JP6324409B2 - ボロン酸誘導体及びその治療的使用 - Google Patents
ボロン酸誘導体及びその治療的使用 Download PDFInfo
- Publication number
- JP6324409B2 JP6324409B2 JP2015551762A JP2015551762A JP6324409B2 JP 6324409 B2 JP6324409 B2 JP 6324409B2 JP 2015551762 A JP2015551762 A JP 2015551762A JP 2015551762 A JP2015551762 A JP 2015551762A JP 6324409 B2 JP6324409 B2 JP 6324409B2
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC1=C*C(*)C1=C Chemical compound CC1=C*C(*)C1=C 0.000 description 12
- HGCIXCUEYOPUTN-UHFFFAOYSA-N C1CC=CCC1 Chemical compound C1CC=CCC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 1
- LBADHWINQQLFJB-UHFFFAOYSA-N CC(Nc([s]1)nnc1/S=C1/Cc2cccc(CO)c2OB1O)=O Chemical compound CC(Nc([s]1)nnc1/S=C1/Cc2cccc(CO)c2OB1O)=O LBADHWINQQLFJB-UHFFFAOYSA-N 0.000 description 1
- SVZUZHXCNGYRED-UHFFFAOYSA-N CC1=C(CNC)OC(O)O1 Chemical compound CC1=C(CNC)OC(O)O1 SVZUZHXCNGYRED-UHFFFAOYSA-N 0.000 description 1
- GDOPTJXRTPNYNR-UHFFFAOYSA-N CC1CCCC1 Chemical compound CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 1
- LNIAITKXVJWRKM-VIFPVBQESA-N CCN/C(/S[C@H]1Cc2cccc(C(O)=O)c2OB1O)=N\N Chemical compound CCN/C(/S[C@H]1Cc2cccc(C(O)=O)c2OB1O)=N\N LNIAITKXVJWRKM-VIFPVBQESA-N 0.000 description 1
- XSQJSGURQRNYDW-ZETCQYMHSA-N CO[C@H](B(O)Oc1c2C(O)=O)Cc1ccc2F Chemical compound CO[C@H](B(O)Oc1c2C(O)=O)Cc1ccc2F XSQJSGURQRNYDW-ZETCQYMHSA-N 0.000 description 1
- PQXJMRITGXZMKX-UHFFFAOYSA-O C[n]1c(SCC2Cc3cccc(C(O)=O)c3OB2[OH2+])nnc1 Chemical compound C[n]1c(SCC2Cc3cccc(C(O)=O)c3OB2[OH2+])nnc1 PQXJMRITGXZMKX-UHFFFAOYSA-O 0.000 description 1
- LWXVHWIOCARWGF-UHFFFAOYSA-N NC(CC/S=C1/Cc2cccc(C(O)=O)c2OB1O)=O Chemical compound NC(CC/S=C1/Cc2cccc(C(O)=O)c2OB1O)=O LWXVHWIOCARWGF-UHFFFAOYSA-N 0.000 description 1
- VEOSCYOZBXQDQH-UHFFFAOYSA-N N[n]1c(SCC2Cc3cccc(C(O)=O)c3OB2O)nnc1 Chemical compound N[n]1c(SCC2Cc3cccc(C(O)=O)c3OB2O)nnc1 VEOSCYOZBXQDQH-UHFFFAOYSA-N 0.000 description 1
- FTZDOPBMJMOQJE-SSDOTTSWSA-N N[n]1c(SC[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)nnc1 Chemical compound N[n]1c(SC[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)nnc1 FTZDOPBMJMOQJE-SSDOTTSWSA-N 0.000 description 1
- NUTWRGPZDMLOHO-UHFFFAOYSA-N OB1OC(C(CO)=CCC2)=C2CC1Sc1ccccc1 Chemical compound OB1OC(C(CO)=CCC2)=C2CC1Sc1ccccc1 NUTWRGPZDMLOHO-UHFFFAOYSA-N 0.000 description 1
- ROWFRCSNKMPYDK-UHFFFAOYSA-O OC(c(cccc1C2)c1OBC2SC1=CN[NH2+]N1)=O Chemical compound OC(c(cccc1C2)c1OBC2SC1=CN[NH2+]N1)=O ROWFRCSNKMPYDK-UHFFFAOYSA-O 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361749204P | 2013-01-04 | 2013-01-04 | |
| US61/749,204 | 2013-01-04 | ||
| US201361780855P | 2013-03-13 | 2013-03-13 | |
| US61/780,855 | 2013-03-13 | ||
| PCT/US2014/010107 WO2014107536A1 (en) | 2013-01-04 | 2014-01-02 | Boronic acid derivatives and therapeutic uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505619A JP2016505619A (ja) | 2016-02-25 |
| JP2016505619A5 JP2016505619A5 (show.php) | 2017-02-09 |
| JP6324409B2 true JP6324409B2 (ja) | 2018-05-16 |
Family
ID=51061420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551762A Expired - Fee Related JP6324409B2 (ja) | 2013-01-04 | 2014-01-02 | ボロン酸誘導体及びその治療的使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9132140B2 (show.php) |
| EP (1) | EP2941247A4 (show.php) |
| JP (1) | JP6324409B2 (show.php) |
| KR (1) | KR20150103270A (show.php) |
| CN (1) | CN104981239B (show.php) |
| AU (1) | AU2014204046B2 (show.php) |
| BR (1) | BR112015016002A2 (show.php) |
| CA (1) | CA2894892A1 (show.php) |
| EA (1) | EA201591004A1 (show.php) |
| MX (1) | MX2015008627A (show.php) |
| TW (1) | TW201431865A (show.php) |
| WO (1) | WO2014107536A1 (show.php) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017526636A (ja) * | 2014-07-01 | 2017-09-14 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | ボロン酸誘導体およびその治療的使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| HUE048859T2 (hu) | 2010-08-10 | 2020-08-28 | Rempex Pharmaceuticals Inc | Gyûrûs bórsavészter származékok, eljárás elõállításukra, és terápiás alkalmazásuk |
| KR102147420B1 (ko) | 2012-12-07 | 2020-08-25 | 베나토알엑스 파마슈티컬스, 인크. | 베타-락타마제 억제제 |
| CA2894891A1 (en) * | 2013-01-04 | 2014-07-10 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9403850B2 (en) | 2013-01-10 | 2016-08-02 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| WO2014151958A1 (en) | 2013-03-14 | 2014-09-25 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| WO2015171398A1 (en) | 2014-05-05 | 2015-11-12 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| ES2750805T3 (es) | 2014-05-05 | 2020-03-27 | Rempex Pharmaceuticals Inc | Síntesis de sales de boronato y usos de las mismas |
| EA201691988A1 (ru) * | 2014-05-19 | 2017-06-30 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
| US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| PL3154989T3 (pl) | 2014-06-11 | 2021-10-18 | VenatoRx Pharmaceuticals, Inc. | Inhibitory beta-laktamaz |
| WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| CN107207537B (zh) | 2014-12-19 | 2019-05-31 | 莱姆派克斯制药公司 | 用于生产硼酸衍生物的设备和连续流方法 |
| WO2016149393A1 (en) | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EP3347008B1 (en) | 2015-09-11 | 2022-03-09 | Venatorx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| CN105116076B (zh) * | 2015-09-28 | 2017-06-30 | 苏州二叶制药有限公司 | 一种头孢地嗪钠有关物质的检测方法 |
| WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| AU2017290060B2 (en) | 2016-06-30 | 2021-07-22 | Qpex Biopharma, Inc | Boronic acid derivatives and therapeutic uses thereof |
| US10889600B2 (en) | 2016-08-04 | 2021-01-12 | VenatoRx Pharmaceuticals, Inc. | Boron-containing compounds |
| PL3592362T3 (pl) | 2017-03-06 | 2025-06-23 | VenatoRx Pharmaceuticals, Inc. | Postacie stałe i kompozycje skojarzone zawierające inhibitor beta-laktamaz i ich zastosowania |
| EP3621615B1 (en) | 2017-05-12 | 2023-11-15 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| CN110959008A (zh) | 2017-05-26 | 2020-04-03 | 维纳拓尔斯制药公司 | 青霉素结合蛋白抑制剂 |
| WO2018218154A1 (en) | 2017-05-26 | 2018-11-29 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| WO2019009370A1 (ja) * | 2017-07-06 | 2019-01-10 | 大日本住友製薬株式会社 | アミド誘導体 |
| WO2019009369A1 (ja) * | 2017-07-06 | 2019-01-10 | 大日本住友製薬株式会社 | イミン誘導体 |
| BR112020007138B1 (pt) | 2017-10-11 | 2023-03-21 | Qpex Biopharma, Inc | Derivados de ácido borônico, métodos de síntese, composição farmacêutica e uso dos mesmos |
| CN109696429A (zh) * | 2018-01-30 | 2019-04-30 | 湖南师范大学 | AO-CoOOH纳米荧光探针及其制备方法和应用 |
| EP3781576B1 (en) * | 2018-04-20 | 2024-06-12 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EP3786168A4 (en) | 2018-04-27 | 2022-03-23 | Sumitomo Dainippon Pharma Co., Ltd. | OXO-SUBSTITUTED COMPOUND |
| US11008304B2 (en) | 2018-05-02 | 2021-05-18 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| CN112469725A (zh) | 2018-05-25 | 2021-03-09 | 维纳拓尔斯制药公司 | 青霉素结合蛋白抑制剂 |
| US10968199B2 (en) | 2018-08-22 | 2021-04-06 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2020106707A1 (en) | 2018-11-19 | 2020-05-28 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US11466033B2 (en) | 2019-03-25 | 2022-10-11 | Enanta Pharmaceuticals, Inc. | Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors |
| PH12022550983A1 (en) | 2019-10-25 | 2023-10-09 | Sumitomo Pharma Co Ltd | Novel substituted condensed ring compound |
| JP2024514055A (ja) * | 2021-04-13 | 2024-03-28 | 上海拓界生物医薬科技有限公司 | β－ラクタマーゼ阻害剤としてのホウ酸誘導体 |
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- 2014-01-02 EP EP14735389.0A patent/EP2941247A4/en not_active Withdrawn
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- 2014-01-02 CN CN201480003994.0A patent/CN104981239B/zh active Active
- 2014-01-02 CA CA2894892A patent/CA2894892A1/en not_active Abandoned
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017526636A (ja) * | 2014-07-01 | 2017-09-14 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | ボロン酸誘導体およびその治療的使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016505619A (ja) | 2016-02-25 |
| BR112015016002A2 (pt) | 2017-07-11 |
| TW201431865A (zh) | 2014-08-16 |
| CN104981239A (zh) | 2015-10-14 |
| EA201591004A1 (ru) | 2016-02-29 |
| AU2014204046A1 (en) | 2015-07-16 |
| CN104981239B (zh) | 2019-01-04 |
| AU2014204046B2 (en) | 2017-02-23 |
| US20140194384A1 (en) | 2014-07-10 |
| WO2014107536A1 (en) | 2014-07-10 |
| MX2015008627A (es) | 2015-09-23 |
| CA2894892A1 (en) | 2014-07-10 |
| KR20150103270A (ko) | 2015-09-09 |
| US9132140B2 (en) | 2015-09-15 |
| EP2941247A4 (en) | 2017-02-08 |
| EP2941247A1 (en) | 2015-11-11 |
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