JP6353654B2 - 抗血管新生剤及びこのような薬剤の使用方法 - Google Patents

抗血管新生剤及びこのような薬剤の使用方法 Download PDF

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Publication number
JP6353654B2
JP6353654B2 JP2013519804A JP2013519804A JP6353654B2 JP 6353654 B2 JP6353654 B2 JP 6353654B2 JP 2013519804 A JP2013519804 A JP 2013519804A JP 2013519804 A JP2013519804 A JP 2013519804A JP 6353654 B2 JP6353654 B2 JP 6353654B2
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Prior art keywords
polypeptide
seq
angiogenic
pharmaceutical composition
agents
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JP2013519804A
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English (en)
Japanese (ja)
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JP2013534538A (ja
Inventor
リュー，ジー‐レン
ヤン，ジェニー・ジェイ
ルー，イン
Original Assignee
ジョージア・ステイト・ユニヴァーシティ・リサーチ・ファウンデイション
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70507—CD2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2013519804A 2010-07-13 2011-07-13 抗血管新生剤及びこのような薬剤の使用方法 Active JP6353654B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36393310P 2010-07-13 2010-07-13
US61/363,933 2010-07-13
PCT/US2011/043907 WO2012009471A1 (en) 2010-07-13 2011-07-13 Anti-angiogenic agent and method of using such agent

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016078990A Division JP2016175913A (ja) 2010-07-13 2016-04-11 抗血管新生剤及びこのような薬剤の使用方法

Publications (2)

Publication Number Publication Date
JP2013534538A JP2013534538A (ja) 2013-09-05
JP6353654B2 true JP6353654B2 (ja) 2018-07-04

Family

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Family Applications (2)

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JP2013519804A Active JP6353654B2 (ja) 2010-07-13 2011-07-13 抗血管新生剤及びこのような薬剤の使用方法
JP2016078990A Pending JP2016175913A (ja) 2010-07-13 2016-04-11 抗血管新生剤及びこのような薬剤の使用方法

Family Applications After (1)

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JP2016078990A Pending JP2016175913A (ja) 2010-07-13 2016-04-11 抗血管新生剤及びこのような薬剤の使用方法

Country Status (12)

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US (2) US9175063B2 (enExample)
EP (2) EP3381462B1 (enExample)
JP (2) JP6353654B2 (enExample)
CN (1) CN103002904B (enExample)
AU (5) AU2011279155B2 (enExample)
CA (1) CA2804753C (enExample)
DK (1) DK2593127T3 (enExample)
ES (2) ES2923430T3 (enExample)
HU (1) HUE040205T2 (enExample)
PL (1) PL2593127T3 (enExample)
PT (2) PT3381462T (enExample)
WO (1) WO2012009471A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2593127T3 (en) * 2010-07-13 2018-07-02 Georgia State Univ Research Foundation ANTIANGIOGENTIC AGENT AND METHOD OF USING SUCH AGENTS
EP4706760A3 (en) * 2015-03-06 2026-05-27 Georgia State University Research Foundation, Inc. Integrin-targeting protein and methods of use thereof
CN110317264B (zh) * 2015-11-10 2022-10-11 孙嘉琳 一种抗肿瘤蛋白内皮抑素的衍生物
CN108148117A (zh) * 2017-12-26 2018-06-12 张艳雪 一种抗菌肽的蛋白质结构特性及其研究方法
EP4665378A2 (en) * 2023-02-14 2025-12-24 Georgia State University Research Foundation, Inc. Anti-angiogenic agent and methods of using such agent
WO2025250689A1 (en) * 2024-05-28 2025-12-04 Georgia State University Research Foundation Combination therapy with angiogenesis protein and immune checkpoint inhibitor with/without chemotherapeutics

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008187A1 (en) * 1989-01-19 1990-07-26 Dana Farber Cancer Institute Soluble two domain cd2 protein
US6162432A (en) * 1991-10-07 2000-12-19 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
JP4596916B2 (ja) * 2002-09-05 2010-12-15 メディミューン，エルエルシー Ｃｄ２拮抗薬を投与することによりｔ細胞悪性腫瘍を予防または治療する方法
EP1718329A4 (en) * 2004-02-06 2008-09-10 Astellas Us Llc Methods of treating skin disorders
JP5377965B2 (ja) * 2005-09-09 2013-12-25 ジョージア ステート ユニバーシティ リサーチ ファウンデーション、インコーポレイテッド 標的化された造影剤および造影剤を標的化するための方法
WO2009146099A2 (en) * 2008-04-02 2009-12-03 Georgia State University Research Foundation, Inc. Contrast agents, methods for preparing contrast agents, and methods of imaging
EP2599497A3 (en) * 2008-09-08 2013-09-25 Hoffman/Barrett, L.L.C. Porphyrazine-chemotherapeutic agents conjugates
DK2593127T3 (en) * 2010-07-13 2018-07-02 Georgia State Univ Research Foundation ANTIANGIOGENTIC AGENT AND METHOD OF USING SUCH AGENTS

Also Published As

Publication number Publication date
JP2016175913A (ja) 2016-10-06
AU2019202174A1 (en) 2019-04-18
EP2593127B1 (en) 2018-05-30
ES2674409T3 (es) 2018-06-29
PL2593127T3 (pl) 2018-11-30
DK2593127T3 (en) 2018-07-02
AU2023202513A1 (en) 2023-05-11
AU2011279155A1 (en) 2013-01-24
CA2804753C (en) 2021-05-25
AU2011279155B2 (en) 2017-03-09
HUE040205T2 (hu) 2019-02-28
ES2923430T3 (es) 2022-09-27
CA2804753A1 (en) 2012-01-19
AU2017201133A1 (en) 2017-03-09
AU2019202174B2 (en) 2020-11-26
US11578114B2 (en) 2023-02-14
PT2593127T (pt) 2018-07-06
EP3381462B1 (en) 2022-06-08
JP2013534538A (ja) 2013-09-05
CN103002904A (zh) 2013-03-27
WO2012009471A1 (en) 2012-01-19
CN103002904B (zh) 2017-01-18
US9175063B2 (en) 2015-11-03
US20160090408A1 (en) 2016-03-31
PT3381462T (pt) 2022-07-22
EP3381462A1 (en) 2018-10-03
AU2021201207A1 (en) 2021-03-11
US20130281357A1 (en) 2013-10-24
EP2593127A1 (en) 2013-05-22

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