EA028611B1 - Азаиндольные соединения, их получение и способы их применения - Google Patents
Азаиндольные соединения, их получение и способы их применения Download PDFInfo
- Publication number
- EA028611B1 EA028611B1 EA201690227A EA201690227A EA028611B1 EA 028611 B1 EA028611 B1 EA 028611B1 EA 201690227 A EA201690227 A EA 201690227A EA 201690227 A EA201690227 A EA 201690227A EA 028611 B1 EA028611 B1 EA 028611B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methyl
- mmol
- represents hydrogen
- pyrrolo
- methoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3196CH2013 | 2013-07-17 | ||
| PCT/US2014/046100 WO2015009525A1 (en) | 2013-07-17 | 2014-07-10 | Azaindole compounds, synthesis thereof, and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201690227A1 EA201690227A1 (ru) | 2016-07-29 |
| EA028611B1 true EA028611B1 (ru) | 2017-12-29 |
Family
ID=51261257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201690227A EA028611B1 (ru) | 2013-07-17 | 2014-07-10 | Азаиндольные соединения, их получение и способы их применения |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9163020B2 (enExample) |
| EP (1) | EP3021947B1 (enExample) |
| JP (1) | JP6366709B2 (enExample) |
| KR (1) | KR102301753B1 (enExample) |
| CN (1) | CN105636646B (enExample) |
| AU (1) | AU2014290598B2 (enExample) |
| CA (1) | CA2918487C (enExample) |
| EA (1) | EA028611B1 (enExample) |
| ES (1) | ES2644025T3 (enExample) |
| WO (1) | WO2015009525A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201512197A (zh) * | 2013-08-30 | 2015-04-01 | Hoffmann La Roche | 吡咯并吡啶或吡唑并吡啶衍生物 |
| GB201317363D0 (en) * | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| US11173113B2 (en) | 2017-12-06 | 2021-11-16 | Prollergy Corporation | Composition and method for reducing allergic response |
| RU2702224C2 (ru) * | 2018-03-29 | 2019-10-07 | Общество С Ограниченной Ответственностью "Мт-Медикалс" | Производные фенил формамидина, обладающие антимикобактериальной активностью |
| KR20210021042A (ko) * | 2018-06-15 | 2021-02-24 | 카딜라 핼쓰캐어 리미티드 | 포유동물 감염 치료를 위한 신규한 화합물 |
| WO2020188405A1 (en) * | 2019-03-20 | 2020-09-24 | Foundation For Neglected Disease Research | Benzimidazoles derivatives as anti-tuberculosis agents |
| CN111393435A (zh) * | 2020-03-16 | 2020-07-10 | 青岛吉澳医药科技有限公司 | 氮杂吲哚酰胺类化合物及其制备方法和用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011113606A1 (en) * | 2010-03-18 | 2011-09-22 | Institut Pasteur Korea | Anti-infective compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1532980A1 (en) * | 2003-11-24 | 2005-05-25 | Novo Nordisk A/S | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes |
| BRPI0812594A2 (pt) * | 2007-08-10 | 2015-06-23 | Lundbeck & Co As H | Composto ou sal ou hidrato do mesmo, composição farmacêutica, métodos para modulação da atividade de um receptor p2x7, para tratamento de uma condição responsiva á modulação do receptor p2x7 em um paciente, para inibição de morte de células gangliônicas retinais em um paciente, para determinação da presença ou ausência de receptor p2x7 em uma amostra, preparação farmacêutica acondicionada, e, uso de um composto ou sal ou hidrato do mesmo. |
-
2014
- 2014-07-10 KR KR1020167004150A patent/KR102301753B1/ko active Active
- 2014-07-10 AU AU2014290598A patent/AU2014290598B2/en active Active
- 2014-07-10 EA EA201690227A patent/EA028611B1/ru unknown
- 2014-07-10 WO PCT/US2014/046100 patent/WO2015009525A1/en not_active Ceased
- 2014-07-10 CN CN201480046182.4A patent/CN105636646B/zh active Active
- 2014-07-10 US US14/327,784 patent/US9163020B2/en active Active
- 2014-07-10 EP EP14745305.4A patent/EP3021947B1/en active Active
- 2014-07-10 ES ES14745305.4T patent/ES2644025T3/es active Active
- 2014-07-10 JP JP2016526988A patent/JP6366709B2/ja active Active
- 2014-07-10 CA CA2918487A patent/CA2918487C/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011113606A1 (en) * | 2010-03-18 | 2011-09-22 | Institut Pasteur Korea | Anti-infective compounds |
Non-Patent Citations (7)
| Title |
|---|
| ANANTHAN S, FAALEOLEA E R, GOLDMAN R C, HOBRATH J V, KWONG C D, LAUGHON B E, MADDRY J A, MEHTA A, RASMUSSEN L, REYNOLDS R C, SECRI: "High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv", TUBERCULOSIS, ELSEVIER, GB, vol. 89, no. 5, 1 September 2009 (2009-09-01), GB, pages 334 - 353, XP002729984, ISSN: 1472-9792, DOI: 10.1016/j.tube.2009.05.008 * |
| BALLELL L, BATES R H, YOUNG R J, ALVAREZ-GOMEZ D, ALVAREZ-RUIZ E, BARROSO V, BLANCO D, CRESPO B, ESCRIBANO J, GONZÁLEZ R, LOZANO S: "Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis", CHEMMEDCHEM, WILEY-VCH, vol. 8, no. 2, 1 February 2013 (2013-02-01), pages 313 - 321, XP002729988, ISSN: 1860-7179, DOI: 10.1002/cmdc.201200428 * |
| BALLELL L, FIELD R A, DUNCAN K, YOUNG R J: "New small-molecule synthetic antimycobacterials", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 49, no. 6, 1 June 2005 (2005-06-01), pages 2153 - 2163, XP002729983, ISSN: 0066-4804, DOI: 10.1128/AAC.49.6.2153-2163.2005 * |
| EKINS S, REYNOLDS R C, KIM H, KOO M S, EKONOMIDIS M, TALAUE M, PAGET S D, WOOLHISER L K, LENAERTS A J, BUNIN B A, CONNELL N, FREUN: "Bayesian Models Leveraging Bioactivity and Cytotoxicity Information for Drug Discovery", CHEMISTRY AND BIOLOGY., CURRENT BIOLOGY, LONDON, GB, vol. 20, no. 3, 21 March 2013 (2013-03-21), GB, pages 370 - 378, XP002729987, ISSN: 1074-5521, DOI: 10.1016/j.chembiol.2013.01.011 * |
| ERIC L. NUERMBERGER, MELVIN K. SPIGELMAN, WING WAI YEW: "Current development and future propects in chemotherapy of tuberculosis", RESPIROLOGY, BLACKWELL PUB., vol. 15, no. 5, 1 July 2010 (2010-07-01), pages 764 - 778, XP002729985, ISSN: 1323-7799, DOI: 10.1111/J.1440-1843.2010.01775.X * |
| REYNOLDS R C, ANANTHAN S, FAALEOLEA E, HOBRATH J V, KWONG C D, MADDOX C, RASMUSSEN L, SOSA M I, THAMMASUVIMOL E, WHITE E L, ZHANG : "High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.", TUBERCULOSIS, ELSEVIER, GB, vol. 92, no. 1, 1 January 2012 (2012-01-01), GB, pages 72 - 83, XP002729986, ISSN: 1472-9792, DOI: 10.1016/J.TUBE.2011.05.005 * |
| ZHANG YING: "The magic bullets and tuberculosis drug targets", ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY., ANNUAL REVIEW INC., PALO ALTO, CA., US, vol. 45, 1 January 2005 (2005-01-01), US, pages 529 - 564, XP002729982, ISSN: 0362-1642, DOI: 10.1146/annurev.pharmtox.45.120403.100120 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014290598B2 (en) | 2018-11-08 |
| EP3021947A1 (en) | 2016-05-25 |
| CA2918487A1 (en) | 2015-01-22 |
| AU2014290598A1 (en) | 2016-02-11 |
| CN105636646A (zh) | 2016-06-01 |
| BR112016000712A2 (pt) | 2022-03-22 |
| CA2918487C (en) | 2021-08-03 |
| JP2016530242A (ja) | 2016-09-29 |
| WO2015009525A1 (en) | 2015-01-22 |
| US9163020B2 (en) | 2015-10-20 |
| EA201690227A1 (ru) | 2016-07-29 |
| JP6366709B2 (ja) | 2018-08-01 |
| CN105636646B (zh) | 2017-12-19 |
| KR20160058757A (ko) | 2016-05-25 |
| KR102301753B1 (ko) | 2021-09-15 |
| ES2644025T3 (es) | 2017-11-27 |
| EP3021947B1 (en) | 2017-08-23 |
| US20150025087A1 (en) | 2015-01-22 |
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