JP6382934B2 - 癌治療のためのａｄｉ−ｐｅｇ２０抗体に対して低減された交差反応性を有するアルギニンデイミナーゼ - Google Patents

癌治療のためのａｄｉ−ｐｅｇ２０抗体に対して低減された交差反応性を有するアルギニンデイミナーゼ Download PDF

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JP6382934B2
JP6382934B2 JP2016502236A JP2016502236A JP6382934B2 JP 6382934 B2 JP6382934 B2 JP 6382934B2 JP 2016502236 A JP2016502236 A JP 2016502236A JP 2016502236 A JP2016502236 A JP 2016502236A JP 6382934 B2 JP6382934 B2 JP 6382934B2
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adi
cancer
adir
peg
therapeutic composition
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JP2016519069A5 (OSRAM
JP2016519069A (ja
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ロバート アルマッシー，
ロバート アルマッシー，
リチャード イー． ショウォルター，
リチャード イー． ショウォルター，
ジェイムズ エー． トムソン，
ジェイムズ エー． トムソン，
ウェス シッソン，
ウェス シッソン，
ウェイ−ジョン シア，
ウェイ−ジョン シア，
リー−チャン チェン，
リー−チャン チェン，
ヤン リー，
ヤン リー，
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ポラリス グループ
ポラリス グループ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03006—Arginine deiminase (3.5.3.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
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  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2016502236A 2013-03-15 2014-03-13 癌治療のためのａｄｉ−ｐｅｇ２０抗体に対して低減された交差反応性を有するアルギニンデイミナーゼ Active JP6382934B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790833P 2013-03-15 2013-03-15
US61/790,833 2013-03-15
PCT/US2014/026766 WO2014151982A2 (en) 2013-03-15 2014-03-13 Arginine deiminase with reduced cross-reactivity toward adi – peg 20 antibodies for cancer treatment

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JP2016519069A JP2016519069A (ja) 2016-06-30
JP2016519069A5 JP2016519069A5 (OSRAM) 2017-04-13
JP6382934B2 true JP6382934B2 (ja) 2018-08-29

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JP2016502236A Active JP6382934B2 (ja) 2013-03-15 2014-03-13 癌治療のためのａｄｉ−ｐｅｇ２０抗体に対して低減された交差反応性を有するアルギニンデイミナーゼ

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Country Link
US (2) US11235037B2 (OSRAM)
EP (2) EP2968482B1 (OSRAM)
JP (1) JP6382934B2 (OSRAM)
KR (2) KR102263038B1 (OSRAM)
CN (1) CN105188739B (OSRAM)
AU (1) AU2014236653B2 (OSRAM)
BR (1) BR112015021483A2 (OSRAM)
CA (1) CA2901795C (OSRAM)
ES (1) ES2805360T3 (OSRAM)
RU (1) RU2015141932A (OSRAM)
SG (1) SG11201507354QA (OSRAM)
WO (1) WO2014151982A2 (OSRAM)

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Publication number Priority date Publication date Assignee Title
EP4582090A3 (en) 2012-04-04 2025-09-17 Polaris Group Composition comprising pegylated arginine deiminase
JP6382934B2 (ja) 2013-03-15 2018-08-29 ポラリス グループ 癌治療のためのａｄｉ−ｐｅｇ２０抗体に対して低減された交差反応性を有するアルギニンデイミナーゼ
CN106794229B (zh) * 2014-03-18 2020-12-18 瑞华药业集团 工程化嵌合聚乙二醇化adi和使用方法
EP3166972B1 (en) 2014-07-08 2020-03-11 TDW Group Antibodies to argininosuccinate synthase and related methods
KR102730989B1 (ko) * 2014-09-16 2024-11-14 티디더블유 그룹 암 치료용 adi-peg 20 항체에 대한 감소된 교차-반응성을 갖는 아르기닌 데이미나아제
TWI699210B (zh) * 2015-03-18 2020-07-21 開曼群島商瑞華藥業集團 工程化之嵌合聚乙二醇化ａｄｉ及使用方法
CN119950689A (zh) 2016-07-05 2025-05-09 北极星药业集团股份有限公司 使用精氨酸耗竭剂的组合癌症免疫疗法
WO2018085551A2 (en) * 2016-11-02 2018-05-11 Polaris Group Formulations of pegylated arginine deiminase
WO2018167780A1 (en) * 2017-03-12 2018-09-20 Yeda Research And Development Co. Ltd. Methods of prognosing and treating cancer
EP3609527B1 (en) * 2017-03-29 2025-07-30 Polaris Group Protein conjugates
CN108324951B (zh) * 2018-04-16 2021-05-25 薛剑峰 一种精氨酸脱亚胺酶注射剂及其制备方法

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JP6382934B2 (ja) 2013-03-15 2018-08-29 ポラリス グループ 癌治療のためのａｄｉ−ｐｅｇ２０抗体に対して低減された交差反応性を有するアルギニンデイミナーゼ
CN106794229B (zh) 2014-03-18 2020-12-18 瑞华药业集团 工程化嵌合聚乙二醇化adi和使用方法
KR102730989B1 (ko) 2014-09-16 2024-11-14 티디더블유 그룹 암 치료용 adi-peg 20 항체에 대한 감소된 교차-반응성을 갖는 아르기닌 데이미나아제

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KR20150129728A (ko) 2015-11-20
US20220105160A1 (en) 2022-04-07
KR20210069126A (ko) 2021-06-10
RU2015141932A (ru) 2017-04-26
CN105188739A (zh) 2015-12-23
US11235037B2 (en) 2022-02-01
EP2968482A2 (en) 2016-01-20
WO2014151982A3 (en) 2015-01-08
ES2805360T3 (es) 2021-02-11
CN105188739B (zh) 2017-06-23
KR102263038B1 (ko) 2021-06-14
SG11201507354QA (en) 2015-10-29
EP2968482A4 (en) 2016-07-20
US20140348814A1 (en) 2014-11-27
EP2968482B1 (en) 2020-05-06
BR112015021483A2 (pt) 2017-10-10
CA2901795A1 (en) 2014-09-25
CA2901795C (en) 2022-08-02
JP2016519069A (ja) 2016-06-30
EP3744341A1 (en) 2020-12-02
KR102455753B1 (ko) 2022-10-17
HK1214139A1 (en) 2016-07-22
WO2014151982A2 (en) 2014-09-25
HK1219232A1 (zh) 2017-03-31
AU2014236653A1 (en) 2015-09-10
AU2014236653B2 (en) 2019-04-18

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