NZ723148A - Fgf-18 compound dosing regimen - Google Patents

Fgf-18 compound dosing regimen

Info

Publication number
NZ723148A
NZ723148A NZ723148A NZ72314815A NZ723148A NZ 723148 A NZ723148 A NZ 723148A NZ 723148 A NZ723148 A NZ 723148A NZ 72314815 A NZ72314815 A NZ 72314815A NZ 723148 A NZ723148 A NZ 723148A
Authority
NZ
New Zealand
Prior art keywords
fgf
cartilage
compound
treatment
weeks
Prior art date
Application number
NZ723148A
Other languages
English (en)
Inventor
Hans Guehring
Christoph H Ladel
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NZ723148A publication Critical patent/NZ723148A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2006IL-1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NZ723148A 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen NZ723148A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14000600 2014-02-20
PCT/EP2015/053624 WO2015124727A1 (en) 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen

Publications (1)

Publication Number Publication Date
NZ723148A true NZ723148A (en) 2022-08-26

Family

ID=50151088

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ723148A NZ723148A (en) 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen
NZ723139A NZ723139A (en) 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ723139A NZ723139A (en) 2014-02-20 2015-02-20 Fgf-18 compound dosing regimen

Country Status (25)

Country Link
US (2) US9724388B2 (enExample)
EP (2) EP3119417B1 (enExample)
JP (2) JP6431082B2 (enExample)
KR (2) KR102410986B1 (enExample)
CN (2) CN106232622A (enExample)
AR (2) AR099510A1 (enExample)
AU (2) AU2015220773B2 (enExample)
BR (2) BR112016018696A2 (enExample)
CA (2) CA2938793A1 (enExample)
DK (2) DK3119417T3 (enExample)
ES (2) ES2688551T3 (enExample)
HR (2) HRP20181570T1 (enExample)
HU (1) HUE040350T2 (enExample)
IL (2) IL247084B (enExample)
LT (2) LT3119417T (enExample)
MX (2) MX2016010871A (enExample)
NZ (2) NZ723148A (enExample)
PL (2) PL3119417T3 (enExample)
PT (2) PT3107559T (enExample)
RS (2) RS57709B1 (enExample)
RU (2) RU2700582C2 (enExample)
SG (2) SG11201606505UA (enExample)
SI (2) SI3107559T1 (enExample)
WO (2) WO2015124727A1 (enExample)
ZA (2) ZA201605547B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10086112B2 (en) 2014-02-20 2018-10-02 Merck Patent Gmbh Implant comprising FGF-18
MX2016010871A (es) 2014-02-20 2016-11-17 Merck Patent Gmbh Regimen de dosificacion del compuesto de factor de crecimiento de fibroblastos 18.
JP6787904B2 (ja) 2015-01-29 2020-11-18 アレス トレーディング ソシエテ アノニム 高度に正に荷電したタンパク質のイムノアッセイ
CN108697702A (zh) 2016-02-22 2018-10-23 诺华股份有限公司 使用fxr激动剂的方法
HUE058848T2 (hu) * 2017-09-29 2022-09-28 Merck Patent Gmbh FGF-18 vegyületre vonatkozó válaszkészség elõrejelzésére szolgáló gyulladásos biomarkerek
SI3687558T1 (sl) 2017-09-29 2022-08-31 Merck Patent Gmbh Presnovni biooznačevalci za napovedovanje odzivnosti na spojino FGF-18
EP3850113B1 (en) 2018-09-10 2024-04-03 Merck Patent GmbH Markers useful in enrichment strategies for the treatment of osteoarthritis
US20220184180A1 (en) * 2019-02-08 2022-06-16 Merck Patent Gmbh Treatment of patients at risk of rapid progression of osteoarthritis
WO2025077768A1 (en) * 2023-10-11 2025-04-17 Sichuan Real & Best Biotech Co., Ltd. Compositions and methods for treating arthritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1551426B1 (en) * 2002-10-07 2014-06-25 ZymoGenetics, Inc. Methods of administering fgf18
US20060009389A1 (en) * 2004-07-06 2006-01-12 Moore Emma E Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method of use
US20070243132A1 (en) * 2005-12-22 2007-10-18 Apollo Life Sciences Limited Transdermal delivery of pharmaceutical agents
AR062522A1 (es) 2006-08-25 2008-11-12 Ares Trading Sa Tratamiento de desordenes en cartilagos
MY148277A (en) * 2006-08-25 2013-03-29 Ares Trading Sa Treatment of cartilage disorders with fgf-18
DE102006043260A1 (de) * 2006-09-11 2008-03-27 Krones Ag Etikettieranlage
WO2012127506A1 (en) * 2011-03-22 2012-09-27 Advinus Therapeutics Limited Substituted fused tricyclic compounds, compositions and medicinal applications thereof
CN106232153B (zh) 2014-02-20 2020-01-17 默克专利有限公司 用于移植和组织工程手术的fgf-18
US10086112B2 (en) 2014-02-20 2018-10-02 Merck Patent Gmbh Implant comprising FGF-18
MX2016010871A (es) 2014-02-20 2016-11-17 Merck Patent Gmbh Regimen de dosificacion del compuesto de factor de crecimiento de fibroblastos 18.

Also Published As

Publication number Publication date
DK3119417T3 (en) 2018-10-22
IL247084B (en) 2019-09-26
PT3107559T (pt) 2018-10-31
CN106456713A (zh) 2017-02-22
KR102410986B1 (ko) 2022-06-17
KR102410988B1 (ko) 2022-06-17
US20170072017A1 (en) 2017-03-16
ZA201605548B (en) 2018-12-19
LT3119417T (lt) 2018-10-25
SG11201606502YA (en) 2016-09-29
ES2688551T3 (es) 2018-11-05
HRP20181570T1 (hr) 2018-11-30
RU2016137292A3 (enExample) 2018-09-17
CA2938793A1 (en) 2015-08-27
BR112016018685A2 (pt) 2017-10-17
AU2015220773B2 (en) 2020-10-08
DK3107559T3 (en) 2018-10-15
HUE040350T2 (hu) 2019-03-28
US9724388B2 (en) 2017-08-08
JP2017512194A (ja) 2017-05-18
MX2016010871A (es) 2016-11-17
HRP20181572T1 (hr) 2018-11-30
EP3119417A1 (en) 2017-01-25
MX2016010872A (es) 2016-11-17
LT3107559T (lt) 2018-10-25
PL3119417T3 (pl) 2019-01-31
RU2700582C2 (ru) 2019-09-18
SI3119417T1 (sl) 2018-11-30
SI3107559T1 (sl) 2018-11-30
ES2689071T3 (es) 2018-11-08
WO2015124731A1 (en) 2015-08-27
JP6431083B2 (ja) 2018-11-28
NZ723139A (en) 2022-12-23
RU2016137289A3 (enExample) 2018-10-19
IL247083B (en) 2019-09-26
SG11201606505UA (en) 2016-09-29
JP6431082B2 (ja) 2018-11-28
US20170056474A1 (en) 2017-03-02
AR099558A1 (es) 2016-08-03
RS57853B1 (sr) 2018-12-31
IL247084A0 (en) 2016-09-29
AU2015220773A1 (en) 2016-09-01
EP3119417B1 (en) 2018-07-11
CN106232622A (zh) 2016-12-14
IL247083A0 (en) 2016-09-29
KR20160116001A (ko) 2016-10-06
PT3119417T (pt) 2018-10-31
KR20160116000A (ko) 2016-10-06
US9889179B2 (en) 2018-02-13
EP3107559B1 (en) 2018-07-11
AU2015220777B2 (en) 2020-10-22
CA2938791A1 (en) 2015-08-27
AR099510A1 (es) 2016-07-27
RS57709B1 (sr) 2018-12-31
AU2015220777A1 (en) 2016-09-01
EP3107559A1 (en) 2016-12-28
BR112016018696A2 (pt) 2017-10-17
PL3107559T3 (pl) 2019-01-31
RU2691946C2 (ru) 2019-06-19
RU2016137289A (ru) 2018-03-21
ZA201605547B (en) 2019-09-25
JP2017507142A (ja) 2017-03-16
WO2015124727A1 (en) 2015-08-27
RU2016137292A (ru) 2018-03-21

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