JP6312670B2 - 開放マイクロ流体チャンネルに関する方法、システムおよび装置 - Google Patents
開放マイクロ流体チャンネルに関する方法、システムおよび装置 Download PDFInfo
- Publication number
- JP6312670B2 JP6312670B2 JP2015524399A JP2015524399A JP6312670B2 JP 6312670 B2 JP6312670 B2 JP 6312670B2 JP 2015524399 A JP2015524399 A JP 2015524399A JP 2015524399 A JP2015524399 A JP 2015524399A JP 6312670 B2 JP6312670 B2 JP 6312670B2
- Authority
- JP
- Japan
- Prior art keywords
- fluid
- channel
- open
- cross
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims description 91
- 239000012530 fluid Substances 0.000 claims description 356
- 239000007788 liquid Substances 0.000 claims description 55
- 238000009736 wetting Methods 0.000 claims description 48
- 239000000463 material Substances 0.000 claims description 45
- 239000000126 substance Substances 0.000 claims description 21
- 239000002245 particle Substances 0.000 claims description 13
- 239000011324 bead Substances 0.000 claims description 12
- 239000008280 blood Substances 0.000 claims description 11
- 210000004369 blood Anatomy 0.000 claims description 11
- 230000007246 mechanism Effects 0.000 claims description 11
- 230000015572 biosynthetic process Effects 0.000 claims description 10
- 230000008859 change Effects 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 7
- 238000011049 filling Methods 0.000 claims description 5
- 230000007704 transition Effects 0.000 claims description 5
- 230000007423 decrease Effects 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 238000009825 accumulation Methods 0.000 claims 1
- 238000013461 design Methods 0.000 description 13
- 239000012491 analyte Substances 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 239000000017 hydrogel Substances 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 5
- 239000010839 body fluid Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000010276 construction Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 0 C[C@]([C@@](C1C2C3)(C4[C@]5(C)C(C6)*(C7C8)C8(C)C(C8)C4C8C5[C@@]13C6C7C1C3)C1(C)C23[N+]([O-])=O)I Chemical compound C[C@]([C@@](C1C2C3)(C4[C@]5(C)C(C6)*(C7C8)C8(C)C(C8)C4C8C5[C@@]13C6C7C1C3)C1(C)C23[N+]([O-])=O)I 0.000 description 4
- 230000002745 absorbent Effects 0.000 description 4
- 239000002250 absorbent Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 230000008021 deposition Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000004049 embossing Methods 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 239000012780 transparent material Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000012921 fluorescence analysis Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000007479 molecular analysis Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
- A61B5/1405—Devices for taking blood samples
- A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150221—Valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
- A61B5/150419—Pointed piercing elements, e.g. needles, lancets for piercing the skin comprising means for capillary action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15103—Piercing procedure
- A61B5/15105—Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0672—Integrated piercing tool
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Dermatology (AREA)
- Manufacturing & Machinery (AREA)
- Pain & Pain Management (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Micromachines (AREA)
Description
本出願は、2012年7月23日出願の米国仮特許出願第61/674,415号明細書、題名“Methods,Systems,and Devices Relating to Open Microfluidic Channels”からの優先権を主張し、参照のためその全体を本明細書に援用する。
pf/pw<cos(θ) (1)
Claims (20)
- 流体の流れを許容するように構成された第1の開放マイクロスケールチャネルを含む開放チャネルマイクロ流体装置であって、前記第1の開放マイクロスケールチャネルの少なくとも1つの部分は、
a.濡れ外周の長さを定義する少なくとも1つの濡れ表面であって、接触角で前記第1の開放マイクロスケールチャネル内を流れる流体と接触する濡れ表面と、
b.自由外周の長さを定義する開放空気/液体界面を含む少なくとも1つの自由表面と、
を含む第1の断面を含み、
前記自由外周の長さと前記濡れ外周の長さとの比は、前記接触角の余弦未満であり、これにより自然毛細管流動を可能にし、
前記装置は、上部部分および底部部分をさらに含み、さらに、前記第1の断面の前記上部部分により画定された第1の自由表面と、外部環境への流体アクセスを提供するために前記第1の断面の前記底部部分に形成された開口により画定された第2の自由表面とを含み、
前記第2の自由表面は、前記第2の自由表面が表面上に貯留する所定の容積の流体と接触し、これにより、前記容積の少なくとも1つの部分の捕捉と、溝内への前記容積の流れとを生じさせるように前記装置の底部部分において画定される、装置。 - 前記濡れ表面が親水性材料を含み、前記開放空気/液体界面は前記第1の開放マイクロスケールチャネルから流体試料を除去するためのまたは前記流体試料の任意の成分を除去するためのアクセスを提供し、第2の毛細管路を受け入れ、これにより第2の流体ネットワーク内への前記流体の流れを許容するように構成される、請求項1に記載の装置。
- 第1または第2の開放空気/液体界面は第2の毛細管路を受け入れ、これにより第2の流体ネットワーク内への前記流体の流れを許容するように構成される、請求項1に記載の装置。
- a.第2の自由外周および第2の濡れ表面を定義する第2の断面であって、前記第2の自由外周または第2の濡れ外周の少なくとも1つが、前記第1の断面の自由外周または濡れ外周と比較して寸法が大きい、第2のチャネル断面と、
b.さらなる流体が前記第2の断面に加えられない限り、前記第1の断面の方向にのみ前記流れが可能になるように、大きな外周の断面と小さな外周の断面との間で前記第1の開放マイクロスケールチャネルが徐々に狭くなるように構成された、前記第1の断面と前記第2の断面間の遷移領域と、
をさらに含む請求項1に記載の装置。 - 前記第1の開放マイクロスケールチャネルは共用領域と流体連通し、少なくとも1つの追加チャンネルもまた前記共用領域と流体連通し、これにより流体追加の同期と無関係な装置充填を許容する、請求項1に記載の装置。
- 前記自由外周と前記濡れ外周との比を低減するように前記第1の開放マイクロスケールチャネル内に配置される追加突起機構をさらに含み、これにより、より大きな自由外周を有する第2のチャネルの上の毛細管充填と、より大きな容積の流体の収集とを許容する、請求項1に記載の装置。
- 前記第1の開放マイクロスケールチャネルは、前記第1の開放マイクロスケールチャネルの濡れ表面に対して配置された材料をさらに含み、前記材料は流れる流体中に取り込まれるように構成される、請求項1に記載の装置。
- 開放マイクロスケールチャネルを使用する方法であって、前記方法は、
a.第1の開放マイクロスケールチャネルへ流体を供給する工程、または第1の開放マイクロスケールチャネルから流体を除去する工程を含み、前記第1の開放マイクロスケールチャネルは、
a.濡れ表面であって、濡れ外周を定義する前記第1の開放マイクロスケールチャネル内を流れる流体と接触する濡れ表面と、
b.自由外周を定義する開放空気/液体界面を含む自由界面と、
を含む第1の断面を含み、
前記流体は前記濡れ表面において、ある接触角を有し、前記接触角は余弦をさらに含み、
さらに、前記自由外周の断面長と前記濡れ外周の断面長との比は前記流体の接触角の余弦未満であり、これにより自然毛細管流動を可能にし、
流体を前記第1の開放マイクロスケールチャネルへ供給する前記工程は、前記第1の開放マイクロスケールチャネルの前記第1の断面の底部部分に形成された開口と、表面上に貯留する流体とを接触させ、これにより、前記容積の少なくとも1つの部分を捕捉し、前記流体を前記第1の開放マイクロスケールチャネル内に引き込む工程を含む、方法。 - 前記流体は血液であり、前記表面は皮膚の表面である、請求項8に記載の方法。
- 第2の開放マイクロスケールチャネルをさらに含み、前記第2の開放マイクロスケールチャネルは、
a.濡れ表面であって、濡れ外周を定義し、ある接触角で前記第1の開放マイクロスケールチャネルを流れる流体と接触する濡れ表面と、
b.自由外周を定義する開放空気/液体界面を含む自由界面と、
を含む第2の断面を含み、
前記第2の開放マイクロスケールチャネルは、チャネル間の流体の流れを可能にするように前記第1の開放マイクロスケールチャネルと流体連通し、さらに、前記第2の開放マイクロスケールチャネルは前記第1の断面の比より小さい自由界面の断面長と濡れ表面の断面長との比を有する第2の断面を有する、請求項8に記載の方法。 - 前記流体を前記第1の開放マイクロスケールチャネルから除去する前記工程は前記第1の開放マイクロスケールチャネル内に画定された前記開口を通して前記流体から物質を除去する工程を含む、請求項8に記載の方法。
- 前記流体から前記物質を除去する前記工程は窓に磁力を印加することにより磁気ビーズを除去する工程を含む、請求項11に記載の方法。
- 前記磁気ビーズを除去する前記工程は、前記窓において固体表面を液体の表面のほぼ近傍に配置するまたはそれに接触させることにより前記磁気ビーズを前記固体表面上にトラップする工程を含む、請求項12に記載の方法。
- 前記流体から前記物質を除去する前記工程は、前記窓において流体界面に接触して配置された材料上で粒子をトラップすることにより粒子を除去する工程を含み、前記材料は粒子同士を結合するように構成された化合物を含む、請求項11に記載の方法。
- 前記開放チャネルは、気泡の形成を防ぐように構成される、請求項1に記載の装置。
- 開放チャネルのネットワークが複数の経路からの流体の集積を許容し、得られた構造は、前記自由表面の特定の幾何学形状を使用して気泡をさらに取り除く、請求項15に記載の装置。
- 前記第1のマイクロスケールチャネルと流体連通し、流体の流れを可能にするように構成される、第2の開放マイクロスケールチャネルをさらに含み、前記第2の開放マイクロスケールチャネルの少なくとも1つの部分は、
a.濡れ外周の長さを定義する少なくとも1つの濡れ表面であって、接触角において前記第2の開放マイクロスケールチャネルを流れる流体と接触する濡れ表面と、
b.自由外周の長さを定義する開放空気/液体界面を含む少なくとも1つの自由表面と、
を含む第2の断面を含み、
第2の自由外周の長さと第2の濡れ外周の長さとの比が接触角の余弦未満であり、これにより自然毛細管流動を可能にする、請求項1に記載の装置。 - 前記第1の開放マイクロスケールチャネルと第2の開放マイクロスケールチャネルとの間の流体の流れが方向の変化を組み込むように、前記第1のマイクロスケールチャネルは第1の方向に向けられた長手方向チャネルであり、前記第2のマイクロスケールチャネルは第2の方向に向けられた長手方向チャネルである、請求項17に記載の装置。
- 流体の流れを許容するように構成される第1の開放マイクロスケールチャネルであって、前記第1の開放マイクロスケールチャネルは、ほぼ四角形の断面を含み、
a.第1の自由外周を定義する上部部分により画定される第1の自由表面を含む上部部分と、
b.第2の自由外周を定義する底部部分により画定される第2の自由表面を含む底部部分と、
c.第1の濡れ外周を定義する第1の濡れ表面であって、第1の接触角で前記第1の開放マイクロスケールチャネルを流れる流体と接触する第1の濡れ表面と、
d.第2の濡れ外周を定義する第2の濡れ表面であって、前記第1の濡れ表面が第2の接触角で前記第1の開放マイクロスケールチャネルを流れる流体と接触する第2の濡れ表面と、
を含み、
前記第1および第2の自由外周と前記第1および第2の濡れ外周との比がそれぞれ前記第1および第2の接触角の余弦未満であり、これにより前記第1の開放マイクロスケールチャネルを通る自然毛細管流動を可能にし、
前記装置は、上部部分および底部部分をさらに含み、さらに、前記第1の断面の前記上部部分により画定された第1の自由表面と、前記第1の断面の前記底部部分に形成された外部環境への流体アクセスを提供するための開口により画定された第2の自由表面とを含み、
前記第2の自由表面は、前記第2の自由表面が表面上に貯留する所定の容積の流体と接触し、これにより、前記容積の少なくとも1つの部分の捕捉と、溝内への前記容積の流れとを生じさせるように前記装置の底部部分において画定される、開放チャネルマイクロ流体装置。 - 前記開放チャネルマイクロ流体装置が、前記装置の表面に関連して、複数の平面における流体の移動を許容することによって3次元の流体の流れを促進するように構成される、請求項19に記載の装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261674415P | 2012-07-23 | 2012-07-23 | |
US61/674,415 | 2012-07-23 | ||
PCT/US2013/051731 WO2014018558A1 (en) | 2012-07-23 | 2013-07-23 | Methods, systems, and devices relating to open microfluidic channels |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2015525882A JP2015525882A (ja) | 2015-09-07 |
JP2015525882A5 JP2015525882A5 (ja) | 2015-10-29 |
JP6312670B2 true JP6312670B2 (ja) | 2018-04-18 |
Family
ID=49997785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015524399A Active JP6312670B2 (ja) | 2012-07-23 | 2013-07-23 | 開放マイクロ流体チャンネルに関する方法、システムおよび装置 |
Country Status (5)
Country | Link |
---|---|
US (2) | US9289763B2 (ja) |
EP (1) | EP2874942B1 (ja) |
JP (1) | JP6312670B2 (ja) |
AU (2) | AU2013293078B2 (ja) |
WO (1) | WO2014018558A1 (ja) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130211289A1 (en) | 2012-01-25 | 2013-08-15 | Tasso, Inc. | Handheld Device for Drawing, Collecting, and Analyzing Bodily Fluid |
US11360076B2 (en) | 2012-03-30 | 2022-06-14 | Weavr Health Corp. | Methods and systems to collect a biological sample |
EP2874942B1 (en) | 2012-07-23 | 2018-09-05 | Tasso, Inc. | Methods and devices relating to open microfluidic channels |
US9861978B2 (en) | 2012-12-05 | 2018-01-09 | Boston Microfluidics, Inc. | Mechanically actuated vacuum controlled fluid collection |
US11358138B2 (en) | 2013-07-19 | 2022-06-14 | Boston Microfluidics Inc. | Fluid sample collection device |
JP2015223562A (ja) * | 2014-05-28 | 2015-12-14 | 国立大学法人お茶の水女子大学 | 微量液体移送デバイス |
CN113440134A (zh) * | 2014-08-01 | 2021-09-28 | 塔索公司 | 用于重力增强的微流体采集、液体的处理和输送的装置、系统和方法 |
US10779757B2 (en) | 2014-08-01 | 2020-09-22 | Tasso, Inc. | Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids |
JP6487190B2 (ja) | 2014-11-21 | 2019-03-20 | サントル ナショナル ドゥラ ルシェルシュ シヤンティフィック | 分子検出システム |
EP4035762B1 (en) | 2015-09-09 | 2023-11-01 | Drawbridge Health, Inc. | Devices for sample collection, stabilization and preservation |
US20180317833A1 (en) * | 2015-10-23 | 2018-11-08 | Eccrine Systems, Inc. | Devices capable of fluid sample concentration for extended sensing of analytes |
JP2019505282A (ja) | 2015-12-21 | 2019-02-28 | タッソ インコーポレイテッド | 体液収集における作動および引き込みのための装置、システム、および方法 |
US10376890B2 (en) | 2016-02-04 | 2019-08-13 | Stacks to the Future LLC | Apparatus, systems and methods for modular microfluidic devices |
US11166658B2 (en) | 2016-07-28 | 2021-11-09 | Invitae Corporation | Blood sampling system and method |
WO2018039305A1 (en) | 2016-08-24 | 2018-03-01 | Becton, Dickinson And Company | A device for obtaining a blood sample |
US10653349B2 (en) | 2016-10-18 | 2020-05-19 | International Business Machines Corporation | Diagnostic apparatus |
WO2018111739A1 (en) | 2016-12-12 | 2018-06-21 | Neoteryx, Llc | Fluid sampling device |
SG10201911882VA (en) | 2017-01-10 | 2020-02-27 | Drawbridge Health Inc | Devices, systems, and methods for sample collection |
CA3044713C (en) * | 2017-01-18 | 2021-01-26 | Precision Nanosystems Inc. | Low complexity flow control in a microfluidic mixer |
GB201701946D0 (en) * | 2017-02-06 | 2017-03-22 | Univ Leeds Innovations Ltd | Fluid flow device |
CN108693349A (zh) * | 2017-06-26 | 2018-10-23 | 宁波奥丞生物科技有限公司 | 用于进行流体检测的微流体检测卡 |
CN111801577A (zh) | 2017-10-27 | 2020-10-20 | 波士顿微流控公司 | 流体样本收集装置 |
US11484877B2 (en) | 2018-05-29 | 2022-11-01 | Weavr Health Corp. | Blood metering device with desiccant and support for storage media and inlay with flange |
CN108927233A (zh) * | 2018-09-06 | 2018-12-04 | 广州大学 | 一种无外力控制单向液体运输的微流控芯片结构及其制作方法 |
CN111295138A (zh) | 2018-09-14 | 2020-06-16 | 塔索公司 | 体液收集装置及相关方法 |
DE102018216308A1 (de) * | 2018-09-25 | 2020-03-26 | Robert Bosch Gmbh | Mikrofluidisches System, Analyseapparat zur Analyse einer Probe und Verfahren zur Handhabung eines Fluidvolumens |
US11772097B2 (en) | 2018-10-19 | 2023-10-03 | Renegadexbio, Pbc | Simultaneous spot test and storage of blood samples |
GB2595060B (en) | 2018-10-23 | 2022-11-02 | Weavr Health Corp | Funnel with extension tube to augment blood collection device |
WO2021046391A2 (en) * | 2019-09-06 | 2021-03-11 | Boston Microfluidics, Inc. | Medium with hydrophobic patterns and break lines defining a blood collection volume |
US11612779B2 (en) * | 2020-11-04 | 2023-03-28 | Timothy Karl Schumacher | Water jug/ water can exercise device/ equipment system |
DE102021205954A1 (de) | 2021-06-11 | 2022-12-15 | Robert Bosch Gesellschaft mit beschränkter Haftung | Mikrofluidische Vorrichtung, Verfahren zum Herstellen einer mikrofluidischen Vorrichtung und Verfahren zum Betreiben einer mikrofluidischen Vorrichtung |
US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
US11478175B1 (en) | 2021-10-20 | 2022-10-25 | Paulus Holdings Limited | Devices for collecting capillary blood and methods for same |
US11957465B2 (en) | 2022-08-23 | 2024-04-16 | Reddrop Dx, Inc. | Accelerated ergonomic collection of capillary blood |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5035865A (en) | 1988-05-17 | 1991-07-30 | Terumo Kabushiki Kaisha | Vacuum blood sample collecting device |
US5145565A (en) | 1989-05-01 | 1992-09-08 | Spacelabs, Inc. | Contamination-free method and apparatus for measuring body fluid chemical parameters |
JP2572823Y2 (ja) | 1992-02-13 | 1998-05-25 | 株式会社アドバンス | 簡易採血器 |
US7828749B2 (en) | 1996-05-17 | 2010-11-09 | Roche Diagnostics Operations, Inc. | Blood and interstitial fluid sampling device |
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6660018B2 (en) | 1999-03-08 | 2003-12-09 | Agilent Technologies, Inc. | Multiple lancet device |
US6132449A (en) | 1999-03-08 | 2000-10-17 | Agilent Technologies, Inc. | Extraction and transportation of blood for analysis |
FR2790684B1 (fr) * | 1999-03-09 | 2001-05-11 | Biomerieux Sa | Appareil permettant en son sein le transfert de liquides par capillarite |
US6856821B2 (en) | 2000-05-26 | 2005-02-15 | Kci Licensing, Inc. | System for combined transcutaneous blood gas monitoring and vacuum assisted wound closure |
US6152942A (en) | 1999-06-14 | 2000-11-28 | Bayer Corporation | Vacuum assisted lancing device |
ATE268642T1 (de) * | 1999-07-07 | 2004-06-15 | 3M Innovative Properties Co | Nachweisgerät mit einer fluid-kontroll- filmschicht mit kapillarkanälen |
US7223364B1 (en) | 1999-07-07 | 2007-05-29 | 3M Innovative Properties Company | Detection article having fluid control film |
CA2290731A1 (en) * | 1999-11-26 | 2001-05-26 | D. Jed Harrison | Apparatus and method for trapping bead based reagents within microfluidic analysis system |
DE60124699T2 (de) * | 2000-05-15 | 2007-09-13 | Tecan Trading Ag | Zweirichtungs-durchfluss-zentrifugalmikrofluid-vorrichtungen |
US6605048B1 (en) | 2000-05-18 | 2003-08-12 | Palco Labs, Inc. | Vacuum device to assist in the drawing of capillary blood samples |
CN1525834A (zh) | 2001-01-22 | 2004-09-01 | - | 具有毛细作用的刺血针装置 |
US6821485B2 (en) * | 2001-02-09 | 2004-11-23 | Wisconsin Alumni Research Foundation | Method and structure for microfluidic flow guiding |
US7476533B2 (en) | 2002-04-19 | 2009-01-13 | Adhesives Research, Inc. | Diagnostic devices for use in the assaying of biological fluids |
GB0113750D0 (en) | 2001-06-06 | 2001-07-25 | Rocket Medical Plc | Autologous blood transfusion apparatus |
US7776608B2 (en) * | 2001-07-09 | 2010-08-17 | Bayer Healthcare Llc | Volume meter testing device and method of use |
DE10134650B4 (de) | 2001-07-20 | 2009-12-03 | Roche Diagnostics Gmbh | System zur Entnahme kleiner Körperflüssigkeitsmengen |
US20030028125A1 (en) | 2001-08-06 | 2003-02-06 | Yuzhakov Vadim V. | Physiological sample collection devices and methods of using the same |
US7569035B1 (en) * | 2001-11-02 | 2009-08-04 | Meridian Medical Technologies, Inc. | Automatic injector with anti-coring needle |
IL146776A (en) | 2001-11-27 | 2010-11-30 | Yoram Alroy | Device for blood sampling under vacuum conditions |
US7343188B2 (en) * | 2002-05-09 | 2008-03-11 | Lifescan, Inc. | Devices and methods for accessing and analyzing physiological fluid |
US7604775B2 (en) * | 2002-08-12 | 2009-10-20 | Bayer Healthcare Llc | Fluid collecting and monitoring device |
CN101690665B (zh) | 2004-03-06 | 2011-12-14 | 霍夫曼-拉罗奇有限公司 | 体液采样设备 |
US20050236566A1 (en) * | 2004-04-26 | 2005-10-27 | Chang Liu | Scanning probe microscope probe with integrated capillary channel |
WO2005115630A2 (en) * | 2004-04-30 | 2005-12-08 | Bioforce Nanosciences, Inc. | Method and apparatus for depositing material onto a surface |
JP4478776B2 (ja) | 2004-08-09 | 2010-06-09 | 独立行政法人物質・材料研究機構 | 血液分析装置及び血液分析方法 |
WO2006032044A2 (en) * | 2004-09-15 | 2006-03-23 | Microchip Biotechnologies, Inc. | Microfluidic devices |
US7323699B2 (en) * | 2005-02-02 | 2008-01-29 | Rave, Llc | Apparatus and method for modifying an object |
US20060171855A1 (en) * | 2005-02-03 | 2006-08-03 | Hongfeng Yin | Devices,systems and methods for multi-dimensional separation |
US7998087B2 (en) | 2006-01-31 | 2011-08-16 | Panasonic Corporation | Blood test apparatus and blood test method |
US9320459B2 (en) | 2006-05-08 | 2016-04-26 | Becton, Dickinson And Company | Gravity-drop safety holder |
US20070276425A1 (en) | 2006-05-29 | 2007-11-29 | Stanley Kim | Painless Blood Sampling Lancet with Bundled Multiple Thin Needles |
WO2008053743A1 (en) * | 2006-10-31 | 2008-05-08 | Panasonic Corporation | Microchip and analyzer using the same |
KR100900511B1 (ko) * | 2007-07-23 | 2009-06-03 | 주식회사 디지탈바이오테크놀러지 | 유체분석용 칩 |
US9033898B2 (en) | 2010-06-23 | 2015-05-19 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
WO2010101620A2 (en) | 2009-03-02 | 2010-09-10 | Seventh Sense Biosystems, Inc. | Systems and methods for creating and using suction blisters or other pooled regions of fluid within the skin |
BRPI1007674B1 (pt) * | 2009-05-07 | 2021-10-13 | International Business Machines Corporation | Cabeça de sonda microfluídica de multicamadas e método de fabricação da mesma |
US20110312751A1 (en) | 2010-06-17 | 2011-12-22 | Geneasys Pty Ltd | Microfluidic device for detection of mitochondrial dna via fluorescence modulated by hybridization |
US8459552B2 (en) | 2010-08-30 | 2013-06-11 | Awis Llc | System and method for the display of a ballestic trajectory adjusted reticule |
US20130211289A1 (en) | 2012-01-25 | 2013-08-15 | Tasso, Inc. | Handheld Device for Drawing, Collecting, and Analyzing Bodily Fluid |
EP2874942B1 (en) | 2012-07-23 | 2018-09-05 | Tasso, Inc. | Methods and devices relating to open microfluidic channels |
US9427707B2 (en) | 2012-08-10 | 2016-08-30 | Jean I. Montagu | Filtering blood |
US9766166B2 (en) | 2013-01-09 | 2017-09-19 | Wisconsin Alumni Research Foundation | Device and method incorporating a slideable lid for extracting a targeted fraction from a sample |
US8728411B2 (en) | 2012-09-05 | 2014-05-20 | Wisconsin Alumni Research Foundation | Device for and method of isolating a fraction in a biological sample |
US11029310B2 (en) | 2013-03-14 | 2021-06-08 | Wisconsin Alumni Research Foundation | Device and method for extracting a targeted fraction from a sample |
-
2013
- 2013-07-23 EP EP13823115.4A patent/EP2874942B1/en active Active
- 2013-07-23 WO PCT/US2013/051731 patent/WO2014018558A1/en active Application Filing
- 2013-07-23 AU AU2013293078A patent/AU2013293078B2/en active Active
- 2013-07-23 US US13/949,108 patent/US9289763B2/en active Active
- 2013-07-23 JP JP2015524399A patent/JP6312670B2/ja active Active
-
2015
- 2015-11-04 US US14/932,485 patent/US9987629B2/en active Active
-
2017
- 2017-12-07 AU AU2017272264A patent/AU2017272264A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2874942A1 (en) | 2015-05-27 |
AU2013293078A2 (en) | 2015-11-05 |
US9289763B2 (en) | 2016-03-22 |
AU2017272264A1 (en) | 2018-01-04 |
EP2874942B1 (en) | 2018-09-05 |
JP2015525882A (ja) | 2015-09-07 |
EP2874942A4 (en) | 2016-03-02 |
WO2014018558A1 (en) | 2014-01-30 |
US20140038306A1 (en) | 2014-02-06 |
US20160051981A1 (en) | 2016-02-25 |
AU2013293078B2 (en) | 2017-09-07 |
AU2013293078A1 (en) | 2015-02-12 |
US9987629B2 (en) | 2018-06-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6312670B2 (ja) | 開放マイクロ流体チャンネルに関する方法、システムおよび装置 | |
US11395614B2 (en) | Methods, systems, and devices relating to open microfluidic channels | |
US10690255B2 (en) | Method and system for pre-programmed self-power microfluidic circuits | |
TWI461689B (zh) | 含有乾粉狀試劑的血液凝固測試用生醫晶片 | |
Wang et al. | Controlling flow behavior of water in microfluidics with a chemically patterned anisotropic wetting surface | |
US20020150502A1 (en) | Surface tension reduction channel | |
CN102650601A (zh) | 用于比色测定的血浆微流体分离 | |
JP2015525882A5 (ja) | ||
CN103429347B (zh) | 使用抗吸附剂以方便样本混合及分析的装置和方法 | |
JP2009175138A (ja) | マイクロチップ | |
CN108693349A (zh) | 用于进行流体检测的微流体检测卡 | |
KR20180054828A (ko) | 면역학적 측정 장치 | |
CN106990239A (zh) | 液流传输方式特异的廉价的霍乱诊断用微流控装置 | |
WO2008086809A1 (en) | A microfluidic device and a kit for performing a test | |
JP2016097353A (ja) | 混合流路及びこの混合流路を備えたマイクロ流体デバイス | |
WO2016157893A1 (ja) | 混合流路及びこの混合流路を備えたマイクロ流体デバイス | |
Balyan et al. | Fabrication and characterization of passive micropump for microfluidics based devices | |
CN107020159A (zh) | 借助于界面特性进行液流驱动的易拆解的霍乱诊断用装置 | |
Unitan | Janus-Type Wicking Microfluidic Devices for Separation and Collection of Plasma from Blood | |
Wägli | Integrated Microfluidic Liquid-Liquid Extraction for Cocaine Detection in Human Saliva | |
Olanrewaju | 3D-Printed Capillaric Circuits for Autonomous Liquid Delivery | |
CN107649203A (zh) | 附加的驱动液流用构件易于卸除的亚型猪流感检测装置 | |
CN107649212A (zh) | 多种亚型猪流感同时检测的多通道微流控芯片装置 | |
CN107649196A (zh) | 液流驱动用附加件易拆解的梅毒诊断用微流控装置 | |
CN107649195A (zh) | 一种试样驱动用附加件可快捷移除的梅毒诊断用装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150831 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160725 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170630 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170808 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20171101 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20171225 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180207 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20180227 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180320 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6312670 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |