TWI817943B - 低刺激性口腔用組合物 - Google Patents
低刺激性口腔用組合物 Download PDFInfo
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- TWI817943B TWI817943B TW107112283A TW107112283A TWI817943B TW I817943 B TWI817943 B TW I817943B TW 107112283 A TW107112283 A TW 107112283A TW 107112283 A TW107112283 A TW 107112283A TW I817943 B TWI817943 B TW I817943B
- Authority
- TW
- Taiwan
- Prior art keywords
- irritation
- surfactant
- composition
- low
- glutamate
- Prior art date
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 229940045944 sodium lauroyl glutamate Drugs 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical group 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本發明涉及低刺激性口腔用組合物，具體涉及含有麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑的高氣泡、低刺激性口腔用組合物，該組合物對口腔黏膜幾乎沒有刺激，使用時氣泡生成性能優異，苦味及令人不適的味道小，使用感優異。
Description
本發明涉及低刺激性口腔用組合物，具體涉及含有麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑的口腔用組合物，該組合物使用時具有優秀的泡沫生成能力，對口腔黏膜幾乎沒有刺激，減少了苦味及令人不適的味道，顯著提升了使用感和偏好性。
在多種形態的口腔用組合物中十二烷基硫酸鈉作為起泡劑使用。十二烷基硫酸鈉與其它陰離子表面活性劑不同，由於其苦味小、氣泡豐富的優點，作為起泡劑被廣泛地使用，也是已知的刺激及誘發炎症的成分。
如上所述，包括十二烷基硫酸鈉的陰離子型表面活性劑通常存在刺激性強的問題。因此，為了緩解強刺激性，同時提升洗淨特性和起泡特性，部分已知技術中一併使用兩性表面活性劑。已知這種兩性表面活性劑相比於陰離子表面活性劑刺激低，與陰離子表面活性劑混合使用時，表面活性劑中的陽離子性特性使得氣泡膜更堅固，提高了氣泡的穩定性。但是，由於大部分的兩性表面活性劑表現出較強的苦味及令人不適的味道，其使用量受到限制。
現有技術文獻
（專利文獻001）韓國專利公開公報第10-2016-0090708號
（專利文獻002）韓國專利公開公報第10-2014-0007406號
為了解決的技術問題
本發明提供高氣泡、低刺激性的口腔用組合物，該組合物通過含有麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑，對口腔黏膜幾乎沒有刺激，使用時氣泡生成性能優異，苦味及令人不適的味道小，使用感優異。
解決問題的手段
為了實現上述目的，本發明特徵涉及的低刺激性口腔用組合物，其特徵在於，該組合物含有麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑。
發明效果
本發明涉及的低刺激性口腔用組合物含有麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑，使用時不但具有非常優異的氣泡生成能力，而且對口腔黏膜幾乎沒有刺激，苦味及令人不適的味道小，使用感優異。
以下，對本發明的低刺激性口腔用組合物進行具體說明。
沒有其它定義方式的話，本說明書中所使用的所有技術及科學用語等均與本領域技術人員常規理解方式相同。一般而言，本說明書中使用的命名法均為本領域所熟知的並且慣用的。
本發明的低刺激性口腔用組合物可以由含有麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑構成。
所述麩胺酸鹽類表面活性劑可以使用月桂醯麩胺酸鈉（Sodium Lauroyl Glutamate），所述醯胺丙基甜菜鹼類表面活性劑可以使用月桂醯胺丙基甜菜鹼（Lauramidopropyl Betaine）。
此時，為了實現目標效果，所述麩胺酸鹽類表面活性劑與所述醯胺丙基甜菜鹼類表面活性劑可以按1-3：1的重量比進行混合，較佳為按1.5-2：1的重量比進行混合。
另外，為了實現目標效果，以組合物總重量為基準，所述麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑的含量可以為0.5-2.5重量%，較佳地，所述麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑的含量為1.0-2.0重量%。
當所述麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑的含量不足0.5重量%，使用時氣泡生成量會很少，當超過2.5重量%時，會由於苦味而降低使用感。
一方面，本發明的低刺激性口腔用組合物為了促進氣泡生成，還可以含有精氨酸。
此時，為了實現目標效果，以組合物總重為基準，所述精氨酸的含量可以為0.1-10重量%。當所述精氨酸的含量不足0.1重量%時，氣泡增加效果低，當超過10重量%時，其難以劑型化，因此不建議。
對本發明的低刺激性口腔用組合物的劑型沒有特別的限定，具體可以為牙膏、口腔清涼劑、牙齒美白劑等劑型。
另外，本發明的低刺激性口腔用組合物根據劑型和使用目的不同，可以含有常用的研磨劑、濕潤劑、輔助起泡劑、黏合劑、甜味劑、pH調節劑、防腐劑、藥效成分、香料、增白劑、色素、溶劑等。
所述研磨劑可以為碳酸鈣、沈降二氧化矽、氫氧化鋁、磷酸氫二鉀和不溶性偏磷酸鈉等，將這些研磨劑單獨或二種以上混合並以組合物的總重量為基準計使用1-60重量%的量。
所述潤濕劑可以為甘油、山梨醇液、聚乙二醇和丙二醇等，將這些潤濕劑單獨或二種以上混合並以組合物的總重量為基準計使用1-80重量%的量。
所述輔助起泡劑可以為將陰離子表面活性劑、兩性表面活性劑、非離子表面活性劑、陽離子型表面活性劑單獨或者二種以上進行混合並以組合物的總重量為基準計使用0.1-10重量%的量，其中，所述陰離子表面活性劑為硫酸鹽類、磺基琥珀酸鹽類、肌氨酸鹽類、磷酸類、羥乙基磺酸鹽類、牛磺酸鹽類等，所述兩性表面活性劑為磺基甜菜鹼類、兩性基乙酸鹽類等，所述非離子表面活性劑為聚氧乙烯山梨坦脂肪酸酯、聚乙二醇（氫化）蓖麻子油、甘油脂肪酸酯、山梨坦脂肪酸酯、蔗糖脂肪酸酯、烷基醇醯胺、烷基葡糖苷等，所述陽離子型表面活性劑為N-烷基二氨乙基甘氨酸等。
所述黏合劑可以為將羧甲基纖維素鈉、羥甲基纖維素、羥乙基纖維素、羥丙基纖維素、黃原膠、卡拉膠、海藻酸鈉等單獨或二種混合並以組合物的總重量為基準計使用0.1-10重量%的量。
所述甜味劑可以為將糖精鈉、阿斯巴甜、甜菊糖、木糖醇、甘草酸等單獨或二種以上混合並以組合物的總重量為基準計使用0.001-1重量%的量。
所述pH調節劑可以為將磷酸二氫鈉、磷酸氫二鈉、磷酸鈉、焦磷酸鈉、檸檬酸、檸檬酸鈉、酒石酸等單獨或者二種以上混合使用；所述防腐劑可以為將對羥基苯甲酸甲酯、對羥基苯甲酸丙酯、苯甲酸鈉等單獨或二種以上混合使用。
所述藥效成分可以為將氟化鈉、單氟磷酸鈉、氟化錫、氯己定、尿囊素氯羥鋁酸鹽（allantoin chlorohydroxyaluminate）、氨基己酸、三氯生、十六烷基氯化吡啶、氯化鋅、鹽酸吡哆辛、維生素E醋酸酯等單獨或者二種以上混合使用。
所述香料可以為將胡椒薄荷油、留蘭香油、薄荷腦、茴香腦等單獨或者二種以上混合並以適當量使用，增白劑可以使用氧化鈦類，色素可以使用食用色素，溶劑可以使用精製水或乙醇等。
如上所述的添加劑可以根據目的和條件而添加不同組分和含量，按照通常的牙膏製備方法進行製備。
以下，通過實施例和試驗例對本發明的內容進一步具體說明。然而，這些實施例和試驗例僅用於理解本發明的內容，並不用於限定本發明的保護範圍，本領域公知的變形、置換和插入等方式也均應視為包含在本發明的範疇中。 ＜製備例＞ 製備牙膏
根據下述表1中的組成製備實施例1、2和對比例1-4，下述表1中的單位是以組合物總重量為基準計的相應成分的重量%。 表1
＜試驗例1＞ 起泡能力評價試驗
對一併使用麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑的牙膏的起泡力進行評價，取上述表1中實施例1、2和對比例1-4的牙膏組合物各5g放入燒杯中稱量，加入45g精製水將總量配至50g後，分別加入250ml量筒中，堵住瓶口，在各8回旋轉180度後的狀態下測定起泡力，重複測定3次。測定是從250ml的刻度進行觀測，記錄從0開始生成氣泡的高度所對應的數位，單位為ml。測定結果如下述表2所示。 表2
由上述表2的結果可知，相較於單獨僅含有月桂醯麩胺酸鈉或月桂醯胺丙基甜菜鹼的對比例1、2而言，包括作為麩胺酸鹽類表面活性劑的月桂醯麩胺酸鈉和作為醯胺丙基甜菜鹼類表面活性劑的月桂醯胺丙基甜菜鹼的實施例1和還含有精氨酸的實施例2的起泡能力更優異。
另外還可知，相較於使用十二烷基硫酸鈉的對比例3和含有在不使用十二烷基硫酸鈉的產品中一般含有的椰油醯麩胺酸鈉和椰油醯胺丙基二甲基甘氨酸液的對比例4而言，實施例1和2的起泡能力也更優異。
因而可知，相較於單獨使用上述成分或者含有現有的一般使用的起泡劑的對比例1-4，同時含有月桂醯麩胺酸鈉和月桂醯胺丙基甜菜鹼或者在此基礎上還含有精氨酸時，其起泡能力更優異。 ＜試驗例2＞ 對口腔黏膜刺激性評價試驗
為了評價同時使用麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑時對口腔黏膜的刺激性，以20名對黏膜刺激敏感的被測試者為試驗物件，在牙刷上取上述實施例1、2和對比例1-4的牙膏組合物各1g，刷牙3分鐘，對口腔黏膜的刺激性進行評價。依據刺激程度的不同，將「沒有感覺到刺激」記為1分，「幾乎沒有感覺到刺激」記為2分，「感覺到刺激」記為3分，「感覺到強烈的刺激」記為4分，以20名的平均值評價對口腔黏膜的刺激性。評價結果如下述表3所示。 表3
由上述表3的結果可知，相較於實施例1、2與對比例1、2和4而言，由含有十二烷基硫酸鈉的對比例3製得的牙膏對口腔黏膜表現出更大的刺激性，相較於單獨使用月桂醯麩胺酸鈉或月桂醯胺丙基甜菜鹼、或者含有現有的一般使用的起泡劑的對比例1-4，本申請發明的實施例1、2對口腔黏膜的刺激性更低。 ＜試驗例3＞ 苦味及令人不適的味道的評價試驗
為了評價同時使用麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑時的使用感，以20名香味審評員為試驗物件，在牙刷上取上述實施例1、2和對比例1-4的牙膏組合物各1g，刷牙3分鐘後，對苦味及令人不適的味道進行評價。根據苦味及令人不適的味道的程度以5分標準法（5分：非常強烈，4分：強烈，3分：普通，2分：較弱，1分：非常弱）分別進行評價，以20名的平均值對苦味及令人不適的味道進行評價。評價結果如下述表4所示。 表4
由上述表4的結果可知，本申請發明的實施例1、2的牙膏組合物的苦味和令人不適的味道的程度遠遠低於對比例1-4，特別是含有椰油醯麩胺酸鈉和椰油醯胺丙基二甲基甘氨酸液的對比例4。
如上所述，本發明的低刺激性口腔用組合物含有麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑，其具有優異的氣泡生成能力的同時對口腔黏膜的刺激極低，減少了苦味及令人不適的味道，使用感優異。
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Claims (5)
- 一種低刺激性口腔用組合物，其特徵在於，該組合物含有麩胺酸鹽類表面活性劑和醯胺丙基甜菜鹼類表面活性劑，並且未含有硫酸鹽類表面活性劑，其中該麩胺酸鹽類表面活性劑為月桂醯麩胺酸鈉，該醯胺丙基甜菜鹼類表面活性劑為月桂醯胺丙基甜菜鹼。
- 如申請專利範圍第1項所述之低刺激性口腔用組合物，其中，以重量為基準，該麩胺酸鹽類表面活性劑與該醯胺丙基甜菜鹼類表面活性劑的混合比為1-3：1。
- 如申請專利範圍第1項所述之低刺激性口腔用組合物，其中，以組合物總重量為基準，該麩胺酸鹽類表面活性劑與該醯胺丙基甜菜鹼類表面活性劑的含量為0.5-2.5重量%。
- 如申請專利範圍第1項所述之低刺激性口腔用組合物，其中，該組合物還含有精氨酸。
- 如申請專利範圍第4項所述之低刺激性口腔用組合物，其中，以組合物總重量為基準，該精氨酸的含量為0.1-10重量%。
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