725A (zh) 2015-05-13
EP2877491B1 (en) 2019-02-27
IL236651B (en) 2019-10-31
US20150139997A1 (en) 2015-05-21
DK2877491T3 (da) 2019-06-03
SG11201500177PA (en) 2015-03-30
PL2877491T3 (pl) 2020-01-31
US10647774B2 (en) 2020-05-12
HK1211044A1 (en) 2016-05-13
CA2878790C (en) 2023-09-26
SI2877491T1 (sl) 2019-08-30
BR112015000449B1 (pt) 2022-12-20
US9611327B2 (en) 2017-04-04
CN104619725B (zh) 2019-04-23
EP3575323B1 (en) 2024-09-11
WO2014009358A1 (en) 2014-01-16
IL269527B (en) 2021-12-01
CA2878790A1 (en) 2014-01-16
SG10201700148UA (en) 2017-02-27
BR112015000449A2 (enExample) 2017-08-15
IL269527A (en) 2019-11-28
JP2015527992A (ja) 2015-09-24
PT2877491T (pt) 2019-06-07
EP2684896A1 (en) 2014-01-15
US20200332016A1 (en) 2020-10-22
EP3575323A1 (en) 2019-12-04
EP2877491A1 (en) 2015-06-03
ES2727486T3 (es) 2019-10-16
US20170260281A1 (en) 2017-09-14
IN2015DN00143A (enExample) 2015-06-12
US20240141057A1 (en) 2024-05-02
IL236651A0 (en) 2015-02-26

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