JP6297506B2 - 齲歯のための置換療法 - Google Patents

齲歯のための置換療法 Download PDF

Info

Publication number
JP6297506B2
JP6297506B2 JP2014558872A JP2014558872A JP6297506B2 JP 6297506 B2 JP6297506 B2 JP 6297506B2 JP 2014558872 A JP2014558872 A JP 2014558872A JP 2014558872 A JP2014558872 A JP 2014558872A JP 6297506 B2 JP6297506 B2 JP 6297506B2
Authority
JP
Japan
Prior art keywords
streptococcus mutans
polynucleotide
recombinant
dha5ala
strain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2014558872A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015509715A5 (enExample
JP2015509715A (ja
Inventor
ジェフリー・ディ・ヒルマン
ジェイムズ・レイフ・スミス
シャワンダ・アール・ウィルソン−スタンフォード
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas A&M University System
Original Assignee
Texas A&M University System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A&M University System filed Critical Texas A&M University System
Publication of JP2015509715A publication Critical patent/JP2015509715A/ja
Publication of JP2015509715A5 publication Critical patent/JP2015509715A5/ja
Application granted granted Critical
Publication of JP6297506B2 publication Critical patent/JP6297506B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/123—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
JP2014558872A 2012-02-27 2013-02-22 齲歯のための置換療法 Expired - Fee Related JP6297506B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261603693P 2012-02-27 2012-02-27
US201261603661P 2012-02-27 2012-02-27
US61/603,661 2012-02-27
US61/603,693 2012-02-27
PCT/US2013/027340 WO2013130351A1 (en) 2012-02-27 2013-02-22 Replacement therapy for dental caries

Publications (3)

Publication Number Publication Date
JP2015509715A JP2015509715A (ja) 2015-04-02
JP2015509715A5 JP2015509715A5 (enExample) 2016-04-07
JP6297506B2 true JP6297506B2 (ja) 2018-03-20

Family

ID=49083172

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014558872A Expired - Fee Related JP6297506B2 (ja) 2012-02-27 2013-02-22 齲歯のための置換療法
JP2014558870A Active JP6309902B2 (ja) 2012-02-27 2013-02-22 ランチビオティクスｍｕ１１４０および改善された薬理学的特性および構造的特徴を有する他のランチビオティクスの変異体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014558870A Active JP6309902B2 (ja) 2012-02-27 2013-02-22 ランチビオティクスｍｕ１１４０および改善された薬理学的特性および構造的特徴を有する他のランチビオティクスの変異体

Country Status (10)

Country Link
US (2) US9963488B2 (enExample)
EP (3) EP2833902A4 (enExample)
JP (2) JP6297506B2 (enExample)
CN (2) CN104321338B (enExample)
AU (2) AU2013226402B2 (enExample)
BR (2) BR112014020659A2 (enExample)
CA (2) CA2865405C (enExample)
HK (2) HK1205519A1 (enExample)
MX (2) MX369443B (enExample)
WO (2) WO2013130349A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201810952PA (en) * 2016-07-15 2019-01-30 Intrexon Corp Lantibiotic variants and uses thereof
US10577399B2 (en) 2016-10-28 2020-03-03 The Texas A&M University System Modified lantibiotics and methods of making and using the modified lantibiotics
WO2020090045A1 (ja) * 2018-10-31 2020-05-07 株式会社村田製作所 抗グラム陰性菌化合物
EP3935067A4 (en) * 2019-03-08 2022-12-07 Fraunhofer USA, Inc. NEW ANTIMICROBIAL LANTIBIOTIC PEPTIDE AND ASSOCIATED USES
CN118490568B (zh) * 2024-07-16 2024-10-18 南昌怀特科技有限公司 一种用于牙齿美白的抑菌凝胶及其制备方法与应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366246A (en) 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US5516682A (en) 1988-07-05 1996-05-14 University Of Maryland Subtilin variant of enhanced stability and activity
GB9423404D0 (en) * 1994-11-19 1995-01-11 Biotech & Biolog Scien Res Production of nisin
US20060198793A1 (en) * 1997-06-10 2006-09-07 University Of Florida Research Foundation Antimicrobial polypeptide, nucleic acid, and methods of use
US5932469A (en) * 1997-06-10 1999-08-03 University Of Florida Antimicrobial polypeptide, nucleic acid, and methods of use
US6964760B2 (en) 1997-06-10 2005-11-15 University Of Florida Research Foundation Antimicrobial polypeptide, nucleic acid, and methods of use
US6251478B1 (en) 1999-12-22 2001-06-26 Balchem Corporation Sensitive substance encapsulation
EP1483366B1 (en) * 2002-02-22 2010-04-14 Blis Technologies Limited Antimicrobial composition
ATE512158T1 (de) 2005-08-12 2011-06-15 Oragenics Inc Differenziell geschützte, orthogonale lanthionintechnologie
US20090215985A1 (en) * 2005-08-12 2009-08-27 Oragenics, Inc. Differentially protected orthogonal lanthionine technology
US7576054B2 (en) * 2005-10-11 2009-08-18 Biosynexus Incorporated Compositions and methods for treating bacteria
US20110150917A1 (en) * 2007-06-12 2011-06-23 The University Of British Columbia Small Cationic Antimicrobial Peptides
DK2176284T3 (da) * 2007-07-20 2013-10-14 Univ Minnesota Lantibiotika og anvendelser deraf
IE20080365A1 (en) * 2008-05-09 2010-03-16 Univ College Cork Nat Univ Ie Nisin derivatives and the use thereof

Also Published As

Publication number Publication date
US9963488B2 (en) 2018-05-08
BR112014020659A2 (pt) 2017-06-27
AU2013226402B2 (en) 2017-05-18
WO2013130349A8 (en) 2014-01-09
HK1205519A1 (en) 2015-12-18
EP2833902A1 (en) 2015-02-11
MX2014010143A (es) 2015-04-08
US20150044146A1 (en) 2015-02-12
WO2013130349A1 (en) 2013-09-06
CA2865395A1 (en) 2013-09-06
JP6309902B2 (ja) 2018-04-11
CN104302307B (zh) 2018-10-26
JP2015509715A (ja) 2015-04-02
CN104321338B (zh) 2018-10-19
MX369443B (es) 2019-11-08
HK1205458A1 (en) 2015-12-18
JP2015509945A (ja) 2015-04-02
WO2013130351A1 (en) 2013-09-06
BR112014020656A2 (pt) 2017-06-27
MX2014010151A (es) 2015-01-14
EP2833902A4 (en) 2016-04-06
CA2865405A1 (en) 2013-09-06
CN104302307A (zh) 2015-01-21
EP3219325A1 (en) 2017-09-20
CN104321338A (zh) 2015-01-28
EP2820036A4 (en) 2016-01-20
AU2013226404A1 (en) 2014-08-21
US20150125503A1 (en) 2015-05-07
EP2820036B1 (en) 2018-06-06
AU2013226402A1 (en) 2014-08-21
EP2820036A1 (en) 2015-01-07
US9260488B2 (en) 2016-02-16
EP3219325B1 (en) 2019-11-06
AU2013226404B2 (en) 2017-11-30
CA2865405C (en) 2021-11-16
MX358060B (es) 2018-08-03

Similar Documents

Publication Publication Date Title
JP4949580B2 (ja) 乳酸菌の配合物並びに感染症および炎症の予防および／または処置のためのその使用
JP5721765B2 (ja) ミュータンス・ストレプトコッキィによって引き起こされる齲蝕を予防および／または治療するための使用および方法
US8444998B2 (en) Probiotic strain and antimicrobial peptide derived therefrom
JP6297506B2 (ja) 齲歯のための置換療法
EP4374845A1 (en) Composition comprising superoxide dismutase and/or bacillus strain spores, and use thereof for improving oral health
US7087228B2 (en) Preventing tooth decay and infective endocarditis using natural oligopeptides
ES2205038T3 (es) Terapia de reemplazo para la caries dental.
Ikeda et al. Purification and certain properties of a bacteriocin from Streptococcus mutans
WO2022016266A1 (en) Probiotic for oral health
Todorov et al. Bacteriocin production and resistance to drugs are advantageous features for Lactobacillus acidophilus La-14, a potential probiotic strain
Hacker et al. Influence of cloned Escherichia coli hemolysin genes, S-fimbriae and serum resistance on pathogenicity in different animal models
WO1990011349A1 (fr) Vaccins contre les bacteries septicemiques
JP5209166B2 (ja) ポルフィロモナス・ジンジバリス（Ｐｏｒｐｈｙｒｏｍｏｎａｓｇｉｎｇｉｖａｌｉｓ）リコンビナントタンパク質と末端切断物
JP4847341B2 (ja) 抗菌性組成物
FR2728170A1 (fr) Vaccin de type acellulaire anti-bordetella
WO2000066616A1 (en) METHODS AND COMPOSITIONS FOR CONTROLLING DENTAL CARIES, AND RECOMBINANT SmaA POLYPEPTIDES USEFUL FOR SAME
US20160213604A1 (en) Compositions and methods for reducing caries-causing oral bacteria
Modi Various Approaches for Prevention of Dental Caries with Emphasis on Probiotics A Review.
WO2023150886A1 (en) Probiotic strain for countering caries pathogens
PR et al. Dental Caries Prevention: A Review of Conventional and Recent Preventive approaches
Wan Construction and characterization of tpr and prT single and double mutants of Porphyromonas gingivalis W83
Wu Identification and characterization of Porphyromonas gingivalis virulence genes using a pPGIVET system
Guthmiller Elucidating a role for Actinobacillus actinomycetemcomitans in periodontal disease
Baldi et al. Brucella abortus A Bile Salt Hydrolase of

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160215

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160215

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161220

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170317

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170704

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171026

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20171107

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180130

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180221

R150 Certificate of patent or registration of utility model

Ref document number: 6297506

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees