JP6449849B2 - 転移のインヒビター - Google Patents

転移のインヒビター Download PDF

Info

Publication number
JP6449849B2
JP6449849B2 JP2016506681A JP2016506681A JP6449849B2 JP 6449849 B2 JP6449849 B2 JP 6449849B2 JP 2016506681 A JP2016506681 A JP 2016506681A JP 2016506681 A JP2016506681 A JP 2016506681A JP 6449849 B2 JP6449849 B2 JP 6449849B2
Authority
JP
Japan
Prior art keywords
seq
peptide
cancer
mans
marcks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2016506681A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016516756A5 (cg-RX-API-DMAC7.html
JP2016516756A (ja
Inventor
パリク,インドゥー
アドラー,ケネス・ビー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
North Carolina State University
Original Assignee
North Carolina State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by North Carolina State University filed Critical North Carolina State University
Publication of JP2016516756A publication Critical patent/JP2016516756A/ja
Publication of JP2016516756A5 publication Critical patent/JP2016516756A5/ja
Application granted granted Critical
Publication of JP6449849B2 publication Critical patent/JP6449849B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Virology (AREA)
JP2016506681A 2013-04-05 2014-04-07 転移のインヒビター Expired - Fee Related JP6449849B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361808966P 2013-04-05 2013-04-05
US61/808,966 2013-04-05
PCT/US2014/033206 WO2014165853A1 (en) 2013-04-05 2014-04-07 Inhibitors of metastasis

Publications (3)

Publication Number Publication Date
JP2016516756A JP2016516756A (ja) 2016-06-09
JP2016516756A5 JP2016516756A5 (cg-RX-API-DMAC7.html) 2017-05-25
JP6449849B2 true JP6449849B2 (ja) 2019-01-09

Family

ID=51654619

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016506681A Expired - Fee Related JP6449849B2 (ja) 2013-04-05 2014-04-07 転移のインヒビター

Country Status (19)

Country Link
US (4) US9408886B2 (cg-RX-API-DMAC7.html)
EP (1) EP2981279B1 (cg-RX-API-DMAC7.html)
JP (1) JP6449849B2 (cg-RX-API-DMAC7.html)
KR (1) KR102191695B1 (cg-RX-API-DMAC7.html)
CN (1) CN105517562B (cg-RX-API-DMAC7.html)
AU (1) AU2014247979B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015025398A2 (cg-RX-API-DMAC7.html)
CA (1) CA2908832C (cg-RX-API-DMAC7.html)
DK (1) DK2981279T3 (cg-RX-API-DMAC7.html)
ES (1) ES2714863T3 (cg-RX-API-DMAC7.html)
HU (1) HUE043971T2 (cg-RX-API-DMAC7.html)
IL (1) IL241937B (cg-RX-API-DMAC7.html)
MX (1) MX363077B (cg-RX-API-DMAC7.html)
PL (1) PL2981279T3 (cg-RX-API-DMAC7.html)
PT (1) PT2981279T (cg-RX-API-DMAC7.html)
RU (1) RU2681213C2 (cg-RX-API-DMAC7.html)
SG (2) SG10201708125PA (cg-RX-API-DMAC7.html)
WO (1) WO2014165853A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201508010B (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2681213C2 (ru) 2013-04-05 2019-03-05 Байомарк Фармасьютикалз, Лтд. Ингибиторы метастазирования
CN108686220A (zh) * 2018-07-13 2018-10-23 刘慧荣 一种针对甲状腺癌的抗肿瘤剂

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8501911B2 (en) 1999-02-24 2013-08-06 Biomarck Pharmaceuticals, Ltd Methods of reducing inflammation and mucus hypersecretion
US7544772B2 (en) * 2001-06-26 2009-06-09 Biomarck Pharmaceuticals, Ltd. Methods for regulating inflammatory mediators and peptides useful therein
US7265088B1 (en) 2000-02-24 2007-09-04 North Carolina State University Method and compositions for altering mucus secretion
AU2002322475B2 (en) 2001-06-26 2008-02-21 North Carolina State University Blocking peptide for inflammatory cell secretion
AU2002362753B9 (en) * 2001-10-05 2008-05-15 The Trustees Of The University Of Pennsylvania Compositions for and methods of treating and preventing sirs/sepsis
DE60308251T2 (de) 2002-04-17 2007-08-30 Canon K.K. Vorrichtung zur Bereitstellung von öffentlichen Schlüsselzertifikaten
US7524926B2 (en) 2005-01-20 2009-04-28 Biomarck Pharmaceuticals, Ltd. Mucin hypersecretion inhibitors and methods of use
WO2006086681A2 (en) * 2005-02-09 2006-08-17 Beth Israel Deaconess Medical Center, Inc. Methods of inhibiting smooth muscle cell migration and proliferation
PT2053915E (pt) * 2006-07-26 2014-08-25 Biomarck Pharmaceuticals Ltd Peptídeos para atenuar a libertação de mediadores inflamatórios
EP2069477A4 (en) 2006-10-06 2010-12-08 Celtaxsys Inc CHEMICAL REPULSION OF CELLS
EP2078204A2 (en) * 2006-10-27 2009-07-15 George Mason Intellectual Properties, Inc. Assay for metastatic colorectal cancer
WO2009062128A2 (en) * 2007-11-08 2009-05-14 Indiana University Research And Technology Corporation Combination drug therapy for the treatment of cancer
EP2105511A1 (en) * 2008-03-28 2009-09-30 Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. Medicament compositions and substances for treatment and identifying adenocarcinoma of the lung
US9073974B2 (en) * 2009-12-21 2015-07-07 The Regents Of The University Of California RGD-containing cyclic peptides
JP6225104B2 (ja) * 2011-04-08 2017-11-01 タフツ メディカル センター インコーポレイテッドTufts Medical Center,Inc. ペプデューシンの設計および使用
RU2681213C2 (ru) 2013-04-05 2019-03-05 Байомарк Фармасьютикалз, Лтд. Ингибиторы метастазирования

Also Published As

Publication number Publication date
RU2015146997A (ru) 2017-05-15
CA2908832A1 (en) 2014-10-09
AU2014247979A1 (en) 2015-10-29
EP2981279A4 (en) 2016-11-09
ES2714863T3 (es) 2019-05-30
MX363077B (es) 2019-03-07
KR20150140736A (ko) 2015-12-16
US9408886B2 (en) 2016-08-09
SG10201708125PA (en) 2017-11-29
CN105517562B (zh) 2018-12-28
ZA201508010B (en) 2017-01-25
RU2015146997A3 (cg-RX-API-DMAC7.html) 2018-03-13
US20210130403A1 (en) 2021-05-06
WO2014165853A1 (en) 2014-10-09
AU2014247979B2 (en) 2018-06-28
US11466054B2 (en) 2022-10-11
US20140302057A1 (en) 2014-10-09
NZ712955A (en) 2021-03-26
US20190119320A1 (en) 2019-04-25
PL2981279T3 (pl) 2019-09-30
HUE043971T2 (hu) 2019-09-30
EP2981279A1 (en) 2016-02-10
JP2016516756A (ja) 2016-06-09
KR102191695B1 (ko) 2020-12-16
CN105517562A (zh) 2016-04-20
EP2981279B1 (en) 2018-12-19
US10683328B2 (en) 2020-06-16
MX2015014036A (es) 2016-02-25
IL241937B (en) 2019-03-31
BR112015025398A2 (pt) 2017-10-10
HK1221159A1 (en) 2017-05-26
DK2981279T3 (en) 2019-03-25
PT2981279T (pt) 2019-03-14
US10011636B2 (en) 2018-07-03
US20170121369A1 (en) 2017-05-04
RU2681213C2 (ru) 2019-03-05
SG11201508249WA (en) 2015-11-27
CA2908832C (en) 2023-01-24

Similar Documents

Publication Publication Date Title
JP6730285B2 (ja) Rna干渉組成物及び悪性腫瘍のための方法
WO2021098679A1 (zh) Fak抑制剂在制备用于治疗nras突变的肿瘤的药物中的用途
CN106659758A (zh) 用于免疫调节的组合物和方法
US11466054B2 (en) Inhibitors of metastasis
AU2016270710A1 (en) Enhancing the therapeutic activity of an immune checkpoint inhibitor
TWI609692B (zh) 新穎stip1多肽及其用途
ES2843724T3 (es) Antagonistas de NMDAR para el tratamiento de la angiogénesis tumoral
US12201671B2 (en) Polypeptides for treatment of cancer
HK1221159B (en) Mareks inhibitor peptides for inhibiting metastasis
TW202031271A (zh) 用於惡性腫瘤之rna干擾輸送配方及方法
US20190290728A1 (en) Methods related to breaking t cell exhaustion
WO2025250689A1 (en) Combination therapy with angiogenesis protein and immune checkpoint inhibitor with/without chemotherapeutics
ES2338400A1 (es) Conjunto de moleculas antiangiogenicas y su uso.
US10413564B2 (en) Compositions and methods for combating drug-resistant cancers
US20220249545A1 (en) Platinum-Based Chemotherapy, Mast Binding Agents, Glucocorticoid Receptor (GR) Binding Agents, and/or HSP90 Binding Agents for Uses in Treating Cancer
Friesel et al. Jacquelyn, J. Ames, Liangru Contois, Jennifer M. Caron, Eric Tweedie, Xuehui Yang, Robert
NZ712955B2 (en) Inhibitors of metastasis

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170406

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170406

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180109

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180406

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180626

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180925

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20181120

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20181206

R150 Certificate of patent or registration of utility model

Ref document number: 6449849

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees