JP6430015B2 - 新規クロモンオキシム誘導体、および代謝型グルタミン酸受容体のアロステリックモジュレーターとしてのそれの使用 - Google Patents

新規クロモンオキシム誘導体、および代謝型グルタミン酸受容体のアロステリックモジュレーターとしてのそれの使用 Download PDF

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JP6430015B2
JP6430015B2 JP2017530425A JP2017530425A JP6430015B2 JP 6430015 B2 JP6430015 B2 JP 6430015B2 JP 2017530425 A JP2017530425 A JP 2017530425A JP 2017530425 A JP2017530425 A JP 2017530425A JP 6430015 B2 JP6430015 B2 JP 6430015B2
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disease
disorder
parkinson
disorders
compound
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JP2017525776A5 (enExample
JP2017525776A (ja
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シャルヴァン,デルフィーヌ
マントー,バティスト
ポメル,ヴァンサン
コンケ,フランソワ
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プレクストン・セラピューティクス・ソシエテ・アノニム
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JP2017530425A 2014-08-27 2015-08-27 新規クロモンオキシム誘導体、および代謝型グルタミン酸受容体のアロステリックモジュレーターとしてのそれの使用 Expired - Fee Related JP6430015B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14182468 2014-08-27
EP14182468.0 2014-08-27
PCT/EP2015/069601 WO2016030444A1 (en) 2014-08-27 2015-08-27 Novel chromone oxime derivative and its use as allosteric modulator of metabotropic glutamate receptors

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JP2017525776A JP2017525776A (ja) 2017-09-07
JP2017525776A5 JP2017525776A5 (enExample) 2017-10-19
JP6430015B2 true JP6430015B2 (ja) 2018-11-28

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US (3) US10017521B2 (enExample)
EP (3) EP3186257B1 (enExample)
JP (1) JP6430015B2 (enExample)
KR (1) KR101870589B1 (enExample)
CN (2) CN110343118A (enExample)
AU (1) AU2015308438B2 (enExample)
CA (1) CA2956191C (enExample)
CY (1) CY1121352T1 (enExample)
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SI (1) SI3186257T1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018528205A (ja) * 2015-08-27 2018-09-27 プレクストン・セラピューティクス・ソシエテ・アノニム レボドパ誘発性ジスキネジア療法のための脳透過性クロモンオキシム誘導体

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20190343T1 (hr) * 2014-08-27 2019-05-31 Prexton Therapeutics Sa Novi kromon oksim derivat i njegova uporaba kao alosterni modulator metabotropnih receptora glutamata
US20220089609A1 (en) 2018-07-26 2022-03-24 Domain Therapeutics Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4

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US4777252A (en) 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
JP3993651B2 (ja) 1994-10-21 2007-10-17 アスビオファーマ株式会社 シクロプロパクロメンカルボン酸誘導体
EP1298129A3 (en) 2001-09-28 2003-06-04 Central Glass Company, Limited Process for producing 4-sustituted benzopyran derivatives
US7132425B2 (en) 2002-12-12 2006-11-07 Hoffmann-La Roche Inc. 5-substituted-six-membered heteroaromatic glucokinase activators
JP2006522124A (ja) 2003-04-03 2006-09-28 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼのインヒビターとして有用な組成物
WO2007011701A1 (en) 2005-07-15 2007-01-25 Transform Pharmaceuticals, Inc. Novel hydrochloride salts of levodopa
GB0713686D0 (en) 2007-07-13 2007-08-22 Addex Pharmaceuticals Sa New compounds 2
EP2181110A2 (en) 2007-07-13 2010-05-05 ADDEX Pharma S.A. Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors
EP2493871B1 (en) * 2009-10-30 2014-09-03 Domain Therapeutics Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
NZ767139A (en) * 2009-12-04 2022-08-26 Sunovion Pharmaceuticals Inc Multicyclic compounds and methods of use thereof
US20140349994A1 (en) * 2012-01-18 2014-11-27 Addex Pharma S.A. Novel 2-Amino-4,5,6,8-Tetrahydropyrazolo[3,4-b]Thiazolo [4,5-d]Azepine Derivatives and Their Use as Allosteric Modulators of Metabotropic Glutamate Receptors
HRP20190343T1 (hr) 2014-08-27 2019-05-31 Prexton Therapeutics Sa Novi kromon oksim derivat i njegova uporaba kao alosterni modulator metabotropnih receptora glutamata
US10532057B2 (en) 2015-08-27 2020-01-14 Prexton Therapeutics Sa Brain-penetrant chromone oxime derivative for the therapy of levodopa-induced dyskinesia

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018528205A (ja) * 2015-08-27 2018-09-27 プレクストン・セラピューティクス・ソシエテ・アノニム レボドパ誘発性ジスキネジア療法のための脳透過性クロモンオキシム誘導体

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ME03339B (me) 2019-10-20
US10017521B2 (en) 2018-07-10
AU2015308438A1 (en) 2017-03-02
CN106715444B (zh) 2019-07-12
LT3186257T (lt) 2019-04-25
NZ728853A (en) 2018-04-27
CA2956191A1 (en) 2016-03-03
HRP20190343T1 (hr) 2019-05-31
CY1121352T1 (el) 2020-05-29
EP3186257B1 (en) 2019-02-06
MA48048A (fr) 2020-02-12
RU2017109818A3 (enExample) 2018-10-01
CA2956191C (en) 2020-01-28
KR101870589B1 (ko) 2018-06-25
WO2016030444A1 (en) 2016-03-03
SI3186257T1 (sl) 2019-07-31
MX369643B (es) 2019-11-15
HUE041941T2 (hu) 2019-06-28
PT3186257T (pt) 2019-03-27
KR20170042624A (ko) 2017-04-19
DK3186257T3 (en) 2019-04-01
US20170253613A1 (en) 2017-09-07
TR201903332T4 (tr) 2019-03-21
EP3502115A1 (en) 2019-06-26
RU2672569C2 (ru) 2018-11-16
US20180291034A1 (en) 2018-10-11
MA52702A (fr) 2021-03-31
IL250287B (en) 2020-02-27
CN106715444A (zh) 2017-05-24
MA40530A (fr) 2017-07-05
JP2017525776A (ja) 2017-09-07
EP3696183A1 (en) 2020-08-19
AU2015308438B2 (en) 2018-12-13
CN110343118A (zh) 2019-10-18
US10442818B2 (en) 2019-10-15
ES2714073T3 (es) 2019-05-27
US20200024285A1 (en) 2020-01-23
MX2017002429A (es) 2017-08-02
RU2017109818A (ru) 2018-10-01
RS58592B1 (sr) 2019-05-31
SMT201900152T1 (it) 2019-05-10
EP3186257A1 (en) 2017-07-05
PL3186257T3 (pl) 2019-07-31
IL250287A0 (en) 2017-03-30

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