JP6434487B2 - 炎症を伴う疾患の治療のためのデスエチルヒドロキシクロロキン - Google Patents

炎症を伴う疾患の治療のためのデスエチルヒドロキシクロロキン Download PDF

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JP6434487B2
JP6434487B2 JP2016503137A JP2016503137A JP6434487B2 JP 6434487 B2 JP6434487 B2 JP 6434487B2 JP 2016503137 A JP2016503137 A JP 2016503137A JP 2016503137 A JP2016503137 A JP 2016503137A JP 6434487 B2 JP6434487 B2 JP 6434487B2
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disease
dhcq
inflammatory
treatment
hcq
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JP2016518338A5 (enExample
JP2016518338A (ja
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エイチ． ロビンソン，ウイリアム
エイチ． ロビンソン，ウイリアム
ソコラブ，ジェレミー
ワン，チャン
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/12—Antivirals
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    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P35/00—Antineoplastic agents
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
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  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
JP2016503137A 2013-03-15 2014-03-14 炎症を伴う疾患の治療のためのデスエチルヒドロキシクロロキン Expired - Fee Related JP6434487B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791320P 2013-03-15 2013-03-15
US61/791,320 2013-03-15
PCT/US2014/029557 WO2014144944A1 (en) 2013-03-15 2014-03-14 Desethylhydroxychloroquine for the treatment of diseases associated with inflammation

Publications (3)

Publication Number Publication Date
JP2016518338A JP2016518338A (ja) 2016-06-23
JP2016518338A5 JP2016518338A5 (enExample) 2017-04-06
JP6434487B2 true JP6434487B2 (ja) 2018-12-05

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JP2016503137A Expired - Fee Related JP6434487B2 (ja) 2013-03-15 2014-03-14 炎症を伴う疾患の治療のためのデスエチルヒドロキシクロロキン

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US (3) US9616057B2 (enExample)
EP (1) EP2967062A4 (enExample)
JP (1) JP6434487B2 (enExample)
CN (2) CN108434138A (enExample)
WO (1) WO2014144944A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6434487B2 (ja) * 2013-03-15 2018-12-05 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 炎症を伴う疾患の治療のためのデスエチルヒドロキシクロロキン
US11501863B2 (en) 2015-04-09 2022-11-15 Diane R. MOULD Systems and methods for patient-specific dosing
WO2017189686A1 (en) * 2016-04-27 2017-11-02 The Board Of Regents Of The University Of Texas System Nurr1 activation in the treatment of metabolic disorders and as an exercise mimetic
CN108095767B (zh) * 2018-01-19 2020-10-02 无锡海斯凯尔医学技术有限公司 组织炎症活动度检测装置
US20200321096A1 (en) * 2019-03-08 2020-10-08 Diane R. MOULD Systems and methods for drug-agnostic patient-specific dosing regimens
GB2594918A (en) * 2020-03-30 2021-11-17 Blackhawk Partners Ltd A pharmaceutical composition comprising hydroxychloroquine, chloroquine, or metabolite thereof
EP3892275A1 (en) * 2020-04-08 2021-10-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Aerosolization of hcq or its metabolites for the treatment of lung infections
US20230398068A1 (en) * 2020-09-14 2023-12-14 Philip Morris Products S.A. Pharmaceutical composition comprising chloroquine and uses thereof
WO2022113887A1 (ja) * 2020-11-27 2022-06-02 京都府公立大学法人 炎症性網膜疾患の判定方法、炎症性網膜疾患治療剤、及び炎症性網膜疾患治療剤のスクリーニング方法
JP2021051776A (ja) * 2020-12-15 2021-04-01 株式会社トプコン 医療情報処理システム及び医療情報処理方法
WO2022256426A1 (en) * 2021-06-04 2022-12-08 Genovate Biotechnology Co. Ltd. Treatment of antiphospholipid syndrome using s-hydroxychloroquine
CN114689770A (zh) * 2022-03-02 2022-07-01 上海长征医院 直接检测尿液中羟氯喹及其三种代谢产物的方法及检测试剂盒
CN115068478B (zh) * 2022-07-22 2024-01-09 上海医药工业有限公司 磷酸萘酚喹在制备治疗自身免疫性疾病药物中的应用

Family Cites Families (18)

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CA784722A (en) * 1968-05-07 W. Dennis Emery Desethylhydroxychloroquine as an anti-inflammatory agent
US341592A (en) * 1886-05-11 Eeubex a
US3019169A (en) * 1958-06-23 1962-01-30 Sterling Drug Inc Salicylate dry shell coating of dry 4-aminoquinoline core, and dry-compressing tablet-making process
US3415932A (en) 1965-05-18 1968-12-10 Sterling Drug Inc 7 - chloro - 4 - [4-(2-hydroxyethylamino)-1-methylbutylamino]quinoline; anti-inflammatory compositions and method using same
US20040229908A1 (en) * 1999-07-13 2004-11-18 Jodi Nelson Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias
US20060014786A1 (en) * 2002-05-17 2006-01-19 Rajeev Raut Opthalmic pharmaceutical compositions and methods for treating ocular inflammation
US20070003636A1 (en) 2003-01-22 2007-01-04 Francois Mach Statins (HMG-COA reductase inhibitors) as a novel type of immunomodulator, immunosuppressor and anti-inflammatory agent
US7410975B2 (en) * 2003-06-20 2008-08-12 Coley Pharmaceutical Group, Inc. Small molecule toll-like receptor (TLR) antagonists
US20050026979A1 (en) * 2003-07-31 2005-02-03 Maha Ghazzi Methods for treating inflammation and inflammation-associated diseases with a statin and ether
US8440695B2 (en) 2005-11-09 2013-05-14 St Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome
FR2898057B1 (fr) * 2006-03-06 2008-07-04 Centre Nat Rech Scient Utilisation de composes derives de l'adenine pour le traitement de lupus
US20080044390A1 (en) 2006-08-11 2008-02-21 Xiaowei Jin Methods and compositions for the treatment of neurodegenerative disorders
EP3087988A3 (en) * 2008-10-06 2017-03-01 Idera Pharmaceuticals, Inc. Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
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US20120202849A1 (en) 2009-10-12 2012-08-09 Anil Pareek Pharmaceutical compositions for the treatment/prophylaxis of non-alcoholic fatty liver disease
KR101813482B1 (ko) * 2010-11-24 2017-12-29 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 시크리터리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비시스 루푸스의 치료 또는 예방을 위한 조성물 및 방법
WO2014031769A2 (en) 2012-08-21 2014-02-27 The Board Of Trustees Of The Leland Stanford Junior University Treatment of diseases associated with inflammation
JP6434487B2 (ja) * 2013-03-15 2018-12-05 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 炎症を伴う疾患の治療のためのデスエチルヒドロキシクロロキン

Also Published As

Publication number Publication date
CN105228453A (zh) 2016-01-06
US20170172998A1 (en) 2017-06-22
WO2014144944A1 (en) 2014-09-18
EP2967062A1 (en) 2016-01-20
US9616057B2 (en) 2017-04-11
CN108434138A (zh) 2018-08-24
JP2016518338A (ja) 2016-06-23
US9931335B2 (en) 2018-04-03
US20140275164A1 (en) 2014-09-18
US20180311231A1 (en) 2018-11-01
EP2967062A4 (en) 2016-10-19
CN105228453B (zh) 2018-05-22

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