JP6366709B2 - アザインドール化合物、その合成、および同化合物の使用方法 - Google Patents

アザインドール化合物、その合成、および同化合物の使用方法 Download PDF

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JP6366709B2
JP6366709B2 JP2016526988A JP2016526988A JP6366709B2 JP 6366709 B2 JP6366709 B2 JP 6366709B2 JP 2016526988 A JP2016526988 A JP 2016526988A JP 2016526988 A JP2016526988 A JP 2016526988A JP 6366709 B2 JP6366709 B2 JP 6366709B2
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methyl
hydrogen
mmol
added
pyridine
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JP2016530242A (ja
JP2016530242A5 (enExample
Inventor
プラビン・エス・シルデ
マルティ・エヌ・ナイク
ビカス・ナラヤン・シンデ
シャフル・ハミード・ペール・モハメド
モナリサ・チャテルジ
ラダ・ケイ・シャンディル
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Foundation For Neglected Disease Research
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Foundation For Neglected Disease Research
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2016526988A 2013-07-17 2014-07-10 アザインドール化合物、その合成、および同化合物の使用方法 Active JP6366709B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN3196CH2013 2013-07-17
IN3196/CHE/2013 2013-07-17
PCT/US2014/046100 WO2015009525A1 (en) 2013-07-17 2014-07-10 Azaindole compounds, synthesis thereof, and methods of using the same

Publications (3)

Publication Number Publication Date
JP2016530242A JP2016530242A (ja) 2016-09-29
JP2016530242A5 JP2016530242A5 (enExample) 2017-08-17
JP6366709B2 true JP6366709B2 (ja) 2018-08-01

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JP2016526988A Active JP6366709B2 (ja) 2013-07-17 2014-07-10 アザインドール化合物、その合成、および同化合物の使用方法

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US (1) US9163020B2 (enExample)
EP (1) EP3021947B1 (enExample)
JP (1) JP6366709B2 (enExample)
KR (1) KR102301753B1 (enExample)
CN (1) CN105636646B (enExample)
AU (1) AU2014290598B2 (enExample)
CA (1) CA2918487C (enExample)
EA (1) EA028611B1 (enExample)
ES (1) ES2644025T3 (enExample)
WO (1) WO2015009525A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201512197A (zh) * 2013-08-30 2015-04-01 Hoffmann La Roche 吡咯并吡啶或吡唑并吡啶衍生物
GB201317363D0 (en) * 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
US11173113B2 (en) 2017-12-06 2021-11-16 Prollergy Corporation Composition and method for reducing allergic response
RU2702224C2 (ru) * 2018-03-29 2019-10-07 Общество С Ограниченной Ответственностью "Мт-Медикалс" Производные фенил формамидина, обладающие антимикобактериальной активностью
KR20210021042A (ko) * 2018-06-15 2021-02-24 카딜라 핼쓰캐어 리미티드 포유동물 감염 치료를 위한 신규한 화합물
WO2020188405A1 (en) * 2019-03-20 2020-09-24 Foundation For Neglected Disease Research Benzimidazoles derivatives as anti-tuberculosis agents
CN111393435A (zh) * 2020-03-16 2020-07-10 青岛吉澳医药科技有限公司 氮杂吲哚酰胺类化合物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1532980A1 (en) * 2003-11-24 2005-05-25 Novo Nordisk A/S N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes
BRPI0812594A2 (pt) * 2007-08-10 2015-06-23 Lundbeck & Co As H Composto ou sal ou hidrato do mesmo, composição farmacêutica, métodos para modulação da atividade de um receptor p2x7, para tratamento de uma condição responsiva á modulação do receptor p2x7 em um paciente, para inibição de morte de células gangliônicas retinais em um paciente, para determinação da presença ou ausência de receptor p2x7 em uma amostra, preparação farmacêutica acondicionada, e, uso de um composto ou sal ou hidrato do mesmo.
MX345762B (es) * 2010-03-18 2017-02-15 Pasteur Institut Korea Compuestos antiinfecciosos.

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Publication number Publication date
AU2014290598B2 (en) 2018-11-08
EP3021947A1 (en) 2016-05-25
CA2918487A1 (en) 2015-01-22
AU2014290598A1 (en) 2016-02-11
CN105636646A (zh) 2016-06-01
BR112016000712A2 (pt) 2022-03-22
CA2918487C (en) 2021-08-03
JP2016530242A (ja) 2016-09-29
WO2015009525A1 (en) 2015-01-22
US9163020B2 (en) 2015-10-20
EA201690227A1 (ru) 2016-07-29
CN105636646B (zh) 2017-12-19
KR20160058757A (ko) 2016-05-25
KR102301753B1 (ko) 2021-09-15
ES2644025T3 (es) 2017-11-27
EP3021947B1 (en) 2017-08-23
EA028611B1 (ru) 2017-12-29
US20150025087A1 (en) 2015-01-22

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