EA028611B1 - Азаиндольные соединения, их получение и способы их применения - Google Patents
Азаиндольные соединения, их получение и способы их применения Download PDFInfo
- Publication number
- EA028611B1 EA028611B1 EA201690227A EA201690227A EA028611B1 EA 028611 B1 EA028611 B1 EA 028611B1 EA 201690227 A EA201690227 A EA 201690227A EA 201690227 A EA201690227 A EA 201690227A EA 028611 B1 EA028611 B1 EA 028611B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methyl
- mmol
- represents hydrogen
- pyrrolo
- methoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3196CH2013 | 2013-07-17 | ||
| PCT/US2014/046100 WO2015009525A1 (en) | 2013-07-17 | 2014-07-10 | Azaindole compounds, synthesis thereof, and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201690227A1 EA201690227A1 (ru) | 2016-07-29 |
| EA028611B1 true EA028611B1 (ru) | 2017-12-29 |
Family
ID=51261257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201690227A EA028611B1 (ru) | 2013-07-17 | 2014-07-10 | Азаиндольные соединения, их получение и способы их применения |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9163020B2 (enExample) |
| EP (1) | EP3021947B1 (enExample) |
| JP (1) | JP6366709B2 (enExample) |
| KR (1) | KR102301753B1 (enExample) |
| CN (1) | CN105636646B (enExample) |
| AU (1) | AU2014290598B2 (enExample) |
| CA (1) | CA2918487C (enExample) |
| EA (1) | EA028611B1 (enExample) |
| ES (1) | ES2644025T3 (enExample) |
| WO (1) | WO2015009525A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201512197A (zh) * | 2013-08-30 | 2015-04-01 | Hoffmann La Roche | 吡咯并吡啶或吡唑并吡啶衍生物 |
| GB201317363D0 (en) * | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| CN111629721A (zh) | 2017-12-06 | 2020-09-04 | 百乐吉公司 | 用于减少过敏反应的组合物和方法 |
| RU2702224C2 (ru) * | 2018-03-29 | 2019-10-07 | Общество С Ограниченной Ответственностью "Мт-Медикалс" | Производные фенил формамидина, обладающие антимикобактериальной активностью |
| CN112543757A (zh) * | 2018-06-15 | 2021-03-23 | 卡迪拉保健有限公司 | 对结核菌具有抗菌活性的缩合氮杂杂芳基化合物 |
| WO2020188405A1 (en) * | 2019-03-20 | 2020-09-24 | Foundation For Neglected Disease Research | Benzimidazoles derivatives as anti-tuberculosis agents |
| CN111393435A (zh) * | 2020-03-16 | 2020-07-10 | 青岛吉澳医药科技有限公司 | 氮杂吲哚酰胺类化合物及其制备方法和用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011113606A1 (en) * | 2010-03-18 | 2011-09-22 | Institut Pasteur Korea | Anti-infective compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1532980A1 (en) * | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
| EP2185560A4 (en) * | 2007-08-10 | 2011-10-05 | Lundbeck & Co As H | HETEROARYLAMIDE ANALOGS |
-
2014
- 2014-07-10 JP JP2016526988A patent/JP6366709B2/ja active Active
- 2014-07-10 US US14/327,784 patent/US9163020B2/en active Active
- 2014-07-10 CN CN201480046182.4A patent/CN105636646B/zh active Active
- 2014-07-10 KR KR1020167004150A patent/KR102301753B1/ko active Active
- 2014-07-10 ES ES14745305.4T patent/ES2644025T3/es active Active
- 2014-07-10 CA CA2918487A patent/CA2918487C/en active Active
- 2014-07-10 WO PCT/US2014/046100 patent/WO2015009525A1/en not_active Ceased
- 2014-07-10 AU AU2014290598A patent/AU2014290598B2/en active Active
- 2014-07-10 EP EP14745305.4A patent/EP3021947B1/en active Active
- 2014-07-10 EA EA201690227A patent/EA028611B1/ru unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011113606A1 (en) * | 2010-03-18 | 2011-09-22 | Institut Pasteur Korea | Anti-infective compounds |
Non-Patent Citations (7)
| Title |
|---|
| ANANTHAN S, FAALEOLEA E R, GOLDMAN R C, HOBRATH J V, KWONG C D, LAUGHON B E, MADDRY J A, MEHTA A, RASMUSSEN L, REYNOLDS R C, SECRI: "High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv", TUBERCULOSIS, ELSEVIER, GB, vol. 89, no. 5, 1 September 2009 (2009-09-01), GB, pages 334 - 353, XP002729984, ISSN: 1472-9792, DOI: 10.1016/j.tube.2009.05.008 * |
| BALLELL L, BATES R H, YOUNG R J, ALVAREZ-GOMEZ D, ALVAREZ-RUIZ E, BARROSO V, BLANCO D, CRESPO B, ESCRIBANO J, GONZÁLEZ R, LOZANO S: "Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis", CHEMMEDCHEM, WILEY-VCH, vol. 8, no. 2, 1 February 2013 (2013-02-01), pages 313 - 321, XP002729988, ISSN: 1860-7179, DOI: 10.1002/cmdc.201200428 * |
| BALLELL L, FIELD R A, DUNCAN K, YOUNG R J: "New small-molecule synthetic antimycobacterials", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 49, no. 6, 1 June 2005 (2005-06-01), pages 2153 - 2163, XP002729983, ISSN: 0066-4804, DOI: 10.1128/AAC.49.6.2153-2163.2005 * |
| EKINS S, REYNOLDS R C, KIM H, KOO M S, EKONOMIDIS M, TALAUE M, PAGET S D, WOOLHISER L K, LENAERTS A J, BUNIN B A, CONNELL N, FREUN: "Bayesian Models Leveraging Bioactivity and Cytotoxicity Information for Drug Discovery", CHEMISTRY AND BIOLOGY., CURRENT BIOLOGY, LONDON, GB, vol. 20, no. 3, 21 March 2013 (2013-03-21), GB, pages 370 - 378, XP002729987, ISSN: 1074-5521, DOI: 10.1016/j.chembiol.2013.01.011 * |
| ERIC L. NUERMBERGER, MELVIN K. SPIGELMAN, WING WAI YEW: "Current development and future propects in chemotherapy of tuberculosis", RESPIROLOGY, BLACKWELL PUB., vol. 15, no. 5, 1 July 2010 (2010-07-01), pages 764 - 778, XP002729985, ISSN: 1323-7799, DOI: 10.1111/J.1440-1843.2010.01775.X * |
| REYNOLDS R C, ANANTHAN S, FAALEOLEA E, HOBRATH J V, KWONG C D, MADDOX C, RASMUSSEN L, SOSA M I, THAMMASUVIMOL E, WHITE E L, ZHANG : "High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.", TUBERCULOSIS, ELSEVIER, GB, vol. 92, no. 1, 1 January 2012 (2012-01-01), GB, pages 72 - 83, XP002729986, ISSN: 1472-9792, DOI: 10.1016/J.TUBE.2011.05.005 * |
| ZHANG YING: "The magic bullets and tuberculosis drug targets", ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY., ANNUAL REVIEW INC., PALO ALTO, CA., US, vol. 45, 1 January 2005 (2005-01-01), US, pages 529 - 564, XP002729982, ISSN: 0362-1642, DOI: 10.1146/annurev.pharmtox.45.120403.100120 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2918487A1 (en) | 2015-01-22 |
| CA2918487C (en) | 2021-08-03 |
| CN105636646A (zh) | 2016-06-01 |
| WO2015009525A1 (en) | 2015-01-22 |
| AU2014290598B2 (en) | 2018-11-08 |
| JP6366709B2 (ja) | 2018-08-01 |
| AU2014290598A1 (en) | 2016-02-11 |
| US9163020B2 (en) | 2015-10-20 |
| EA201690227A1 (ru) | 2016-07-29 |
| KR102301753B1 (ko) | 2021-09-15 |
| JP2016530242A (ja) | 2016-09-29 |
| CN105636646B (zh) | 2017-12-19 |
| EP3021947B1 (en) | 2017-08-23 |
| KR20160058757A (ko) | 2016-05-25 |
| EP3021947A1 (en) | 2016-05-25 |
| ES2644025T3 (es) | 2017-11-27 |
| BR112016000712A2 (pt) | 2022-03-22 |
| US20150025087A1 (en) | 2015-01-22 |
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