JP6433490B2 - シリカハイドロゲルコンポジット - Google Patents

シリカハイドロゲルコンポジット Download PDF

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Publication number
JP6433490B2
JP6433490B2 JP2016520558A JP2016520558A JP6433490B2 JP 6433490 B2 JP6433490 B2 JP 6433490B2 JP 2016520558 A JP2016520558 A JP 2016520558A JP 2016520558 A JP2016520558 A JP 2016520558A JP 6433490 B2 JP6433490 B2 JP 6433490B2
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Prior art keywords
silica
microparticles
sol
composite
hydrogel
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JP2016520558A
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English (en)
Japanese (ja)
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JP2016522243A5 (enExample
JP2016522243A (ja
Inventor
ヨキネン、ミカ
ヤロネン、ハリー
ホルスバク、アリ−ペッカ
Original Assignee
デルシテク オサケ ユキチュア
デルシテク オサケ ユキチュア
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Publication of JP2016522243A5 publication Critical patent/JP2016522243A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0073—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form semi-solid, gel, hydrogel, ointment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicon Compounds (AREA)
JP2016520558A 2013-06-24 2014-06-18 シリカハイドロゲルコンポジット Active JP6433490B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20135685 2013-06-24
FI20135685 2013-06-24
PCT/FI2014/050492 WO2014207304A1 (en) 2013-06-24 2014-06-18 Silica hydrogel composite

Publications (3)

Publication Number Publication Date
JP2016522243A JP2016522243A (ja) 2016-07-28
JP2016522243A5 JP2016522243A5 (enExample) 2017-07-20
JP6433490B2 true JP6433490B2 (ja) 2018-12-05

Family

ID=51178958

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016520558A Active JP6433490B2 (ja) 2013-06-24 2014-06-18 シリカハイドロゲルコンポジット

Country Status (14)

Country Link
US (1) US9949922B2 (enExample)
EP (1) EP3013317B1 (enExample)
JP (1) JP6433490B2 (enExample)
CN (1) CN105451713B (enExample)
AU (1) AU2014300888B2 (enExample)
CA (1) CA2912483C (enExample)
DK (1) DK3013317T3 (enExample)
ES (1) ES2768606T3 (enExample)
HR (1) HRP20200134T1 (enExample)
HU (1) HUE047897T2 (enExample)
LT (1) LT3013317T (enExample)
PL (1) PL3013317T3 (enExample)
PT (1) PT3013317T (enExample)
WO (1) WO2014207304A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
MX2018004797A (es) 2015-10-22 2018-09-06 Delsitech Oy Formulacion de liberacion prolongada a base de un compuesto de hidrogel.
FI20155779A7 (fi) * 2015-10-30 2017-05-01 Solani Therapeutics Ltd Ei-steroidaalisen anti-inflammatorisen lääkkeen hidastetusti vapautuva annostelu
US11772061B2 (en) * 2016-11-30 2023-10-03 Brown University Methods of fabricating hyper compliant polymer particles and methods of use and compositions
CN111770763A (zh) * 2018-01-23 2020-10-13 埃森德生物制药有限公司 增强型病毒递送制剂
JP2021531328A (ja) 2018-06-19 2021-11-18 セラ セラピューティクス エルエルシー 神経栄養剤、アポトーシスシグナリング断片化阻害剤（ＦＡＳ）もしくはＦＡＳリガンド（ＦＡＳＬ）阻害剤、腫瘍壊死因子α（ＴＮＦ−α）もしくはＴＮＦ受容体阻害剤、ミトコンドリアペプチド、オリゴヌクレオチド、ケモカイン阻害剤、またはシステイン−アスパラギン酸プロテアーゼを含む薬剤送達系
US20210121534A1 (en) 2018-06-19 2021-04-29 Cella Therapeutics, Llc Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a cnp compound, an npr-b compound, a tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension
KR20200051916A (ko) * 2018-11-05 2020-05-14 주식회사 메디포럼제약 고세렐린을 포함하는 실리카 하이드로겔 조성물
EP4009857B1 (en) 2019-08-06 2025-08-20 DOSE Medical Corporation Bioerodible cross-linked hydrogel implants and related methods of use
CN111443012B (zh) * 2020-04-09 2021-07-20 华南理工大学 基于复合波等变率温度扫描流变的聚合物凝胶点表征方法
WO2021250626A2 (en) 2020-06-12 2021-12-16 Glaxosmithkline Biologicals Sa Dock tag system
JP2023532778A (ja) * 2020-07-07 2023-07-31 デルシテック オサケユイチア シリカハイドロゲルコンポジットおよびその使用
CN116322778A (zh) * 2020-10-01 2023-06-23 斯坦德米洛克斯制药公司 水凝胶材料
EP4580600A1 (en) 2022-09-01 2025-07-09 Optifye Therapeutics AG Ophthalmic compositions
WO2024256756A1 (en) 2023-06-15 2024-12-19 Delsitech Oy Injectable composite depot

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ297042B6 (cs) * 1996-05-29 2006-08-16 Delsitechoy Dodávkové zarízení pro pomalé uvolnování biologicky úcinného cinidla, jeho pouzití a farmaceutický prostredek s jeho obsahem
DE10301669A1 (de) * 2003-01-17 2004-07-29 Gesellschaft zur Förderung von Medizin-, Bio- und Umwelttechnologien e.V. Bioaktive keramische Kompositmaterialien und Verfahren zu deren Herstellung
US10149825B2 (en) 2004-02-27 2018-12-11 Delsitech Oy Method for preparing adjustably bioresorbable sol-gel derived SiO2
GB0420016D0 (en) * 2004-09-09 2004-10-13 Leuven K U Res & Dev Controlled release oral delivery system
EP2023893B1 (en) 2006-05-23 2018-03-14 DelSiTech Oy Method for storing silica-based material
FI20070174A0 (fi) 2007-02-28 2007-02-28 Delsitech Oy Menetelmä silikakoostumusten valmistamiseksi, silikakoostumukset ja niiden käytöt
US20090324695A1 (en) 2008-05-30 2009-12-31 Paul Ducheyne Biocompatible polymer ceramic composite matrices
KR101068873B1 (ko) 2008-11-28 2011-09-30 연세대학교 산학협력단 바이오마커가 고정된 실리카 나노입자를 함유하는 하이드로젤 및 그 제조방법
US9987225B2 (en) 2009-09-30 2018-06-05 Ottawa Hospital Research Institute Crosslinked hydrogels and related method of preparation

Also Published As

Publication number Publication date
AU2014300888B2 (en) 2019-01-17
CA2912483C (en) 2021-06-15
EP3013317B1 (en) 2019-12-04
PT3013317T (pt) 2020-02-19
DK3013317T3 (da) 2020-02-17
AU2014300888A1 (en) 2015-12-10
ES2768606T3 (es) 2020-06-23
WO2014207304A1 (en) 2014-12-31
CN105451713A (zh) 2016-03-30
EP3013317A1 (en) 2016-05-04
CN105451713B (zh) 2019-04-23
US9949922B2 (en) 2018-04-24
CA2912483A1 (en) 2014-12-31
HUE047897T2 (hu) 2020-05-28
HRP20200134T1 (hr) 2020-08-21
PL3013317T3 (pl) 2020-05-18
US20160136088A1 (en) 2016-05-19
JP2016522243A (ja) 2016-07-28
LT3013317T (lt) 2020-03-10

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