JP6431082B2 - Ｆｇｆ−１８化合物の投与計画 - Google Patents

Ｆｇｆ−１８化合物の投与計画 Download PDF

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Publication number
JP6431082B2
JP6431082B2 JP2016553284A JP2016553284A JP6431082B2 JP 6431082 B2 JP6431082 B2 JP 6431082B2 JP 2016553284 A JP2016553284 A JP 2016553284A JP 2016553284 A JP2016553284 A JP 2016553284A JP 6431082 B2 JP6431082 B2 JP 6431082B2
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Prior art keywords
cartilage
fgf
pharmaceutical composition
weeks
administered
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Japanese (ja)
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JP2017507142A (ja
JP2017507142A5 (enExample
Inventor
ハー．ラーデル クリストフ
ハー．ラーデル クリストフ
ゲーリング ハンス
ゲーリング ハンス
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Merck Patent GmbH
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Merck Patent GmbH
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2006—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016553284A 2014-02-20 2015-02-20 Ｆｇｆ−１８化合物の投与計画 Active JP6431082B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14000600 2014-02-20
EP14000600.8 2014-02-20
PCT/EP2015/053631 WO2015124731A1 (en) 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen

Publications (3)

Publication Number Publication Date
JP2017507142A JP2017507142A (ja) 2017-03-16
JP2017507142A5 JP2017507142A5 (enExample) 2018-03-01
JP6431082B2 true JP6431082B2 (ja) 2018-11-28

Family

ID=50151088

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016553284A Active JP6431082B2 (ja) 2014-02-20 2015-02-20 Ｆｇｆ−１８化合物の投与計画
JP2016553329A Active JP6431083B2 (ja) 2014-02-20 2015-02-20 Ｆｇｆ−１８化合物の投与計画

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016553329A Active JP6431083B2 (ja) 2014-02-20 2015-02-20 Ｆｇｆ−１８化合物の投与計画

Country Status (25)

Country Link
US (2) US9889179B2 (enExample)
EP (2) EP3119417B1 (enExample)
JP (2) JP6431082B2 (enExample)
KR (2) KR102410986B1 (enExample)
CN (2) CN106232622A (enExample)
AR (2) AR099510A1 (enExample)
AU (2) AU2015220773B2 (enExample)
BR (2) BR112016018685A2 (enExample)
CA (2) CA2938793A1 (enExample)
DK (2) DK3119417T3 (enExample)
ES (2) ES2689071T3 (enExample)
HR (2) HRP20181572T1 (enExample)
HU (1) HUE040350T2 (enExample)
IL (2) IL247084B (enExample)
LT (2) LT3119417T (enExample)
MX (2) MX2016010871A (enExample)
NZ (1) NZ723148A (enExample)
PL (2) PL3107559T3 (enExample)
PT (2) PT3107559T (enExample)
RS (2) RS57853B1 (enExample)
RU (2) RU2691946C2 (enExample)
SG (2) SG11201606505UA (enExample)
SI (2) SI3119417T1 (enExample)
WO (2) WO2015124731A1 (enExample)
ZA (2) ZA201605548B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016018681B1 (pt) 2014-02-20 2021-01-05 Merck Patent Gmbh sistema de distribuição de substâncias que compreende pelo menos um material polimérico formador de uma matriz e um fármaco anabólico, processo de produção do mesmo e artigo de manufatura
EP3119417B1 (en) 2014-02-20 2018-07-11 Merck Patent GmbH Fgf-18 compound dosing regimen
WO2016120387A1 (en) 2015-01-29 2016-08-04 Ares Trading S.A. Immunoassays for high positively charged proteins
CN108697702A (zh) 2016-02-22 2018-10-23 诺华股份有限公司 使用fxr激动剂的方法
RS63292B1 (sr) * 2017-09-29 2022-06-30 Merck Patent Gmbh Inflamatorni biomarkeri za predviđanje responsivnosti na jedinjenje fgf-18
SI3687558T1 (sl) 2017-09-29 2022-08-31 Merck Patent Gmbh Presnovni biooznačevalci za napovedovanje odzivnosti na spojino FGF-18
IL281333B2 (en) 2018-09-10 2025-11-01 Merck Patent Gmbh A method for reducing risk in a clinical trial
JP7671249B2 (ja) * 2019-02-08 2025-05-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 変形性関節症が急速に進行するリスクがある患者の治療
WO2025077768A1 (en) * 2023-10-11 2025-04-17 Sichuan Real & Best Biotech Co., Ltd. Compositions and methods for treating arthritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003279835B2 (en) * 2002-10-07 2009-09-10 Zymogenetics, Inc. Methods of administering FGF18
ES2706848T3 (es) * 2004-07-06 2019-04-01 Zymogenetics Inc Composición farmacéutica que comprende FGF18 y antagonista de IL-1 y método de uso
WO2007070983A1 (en) * 2005-12-22 2007-06-28 Apollo Life Sciences Limited Transdermal delivery of pharmaceutical agents
ES2392883T3 (es) * 2006-08-25 2012-12-14 Ares Trading S.A. Tratamiento de trastornos de cartílagos con FGF-18
HRP20120643T1 (hr) * 2006-08-25 2012-08-31 Ares Trading S.A. Liječenje poremećaja hrskavice sa fgf-18
DE102006043260A1 (de) * 2006-09-11 2008-03-27 Krones Ag Etikettieranlage
BR112013024267A2 (pt) * 2011-03-22 2018-06-26 Advinus Therapeutics Ltd compostos tricíclicos fundidos substituídos, composições e aplicações medicinais dos mesmos.
BR112016018681B1 (pt) 2014-02-20 2021-01-05 Merck Patent Gmbh sistema de distribuição de substâncias que compreende pelo menos um material polimérico formador de uma matriz e um fármaco anabólico, processo de produção do mesmo e artigo de manufatura
ES2676318T3 (es) 2014-02-20 2018-07-18 Merck Patent Gmbh FGF-18 en procedimientos de trasplante de injertos y de ingeniería tisular
EP3119417B1 (en) 2014-02-20 2018-07-11 Merck Patent GmbH Fgf-18 compound dosing regimen

Also Published As

Publication number Publication date
AR099510A1 (es) 2016-07-27
RU2016137292A3 (enExample) 2018-09-17
KR102410986B1 (ko) 2022-06-17
RU2016137289A3 (enExample) 2018-10-19
BR112016018685A2 (pt) 2017-10-17
EP3119417B1 (en) 2018-07-11
US20170072017A1 (en) 2017-03-16
PT3119417T (pt) 2018-10-31
NZ723139A (en) 2022-12-23
ZA201605548B (en) 2018-12-19
US9889179B2 (en) 2018-02-13
US20170056474A1 (en) 2017-03-02
RS57709B1 (sr) 2018-12-31
JP2017507142A (ja) 2017-03-16
JP6431083B2 (ja) 2018-11-28
LT3107559T (lt) 2018-10-25
AU2015220777B2 (en) 2020-10-22
ES2689071T3 (es) 2018-11-08
NZ723148A (en) 2022-08-26
EP3119417A1 (en) 2017-01-25
SG11201606502YA (en) 2016-09-29
DK3107559T3 (en) 2018-10-15
RS57853B1 (sr) 2018-12-31
HUE040350T2 (hu) 2019-03-28
BR112016018696A2 (pt) 2017-10-17
WO2015124727A1 (en) 2015-08-27
AU2015220777A1 (en) 2016-09-01
LT3119417T (lt) 2018-10-25
MX2016010871A (es) 2016-11-17
ES2688551T3 (es) 2018-11-05
EP3107559A1 (en) 2016-12-28
RU2700582C2 (ru) 2019-09-18
CN106456713A (zh) 2017-02-22
CA2938793A1 (en) 2015-08-27
AU2015220773B2 (en) 2020-10-08
CN106232622A (zh) 2016-12-14
KR20160116000A (ko) 2016-10-06
ZA201605547B (en) 2019-09-25
RU2691946C2 (ru) 2019-06-19
HRP20181570T1 (hr) 2018-11-30
EP3107559B1 (en) 2018-07-11
SI3119417T1 (sl) 2018-11-30
KR102410988B1 (ko) 2022-06-17
HRP20181572T1 (hr) 2018-11-30
AR099558A1 (es) 2016-08-03
SG11201606505UA (en) 2016-09-29
IL247083A0 (en) 2016-09-29
IL247084B (en) 2019-09-26
PL3107559T3 (pl) 2019-01-31
CA2938791A1 (en) 2015-08-27
JP2017512194A (ja) 2017-05-18
AU2015220773A1 (en) 2016-09-01
WO2015124731A1 (en) 2015-08-27
PL3119417T3 (pl) 2019-01-31
RU2016137292A (ru) 2018-03-21
US9724388B2 (en) 2017-08-08
IL247083B (en) 2019-09-26
MX2016010872A (es) 2016-11-17
RU2016137289A (ru) 2018-03-21
SI3107559T1 (sl) 2018-11-30
DK3119417T3 (en) 2018-10-22
KR20160116001A (ko) 2016-10-06
PT3107559T (pt) 2018-10-31
IL247084A0 (en) 2016-09-29

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