JP6313419B2 - 癌幹細胞の処置のためのアンチセンスオリゴヌクレオチド - Google Patents

癌幹細胞の処置のためのアンチセンスオリゴヌクレオチド Download PDF

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JP6313419B2
JP6313419B2 JP2016503160A JP2016503160A JP6313419B2 JP 6313419 B2 JP6313419 B2 JP 6313419B2 JP 2016503160 A JP2016503160 A JP 2016503160A JP 2016503160 A JP2016503160 A JP 2016503160A JP 6313419 B2 JP6313419 B2 JP 6313419B2
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cancer
oligonucleotide
individual
oligonucleotides
seq
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JP2016519084A5 (cg-RX-API-DMAC10.html
JP2016519084A (ja
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エリス， ルイス オー． ブルヅィオ
エリス， ルイス オー． ブルヅィオ
メネンデス ヴェロニカ エー． ブルヅィオ，
メネンデス ヴェロニカ エー． ブルヅィオ，
オラバリイア， ジェイム イー． ヴィレガス
オラバリイア， ジェイム イー． ヴィレガス
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アンデス バイオテクノロジーズ グローバル， インコーポレイテッド
アンデス バイオテクノロジーズ グローバル， インコーポレイテッド
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
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    • C12N2320/31—Combination therapy
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/65—MicroRNA
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    • C12N2501/999—Small molecules not provided for elsewhere
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells

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  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016503160A 2013-03-14 2014-03-14 癌幹細胞の処置のためのアンチセンスオリゴヌクレオチド Expired - Fee Related JP6313419B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361785269P 2013-03-14 2013-03-14
US61/785,269 2013-03-14
US201361790072P 2013-03-15 2013-03-15
US61/790,072 2013-03-15
US201461937438P 2014-02-07 2014-02-07
US61/937,438 2014-02-07
PCT/US2014/029606 WO2014153209A1 (en) 2013-03-14 2014-03-14 Antisense oligonucletotides for treatment of cancer stem cells

Publications (3)

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JP2016519084A JP2016519084A (ja) 2016-06-30
JP2016519084A5 JP2016519084A5 (cg-RX-API-DMAC10.html) 2017-11-30
JP6313419B2 true JP6313419B2 (ja) 2018-04-18

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US (3) US9862944B2 (cg-RX-API-DMAC10.html)
EP (1) EP2970970B1 (cg-RX-API-DMAC10.html)
JP (1) JP6313419B2 (cg-RX-API-DMAC10.html)
CN (2) CN115518073A (cg-RX-API-DMAC10.html)
BR (1) BR112015022308A8 (cg-RX-API-DMAC10.html)
CA (1) CA2906198C (cg-RX-API-DMAC10.html)
CL (1) CL2015002612A1 (cg-RX-API-DMAC10.html)
DK (1) DK2970970T3 (cg-RX-API-DMAC10.html)
ES (1) ES2708650T3 (cg-RX-API-DMAC10.html)
HU (1) HUE042738T2 (cg-RX-API-DMAC10.html)
MX (1) MX359337B (cg-RX-API-DMAC10.html)
PL (1) PL2970970T3 (cg-RX-API-DMAC10.html)
WO (1) WO2014153209A1 (cg-RX-API-DMAC10.html)

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US9862944B2 (en) 2013-03-14 2018-01-09 Andes Biotechnologies S.A. Antisense oligonucleotides for treatment of cancer stem cells
BR112015022621A2 (pt) 2013-03-14 2017-10-31 Andes Biotechnologies S A métodos para detecção e tratamento de mieloma múltiplo
WO2019103578A1 (ko) * 2017-11-27 2019-05-31 (주)프로스테믹스 올리고뉴클레오티드 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물
EP3954764B8 (en) * 2019-04-11 2025-04-30 GeneX Health Co., Ltd METHOD FOR CULTURING PRIMARY GASTRIC CANCER CELLS AND GALLBLADDER AND BILATERAL DUCT CANCER CELLS, AND SUPPORTING REAGENTS
CN113893261B (zh) * 2021-06-22 2023-01-13 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） circITGB6-ASO与铂类化疗药物联合使用在制备治疗卵巢癌的药物中的应用

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Publication number Publication date
CN115518073A (zh) 2022-12-27
US20160138015A1 (en) 2016-05-19
MX2015012063A (es) 2016-04-06
US9862944B2 (en) 2018-01-09
BR112015022308A2 (pt) 2017-10-10
HUE042738T2 (hu) 2019-07-29
CL2015002612A1 (es) 2016-08-26
WO2014153209A1 (en) 2014-09-25
HK1220482A1 (en) 2017-05-05
US20180171335A1 (en) 2018-06-21
ES2708650T3 (es) 2019-04-10
EP2970970A1 (en) 2016-01-20
CA2906198A1 (en) 2014-09-25
EP2970970A4 (en) 2016-10-19
US10457943B2 (en) 2019-10-29
BR112015022308A8 (pt) 2018-01-23
WO2014153209A8 (en) 2015-02-26
MX359337B (es) 2018-07-09
US11319535B2 (en) 2022-05-03
DK2970970T3 (en) 2019-02-11
EP2970970B1 (en) 2018-12-12
CN105229150A (zh) 2016-01-06
US20200239885A1 (en) 2020-07-30
JP2016519084A (ja) 2016-06-30
PL2970970T3 (pl) 2019-06-28
CA2906198C (en) 2022-11-29

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