JP6371303B2 - 目標物質のインビトロ磁気共鳴検出 - Google Patents

目標物質のインビトロ磁気共鳴検出 Download PDF

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Publication number
JP6371303B2
JP6371303B2 JP2015547053A JP2015547053A JP6371303B2 JP 6371303 B2 JP6371303 B2 JP 6371303B2 JP 2015547053 A JP2015547053 A JP 2015547053A JP 2015547053 A JP2015547053 A JP 2015547053A JP 6371303 B2 JP6371303 B2 JP 6371303B2
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Japan
Prior art keywords
target substance
2bound
magnetic nanoparticles
2free
sample
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Expired - Fee Related
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JP2015547053A
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English (en)
Japanese (ja)
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JP2016503159A (ja
JP2016503159A5 (enExample
Inventor
ヴェンカテサン，ラメシュ
バラシュブラマニアン，アルン
アトレッヤ，チャンダン・ラマスワミィ
ヘッジ，ラヴィ
ムクハージェ，リティカ・アッパル
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General Electric Co
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General Electric Co
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Priority claimed from GB201301992A external-priority patent/GB201301992D0/en
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Publication of JP2016503159A5 publication Critical patent/JP2016503159A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/32—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Bacillus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2015547053A 2012-12-17 2013-12-13 目標物質のインビトロ磁気共鳴検出 Expired - Fee Related JP6371303B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN3886/DEL/2012 2012-12-17
IN3886DE2012 2012-12-17
GB201301992A GB201301992D0 (en) 2013-02-05 2013-02-05 In-vitro magnetic resonance detection of a target substance
GB1301992.2 2013-02-05
PCT/EP2013/076569 WO2014095645A1 (en) 2012-12-17 2013-12-13 In-vitro magnetic resonance detection of a target substance

Publications (3)

Publication Number Publication Date
JP2016503159A JP2016503159A (ja) 2016-02-01
JP2016503159A5 JP2016503159A5 (enExample) 2017-01-26
JP6371303B2 true JP6371303B2 (ja) 2018-08-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015547053A Expired - Fee Related JP6371303B2 (ja) 2012-12-17 2013-12-13 目標物質のインビトロ磁気共鳴検出

Country Status (5)

Country Link
US (1) US10156567B2 (enExample)
EP (1) EP2932289A1 (enExample)
JP (1) JP6371303B2 (enExample)
CN (1) CN104871026B (enExample)
WO (1) WO2014095645A1 (enExample)

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* Cited by examiner, † Cited by third party
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JP6244289B2 (ja) * 2014-10-29 2017-12-06 学校法人 神野学園 クドア・セプテンプンクタータの検出方法
CN109477873A (zh) 2016-07-21 2019-03-15 西门子医疗保健诊断公司 用于ivd自动化系统的磁屏蔽
CN107478834A (zh) * 2017-09-05 2017-12-15 杨蕾 一种检测沙门氏菌磁共振成像试剂盒的制备方法
EP3575813B1 (en) * 2018-05-30 2022-06-29 Siemens Healthcare GmbH Quantitative mapping of a magnetic resonance imaging parameter by data-driven signal-model learning
CN109658468B (zh) * 2018-12-12 2022-12-13 深圳先进技术研究院 磁共振参数成像方法、装置、设备及存储介质
EP4047356A4 (en) * 2019-10-17 2023-11-22 Riken DETECTION METHOD AND SYSTEM FOR DETECTION OF MASTITIS IN A DOMESTIC ANIMAL
IL295143B2 (en) * 2020-02-13 2026-02-01 Hoffmann La Roche A method for determining the loading state of AAV particles using nuclear magnetic resonance relaxometry
CN112611868A (zh) * 2020-12-18 2021-04-06 厦门大学 一种用于磁共振分析方法检测新型冠状病毒的探针及其制备方法
EP4423520A4 (en) * 2021-10-28 2025-09-03 Massachusetts Inst Technology MAGNETIC RESONANCE MICRORELAXOMETRY (MMRR) FOR RAPID AND NON-INVASIVE DETECTION OF SENESCENCE IN MESENCHYMAL STEM CELLS
EP4732029A1 (en) * 2023-06-20 2026-04-29 Regents of the University of Michigan Methods for magnetic resonance molecular imaging of nanoconstructs and uses thereof

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US20030028093A1 (en) * 2001-04-20 2003-02-06 Yong Ke Exponential decay modeling in spectroscopy
US7088102B1 (en) 2005-03-03 2006-08-08 Varian, Inc. Rapid sample multiplexing
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EP1880228B1 (en) 2005-05-09 2011-07-06 The General Hospital Corporation Water relaxation-based sensors
US7560289B2 (en) * 2005-11-16 2009-07-14 Chin-Yih Rex Hong Methods of quantitatively measuring biomolecules
US20070166730A1 (en) 2006-01-19 2007-07-19 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
DE102007009494A1 (de) * 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
US8421458B2 (en) * 2007-09-28 2013-04-16 T2 Biosystems, Inc. NMR diagnostics by means of a plastic sample container
WO2009045551A1 (en) * 2007-10-04 2009-04-09 The General Hospital Corporation Miniaturized magnetic resonance systems and methods
DE102007049701B4 (de) 2007-10-17 2010-09-23 Bruker Biospin Ag NMR-Messkopf mit mehreren Resonatorsystemen zur simultanen Vermessung mehrerer Messproben in einem gekoppelten Mode
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CN105920620A (zh) * 2016-06-21 2016-09-07 东南大学 磁性荧光多模态纳米生物探针及其制备方法和应用

Also Published As

Publication number Publication date
JP2016503159A (ja) 2016-02-01
EP2932289A1 (en) 2015-10-21
CN104871026B (zh) 2020-01-10
WO2014095645A1 (en) 2014-06-26
US10156567B2 (en) 2018-12-18
CN104871026A (zh) 2015-08-26
US20160195526A1 (en) 2016-07-07

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