JP6321673B2 - 放射線と組み合わせて使用するための放射線増感剤化合物 - Google Patents
放射線と組み合わせて使用するための放射線増感剤化合物 Download PDFInfo
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- JP6321673B2 JP6321673B2 JP2015548130A JP2015548130A JP6321673B2 JP 6321673 B2 JP6321673 B2 JP 6321673B2 JP 2015548130 A JP2015548130 A JP 2015548130A JP 2015548130 A JP2015548130 A JP 2015548130A JP 6321673 B2 JP6321673 B2 JP 6321673B2
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- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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- C07—ORGANIC CHEMISTRY
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
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| US201261797983P | 2012-12-20 | 2012-12-20 | |
| US61/797,983 | 2012-12-20 | ||
| PCT/CA2013/051005 WO2014094178A1 (en) | 2012-12-20 | 2013-12-20 | Radiosensitizer compounds for use in combination with radiation |
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| JP2016504325A JP2016504325A (ja) | 2016-02-12 |
| JP2016504325A5 JP2016504325A5 (OSRAM) | 2017-02-09 |
| JP6321673B2 true JP6321673B2 (ja) | 2018-05-09 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2016534048A (ja) * | 2013-10-08 | 2016-11-04 | チン−ビン ルー， | 標的化化学療法に使用するための非白金ベースの抗がん化合物 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| PL3277284T3 (pl) * | 2015-04-02 | 2021-03-08 | Proximagen, Llc | Nowe terapie nowotworu |
| CN106045932B (zh) * | 2016-06-06 | 2018-05-15 | 浙江省肿瘤医院 | 一种具有放射增敏作用的化合物及其应用 |
| JP6955243B2 (ja) * | 2017-02-24 | 2021-10-27 | 学校法人北里研究所 | ネクローシスの検出キット及びその使用 |
| EP3804719A4 (en) * | 2018-05-30 | 2022-03-30 | Pharos Ibio Co., Ltd. | Use of 2,3,5-substituted thiophene compound for enhancement of radiotherapy |
| WO2021224186A1 (en) * | 2020-05-04 | 2021-11-11 | Institut Curie | New pyridine derivatives as radiosensitizers |
| CN114478524A (zh) * | 2022-03-15 | 2022-05-13 | 江苏省肿瘤医院 | 1,8-萘啶类化合物及其应用 |
| CN114560799A (zh) * | 2022-03-15 | 2022-05-31 | 江苏省肿瘤医院 | 腈基取代苯基类化合物及其应用 |
| CN120501862B (zh) * | 2025-07-18 | 2025-10-10 | 四川大学华西医院 | 一种能够放射增敏和防护放射性损伤的双效化合物、包含其的组合物及其应用 |
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| JPS5011451B1 (OSRAM) * | 1969-05-05 | 1975-05-01 | ||
| GB1363735A (en) * | 1970-10-23 | 1974-08-14 | Hoechst Ag | Process for the manufacture of benzimidazolones |
| US3822261A (en) * | 1972-10-30 | 1974-07-02 | Dow Chemical Co | 5,6-dihalo-2-fluoroalkyl-1h-imidazo(4,5-b)pyrazines |
| GR72941B (OSRAM) * | 1978-10-20 | 1984-01-16 | Lilly Co Eli | |
| US4210647A (en) * | 1979-06-18 | 1980-07-01 | Eli Lilly And Company | Antiviral combinations |
| JPS597175A (ja) * | 1982-07-01 | 1984-01-14 | メルク・エンド・カムパニ−・インコ−ポレ−テツド | 放射線治療用添加剤として有用な、クロロニトロアミノピラジン及びアルキルアミノピラジンのアミノとアミド誘導体 |
| GB8722488D0 (en) * | 1987-09-24 | 1987-10-28 | Fujisawa Pharmaceutical Co | Imidazopyridine compound |
| CA2138026C (en) * | 1992-06-22 | 2003-09-09 | Eckard Weber | Novel 1,4-dihydroquinoxaline-2,3-diones and uses therefor as glycine receptor antagonists |
| EP0743855A1 (en) * | 1994-01-03 | 1996-11-27 | Acea Pharmaceuticals, Inc. | 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/nmda receptor |
| US5753687A (en) * | 1995-06-19 | 1998-05-19 | Ontogen Corporation | Modulators of proteins with phosphotryrosine recognition units |
| CA2397665A1 (en) * | 2000-01-24 | 2001-07-26 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
| US6538010B1 (en) * | 2000-11-08 | 2003-03-25 | Research Triangle Institute | Compounds and methods for promoting smoking cessation |
| GB0428082D0 (en) * | 2004-12-22 | 2005-01-26 | Welcome Trust The Ltd | Therapeutic compounds |
| US20090137640A1 (en) * | 2005-04-01 | 2009-05-28 | Taiho Pharmaceutical Co.Ltd | Potentiator for radiation therapy comprising pyridine derivative as active ingredient |
| CN101155782B (zh) * | 2005-04-01 | 2011-05-04 | 大鹏药品工业株式会社 | 以吡啶衍生物为有效成分的放射线治疗增强剂 |
| JP2010500372A (ja) * | 2006-08-09 | 2010-01-07 | スミスクライン ビーチャム コーポレーション | オピオイド受容体に対するアンタゴニストまたはインバースアゴニストとしての新規化合物 |
| US8088767B2 (en) * | 2006-09-28 | 2012-01-03 | Exelixis, Inc. | JAK-2 modulators and methods of use |
| JP5178738B2 (ja) * | 2006-12-20 | 2013-04-10 | メルク・シャープ・アンド・ドーム・コーポレーション | 新規なｊｎｋ阻害剤 |
| WO2010054398A1 (en) * | 2008-11-10 | 2010-05-14 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US20120156311A1 (en) * | 2009-09-01 | 2012-06-21 | Lu qing-bin | Combination therapy for cancer comprising a platinum-based antineoplastic agent and a biocompatible electron donor |
| US8962631B2 (en) * | 2010-05-12 | 2015-02-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| GB201017345D0 (en) * | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016534048A (ja) * | 2013-10-08 | 2016-11-04 | チン−ビン ルー， | 標的化化学療法に使用するための非白金ベースの抗がん化合物 |
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| CN105164107A (zh) | 2015-12-16 |
| US20150343059A1 (en) | 2015-12-03 |
| CN105164107B (zh) | 2017-12-05 |
| EP2935215A1 (en) | 2015-10-28 |
| EP2935215B1 (en) | 2019-11-13 |
| MX2015008010A (es) | 2016-04-26 |
| JP2016504325A (ja) | 2016-02-12 |
| CA2895526C (en) | 2021-08-24 |
| BR112015014855A2 (pt) | 2017-07-11 |
| US9655965B2 (en) | 2017-05-23 |
| KR102278760B1 (ko) | 2021-07-20 |
| CA2895526A1 (en) | 2014-06-26 |
| KR20150120953A (ko) | 2015-10-28 |
| EP2935215A4 (en) | 2016-10-26 |
| WO2014094178A1 (en) | 2014-06-26 |
| AU2013362757B2 (en) | 2018-06-14 |
| AU2013362757A1 (en) | 2015-07-30 |
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