JP6448366B2 - ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 - Google Patents

ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 Download PDF

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JP6448366B2
JP6448366B2 JP2014513785A JP2014513785A JP6448366B2 JP 6448366 B2 JP6448366 B2 JP 6448366B2 JP 2014513785 A JP2014513785 A JP 2014513785A JP 2014513785 A JP2014513785 A JP 2014513785A JP 6448366 B2 JP6448366 B2 JP 6448366B2
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skq1
skq1h
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pharmaceutical
ascorbic acid
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JP2014515407A5 (enExample
JP2014515407A (ja
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マキシム ブイ． スクラチェフ
マキシム ブイ． スクラチェフ
ウラジミール ピー． スクラチェフ
ウラジミール ピー． スクラチェフ
アンドレイ エー． ザミャートニン
アンドレイ エー． ザミャートニン
エウゲニー エス． エフレーモフ
エウゲニー エス． エフレーモフ
ヴァディム エヌ． タシュリテスキ
ヴァディム エヌ． タシュリテスキ
ローマン エイ． ジノフキン
ローマン エイ． ジノフキン
マキシム ブイ． エゴロフ
マキシム ブイ． エゴロフ
ローレンス ティー． フリードホフ
ローレンス ティー． フリードホフ
オルガ ワイ． プレツシュキナ
オルガ ワイ． プレツシュキナ
アレクサンドル エイ． アンドレエフ‐アンドレエフスキー
アレクサンドル エイ． アンドレエフ‐アンドレエフスキー
タチアナ ブイ． ジネビッチ
タチアナ ブイ． ジネビッチ
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ミトテック ソシエテ アノニム
ミトテック ソシエテ アノニム
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • C07F9/28—Phosphorus compounds with one or more P—C bonds
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  • Dermatology (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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JP2014513785A 2011-06-03 2012-06-04 ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用 Active JP6448366B2 (ja)

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US201161492940P 2011-06-03 2011-06-03
US61/492,940 2011-06-03
PCT/US2012/040711 WO2012167236A1 (en) 2011-06-03 2012-06-04 Oral formulations of mitochondrially-targeted antioxidants and their preparation and use

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JP2014515407A5 JP2014515407A5 (enExample) 2015-07-02
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JP2017196849A Active JP6461276B2 (ja) 2011-06-03 2017-10-10 ミトコンドリアを標的とする抗酸化剤の経口製剤ならびにそれらの調製および使用

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US (2) US9192676B2 (enExample)
EP (1) EP2714024B1 (enExample)
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CN (1) CN103764132B (enExample)
AU (1) AU2012261854B2 (enExample)
BR (1) BR112013030605A2 (enExample)
CA (1) CA2837437C (enExample)
EA (1) EA031399B1 (enExample)
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WO2014116591A2 (en) * 2013-01-22 2014-07-31 Mitotech Sa Pharmaceutical formulations containing mitochondrially-targeted antioxidants
EP3030267A2 (en) * 2013-04-11 2016-06-15 Mitotech SA Mitochondrially-targeted timoquinones and toluquinones
EP3116470B1 (en) * 2014-02-25 2019-05-08 Mitotech SA Cosmetic compositions of mitochondrially targeted antioxidants
WO2019139831A1 (en) * 2018-01-10 2019-07-18 Dana-Farber Cancer Institute, Inc. Methods for identification, assessment, prevention, and treatment of metabolic disorders using succinate
EP4072512A4 (en) * 2019-12-10 2024-01-10 Mitotech S.A. POLYMER MATRICES FOR VARIOUS COMPOSITIONS OF MITOCHONDRIALLY DIRECTED ANTIOXIDANTS
JP2023520698A (ja) * 2020-04-03 2023-05-18 ミトテック ソシエテ アノニム 重度の炎症状態を処置するためのミトコンドリア標的抗酸化物質の使用
CN114344274A (zh) * 2022-01-05 2022-04-15 盖茨汉普(武汉)植物应用研究有限公司 一种Mitoq抗氧化硬胶囊配方及制备工艺
AU2024359416A1 (en) * 2023-10-11 2026-05-28 Mitotech S.A. Mitochondria-targeted antioxidants for use in the treatment of cell balloooning-associated diseases, such as non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash)

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JP6461276B2 (ja) 2019-01-30
US20150025043A1 (en) 2015-01-22
EP2714024A1 (en) 2014-04-09
CN103764132B (zh) 2017-04-12
US9192676B2 (en) 2015-11-24
CA2837437C (en) 2020-12-15
CN103764132A (zh) 2014-04-30
US9572890B2 (en) 2017-02-21
BR112013030605A2 (pt) 2016-12-13
EP2714024A4 (en) 2014-12-31
CA2837437A1 (en) 2012-12-06
US20160038603A1 (en) 2016-02-11
WO2012167236A1 (en) 2012-12-06
EA031399B1 (ru) 2018-12-28
ES2704064T3 (es) 2019-03-14
JP2014515407A (ja) 2014-06-30
EA201301321A1 (ru) 2014-11-28
EP2714024B1 (en) 2018-10-03
AU2012261854B2 (en) 2017-11-16

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