CN105263464B - 含金刚石颗粒的口腔用组合物 - Google Patents
含金刚石颗粒的口腔用组合物 Download PDFInfo
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- CN105263464B CN105263464B CN201480032611.2A CN201480032611A CN105263464B CN 105263464 B CN105263464 B CN 105263464B CN 201480032611 A CN201480032611 A CN 201480032611A CN 105263464 B CN105263464 B CN 105263464B
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- Prior art keywords
- dioxide granule
- composition
- silica dioxide
- oral cavity
- diamond particles
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Abstract
本发明的目标是提供一种口腔用组合物,其具有优越的清扫性和平滑性。本发明提供含有金刚石颗粒和二氧化硅颗粒的口腔用组合物。
Description
技术领域
本发明涉及含金刚石颗粒的口腔用组合物,并且更具体地涉及包含金刚石颗粒和二氧化硅颗粒的口腔用的组合物。本申请要求2013年6月7日提交的日本专利申请号2013-120778的优先权。此专利申请的说明书和/或附图中公开的内容通过引用并入本文。
背景技术
牙齿的着色是由称为“色斑(stain)”的显色物质在牙齿上的沉积所致。这导致关于审美的严重问题。作为除去色斑的手段,通常的方法是用例如牙刷等用具将例如含有牙齿研磨剂(dental abrasive)的磨齿组合物(dentifrice composition)等口腔用组合物含在口中,并刷扫牙齿。期望口腔用组合物不仅有效去除色斑,也使得使用后牙齿表面光滑,因此使色斑等难以附着至牙齿,并因此提供保持牙齿美观的效果。
通常认为含有研磨力较高的牙齿研磨剂的口腔用组合物具有较大的清扫性和平滑性。然而,当研磨力高时,有对牙齿的磨耗可能超出必要的风险。在此情况下,虽然可以除去色斑,但牙齿本身将会随时间而磨耗。当牙齿表面过度磨耗时,可暴露牙本质而可导致知觉过敏。此外,由于暴露的牙本质耐酸性低,可助长龋齿。此外,即使组合物有高研磨力,也难以预测组合物是否可使牙齿表面光滑,并且其可能在牙齿表面上造成不必要的研磨,导致凹凸的表面。
如上所述,口腔用组合物必须具有色斑除去能力(下文也称为“清扫性”)和使牙齿表面光滑的能力(下文也称为“平滑性”)。
引用列表
专利文献
专利文献1:WO 10/060653
发明内容
发明要解决的问题
本申请的目标是提供一种具有优异的清扫性和平滑性的口腔用组合物。
用于解决问题的方案
本发明人发现,含有金刚石颗粒和二氧化硅颗粒的口腔用组合物具有优异的清扫性和平滑性。发明人在此发现基础上进行进一步改进而完成了本发明。
特别地,本发明涵盖例如下列各项所记载的主题。
项1。一种口腔用组合物,其包含金刚石颗粒和二氧化硅颗粒。
项2。根据项1所述的口腔用组合物,其中所述金刚石颗粒的平均粒径(d50)为0.5至5μm。
项3。根据项1所述的口腔用组合物,其中所述二氧化硅颗粒的平均粒径(d50)为0.5至20μm。
项4。根据项1至3任一项所述的口腔用组合物,其中所述金刚石颗粒以0.01至0.5质量%的量存在。
项5。根据项1至4任一项所述的口腔用组合物,其中所述二氧化硅颗粒包含第一二氧化硅颗粒和第二二氧化硅颗粒的组合,所述第一二氧化硅颗粒具有3至5.5μm的平均粒径(d50)和20至80(mL/100g)的吸油量,所述第二二氧化硅颗粒具有6至15μm的平均粒径(d50)和90至150(mL/100g)的吸油量。
项6。根据项1至5任一项所述的口腔用组合物,其中相对于每0.01至0.5质量份的金刚石颗粒,所述二氧化硅颗粒以1至35质量份的量存在。
发明的效果
用本发明的口腔用组合物来处理(例如刷扫)牙齿可有效地除去色斑,并也可使得使用后牙齿表面光滑,来保持牙齿美观。特别地,本发明的口腔用组合物具有优异的清扫性和平滑性。
具体实施方式
下文将更详细地描述本发明。
本发明的口腔用组合物包含金刚石颗粒和二氧化硅颗粒。
金刚石颗粒的平均粒径(对应累积粒径分布50%的粒径(即50%累积直径))优选为0.5至5μm,更优选1至4μm,并甚至更优选2至3μm。
此外,金刚石颗粒的99%累积直径(d99)优选7μm以下,更优选5μm以下,并甚至更优选4.5μm以下。
此外,金刚石颗粒的10%累积直径(d10)优选0.1μm以上,更优选0.5μm以上,甚至更优选1μm以上,并还更优选1.8μm以上。
关于上述d50、d99和d10的条件(优选范围),优选满足d50条件的金刚石颗粒。更优选满足d50和d99条件的金刚石颗粒,并甚至更优选满足d50、d99和d10条件的金刚石颗粒。
作为此类金刚石颗粒,可使用天然物或合成物。合成物可通过例如高温高压合成法、化学气相沉积法、爆轰合成法(detonation synthesis method)或超声空化法(ultrasonic cavitation method)等已知方法来生产。
本文所指的金刚石颗粒的累积直径是基于库尔特原理(Coulter Principle)(电感应区法)用水作为分散剂而测定的值(即,用库尔特计数器获得的值)。此值可通过例如使用Multisizer 3库尔特计数器(Beckman Coulter,Inc.生产)来测定。
本发明的口腔用组合物中含有的二氧化硅颗粒可以是例如,已知用于口腔用组合物,并通过湿法或干法合成的二氧化硅。由于湿法合成的二氧化硅在清扫性和研磨性之间的平衡适合在本发明中使用,优选通过湿法合成的二氧化硅。湿法的实例包括沉淀法和凝胶法。通过湿法获得的二氧化硅可大致分类为通过沉淀法合成的沉淀二氧化硅,和通过凝胶法合成的凝胶二氧化硅。在本发明中,可使用任何类型的二氧化硅。沉淀二氧化硅比凝胶二氧化硅常常更优选,但不受限制。短语“常常更优选”意指在下文记载的平均粒径和吸油量,以及BET比表面积方面,沉淀二氧化硅常常具有更优选的值。
商购可得的二氧化硅产品可用作本发明中使用的二氧化硅颗粒。沉淀二氧化硅的实例包括Aerosil、Ultrasil、Carplex(均为Evonik Degussa生产),Aerosil(JapanAerosil Co.,Ltd.生产),Zeodent(Huber Corporation生产),Excelia、Reolosil(均为Tokuyama Corporation生产),Syilsia(Fuji Sylsia Chemical Ltd.生产),Sorbosil(Ineos Silicas Ltd.生产),Denka熔融二氧化硅(Denki Kagaku Kogo Kabushiki Kaisha生产),Nipsil和Nipgel(均为Tosoh Silica Corporation生产),Zeosil、Tixosil(SolvayS.A.生产)等。在这些当中,例如,Zeodent(Huber Corporation生产),Sorbosil AC(PCCorporation生产),和Texosil(Phodia Co.,Ltd.生产),它们都是沉淀二氧化硅颗粒,是优选的。
二氧化硅颗粒的平均粒径(d50)优选0.5至20μm,更优选1至15μm,甚至更优选2至13μm,并还甚至更优选3.5至13μm。二氧化硅颗粒的吸油量(根据JIS K5101的亚麻子油吸油量)优选10至200(mL/100g),更优选20至150(mL/100g),甚至更优选25至140(mL/100g),并还甚至更优选30至135(mL/100g)。
本发明的口腔用组合物中含有的二氧化硅颗粒优选包括有不同性质的二氧化硅颗粒的组合。虽然可使用两种或多种(例如2、3、4或5种)二氧化硅颗粒的组合,但最优选使用两种具有不同性质的二氧化硅颗粒的组合。两种具有不同性质的二氧化硅颗粒的实例如下所示。当组合使用的两种二氧化硅颗粒分别称作“第一二氧化硅颗粒”和“第二二氧化硅颗粒”时,第一二氧化硅颗粒优选具有3至5.5μm(更优选在3.5至5μm的范围内)的平均粒径(d50),和20至80(mL/100g)(更优选在30至70(mL/100g)的范围内)的吸油量(根据JISK5101的亚麻子油吸油量)。第二二氧化硅颗粒优选具有6至15μm(更优选在6至12μm的范围内)的平均粒径(d50),和90至150(mL/100g)(更优选在90至140(mL/100g)的范围内)的吸油量(根据JIS K5101的亚麻子油吸油量)。
本文所指的二氧化硅的平均粒径(d50)是通过激光衍射散射用水作为分散剂测定的值。该值可例如用低功率He/Ne激光、使用基于夫琅和费衍射(Fraunhofer diffraction)原理的Malvern Mastersizer来测定。
本发明的口腔用组合物包含金刚石颗粒的量优选0.01至0.5质量%,更优选0.05至0.2质量%。本发明的口腔用组合物包含二氧化硅颗粒的量优选1至35质量%,更优选2至30质量%。
本发明的口腔用组合物中,相对于每0.01至0.5质量份(优选0.05至0.2质量份)的金刚石颗粒,包含的二氧化硅颗粒的量优选1至35质量份,更优选5至30质量份。特别地,更优选相对于每0.01至0.5质量份的金刚石颗粒,以15至30质量份的量使用二氧化硅颗粒。特别优选相对于每0.05至0.2质量份的金刚石颗粒,以20至30质量份的量使用二氧化硅颗粒。
当第一二氧化硅颗粒和第二二氧化硅颗粒的组合用作二氧化硅颗粒时,相对于每质量份的第一二氧化硅颗粒,使用的第二二氧化硅颗粒的量优选0.5至25质量份,更优选1至20质量份,甚至更优选1至10质量份,还更优选1至5质量份,甚至还更优选1.5至4.5质量份,特别优选2至4质量份,并最优选2.5至3.5质量份。
组合物中第一二氧化硅颗粒的量优选2至8质量%,更优选3至7质量%,组合物中第二二氧化硅颗粒的量优选2至25质量%,并更优选5至22质量%。
本发明的口腔用组合物可通过用已知方法来生产。本发明的口腔用组合物可用于牙齿和义齿,并可通过常规手段形成不同形式的磨齿剂(dentifrice),例如糊状磨齿剂、粉状磨齿剂、膏状磨齿剂、凝胶状磨齿剂、液体磨齿剂和糊剂(pastes)等。特别地,优选糊状磨齿剂、粉状磨齿剂、膏状磨齿剂或凝胶状磨齿剂。
本发明的口腔用组合物可通过将金刚石颗粒和二氧化硅颗粒(以及按需的其它成分)与口腔中药学上可接受或卫生上可接受的基材混合而生产。此类基材的实例包括水、甘油、乙二醇、二苷醇、聚乙二醇、丙二醇、聚丙二醇、山梨糖醇、木糖醇、乳糖醇、甘露糖醇和乙醇等。
本发明的口腔用组合物可含有通常掺入口腔用组合物的其它成分(任选成分)。
可掺入的表面活性剂的实例包括非离子表面活性剂、阴离子表面活性剂和两性表面活性剂。非离子表面活性剂的具体实例包括脂肪酸酯、脂肪酸烷醇酰胺、失水山梨糖醇脂肪酸酯、脂肪酸单甘油酯、脂肪酸聚甘油酯、聚氧乙烯烷基苯基醚、烷基糖苷、癸二酸二乙酯、聚氧乙烯氢化蓖麻油和聚氧乙烯山梨糖醇酐脂肪酸酯等。阴离子表面活性剂的实例包括烷基硫酸盐(例如十二烷基硫酸钠)、聚氧乙烯烷基醚硫酸盐、烷基磺基琥珀酸盐、聚氧乙烯烷基醚磺基琥珀酸盐、N-酰基氨基酸盐、N-酰基牛磺酸盐、烷基醚羧酸盐、烷基磷酸盐、聚氧乙烯烷基醚磷酸盐、脂肪酸单甘油酯硫酸盐和烷基磺基乙酸盐等。两性表面活性剂的实例包括烷基二甲基氨基乙酸甜菜碱、烷基酰胺基丙基二甲基氨基乙酸甜菜碱、N-酰基-N-羧甲基-N-羟乙基乙二胺和N-烷基氨基乙基甘氨酸等。这些表面活性剂可单独使用或以两种或多种的组合使用。此类表面活性剂通常以基于组合物总质量的0.1至10质量%的量掺入。
可掺入的增稠剂的实例包括纤维素衍生物,例如卡拉胶、羧甲基纤维素或其盐、羟丙基纤维素、羟丙基甲基纤维素、羟乙基纤维素和结晶纤维素-羧甲纤维素(carmellose)钠;胶类,例如黄原胶、黄蓍胶、刺梧桐胶、阿拉伯胶、结冷胶(gellan gum);合成粘结剂,例如聚乙烯醇、聚丙烯酸钠、聚羧乙烯和聚乙烯吡咯烷酮;无机粘结剂,例如增稠性二氧化硅、硅烷化二氧化硅、铝二氧化硅凝胶和硅酸镁铝(veegum);海藻酸钠、果胶、大豆多糖类、硫酸软骨素钠和透明质酸钠等。这些增稠剂可单独使用或者以两种或多种的组合使用。此类增稠剂通常按0.01至20质量%的量掺入。
可掺入的香味剂的实例包括薄荷脑、羧酸、茴香脑、丁香酚、水杨酸甲酯、柠檬烯、罗勒烯、正癸醇、香茅醛、α-萜品醇、乙酸甲酯、乙酸香茅酯、甲基丁香酚、桉树脑、芳樟醇、乙基芳樟醇、百里香酚、留兰香油、欧薄荷油(peppermint oil)、柠檬油、橙油、鼠尾草油、迷迭香油、桂皮油、紫苏植物油(beefsteak plant oil)、冬青油、丁香油、桉树油、甜椒油、d-樟脑、d-冰片、茴香油、肉桂油、肉桂醛、薄荷油(mint oil)、香草醛等的香料。这些香料可单独使用或以两种或多种的组合使用。此类香料通常可按基于组合物总质量的0.01至1质量%的量使用。
可掺入的甜味剂的实例包括糖精钠、丁磺氨钾、甜菊糖、甜菊提取物、新橙皮苷二氢查尔酮、甘草甜、紫苏亭、索马甜(thaumatin)、天冬氨酰苯丙氨酰甲基酯和对甲氧基肉桂醛等。这些甜味剂可单独使用或以两种或多种的组合使用。此类甜味剂通常可按基于组合物总质量的0.01至1质量%的量掺入。
可掺入的润湿剂的实例包括山梨糖醇、乙二醇、丙二醇、甘油、1,3-丁二醇、聚丙二醇、木糖醇、麦芽糖醇、乳糖醇、帕拉金糖醇(Palatinit)和聚乙二醇等。这些润湿剂可单独使用或以两种或多种的组合使用。
可掺入的防腐剂的实例包括对羟基苯甲酸酯类,例如对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯、和对羟基苯甲酸丁酯;苯甲酸钠、苯氧乙醇和盐酸烷基二氨基乙基甘氨酸等。这些防腐剂可单独使用或以两种或多种的组合使用。
可掺入的着色剂的实例包括法定色素,例如蓝色1号、黄色4号、红色202号和绿色3号;矿物系色素,例如群青、强化群青和普鲁士蓝;以及氧化钛;等。这些着色剂可单独使用或者按两种或多种的组合使用。
可掺入的pH调节剂的实例包括柠檬酸、磷酸、苹果酸、焦磷酸、乳酸、酒石酸、甘油磷酸、乙酸、硝酸、它们的化学上可接受的盐、氢氧化钠等。这些pH调节剂可单独使用或以两种或多种的组合使用,使所得的组合物的pH为4至8,更优选5至7。此类pH调节剂可例如按0.01至2重量%的量掺入。
本发明的口腔用组合物可包含作为药效成分的:阳离子性杀菌剂,例如西吡氯铵、苯扎氯铵、苄索氯铵和盐酸氯己定;维生素E类,例如dl-α-生育酚醋酸酯、生育酚琥珀酸酯和生育酚烟酸酯;两性杀菌剂,例如十二烷基二氨基乙基甘氨酸;非离子性杀菌剂,例如三氯生和异丙基甲基酚;酶,例如葡聚糖酶、淀粉酶、蛋白酶、齿斑葡聚糖酶(mutanase)、溶菌酶和裂解酶;氟化物,例如单氟磷酸钠、氟化钠和氟化亚锡;凝血酸、ε-氨基己酸、氯羟基尿囊素铝、二氢胆固醇、甘草亭酸(glycyrrhetinic acid)、甘油磷酸酯、叶绿素、氯化钠、卡罗肽(calpeptide)、甘草酸二钾、尿囊素、扁柏酚、硝酸钾等。这些成分可单独使用或以两种或多种的组合使用。
对充填本发明的口腔用组合物的容器没有特别限制。例如,可使用玻璃、金属、塑料或层压材料等制成的容器。此外,容器的形状也不特别限制,例如,可使用如瓶、杯、袋或管等容器。
实施例
本发明参照下文的实施例更详细地描述,但不限于这些实施例。下列实施例中使用的金刚石颗粒购自Microdiamant,实施例中使用的二氧化硅颗粒购自J.M.HuberCorporation。
口腔用组合物的制备
实施例1至12和比较例1至4中的口腔用组合物(糊剂)按照下列表1和2中示出的配方制备。具体地,将除了金刚石颗粒、研磨性二氧化硅颗粒、香料和发泡剂(磺基琥珀酸钠和十二烷基硫酸钠)以外的起始材料混合。添加金刚石颗粒和研磨性二氧化硅颗粒,搅拌并均质化所得的混合物。进一步,添加香料,搅拌并均质化所得的混合物。最后,添加发泡剂,搅拌并均质化所得的混合物(此过程也作消泡处理的功能)。表1和2中所有关于组分的数值均为质量%。
两种类型的商购可得的沉淀二氧化硅产品用作二氧化硅颗粒。它们称为“二氧化硅颗粒a”和“二氧化硅颗粒b”。这些商购可得的二氧化硅产品的规格如下所述。二氧化硅颗粒a具有3.5至5μm的平均粒径(d50)和30至70(mL/100g)的吸油量(根据JIS K5101的亚麻子油吸油量)。二氧化硅颗粒b具有6至12μm的平均粒径(d50)和90至135(mL/100g)的吸油量(根据JIS K5101的亚麻子油吸油量)。
使用的金刚石颗粒具有2.4至3μm(约2.8μm)的平均粒径(d50)、1.8μm以上的d10和4.5μm以下的d99。
二氧化硅颗粒的粒径(d50)通过用低功率He/Ne激光、使用基于夫琅和费衍射原理的Malvern Mastersizer来测定。金刚石颗粒的累积直径通过使用Multisizer 3库尔特计数器(Beckman Coulter,Inc.生产)来测定。
口腔用组合物的评价
按下文所示的方式,评价所获得的口腔用组合物的清扫性和平滑性。表2示出结果。
清扫性的评价方法
用自动精密切割机将牛釉质齿片切割成长3mm×宽3mm的尺寸。每块两片,用牙科用聚合物树脂(Orthofast树脂,GC Corporation生产)包埋。干燥后,齿片的表面用自动抛光装置和抛光纸来进行镜面抛光,用离子交换水洗涤,并干燥。为确定初期色差,用色彩色差计(CR-241,Konica Minolta Sensing,Inc.生产)以1.8-mm直径测量面积来测定L*、a*和b*值(如此获得的L、a和b值分别记为L0、a0和b0)。
此外,对进行了初期色差测定的齿片表面,通过顺次用0.2M盐酸、饱和碳酸钠水溶液、蒸馏水、1%(v/v)肌醇六磷酸和蒸馏水浸渍来浸蚀。
接着,以下列方式将色斑附着在经浸蚀的齿片表面。使用的色斑液(stainingfluid)的制备方法是:将4份商购的茶包置于约1.2L热水中,将水煮沸10分钟,所得的红茶溶液冷却至室温,添加3.4g商购的速溶咖啡和2.5g II型猪胃粘蛋白(Sigma-AldrichCo.LLC生产)。
齿片置于色斑附着装置上。添加色斑液,旋转机器,色斑附着处理持续5至6天。每天用新色斑液更换原色斑液1次。然后用色斑液中添加1g氯化铁的处理液处理齿片1或2天,直至L*值变为30以下。用离子交换水洗涤齿片并干燥后,测定色差(L1、a1、b1)。
色斑附着后的齿片装在ISO-标准刷洗机中。在实施例和比较例获得的各口腔用组合物的3倍稀释(60ml)中,以150g的载荷、150rpm的速率,反复刷洗色斑附着的齿片3,000次。干燥后,测定色差(L2、a2、b2)。根据下式计算色斑除去力(ΔE)(小数点以下四舍五入)并评价。表2示出作为反映清扫性的ΔE。
提供ΔE=(ΔE1/ΔE0)×100
但是,
ΔE1={(L2-L1)2+(a2-a1)2+(b2-b1)2}1/2
ΔE0={(L2-L0)2+(a2-a0)2+(b2-b0)2}1/2
(即,ΔE1等于(L2-L1)的平方、(a2-a1)的平方与(b2-b1)的平方之和的平方根,ΔE0等于(L2-L0)的平方、(a2-a0)的平方与(b2-b0)的平方之和的平方根)。
平滑化的评价方法
用自动精密切割机将牛釉质齿片切割成长3mm×宽6mm的尺寸。每块一片,用牙科用聚合物树脂(Orthofast树脂,GC Corporation生产)包埋。干燥后,齿片的表面用自动抛光装置和抛光纸来进行镜面抛光。
齿片表面通过顺次用0.2M盐酸、蒸馏水、饱和碳酸钠水溶液、蒸馏水和1%(v/v)肌醇六磷酸浸渍来浸蚀。
将胶带(Scotch brand tape,10mm;Sumitomo 3M)贴在一半的牙齿表面以保护表面后,将齿片装在ISO-标准刷洗机中。在实施例和比较例的口腔用组合物的3倍稀释(60ml)中,以150g的载荷、150rpm的速率,反复刷洗齿片3,000次。
刷洗后,用形状测定激光显微镜(VK-8700,Keyence Corporation生产)测定500μm×500μm的单位面积的算术平均粗糙度(Ra)并评价。用胶带保护的表面的Ra记为试验前Ra。按照下式计算平滑性。
平滑性={(试验前Ra-试验后Ra)/试验前Ra}×100
表1
浓缩甘油 | 10 |
聚乙二醇400 | 3 |
山梨糖醇溶液(70%) | 15 |
聚氧乙烯氢化蓖麻油 | 0.5 |
糖精钠 | 0.2 |
甜菊提取物 | 0.1 |
二氧化硅颗粒a | 见表2. |
二氧化硅颗粒b | 见表2. |
金刚石颗粒 | 见表2. |
羧甲基纤维素钠 | 0.5 |
黄原胶 | 0.5 |
香料 | 0.1 |
聚氧乙烯烷基(C12-14)磺基琥珀酸二钠 | 4 |
十二烷基硫酸钠 | 1 |
纯水 | 余量 |
合计 | 100 |
表2
结果示出,本发明的包含金刚石颗粒和二氧化硅颗粒的口腔用组合物具有优异的清扫性和平滑性。
配方例如下所示。下列金刚石颗粒和二氧化硅颗粒用于配方例。此处的量(%)是指质量%。
使用的金刚石颗粒和二氧化硅颗粒
金刚石颗粒A:平均粒径:2.8μm(d50),1.8μm以上(d10),4.5μm以下(d99)。
金刚石颗粒B:平均粒径:0.6μm(d50),0.1μm以上(d10),2μm以下(d99)。
金刚石颗粒C:平均粒径:4.9μm(d50),1.8μm以上(d10),7μm以下(d99)。
金刚石颗粒D:平均粒径:2μm(d50),1μm以上(d10),4.5μm以下(d99)。
金刚石颗粒E:平均粒径:2.1μm(d50),1.3μm以上(d10),4.5μm以下(d99)。
金刚石颗粒F:平均粒径:3μm(d50),1.8μm以上(d10),5μm以下(d99)。
二氧化硅颗粒A:平均粒径:4.5μm(d50),吸油量:52(mL/100g)。
二氧化硅颗粒B:平均粒径:10.5μm(d50),吸油量:118(mL/100g)。
二氧化硅颗粒C:平均粒径:3.2μm(d50),吸油量:76(mL/100g)。
二氧化硅颗粒D:平均粒径:14.5μm(d50),吸油量:146(mL/100g)。
二氧化硅颗粒E:平均粒径:5.3μm(d50),吸油量:78(mL/100g)。
二氧化硅颗粒F:平均粒径6.3μm(d50),吸油量:139(mL/100g)。
二氧化硅颗粒G:平均粒径:5.1μm(d50),吸油量:28(mL/100g)。
二氧化硅颗粒H:平均粒径:6.3μm(d50),吸油量:99(mL/100g)。
二氧化硅颗粒I:平均粒径:3.4μm(d50),吸油量:30(mL/100g)。
二氧化硅颗粒J:平均粒径:13.3μm(d50),吸油量:94(mL/100g)。
[配方例1]糊状磨齿剂
[配方例2]凝胶状磨齿剂
[配方例3]凝胶状磨齿剂
[配方例4]凝胶状磨齿剂
[配方例5]糊状磨齿剂
[配方例6]液体磨齿剂
[配方例7]糊状磨齿剂
[配方例8]糊状磨齿剂
[配方例9]糊状磨齿剂
[配方例10]糊状磨齿剂
[配方例11]液体磨齿剂
[配方例12]糊状磨齿剂
[配方例13]液体磨齿剂
[配方例14]糊状磨齿剂
[配方例15]糊状磨齿剂
[配方例16]糊状磨齿剂
[配方例17]糊状磨齿剂
[配方例18]糊状磨齿剂
[配方例19]糊状磨齿剂
[配方例20]糊状磨齿剂
[配方例21]糊状磨齿剂
[配方例22]糊状磨齿剂
[配方例23]糊状磨齿剂
[配方例24]凝胶状磨齿剂
[配方例25]糊状磨齿剂
[配方例26]糊状磨齿剂
[配方例27]糊状磨齿剂
[配方例28]糊状磨齿剂
Claims (4)
1.一种口腔用组合物,其包含金刚石颗粒和二氧化硅颗粒,
其中所述二氧化硅颗粒包含第一二氧化硅颗粒和第二二氧化硅颗粒的组合,所述第一二氧化硅颗粒具有3至5.5μm的平均粒径(d50)和20至80(mL/100g)的吸油量,所述第二二氧化硅颗粒具有6至15μm的平均粒径(d50)和90至150(mL/100g)的吸油量,
相对于每质量份的所述第一二氧化硅颗粒,包含的所述第二二氧化硅颗粒的量为2至4.5质量份。
2.根据权利要求1所述的口腔用组合物,其中所述金刚石颗粒的平均粒径(d50)为0.5至5μm。
3.根据权利要求1或2所述的口腔用组合物,其中所述金刚石颗粒以0.01至0.5质量%的量存在。
4.根据权利要求1或2所述的口腔用组合物,其中相对于每0.01至0.5质量份的所述金刚石颗粒,所述二氧化硅颗粒以1至35质量份的量存在。
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CN108524297A (zh) * | 2017-03-03 | 2018-09-14 | 宁波高新区凡迈科技有限公司 | 一种钻石牙膏 |
JP7337481B2 (ja) * | 2017-10-12 | 2023-09-04 | サンスター株式会社 | 口腔用組成物 |
GB201811065D0 (en) * | 2018-07-05 | 2018-08-22 | GlaxoSmithKline Consumer Healthcare UK IP Ltd | Novel composition |
CN113226250A (zh) * | 2018-12-20 | 2021-08-06 | 高露洁-棕榄公司 | 口腔护理组合物 |
TW202231580A (zh) * | 2020-12-11 | 2022-08-16 | 英商Pq矽石英國有限公司 | 研磨性矽石粒子 |
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CN101340885A (zh) * | 2005-12-21 | 2009-01-07 | 高露洁-棕榄公司 | 清洁和/或抛光组合物及其使用方法 |
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US4021263A (en) * | 1972-01-03 | 1977-05-03 | Johnson & Johnson | Polishing compositions |
JP2004238321A (ja) * | 2003-02-05 | 2004-08-26 | Kao Corp | 口腔用組成物 |
JP2007091636A (ja) * | 2005-09-29 | 2007-04-12 | Gc Corp | 歯科研磨用組成物 |
US20090130627A1 (en) * | 2007-11-16 | 2009-05-21 | Michael Herman | Diamond dust polishing cloth for natural tooth enamel and dental veneers |
EP2361120B1 (en) * | 2008-11-27 | 2015-08-12 | Amc Abrasives Marketing&Consulting LLP | Dental care products with diamond particles |
US8883178B2 (en) * | 2008-11-27 | 2014-11-11 | Amc Abrasives Marketing & Consulting Llp | Dental care products with diamond particles |
US9724541B2 (en) * | 2009-04-06 | 2017-08-08 | Lisa Marie Kao | Dental cleaning and polishing composition comprising diamond particles |
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2014
- 2014-06-05 JP JP2015521481A patent/JP6367190B2/ja active Active
- 2014-06-05 CA CA2914211A patent/CA2914211A1/en not_active Abandoned
- 2014-06-05 WO PCT/JP2014/064933 patent/WO2014196591A1/ja active Application Filing
- 2014-06-05 EP EP14808142.5A patent/EP3006012A4/en not_active Withdrawn
- 2014-06-05 CN CN201480032611.2A patent/CN105263464B/zh active Active
- 2014-06-05 US US14/895,301 patent/US20160120769A1/en not_active Abandoned
- 2014-06-06 TW TW103119719A patent/TW201534328A/zh unknown
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CN101340885A (zh) * | 2005-12-21 | 2009-01-07 | 高露洁-棕榄公司 | 清洁和/或抛光组合物及其使用方法 |
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US20160120769A1 (en) | 2016-05-05 |
JP6367190B2 (ja) | 2018-08-01 |
WO2014196591A1 (ja) | 2014-12-11 |
CA2914211A1 (en) | 2014-12-11 |
CN105263464A (zh) | 2016-01-20 |
EP3006012A1 (en) | 2016-04-13 |
EP3006012A4 (en) | 2016-11-30 |
TW201534328A (zh) | 2015-09-16 |
JPWO2014196591A1 (ja) | 2017-02-23 |
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