RU2672569C2 - Новое производное оксима хромона и его использование в качестве аллостерического модулятора метаботропных рецепторов глутамата - Google Patents

Новое производное оксима хромона и его использование в качестве аллостерического модулятора метаботропных рецепторов глутамата Download PDF

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RU2672569C2
RU2672569C2 RU2017109818A RU2017109818A RU2672569C2 RU 2672569 C2 RU2672569 C2 RU 2672569C2 RU 2017109818 A RU2017109818 A RU 2017109818A RU 2017109818 A RU2017109818 A RU 2017109818A RU 2672569 C2 RU2672569 C2 RU 2672569C2
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compound
formula
disease
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pxt002331
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Дельфин ШАРВЕН
Батист МАНТО
Венсан Помель
Франсуа КОНКЕ
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Прекстон Терапьютикс Са
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    • C—CHEMISTRY; METALLURGY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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RU2017109818A 2014-08-27 2015-08-27 Новое производное оксима хромона и его использование в качестве аллостерического модулятора метаботропных рецепторов глутамата RU2672569C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14182468 2014-08-27
EP14182468.0 2014-08-27
PCT/EP2015/069601 WO2016030444A1 (en) 2014-08-27 2015-08-27 Novel chromone oxime derivative and its use as allosteric modulator of metabotropic glutamate receptors

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RU2017109818A RU2017109818A (ru) 2018-10-01
RU2017109818A3 RU2017109818A3 (enExample) 2018-10-01
RU2672569C2 true RU2672569C2 (ru) 2018-11-16

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3186257T1 (sl) * 2014-08-27 2019-07-31 Prexton Therapeutics Sa Novi derivat kromon oksima in njegova uporaba kot alosterični modulator metabotropnih glutamatnih receptorjev
US10532057B2 (en) * 2015-08-27 2020-01-14 Prexton Therapeutics Sa Brain-penetrant chromone oxime derivative for the therapy of levodopa-induced dyskinesia
JP7633676B2 (ja) 2018-07-26 2025-02-20 ドメイン・セラピューティクス 置換キナゾリノン誘導体、及びｍＧｌｕＲ４のポジティブアロステリック調節剤としてのその使用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011051478A1 (en) * 2009-10-30 2011-05-05 Domain Therapeutics Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
RU2557059C2 (ru) * 2009-12-04 2015-07-20 Суновион Фармасьютикалз, Инк. Полициклические соединения и способы их применения

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US4065467A (en) 1973-12-27 1977-12-27 Carlo Erba, S. P. A. 5:6-Benzo δ-pyrone derivatives and process for their preparation
US4777252A (en) 1987-08-13 1988-10-11 E. R. Squibb & Sons, Inc. 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
JP3993651B2 (ja) * 1994-10-21 2007-10-17 アスビオファーマ株式会社 シクロプロパクロメンカルボン酸誘導体
EP1298129A3 (en) 2001-09-28 2003-06-04 Central Glass Company, Limited Process for producing 4-sustituted benzopyran derivatives
US7132425B2 (en) 2002-12-12 2006-11-07 Hoffmann-La Roche Inc. 5-substituted-six-membered heteroaromatic glucokinase activators
US7547794B2 (en) 2003-04-03 2009-06-16 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
US20070027216A1 (en) 2005-07-15 2007-02-01 Bridget Larson Novel hydrochloride salts of levodopa
WO2009010455A2 (en) 2007-07-13 2009-01-22 Addex Pharma S.A. Pyrazole derivatives as modulators of metabotropic glutamate receptors
GB0713686D0 (en) 2007-07-13 2007-08-22 Addex Pharmaceuticals Sa New compounds 2
WO2013107862A1 (en) * 2012-01-18 2013-07-25 Addex Pharma S.A. NOVEL 2-AMINO-4,5,6,8-TETRAHYDROPYRAZOLO[3,4-b]THIAZOLO [4,5-d]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
SI3186257T1 (sl) * 2014-08-27 2019-07-31 Prexton Therapeutics Sa Novi derivat kromon oksima in njegova uporaba kot alosterični modulator metabotropnih glutamatnih receptorjev
US10532057B2 (en) 2015-08-27 2020-01-14 Prexton Therapeutics Sa Brain-penetrant chromone oxime derivative for the therapy of levodopa-induced dyskinesia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011051478A1 (en) * 2009-10-30 2011-05-05 Domain Therapeutics Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
RU2557059C2 (ru) * 2009-12-04 2015-07-20 Суновион Фармасьютикалз, Инк. Полициклические соединения и способы их применения

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EP3186257B1 (en) 2019-02-06
US10442818B2 (en) 2019-10-15
IL250287A0 (en) 2017-03-30
MA48048A (fr) 2020-02-12
MA40530A (fr) 2017-07-05
SMT201900152T1 (it) 2019-05-10
HRP20190343T1 (hr) 2019-05-31
KR101870589B1 (ko) 2018-06-25
US20180291034A1 (en) 2018-10-11
CY1121352T1 (el) 2020-05-29
CN106715444B (zh) 2019-07-12
LT3186257T (lt) 2019-04-25
TR201903332T4 (tr) 2019-03-21
CA2956191C (en) 2020-01-28
CA2956191A1 (en) 2016-03-03
NZ728853A (en) 2018-04-27
JP2017525776A (ja) 2017-09-07
ES2714073T3 (es) 2019-05-27
CN110343118A (zh) 2019-10-18
SI3186257T1 (sl) 2019-07-31
JP6430015B2 (ja) 2018-11-28
AU2015308438B2 (en) 2018-12-13
AU2015308438A1 (en) 2017-03-02
IL250287B (en) 2020-02-27
RU2017109818A (ru) 2018-10-01
PT3186257T (pt) 2019-03-27
HUE041941T2 (hu) 2019-06-28
PL3186257T3 (pl) 2019-07-31
EP3502115A1 (en) 2019-06-26
MA52702A (fr) 2021-03-31
EP3186257A1 (en) 2017-07-05
MX2017002429A (es) 2017-08-02
DK3186257T3 (en) 2019-04-01
US20170253613A1 (en) 2017-09-07
US20200024285A1 (en) 2020-01-23
RU2017109818A3 (enExample) 2018-10-01
ME03339B (me) 2019-10-20
EP3696183A1 (en) 2020-08-19
KR20170042624A (ko) 2017-04-19
CN106715444A (zh) 2017-05-24
US10017521B2 (en) 2018-07-10
WO2016030444A1 (en) 2016-03-03
MX369643B (es) 2019-11-15
RS58592B1 (sr) 2019-05-31

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