JP6385845B2 - 新規フルオレン化合物及びその製造方法 - Google Patents
新規フルオレン化合物及びその製造方法 Download PDFInfo
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- JP6385845B2 JP6385845B2 JP2015022158A JP2015022158A JP6385845B2 JP 6385845 B2 JP6385845 B2 JP 6385845B2 JP 2015022158 A JP2015022158 A JP 2015022158A JP 2015022158 A JP2015022158 A JP 2015022158A JP 6385845 B2 JP6385845 B2 JP 6385845B2
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- fluorene
- fluorene compound
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- -1 fluorene compound Chemical class 0.000 title claims description 61
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N o-biphenylenemethane Natural products C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 title claims description 59
- 238000000034 method Methods 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims description 36
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 28
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 21
- 125000001424 substituent group Chemical group 0.000 claims description 19
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 7
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 230000007062 hydrolysis Effects 0.000 claims description 4
- 238000006460 hydrolysis reaction Methods 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 description 22
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 18
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 18
- 229920000642 polymer Polymers 0.000 description 16
- 239000002904 solvent Substances 0.000 description 16
- 239000002585 base Substances 0.000 description 15
- 230000015572 biosynthetic process Effects 0.000 description 15
- 238000003786 synthesis reaction Methods 0.000 description 15
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 14
- 125000000217 alkyl group Chemical group 0.000 description 13
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
- 125000003118 aryl group Chemical group 0.000 description 12
- 125000003545 alkoxy group Chemical group 0.000 description 11
- 125000003710 aryl alkyl group Chemical group 0.000 description 11
- 125000000000 cycloalkoxy group Chemical group 0.000 description 11
- 125000000753 cycloalkyl group Chemical group 0.000 description 11
- 239000000178 monomer Substances 0.000 description 11
- 150000002430 hydrocarbons Chemical group 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 230000000704 physical effect Effects 0.000 description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
- 230000009257 reactivity Effects 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- 238000006467 substitution reaction Methods 0.000 description 5
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- GOHHRCHIZNXLOS-UHFFFAOYSA-N C1=CC=C2C(=C1)C3=CC=CC=C3C2(C4=C(OC5=CC=CC=C5O4)C#N)C6=C(OC7=CC=CC=C7O6)C#N Chemical compound C1=CC=C2C(=C1)C3=CC=CC=C3C2(C4=C(OC5=CC=CC=C5O4)C#N)C6=C(OC7=CC=CC=C7O6)C#N GOHHRCHIZNXLOS-UHFFFAOYSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- 238000001953 recrystallisation Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- BTBFCBQZFMQBNT-UHFFFAOYSA-N 3,4-difluorobenzonitrile Chemical compound FC1=CC=C(C#N)C=C1F BTBFCBQZFMQBNT-UHFFFAOYSA-N 0.000 description 3
- AXUANSIJOIVMJB-UHFFFAOYSA-N C(#N)C1=C(C=CC=2OC3=C(OC21)C=CC=C3)C3(C2=CC=CC=C2C=2C=CC=CC32)C3=C(C2=C(OC1=C(O2)C=CC=C1)C=C3)C#N Chemical compound C(#N)C1=C(C=CC=2OC3=C(OC21)C=CC=C3)C3(C2=CC=CC=C2C=2C=CC=CC32)C3=C(C2=C(OC1=C(O2)C=CC=C1)C=C3)C#N AXUANSIJOIVMJB-UHFFFAOYSA-N 0.000 description 3
- 0 Cc1c(*)cc2Oc(cc(C3(c(cccc4)c4-c4c3cccc4)c3ccc4Oc(cc(*)c(*)c5)c5Oc4c3)cc3)c3Oc2c1 Chemical compound Cc1c(*)cc2Oc(cc(C3(c(cccc4)c4-c4c3cccc4)c3ccc4Oc(cc(*)c(*)c5)c5Oc4c3)cc3)c3Oc2c1 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 239000003480 eluent Substances 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 150000002220 fluorenes Chemical class 0.000 description 3
- 230000009477 glass transition Effects 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000002194 synthesizing effect Effects 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 2
- 229940093475 2-ethoxyethanol Drugs 0.000 description 2
- NUDSREQIJYWLRA-UHFFFAOYSA-N 4-[9-(4-hydroxy-3-methylphenyl)fluoren-9-yl]-2-methylphenol Chemical compound C1=C(O)C(C)=CC(C2(C3=CC=CC=C3C3=CC=CC=C32)C=2C=C(C)C(O)=CC=2)=C1 NUDSREQIJYWLRA-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- NDRCZLIARTUTFK-UHFFFAOYSA-N C(=O)(O)C1=C(C=CC=2OC3=C(OC21)C=CC=C3)C3(C2=CC=CC=C2C=2C=CC=CC32)C3=C(C2=C(OC1=C(O2)C=CC=C1)C=C3)C(=O)O Chemical compound C(=O)(O)C1=C(C=CC=2OC3=C(OC21)C=CC=C3)C3(C2=CC=CC=C2C=2C=CC=CC32)C3=C(C2=C(OC1=C(O2)C=CC=C1)C=C3)C(=O)O NDRCZLIARTUTFK-UHFFFAOYSA-N 0.000 description 2
- WKVHOWMRUBONOS-UHFFFAOYSA-N C(=O)(O)C1=CC2=C(OC3=C(O2)C=CC(=C3)C3(C2=CC=CC=C2C=2C=CC=CC32)C3=CC2=C(OC4=C(O2)C=CC(=C4)C(=O)O)C=C3)C=C1 Chemical group C(=O)(O)C1=CC2=C(OC3=C(O2)C=CC(=C3)C3(C2=CC=CC=C2C=2C=CC=CC32)C3=CC2=C(OC4=C(O2)C=CC(=C4)C(=O)O)C=C3)C=C1 WKVHOWMRUBONOS-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000005456 alcohol based solvent Substances 0.000 description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 239000012300 argon atmosphere Substances 0.000 description 2
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 150000001793 charged compounds Chemical class 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 150000001991 dicarboxylic acids Chemical class 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 239000004210 ether based solvent Substances 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000000434 field desorption mass spectrometry Methods 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 239000005453 ketone based solvent Substances 0.000 description 2
- SIAPCJWMELPYOE-UHFFFAOYSA-N lithium hydride Chemical compound [LiH] SIAPCJWMELPYOE-UHFFFAOYSA-N 0.000 description 2
- 229910000103 lithium hydride Inorganic materials 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 150000002825 nitriles Chemical class 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000010898 silica gel chromatography Methods 0.000 description 2
- 229910000104 sodium hydride Inorganic materials 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 239000013585 weight reducing agent Substances 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 1
- 125000006713 (C5-C10) cycloalkyl group Chemical group 0.000 description 1
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 description 1
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- APQIUTYORBAGEZ-UHFFFAOYSA-N 1,1-dibromoethane Chemical compound CC(Br)Br APQIUTYORBAGEZ-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- NQXNYVAALXGLQT-UHFFFAOYSA-N 2-[4-[9-[4-(2-hydroxyethoxy)phenyl]fluoren-9-yl]phenoxy]ethanol Chemical compound C1=CC(OCCO)=CC=C1C1(C=2C=CC(OCCO)=CC=2)C2=CC=CC=C2C2=CC=CC=C21 NQXNYVAALXGLQT-UHFFFAOYSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- KUWBYWUSERRVQP-UHFFFAOYSA-N 3,4-dichlorobenzonitrile Chemical compound ClC1=CC=C(C#N)C=C1Cl KUWBYWUSERRVQP-UHFFFAOYSA-N 0.000 description 1
- CSDQQAQKBAQLLE-UHFFFAOYSA-N 4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Chemical compound C1=CC(Cl)=CC=C1C1C(C=CS2)=C2CCN1 CSDQQAQKBAQLLE-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 229930185605 Bisphenol Natural products 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- RAGODIJPKQJICJ-UHFFFAOYSA-N C1=CC=C2C(=C1)C3=CC=CC=C3C2(C4=C(OC5=CC=CC=C5O4)C(=O)O)C6=C(OC7=CC=CC=C7O6)C(=O)O Chemical compound C1=CC=C2C(=C1)C3=CC=CC=C3C2(C4=C(OC5=CC=CC=C5O4)C(=O)O)C6=C(OC7=CC=CC=C7O6)C(=O)O RAGODIJPKQJICJ-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- OUHGMKUPMHCJJJ-UHFFFAOYSA-N N#CC(C=C1)=CC2=C1OC(C=C(C1(C3=CC=CC=C3C3=C1C=CC=C3)C(C=C1)=CC3=C1OC(C=C(C=C1)C#N)=C1O3)C=C1)=C1O2 Chemical group N#CC(C=C1)=CC2=C1OC(C=C(C1(C3=CC=CC=C3C3=C1C=CC=C3)C(C=C1)=CC3=C1OC(C=C(C=C1)C#N)=C1O3)C=C1)=C1O2 OUHGMKUPMHCJJJ-UHFFFAOYSA-N 0.000 description 1
- YJPWRAFZRJBTDS-UHFFFAOYSA-N N#Cc(cc1)cc2c1Oc1ccc(C3(c(cccc4)c4-c4c3cccc4)c(cc3)cc(Oc4c5)c3Oc4ccc5C#N)cc1O2 Chemical compound N#Cc(cc1)cc2c1Oc1ccc(C3(c(cccc4)c4-c4c3cccc4)c(cc3)cc(Oc4c5)c3Oc4ccc5C#N)cc1O2 YJPWRAFZRJBTDS-UHFFFAOYSA-N 0.000 description 1
- KLLDLFFISLWQLU-UHFFFAOYSA-N N#Cc1ccc2Oc(cc(C3(c4ccccc4-c4c3cccc4)c3ccc4Oc(ccc(C#N)c5)c5Oc4c3)cc3)c3Oc2c1 Chemical compound N#Cc1ccc2Oc(cc(C3(c4ccccc4-c4c3cccc4)c3ccc4Oc(ccc(C#N)c5)c5Oc4c3)cc3)c3Oc2c1 KLLDLFFISLWQLU-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- RAIOQXXWEGZKAI-UHFFFAOYSA-N Oc1ccc(C2(c(cccc3)c3-c3c2cccc3)c(cc2)cc(O)c2O)cc1O Chemical compound Oc1ccc(C2(c(cccc3)c3-c3c2cccc3)c(cc2)cc(O)c2O)cc1O RAIOQXXWEGZKAI-UHFFFAOYSA-N 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- AUALQMFGWLZREY-UHFFFAOYSA-N acetonitrile;methanol Chemical compound OC.CC#N AUALQMFGWLZREY-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- NEHMKBQYUWJMIP-NJFSPNSNSA-N chloro(114C)methane Chemical compound [14CH3]Cl NEHMKBQYUWJMIP-NJFSPNSNSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000002933 cyclohexyloxy group Chemical group C1(CCCCC1)O* 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- BLHLJVCOVBYQQS-UHFFFAOYSA-N ethyllithium Chemical compound [Li]CC BLHLJVCOVBYQQS-UHFFFAOYSA-N 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 125000002510 isobutoxy group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])O* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- UBJFKNSINUCEAL-UHFFFAOYSA-N lithium;2-methylpropane Chemical compound [Li+].C[C-](C)C UBJFKNSINUCEAL-UHFFFAOYSA-N 0.000 description 1
- WGOPGODQLGJZGL-UHFFFAOYSA-N lithium;butane Chemical compound [Li+].CC[CH-]C WGOPGODQLGJZGL-UHFFFAOYSA-N 0.000 description 1
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- DVSDBMFJEQPWNO-UHFFFAOYSA-N methyllithium Chemical compound C[Li] DVSDBMFJEQPWNO-UHFFFAOYSA-N 0.000 description 1
- 125000006606 n-butoxy group Chemical group 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- NFBOHOGPQUYFRF-UHFFFAOYSA-N oxanthrene Chemical group C1=CC=C2OC3=CC=CC=C3OC2=C1 NFBOHOGPQUYFRF-UHFFFAOYSA-N 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- NHKJPPKXDNZFBJ-UHFFFAOYSA-N phenyllithium Chemical compound [Li]C1=CC=CC=C1 NHKJPPKXDNZFBJ-UHFFFAOYSA-N 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
- 239000011342 resin composition Substances 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 125000005023 xylyl group Chemical group 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
で示されるフルオレン化合物。
で示される、項1に記載のフルオレン化合物。
で示される、項2に記載のフルオレン化合物。
で示される、項1に記載のフルオレン化合物。
で示される、項4に記載のフルオレン化合物。
一般式(2):
で示される化合物と、
一般式(3):
で示される化合物とを、
塩基の存在下で反応させる工程
を備える、製造方法。
で示される化合物を、酸又は塩基の存在下で加水分解処理に供する工程
を備える、製造方法。
本発明のフルオレン化合物は、一般式(1):
で表されるフルオレン化合物である。
で示されるフルオレン化合物が好ましく、一般式(1A1):
で示されるフルオレン化合物がより好ましい。
で示されるフルオレン化合物が好ましく、一般式(1B1):
で示されるフルオレン化合物がより好ましい。
本発明のフルオレン化合物は、例えば、以下の反応式:
で示される経路に沿って合成することができる。
一般式(2)において、R1a、R1b、R2c、R2d、n1、n2、m3及びm4は前記説明したものを採用することができる。好ましい具体例も同様である。
一般式(1A)で示される本発明のフルオレン化合物を用いて、一般式(1B)で示される本発明のフルオレン化合物を合成する際の加水分解条件としては、特に制限されないが、強酸又は強塩基の存在下で行うことが好ましい。
示差走査熱量計(DSC;エスアイアイ・ナノテクノロジー(株)製、EXSTAR DSC6200)を用い、窒素雰囲気下で、ガラス転移温度を測定した。
使用機器:ジーエルサイエンス 7400シリーズ
検出機 :PDA Detector GL7452A λ=254nm
カラム :関東化学(株) Mightsil 4.6×150mm RP−18 GP
溶出液 :アセトニトリル:水=6:4
流速 :1ml/分。
使用機器:日本電子(株) 400MHz FT−NMR ECX−400
溶媒 :ジメチルスルホキシド(DMSO)−d6。
使用機器:エスアイアイ・ナノテクノロジー(株)TG/DTA6200
昇温プログラム:30℃−520℃ 10℃/分。
68.58%ビスカテコールフルオレン(BCAF)2.00g(3.59mmol)のイソプロピルアルコール(IPA)溶液、3,4−ジフルオロベンゾニトリル1.77g(12.74mmol)をN,N−ジメチルホルムアミド(DMF)20mLに溶解した。この溶液に炭酸カリウム4.00g(28.94mmol)を加え、アルゴン雰囲気下バス温140℃で3時間加熱撹拌した。BCAF及び3,4−ジフルオロベンゾニトリルの消失をHPLCにて確認した。反応液に水を加え生じた沈澱を濾集した。沈澱をトルエンに溶解して2回水洗し、硫酸マグネシウムで乾燥後、濾過し濾液を減圧濃縮した。得られた残渣をシリカゲルカラムクロマトグラフィ(溶出液:トルエン)で精製し、主生成物1.2gを得た。主生成物は、9,9−ビス(シアノベンゾ[1,4]ジオキシン−2−イル)フルオレン(BCNDF)と考えられた(収率57.6%)。なお、実施例1で得られたBCNDFは、
FD−MS
m/z=580に分子イオン観測(分子量580.59)。
実施例1で得たBCNDF0.83g(1.43mmol)を2−メトキシエタノール10mLに溶解した。水酸化カリウム1.01g(18.0mmol)を水1mLに溶解し、BCNDF溶液に加えた。バス温140℃で2時間加熱撹拌した。約30分後からアンモニア臭がした。放冷後水を加え、約1mol/Lの塩酸で中和した後、酢酸エチルで抽出した。有機層を2回水洗し硫酸マグネシウムで乾燥後、濾過し濾液を減圧濃縮した。得られた固体をアセトン-水から再結晶(再沈澱)した。白色固体の9,9−ビス(シアノベンゾ[1,4]ジオキシン−2−イル)フルオレン(BCDF)を0.83g得た(収率93.8%)。なお、実施例2で得られたBCDFは、
1H−NMR(DMSO−d6)
ppm:8.0(2H)、7.5(10H)、7.0(4H)、6.8(4H)
FD−MS
m/z=618に分子イオン観測(分子量618.59)。
3,4−ジフルオロベンゾニトリル1.77g(12.74mmol)を1.23g(8.8mmol)使用した他は、実施例1と同様にして9,9−ビス(シアノベンゾ[1,4]ジオキシン−2−イル)フルオレン(BCNDF)を1.63g得た。収率は78.3%であった。
68.58%ビスカテコールフルオレン(BCAF)20.67g(37.1mmol)のイソプロピルアルコール(IPA)溶液、3,4−ジクロロベンゾニトリル12.95g(75.3mmol)をN,N−ジメチルホルムアミド(DMF)100mLに溶解した。この溶液に炭酸カリウム20.39g(147mmol)を加え、アルゴン雰囲気下バス温140℃で17時間加熱撹拌した。反応液をロータリーエバポレータでできるだけ減圧濃縮した。残渣に水を加え沈澱を濾集した。得られた沈澱を60℃で17時間温風乾燥した後さらに60℃で6時間減圧乾燥した。得られた固体とトルエンに加熱溶解し、不溶分を濾過した。濾液を減圧濃縮し、得られた残渣を溶出液トルエンのシリカゲルカラムクロマトグラフィで精製し、主生成物17.0gを得た。主生成物は、9,9−ビス(シアノベンゾ[1,4]ジオキシン−2−イル)フルオレン(BCNDF)と考えられた(収率79.0%)。
BCNDF0.83g(1.43mmol)に代えてBCNDFを1.20g(2.07mmol)、2−メトキシエタノール10mLに代えて2−エトキシエタノールを12ml、水酸化カリウム1.01g(18mmol)に代えて水酸化ナトリウムを1.14g(28.5mmol)使用し、バス温120℃で5時間加熱撹拌した他は、実施例2と同様にして、白色固体の9,9−ビス(カルボキシベンゾ[1,4]ジオキシン−2−イル)フルオレン(BCDF)を1.22g得た(収率99%)。
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