AU2011279155B2 - Anti-angiogenic agent and method of using such agent - Google Patents

Anti-angiogenic agent and method of using such agent Download PDF

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Publication number
AU2011279155B2
AU2011279155B2 AU2011279155A AU2011279155A AU2011279155B2 AU 2011279155 B2 AU2011279155 B2 AU 2011279155B2 AU 2011279155 A AU2011279155 A AU 2011279155A AU 2011279155 A AU2011279155 A AU 2011279155A AU 2011279155 B2 AU2011279155 B2 AU 2011279155B2
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AU
Australia
Prior art keywords
polypeptide
agent
angiogenic agent
angiogenic
amino acid
Prior art date
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Active
Application number
AU2011279155A
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English (en)
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AU2011279155A1 (en
Inventor
Zhi-Ren Liu
Yin LU
Jenny J. Yang
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Georgia State University Research Foundation Inc
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Georgia State University Research Foundation Inc
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Filing date
Publication date
Application filed by Georgia State University Research Foundation Inc filed Critical Georgia State University Research Foundation Inc
Publication of AU2011279155A1 publication Critical patent/AU2011279155A1/en
Priority to AU2017201133A priority Critical patent/AU2017201133A1/en
Application granted granted Critical
Publication of AU2011279155B2 publication Critical patent/AU2011279155B2/en
Priority to AU2019202174A priority patent/AU2019202174B2/en
Priority to AU2021201207A priority patent/AU2021201207A1/en
Priority to AU2023202513A priority patent/AU2023202513A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70507—CD2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AU2011279155A 2010-07-13 2011-07-13 Anti-angiogenic agent and method of using such agent Active AU2011279155B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2017201133A AU2017201133A1 (en) 2010-07-13 2017-02-20 Anti-Angiogenic Agent and Method of Using Such Agent
AU2019202174A AU2019202174B2 (en) 2010-07-13 2019-03-29 Anti-angiogenic agent and method of using such agent
AU2021201207A AU2021201207A1 (en) 2010-07-13 2021-02-24 Anti-angiogenic agent and method of using such agent
AU2023202513A AU2023202513A1 (en) 2010-07-13 2023-04-26 Anti-angiogenic agent and method of using such agent

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36393310P 2010-07-13 2010-07-13
US61/363,933 2010-07-13
PCT/US2011/043907 WO2012009471A1 (en) 2010-07-13 2011-07-13 Anti-angiogenic agent and method of using such agent

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017201133A Division AU2017201133A1 (en) 2010-07-13 2017-02-20 Anti-Angiogenic Agent and Method of Using Such Agent

Publications (2)

Publication Number Publication Date
AU2011279155A1 AU2011279155A1 (en) 2013-01-24
AU2011279155B2 true AU2011279155B2 (en) 2017-03-09

Family

ID=44629339

Family Applications (5)

Application Number Title Priority Date Filing Date
AU2011279155A Active AU2011279155B2 (en) 2010-07-13 2011-07-13 Anti-angiogenic agent and method of using such agent
AU2017201133A Abandoned AU2017201133A1 (en) 2010-07-13 2017-02-20 Anti-Angiogenic Agent and Method of Using Such Agent
AU2019202174A Active AU2019202174B2 (en) 2010-07-13 2019-03-29 Anti-angiogenic agent and method of using such agent
AU2021201207A Abandoned AU2021201207A1 (en) 2010-07-13 2021-02-24 Anti-angiogenic agent and method of using such agent
AU2023202513A Abandoned AU2023202513A1 (en) 2010-07-13 2023-04-26 Anti-angiogenic agent and method of using such agent

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2017201133A Abandoned AU2017201133A1 (en) 2010-07-13 2017-02-20 Anti-Angiogenic Agent and Method of Using Such Agent
AU2019202174A Active AU2019202174B2 (en) 2010-07-13 2019-03-29 Anti-angiogenic agent and method of using such agent
AU2021201207A Abandoned AU2021201207A1 (en) 2010-07-13 2021-02-24 Anti-angiogenic agent and method of using such agent
AU2023202513A Abandoned AU2023202513A1 (en) 2010-07-13 2023-04-26 Anti-angiogenic agent and method of using such agent

Country Status (12)

Country Link
US (2) US9175063B2 (enExample)
EP (2) EP3381462B1 (enExample)
JP (2) JP6353654B2 (enExample)
CN (1) CN103002904B (enExample)
AU (5) AU2011279155B2 (enExample)
CA (1) CA2804753C (enExample)
DK (1) DK2593127T3 (enExample)
ES (2) ES2923430T3 (enExample)
HU (1) HUE040205T2 (enExample)
PL (1) PL2593127T3 (enExample)
PT (2) PT3381462T (enExample)
WO (1) WO2012009471A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2593127T3 (en) * 2010-07-13 2018-07-02 Georgia State Univ Research Foundation ANTIANGIOGENTIC AGENT AND METHOD OF USING SUCH AGENTS
EP4706760A3 (en) * 2015-03-06 2026-05-27 Georgia State University Research Foundation, Inc. Integrin-targeting protein and methods of use thereof
CN110317264B (zh) * 2015-11-10 2022-10-11 孙嘉琳 一种抗肿瘤蛋白内皮抑素的衍生物
CN108148117A (zh) * 2017-12-26 2018-06-12 张艳雪 一种抗菌肽的蛋白质结构特性及其研究方法
EP4665378A2 (en) * 2023-02-14 2025-12-24 Georgia State University Research Foundation, Inc. Anti-angiogenic agent and methods of using such agent
WO2025250689A1 (en) * 2024-05-28 2025-12-04 Georgia State University Research Foundation Combination therapy with angiogenesis protein and immune checkpoint inhibitor with/without chemotherapeutics

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008187A1 (en) * 1989-01-19 1990-07-26 Dana Farber Cancer Institute Soluble two domain cd2 protein
WO2005077018A2 (en) * 2004-02-06 2005-08-25 Astellas Us Llc Methods of treating skin disorders
WO2009146099A2 (en) * 2008-04-02 2009-12-03 Georgia State University Research Foundation, Inc. Contrast agents, methods for preparing contrast agents, and methods of imaging
WO2010028216A2 (en) * 2008-09-08 2010-03-11 Hoffman/Barrett, L.L.C. Porphyrazine optical and dual optical/mr contrast and therapeutic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162432A (en) * 1991-10-07 2000-12-19 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
JP4596916B2 (ja) * 2002-09-05 2010-12-15 メディミューン，エルエルシー Ｃｄ２拮抗薬を投与することによりｔ細胞悪性腫瘍を予防または治療する方法
JP5377965B2 (ja) * 2005-09-09 2013-12-25 ジョージア ステート ユニバーシティ リサーチ ファウンデーション、インコーポレイテッド 標的化された造影剤および造影剤を標的化するための方法
DK2593127T3 (en) * 2010-07-13 2018-07-02 Georgia State Univ Research Foundation ANTIANGIOGENTIC AGENT AND METHOD OF USING SUCH AGENTS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008187A1 (en) * 1989-01-19 1990-07-26 Dana Farber Cancer Institute Soluble two domain cd2 protein
WO2005077018A2 (en) * 2004-02-06 2005-08-25 Astellas Us Llc Methods of treating skin disorders
WO2009146099A2 (en) * 2008-04-02 2009-12-03 Georgia State University Research Foundation, Inc. Contrast agents, methods for preparing contrast agents, and methods of imaging
WO2010028216A2 (en) * 2008-09-08 2010-03-11 Hoffman/Barrett, L.L.C. Porphyrazine optical and dual optical/mr contrast and therapeutic agents

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BODIAN, D. L. ET. AL. Structure, 1994, 2(8), 755-766 *
DRISCOLL, P. C. ET. AL. Nature, 1991, 353, 762-765 *
FERRARA, N. ET. AL. Nature Reviews/Drug Discovery, 2004, 3, 391-400 *
GARCIA, A. A. ET. AL. Journal of Clinical Oncology, 2008, 26, 76-82 *
KOZIN, S. V. ET. AL. Cancer Research, 2001, 61, 39-44 *
MURRAY, A. J. ET. AL. Proceedings of National Academy of Sciences, USA, 1995, 92, 7337-7341 *
SEED, B. ET. AL. Proceedings of National Academy of Sciences, USA, 1987, 84, 3365-3369 *
WITHKA, J. M. ET. AL. Structure, 1993, 1, 69-81 *

Also Published As

Publication number Publication date
JP2016175913A (ja) 2016-10-06
AU2019202174A1 (en) 2019-04-18
EP2593127B1 (en) 2018-05-30
ES2674409T3 (es) 2018-06-29
PL2593127T3 (pl) 2018-11-30
DK2593127T3 (en) 2018-07-02
AU2023202513A1 (en) 2023-05-11
AU2011279155A1 (en) 2013-01-24
CA2804753C (en) 2021-05-25
HUE040205T2 (hu) 2019-02-28
ES2923430T3 (es) 2022-09-27
CA2804753A1 (en) 2012-01-19
AU2017201133A1 (en) 2017-03-09
AU2019202174B2 (en) 2020-11-26
US11578114B2 (en) 2023-02-14
PT2593127T (pt) 2018-07-06
EP3381462B1 (en) 2022-06-08
JP2013534538A (ja) 2013-09-05
CN103002904A (zh) 2013-03-27
WO2012009471A1 (en) 2012-01-19
JP6353654B2 (ja) 2018-07-04
CN103002904B (zh) 2017-01-18
US9175063B2 (en) 2015-11-03
US20160090408A1 (en) 2016-03-31
PT3381462T (pt) 2022-07-22
EP3381462A1 (en) 2018-10-03
AU2021201207A1 (en) 2021-03-11
US20130281357A1 (en) 2013-10-24
EP2593127A1 (en) 2013-05-22

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