JP6353064B2 - Nudt15遺伝子内の単一塩基多型マーカーを含むチオプリン誘導白血球減少症の発病危険予測用組成物 - Google Patents

Nudt15遺伝子内の単一塩基多型マーカーを含むチオプリン誘導白血球減少症の発病危険予測用組成物 Download PDF

Info

Publication number
JP6353064B2
JP6353064B2 JP2016548253A JP2016548253A JP6353064B2 JP 6353064 B2 JP6353064 B2 JP 6353064B2 JP 2016548253 A JP2016548253 A JP 2016548253A JP 2016548253 A JP2016548253 A JP 2016548253A JP 6353064 B2 JP6353064 B2 JP 6353064B2
Authority
JP
Japan
Prior art keywords
leukopenia
thiopurine
risk
predicting
nucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016548253A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017503523A (ja
Inventor
キュヨン ソン
キュヨン ソン
ソッキュ ヤン
ソッキュ ヤン
Original Assignee
ユニヴァーシティー オブ ウルサン ファウンデイション フォー インダストリー コーオペレイション
ユニヴァーシティー オブ ウルサン ファウンデイション フォー インダストリー コーオペレイション
ジ アサン ファウンデーション
ジ アサン ファウンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニヴァーシティー オブ ウルサン ファウンデイション フォー インダストリー コーオペレイション, ユニヴァーシティー オブ ウルサン ファウンデイション フォー インダストリー コーオペレイション, ジ アサン ファウンデーション, ジ アサン ファウンデーション filed Critical ユニヴァーシティー オブ ウルサン ファウンデイション フォー インダストリー コーオペレイション
Priority claimed from PCT/KR2014/013050 external-priority patent/WO2015111852A1/ko
Publication of JP2017503523A publication Critical patent/JP2017503523A/ja
Application granted granted Critical
Publication of JP6353064B2 publication Critical patent/JP6353064B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016548253A 2014-01-22 2014-12-30 Nudt15遺伝子内の単一塩基多型マーカーを含むチオプリン誘導白血球減少症の発病危険予測用組成物 Active JP6353064B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR10-2014-0007821 2014-01-22
KR20140007821 2014-01-22
KR1020140193130A KR101704143B1 (ko) 2014-01-22 2014-12-30 Nudt15 유전자 내의 단일염기다형성 마커를 포함하는 티오퓨린 유도 백혈구 감소증 발병 위험 예측용 조성물
PCT/KR2014/013050 WO2015111852A1 (ko) 2014-01-22 2014-12-30 Nudt15 유전자 내의 단일염기다형성 마커를 포함하는 티오퓨린 유도 백혈구 감소증 발병 위험 예측용 조성물
KR10-2014-0193130 2014-12-30

Publications (2)

Publication Number Publication Date
JP2017503523A JP2017503523A (ja) 2017-02-02
JP6353064B2 true JP6353064B2 (ja) 2018-07-04

Family

ID=53877285

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016548253A Active JP6353064B2 (ja) 2014-01-22 2014-12-30 Nudt15遺伝子内の単一塩基多型マーカーを含むチオプリン誘導白血球減少症の発病危険予測用組成物

Country Status (3)

Country Link
JP (1) JP6353064B2 (zh)
KR (1) KR101704143B1 (zh)
CN (1) CN106536749B (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107299137A (zh) * 2017-07-06 2017-10-27 广州海思医疗科技有限公司 一组高特异性的nudt15引物及探针
CN107574239A (zh) * 2017-10-25 2018-01-12 广州和康医疗技术有限公司 一种检测硫嘌呤药物snp位点基因型的检测方法及试剂盒
CN107988354B (zh) * 2017-12-13 2021-05-14 广州迈景基因医学科技有限公司 Nudt15基因分型用的引物、试剂盒及方法
KR102304555B1 (ko) 2018-12-28 2021-09-27 서울대학교 산학협력단 약물 유도 백혈구 감소증 발병 위험 예측용 crim1 유전자 단일염기다형성 마커 및 이를 이용한 백혈구 감소증 발병 위험 예측 방법
WO2020153617A1 (ko) * 2019-01-25 2020-07-30 서울대학교 산학협력단 약물 유도 백혈구 감소증 발병 위험 예측용 il6 유전자 단일염기다형성 마커 및 이를 이용한 백혈구 감소증 발병 위험 예측 방법
CN114250289A (zh) * 2021-11-01 2022-03-29 济南艾迪康医学检验中心有限公司 检测NUDT15基因c.37_42dup GGAGTC突变的引物、方法和试剂盒

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1961825A1 (en) * 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Method for predicting the occurrence of metastasis in breast cancer patients
JP6017117B2 (ja) * 2011-05-02 2016-10-26 株式会社 ハプロファーマ 炎症性腸疾患患者におけるアザチオプリン(azt)の血中濃度の安定性を予測するジェネティックバイオマーカー
KR101369045B1 (ko) * 2013-10-16 2014-03-03 울산대학교 산학협력단 한국인의 궤양성 대장염 및 크론병 위험 예측용 다형성 마커, 이를 이용한 대장염 또는 크론병 위험 예측 방법

Also Published As

Publication number Publication date
KR20150088175A (ko) 2015-07-31
JP2017503523A (ja) 2017-02-02
CN106536749B (zh) 2020-02-14
KR101704143B1 (ko) 2017-02-09
CN106536749A (zh) 2017-03-22

Similar Documents

Publication Publication Date Title
Stein et al. A decade of research on the 17q12-21 asthma locus: piecing together the puzzle
JP6353064B2 (ja) Nudt15遺伝子内の単一塩基多型マーカーを含むチオプリン誘導白血球減少症の発病危険予測用組成物
Schaefer et al. Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis
Cummings et al. Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype
Iida et al. A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese
Binder et al. Common and low frequency variants in MERTK are independently associated with multiple sclerosis susceptibility with discordant association dependent upon HLA-DRB1* 15: 01 status
EP3332031B1 (en) Snp rs12603226 as a predictive marker for nafld
TW201812125A (zh) 使用藥物基因體學標記的組合物及方法
Haylett et al. Mutations in the parkin gene are a minor cause of Parkinson's disease in the South African population
US10787708B2 (en) Method of identifying a gene associated with a disease or pathological condition of the disease
Miner et al. What telomeres teach us about MS
Yu et al. Single nucleotide polymorphism rs1333049 on chromosome 9p21. 3 is associated with Alzheimer's disease in Han Chinese
Can et al. Tyrosine kinase-2 gene polymorphisms are associated with ulcerative colitis and Crohn's disease in Turkish Population
Ahani et al. RB1 gene mutations in Iranian patients with retinoblastoma: report of four novel mutations
WO2015111852A1 (ko) Nudt15 유전자 내의 단일염기다형성 마커를 포함하는 티오퓨린 유도 백혈구 감소증 발병 위험 예측용 조성물
JP2022528182A (ja) 神経膠腫の診断用または予後予測用の組成物、及びそれに係わる情報を提供する方法
JP5427352B2 (ja) ヒト体脂肪量と関連する遺伝子多型に基づく肥満発症リスクの判定方法
KR101497282B1 (ko) 크론병 감수성 진단용 폴리뉴클레오티드 마커 조성물
Yan et al. Case Report: Identification Pathogenic Abnormal Splicing of BBS1 Causing Bardet–Biedl Syndrome Type I (BBS1) due to Missense Mutation
KR101529008B1 (ko) 크론병 감수성 진단용 폴리뉴클레오티드 마커 조성물
JP5895317B2 (ja) 第10染色体長腕24領域の一塩基多型に基づく骨・関節疾患の検査方法
KR101598328B1 (ko) Dna 복제수 변이를 이용한 강직성 척추염 발병 저위험도 예측용 조성물 및 이를 이용한 예측 방법
Zhong et al. Correlation study between ADA and IFN-γ gene polymorphisms and the risk of developing tuberculous pericarditis
KR101545097B1 (ko) 크론병 감수성 진단용 폴리뉴클레오티드 마커 조성물
KR102158726B1 (ko) Itpr3 유전자 업스트림의 유전자간 영역을 포함하는 지연성 허혈 진단용 dna 메틸화 마커 조성물

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160829

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170711

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171004

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171211

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171215

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180508

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180607

R150 Certificate of patent or registration of utility model

Ref document number: 6353064

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250