JP6417413B2 - 多様な腫瘍に対する抗体依存性細胞毒性を誘発するキメラ受容体 - Google Patents

多様な腫瘍に対する抗体依存性細胞毒性を誘発するキメラ受容体 Download PDF

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JP6417413B2
JP6417413B2 JP2016524494A JP2016524494A JP6417413B2 JP 6417413 B2 JP6417413 B2 JP 6417413B2 JP 2016524494 A JP2016524494 A JP 2016524494A JP 2016524494 A JP2016524494 A JP 2016524494A JP 6417413 B2 JP6417413 B2 JP 6417413B2
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cells
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cancer
lymphocytes
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ダリオ・カンパーナ
コウ・クドウ
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St. Jude Children's Research Hospital
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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JP2016524494A 2013-10-17 2014-10-17 多様な腫瘍に対する抗体依存性細胞毒性を誘発するキメラ受容体 Active JP6417413B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361892218P 2013-10-17 2013-10-17
US61/892,218 2013-10-17
US201462026243P 2014-07-18 2014-07-18
US62/026,243 2014-07-18
PCT/US2014/060999 WO2015058018A1 (en) 2013-10-17 2014-10-17 Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors

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JP2016534717A JP2016534717A (ja) 2016-11-10
JP2016534717A5 JP2016534717A5 (enExample) 2017-11-24
JP6417413B2 true JP6417413B2 (ja) 2018-11-07

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EP (1) EP3057986B1 (enExample)
JP (1) JP6417413B2 (enExample)
KR (1) KR102308597B1 (enExample)
CN (1) CN105683214B (enExample)
AU (1) AU2014337195B2 (enExample)
BR (1) BR112016007695A2 (enExample)
CA (1) CA2926267C (enExample)
IL (1) IL245088A0 (enExample)
SG (1) SG11201602979RA (enExample)
WO (1) WO2015058018A1 (enExample)
ZA (1) ZA201602798B (enExample)

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SG11201602979RA (en) 2016-05-30
WO2015058018A1 (en) 2015-04-23
IL245088A0 (en) 2016-06-30
CA2926267C (en) 2023-08-01
CN105683214A (zh) 2016-06-15
AU2014337195B2 (en) 2018-11-08
KR102308597B1 (ko) 2021-10-01
CA2926267A1 (en) 2015-04-23
ZA201602798B (en) 2018-12-19
CN105683214B (zh) 2021-03-09
JP2016534717A (ja) 2016-11-10
KR20160062762A (ko) 2016-06-02
BR112016007695A2 (pt) 2017-09-12
EP3057986A4 (en) 2017-03-15
AU2014337195A1 (en) 2016-04-21
EP3057986B1 (en) 2017-12-27
EP3057986A1 (en) 2016-08-24

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