JP6336424B2 - 抗菌剤および海洋生物の腸炎ビブリオの感染による疾病を抑制する方法 - Google Patents
抗菌剤および海洋生物の腸炎ビブリオの感染による疾病を抑制する方法 Download PDFInfo
- Publication number
- JP6336424B2 JP6336424B2 JP2015200735A JP2015200735A JP6336424B2 JP 6336424 B2 JP6336424 B2 JP 6336424B2 JP 2015200735 A JP2015200735 A JP 2015200735A JP 2015200735 A JP2015200735 A JP 2015200735A JP 6336424 B2 JP6336424 B2 JP 6336424B2
- Authority
- JP
- Japan
- Prior art keywords
- propyl gallate
- vibrio parahaemolyticus
- concentration
- infection
- antibacterial activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003242 anti bacterial agent Substances 0.000 title claims description 30
- 241000607272 Vibrio parahaemolyticus Species 0.000 title claims description 21
- 238000000034 method Methods 0.000 title claims description 15
- 201000010099 disease Diseases 0.000 title claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 7
- 208000015181 infectious disease Diseases 0.000 title claims description 6
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims description 72
- 239000000473 propyl gallate Substances 0.000 claims description 36
- 229940075579 propyl gallate Drugs 0.000 claims description 36
- 235000010388 propyl gallate Nutrition 0.000 claims description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000009395 breeding Methods 0.000 claims description 7
- 230000001488 breeding effect Effects 0.000 claims description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 23
- 230000000052 comparative effect Effects 0.000 description 14
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallyl group Chemical group C1(=C(C(=CC=C1)O)O)O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 14
- 229940088710 antibiotic agent Drugs 0.000 description 11
- 239000007788 liquid Substances 0.000 description 8
- 229960005091 chloramphenicol Drugs 0.000 description 7
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 7
- 239000004098 Tetracycline Substances 0.000 description 6
- 229960002180 tetracycline Drugs 0.000 description 6
- 229930101283 tetracycline Natural products 0.000 description 6
- 235000019364 tetracycline Nutrition 0.000 description 6
- 150000003522 tetracyclines Chemical class 0.000 description 6
- 241000238557 Decapoda Species 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 5
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 5
- 229940079877 pyrogallol Drugs 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 4
- 235000005487 catechin Nutrition 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 235000013373 food additive Nutrition 0.000 description 4
- 239000002778 food additive Substances 0.000 description 4
- 230000002411 adverse Effects 0.000 description 3
- 238000009360 aquaculture Methods 0.000 description 3
- 244000144974 aquaculture Species 0.000 description 3
- 229950001002 cianidanol Drugs 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 238000009313 farming Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 241000234314 Zingiber Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 150000001765 catechin Chemical class 0.000 description 1
- XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000005584 early death Effects 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229960004989 tetracycline hydrochloride Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015200735A JP6336424B2 (ja) | 2015-10-09 | 2015-10-09 | 抗菌剤および海洋生物の腸炎ビブリオの感染による疾病を抑制する方法 |
| PCT/JP2016/080088 WO2017061630A1 (ja) | 2015-10-09 | 2016-10-11 | 抗菌剤および海洋生物の腸炎ビブリオの感染による疾病を抑制する方法 |
| CN201680052993.4A CN108024985A (zh) | 2015-10-09 | 2016-10-11 | 抗微生物剂和抑制海洋生物副溶血弧菌感染引起的疾病的方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015200735A JP6336424B2 (ja) | 2015-10-09 | 2015-10-09 | 抗菌剤および海洋生物の腸炎ビブリオの感染による疾病を抑制する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017071583A JP2017071583A (ja) | 2017-04-13 |
| JP2017071583A5 JP2017071583A5 (enExample) | 2018-04-26 |
| JP6336424B2 true JP6336424B2 (ja) | 2018-06-06 |
Family
ID=58487830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015200735A Active JP6336424B2 (ja) | 2015-10-09 | 2015-10-09 | 抗菌剤および海洋生物の腸炎ビブリオの感染による疾病を抑制する方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6336424B2 (enExample) |
| CN (1) | CN108024985A (enExample) |
| WO (1) | WO2017061630A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112450355A (zh) * | 2020-11-23 | 2021-03-09 | 大连工业大学 | 一种抗菌肽Cm-CATH2抑制海产品中副溶血性弧菌的应用及用途 |
| CN115400105B (zh) * | 2022-10-12 | 2023-08-22 | 湖北省农业科学院畜牧兽医研究所 | 焦棓酸在制备抗马链球菌兽疫亚种药物中的应用 |
| CN115501214B (zh) * | 2022-10-14 | 2023-09-22 | 湖北省农业科学院畜牧兽医研究所 | 焦棓酸与磺胺异恶唑组合物及其在抑制猪链球菌2型中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1143441A (ja) * | 1997-07-29 | 1999-02-16 | Ichimaru Pharcos Co Ltd | 魚介類の疾病予防治療剤 |
| JP4571783B2 (ja) * | 2003-04-14 | 2010-10-27 | 林原 健 | 抗微生物剤 |
| JP2006306836A (ja) * | 2005-01-11 | 2006-11-09 | Microbiotech:Kk | 抗ウイルス・抗炎症作用薬剤組成物 |
| CN101636156B (zh) * | 2006-12-28 | 2012-05-02 | 株式会社微生物科技 | 没食子酸烷基酯的药物组合物 |
| CN104872416A (zh) * | 2015-05-05 | 2015-09-02 | 中国林业科学研究院林产化学工业研究所 | 五倍子提取物的应用 |
-
2015
- 2015-10-09 JP JP2015200735A patent/JP6336424B2/ja active Active
-
2016
- 2016-10-11 WO PCT/JP2016/080088 patent/WO2017061630A1/ja not_active Ceased
- 2016-10-11 CN CN201680052993.4A patent/CN108024985A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN108024985A (zh) | 2018-05-11 |
| JP2017071583A (ja) | 2017-04-13 |
| WO2017061630A1 (ja) | 2017-04-13 |
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