JP2015509715A5 - - Google Patents
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- Publication number
- JP2015509715A5 JP2015509715A5 JP2014558872A JP2014558872A JP2015509715A5 JP 2015509715 A5 JP2015509715 A5 JP 2015509715A5 JP 2014558872 A JP2014558872 A JP 2014558872A JP 2014558872 A JP2014558872 A JP 2014558872A JP 2015509715 A5 JP2015509715 A5 JP 2015509715A5
- Authority
- JP
- Japan
- Prior art keywords
- streptococcus mutans
- mutation
- mutans strain
- polynucleotide
- isolated recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000194019 Streptococcus mutans Species 0.000 claims 15
- 230000035772 mutation Effects 0.000 claims 11
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 4
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- 238000003786 synthesis reaction Methods 0.000 claims 4
- 108010062877 Bacteriocins Proteins 0.000 claims 3
- 150000008574 D-amino acids Chemical class 0.000 claims 3
- 241000283984 Rodentia Species 0.000 claims 2
- 208000002925 dental caries Diseases 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 102220628388 Annexin A10_F1Y_mutation Human genes 0.000 claims 1
- 102220546214 Cell division cycle-associated protein 2_W4D_mutation Human genes 0.000 claims 1
- 241000628997 Flos Species 0.000 claims 1
- 241000588902 Zymomonas mobilis Species 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 229940068682 chewable tablet Drugs 0.000 claims 1
- 239000007910 chewable tablet Substances 0.000 claims 1
- 229940112822 chewing gum Drugs 0.000 claims 1
- 235000015218 chewing gum Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 239000002324 mouth wash Substances 0.000 claims 1
- 229940051866 mouthwash Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229940034610 toothpaste Drugs 0.000 claims 1
- 239000000606 toothpaste Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261603661P | 2012-02-27 | 2012-02-27 | |
| US201261603693P | 2012-02-27 | 2012-02-27 | |
| US61/603,661 | 2012-02-27 | ||
| US61/603,693 | 2012-02-27 | ||
| PCT/US2013/027340 WO2013130351A1 (en) | 2012-02-27 | 2013-02-22 | Replacement therapy for dental caries |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509715A JP2015509715A (ja) | 2015-04-02 |
| JP2015509715A5 true JP2015509715A5 (enExample) | 2016-04-07 |
| JP6297506B2 JP6297506B2 (ja) | 2018-03-20 |
Family
ID=49083172
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558870A Active JP6309902B2 (ja) | 2012-02-27 | 2013-02-22 | ランチビオティクスｍｕ１１４０および改善された薬理学的特性および構造的特徴を有する他のランチビオティクスの変異体 |
| JP2014558872A Expired - Fee Related JP6297506B2 (ja) | 2012-02-27 | 2013-02-22 | 齲歯のための置換療法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558870A Active JP6309902B2 (ja) | 2012-02-27 | 2013-02-22 | ランチビオティクスｍｕ１１４０および改善された薬理学的特性および構造的特徴を有する他のランチビオティクスの変異体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9963488B2 (enExample) |
| EP (3) | EP2820036B1 (enExample) |
| JP (2) | JP6309902B2 (enExample) |
| CN (2) | CN104321338B (enExample) |
| AU (2) | AU2013226404B2 (enExample) |
| BR (2) | BR112014020659A2 (enExample) |
| CA (2) | CA2865405C (enExample) |
| HK (2) | HK1205519A1 (enExample) |
| MX (2) | MX358060B (enExample) |
| WO (2) | WO2013130351A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017296061B2 (en) * | 2016-07-15 | 2021-07-15 | Eleszto Genetika, Inc. | Lantibiotic variants and uses thereof |
| US10577399B2 (en) | 2016-10-28 | 2020-03-03 | The Texas A&M University System | Modified lantibiotics and methods of making and using the modified lantibiotics |
| CN113039196B (zh) * | 2018-10-31 | 2025-03-18 | 株式会社村田制作所 | 抗革兰氏阴性菌化合物 |
| WO2020185562A1 (en) * | 2019-03-08 | 2020-09-17 | Fraunhofer Usa, Inc. | Novel antimicrobial lantibiotic peptide and uses thereof |
| CN118490568B (zh) * | 2024-07-16 | 2024-10-18 | 南昌怀特科技有限公司 | 一种用于牙齿美白的抑菌凝胶及其制备方法与应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366246A (en) | 1977-11-08 | 1982-12-28 | Genentech, Inc. | Method for microbial polypeptide expression |
| US5516682A (en) * | 1988-07-05 | 1996-05-14 | University Of Maryland | Subtilin variant of enhanced stability and activity |
| GB9423404D0 (en) * | 1994-11-19 | 1995-01-11 | Biotech & Biolog Scien Res | Production of nisin |
| US20060198793A1 (en) * | 1997-06-10 | 2006-09-07 | University Of Florida Research Foundation | Antimicrobial polypeptide, nucleic acid, and methods of use |
| US5932469A (en) * | 1997-06-10 | 1999-08-03 | University Of Florida | Antimicrobial polypeptide, nucleic acid, and methods of use |
| US6964760B2 (en) | 1997-06-10 | 2005-11-15 | University Of Florida Research Foundation | Antimicrobial polypeptide, nucleic acid, and methods of use |
| US6251478B1 (en) | 1999-12-22 | 2001-06-26 | Balchem Corporation | Sensitive substance encapsulation |
| CA2475310C (en) | 2002-02-22 | 2013-02-12 | Blis Technologies Limited | Antimicrobial streptococcus salivarius strain and use thereof for preventing dental caries |
| ATE512158T1 (de) | 2005-08-12 | 2011-06-15 | Oragenics Inc | Differenziell geschützte, orthogonale lanthionintechnologie |
| US20090215985A1 (en) | 2005-08-12 | 2009-08-27 | Oragenics, Inc. | Differentially protected orthogonal lanthionine technology |
| US7576054B2 (en) * | 2005-10-11 | 2009-08-18 | Biosynexus Incorporated | Compositions and methods for treating bacteria |
| US20110150917A1 (en) * | 2007-06-12 | 2011-06-23 | The University Of British Columbia | Small Cationic Antimicrobial Peptides |
| JP2010534063A (ja) * | 2007-07-20 | 2010-11-04 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ランチビオティックス及びこれらの使用 |
| IE20080365A1 (en) * | 2008-05-09 | 2010-03-16 | Univ College Cork Nat Univ Ie | Nisin derivatives and the use thereof |
-
2013
- 2013-02-22 CA CA2865405A patent/CA2865405C/en active Active
- 2013-02-22 MX MX2014010143A patent/MX358060B/es active IP Right Grant
- 2013-02-22 JP JP2014558870A patent/JP6309902B2/ja active Active
- 2013-02-22 WO PCT/US2013/027340 patent/WO2013130351A1/en not_active Ceased
- 2013-02-22 US US14/381,420 patent/US9963488B2/en active Active
- 2013-02-22 EP EP13755436.6A patent/EP2820036B1/en active Active
- 2013-02-22 EP EP17000662.1A patent/EP3219325B1/en active Active
- 2013-02-22 CN CN201380011223.1A patent/CN104321338B/zh not_active Expired - Fee Related
- 2013-02-22 BR BR112014020659A patent/BR112014020659A2/pt not_active IP Right Cessation
- 2013-02-22 HK HK15106032.0A patent/HK1205519A1/xx unknown
- 2013-02-22 EP EP13755353.3A patent/EP2833902A4/en not_active Withdrawn
- 2013-02-22 US US14/381,524 patent/US9260488B2/en active Active
- 2013-02-22 CN CN201380011187.9A patent/CN104302307B/zh not_active Expired - Fee Related
- 2013-02-22 CA CA2865395A patent/CA2865395A1/en not_active Abandoned
- 2013-02-22 AU AU2013226404A patent/AU2013226404B2/en not_active Ceased
- 2013-02-22 HK HK15106033.9A patent/HK1205458A1/xx unknown
- 2013-02-22 BR BR112014020656A patent/BR112014020656A2/pt not_active Application Discontinuation
- 2013-02-22 MX MX2014010151A patent/MX369443B/es active IP Right Grant
- 2013-02-22 WO PCT/US2013/027336 patent/WO2013130349A1/en not_active Ceased
- 2013-02-22 AU AU2013226402A patent/AU2013226402B2/en not_active Ceased
- 2013-02-22 JP JP2014558872A patent/JP6297506B2/ja not_active Expired - Fee Related
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