CA2938791A1 - Fgf-18 compound dosing regimen - Google Patents

Fgf-18 compound dosing regimen Download PDF

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Publication number
CA2938791A1
CA2938791A1 CA2938791A CA2938791A CA2938791A1 CA 2938791 A1 CA2938791 A1 CA 2938791A1 CA 2938791 A CA2938791 A CA 2938791A CA 2938791 A CA2938791 A CA 2938791A CA 2938791 A1 CA2938791 A1 CA 2938791A1
Authority
CA
Canada
Prior art keywords
fgf
compound
cartilage
weeks
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2938791A
Other languages
English (en)
French (fr)
Inventor
Christoph H. Ladel
Hans Guehring
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CA2938791A1 publication Critical patent/CA2938791A1/en
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2006IL-1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2938791A 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen Abandoned CA2938791A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14000600.8 2014-02-20
EP14000600 2014-02-20
PCT/EP2015/053624 WO2015124727A1 (en) 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen

Publications (1)

Publication Number Publication Date
CA2938791A1 true CA2938791A1 (en) 2015-08-27

Family

ID=50151088

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2938791A Abandoned CA2938791A1 (en) 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen
CA2938793A Pending CA2938793A1 (en) 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2938793A Pending CA2938793A1 (en) 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen

Country Status (25)

Country Link
US (2) US9889179B2 (enExample)
EP (2) EP3119417B1 (enExample)
JP (2) JP6431083B2 (enExample)
KR (2) KR102410988B1 (enExample)
CN (2) CN106456713A (enExample)
AR (2) AR099558A1 (enExample)
AU (2) AU2015220773B2 (enExample)
BR (2) BR112016018696A2 (enExample)
CA (2) CA2938791A1 (enExample)
DK (2) DK3107559T3 (enExample)
ES (2) ES2688551T3 (enExample)
HR (2) HRP20181570T1 (enExample)
HU (1) HUE040350T2 (enExample)
IL (2) IL247084B (enExample)
LT (2) LT3119417T (enExample)
MX (2) MX2016010871A (enExample)
NZ (2) NZ723148A (enExample)
PL (2) PL3107559T3 (enExample)
PT (2) PT3119417T (enExample)
RS (2) RS57853B1 (enExample)
RU (2) RU2700582C2 (enExample)
SG (2) SG11201606502YA (enExample)
SI (2) SI3119417T1 (enExample)
WO (2) WO2015124731A1 (enExample)
ZA (2) ZA201605547B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20181570T1 (hr) 2014-02-20 2018-11-30 Merck Patent Gmbh Režim doziranja spoja fgf-18
AR099556A1 (es) 2014-02-20 2016-08-03 Merck Patent Gmbh Implante que contiene fgf-18
EP3250925B1 (en) 2015-01-29 2019-04-10 Ares Trading S.A. Immunoassays for highly positively charged proteins
BR112018016310A2 (pt) 2016-02-22 2018-12-26 Novartis Ag métodos para uso de agonistas de fxr
HRP20220737T1 (hr) * 2017-09-29 2022-09-02 Merck Patent Gmbh Upalni biomarkeri za predviđanje odgovaranja na spoj fgf-18
DK3687558T3 (da) 2017-09-29 2022-06-20 Merck Patent Gmbh Metaboliske biomarkører til forudsigelse af modtageligheden på fgf-18 forbindelse
ES2980597T3 (es) 2018-09-10 2024-10-02 Merck Patent Gmbh Marcadores útiles en las estrategias de enriquecimiento para el tratamiento de la artrosis
WO2020161341A1 (en) * 2019-02-08 2020-08-13 Merck Patent Gmbh Treatment of patients at risk of rapid progression of osteoarthritis
WO2025077768A1 (en) * 2023-10-11 2025-04-17 Sichuan Real & Best Biotech Co., Ltd. Compositions and methods for treating arthritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003279835B2 (en) * 2002-10-07 2009-09-10 Zymogenetics, Inc. Methods of administering FGF18
US20060009389A1 (en) 2004-07-06 2006-01-12 Moore Emma E Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method of use
AU2006326870A1 (en) * 2005-12-22 2007-06-28 Apollo Life Sciences Transdermal delivery of pharmaceutical agents
PT2054050E (pt) * 2006-08-25 2012-09-17 Ares Trading Sa Tratamento de patologias da cartilagem
EP2054050B1 (en) * 2006-08-25 2012-08-08 Ares Trading S.A. Treatment of cartilage disorders with fgf-18
DE102006043260A1 (de) * 2006-09-11 2008-03-27 Krones Ag Etikettieranlage
CA2830882C (en) * 2011-03-22 2021-03-16 Dinesh Barawkar Substituted fused tricyclic compounds, compositions and medicinal applications thereof
SG11201606696UA (en) 2014-02-20 2016-09-29 Merck Patent Gmbh Fgf-18 in graft transplantation and tissue engineering procedures
HRP20181570T1 (hr) 2014-02-20 2018-11-30 Merck Patent Gmbh Režim doziranja spoja fgf-18
AR099556A1 (es) 2014-02-20 2016-08-03 Merck Patent Gmbh Implante que contiene fgf-18

Also Published As

Publication number Publication date
KR102410988B1 (ko) 2022-06-17
JP6431082B2 (ja) 2018-11-28
KR20160116001A (ko) 2016-10-06
KR20160116000A (ko) 2016-10-06
WO2015124731A1 (en) 2015-08-27
MX2016010872A (es) 2016-11-17
EP3107559A1 (en) 2016-12-28
ZA201605548B (en) 2018-12-19
BR112016018696A2 (pt) 2017-10-17
AR099510A1 (es) 2016-07-27
AU2015220773B2 (en) 2020-10-08
SI3119417T1 (sl) 2018-11-30
PT3107559T (pt) 2018-10-31
EP3119417B1 (en) 2018-07-11
PL3119417T3 (pl) 2019-01-31
CN106456713A (zh) 2017-02-22
IL247084A0 (en) 2016-09-29
RU2700582C2 (ru) 2019-09-18
HUE040350T2 (hu) 2019-03-28
WO2015124727A1 (en) 2015-08-27
IL247084B (en) 2019-09-26
SI3107559T1 (sl) 2018-11-30
HRP20181570T1 (hr) 2018-11-30
AR099558A1 (es) 2016-08-03
EP3119417A1 (en) 2017-01-25
RS57709B1 (sr) 2018-12-31
AU2015220773A1 (en) 2016-09-01
LT3107559T (lt) 2018-10-25
DK3119417T3 (en) 2018-10-22
NZ723148A (en) 2022-08-26
RU2016137292A3 (enExample) 2018-09-17
RS57853B1 (sr) 2018-12-31
ES2688551T3 (es) 2018-11-05
NZ723139A (en) 2022-12-23
ES2689071T3 (es) 2018-11-08
RU2016137289A (ru) 2018-03-21
US9724388B2 (en) 2017-08-08
RU2016137292A (ru) 2018-03-21
DK3107559T3 (en) 2018-10-15
SG11201606505UA (en) 2016-09-29
HRP20181572T1 (hr) 2018-11-30
PL3107559T3 (pl) 2019-01-31
BR112016018685A2 (pt) 2017-10-17
PT3119417T (pt) 2018-10-31
AU2015220777B2 (en) 2020-10-22
US20170056474A1 (en) 2017-03-02
IL247083B (en) 2019-09-26
AU2015220777A1 (en) 2016-09-01
EP3107559B1 (en) 2018-07-11
JP2017507142A (ja) 2017-03-16
RU2691946C2 (ru) 2019-06-19
CN106232622A (zh) 2016-12-14
CA2938793A1 (en) 2015-08-27
IL247083A0 (en) 2016-09-29
MX2016010871A (es) 2016-11-17
RU2016137289A3 (enExample) 2018-10-19
LT3119417T (lt) 2018-10-25
ZA201605547B (en) 2019-09-25
JP2017512194A (ja) 2017-05-18
US9889179B2 (en) 2018-02-13
SG11201606502YA (en) 2016-09-29
US20170072017A1 (en) 2017-03-16
JP6431083B2 (ja) 2018-11-28
KR102410986B1 (ko) 2022-06-17

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Legal Events

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EEER Examination request

Effective date: 20200130

EEER Examination request

Effective date: 20200130

EEER Examination request

Effective date: 20200130

FZDE Discontinued

Effective date: 20230802