JP6294076B2 - 多量体ペプチド - Google Patents

多量体ペプチド Download PDF

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Publication number
JP6294076B2
JP6294076B2 JP2013547811A JP2013547811A JP6294076B2 JP 6294076 B2 JP6294076 B2 JP 6294076B2 JP 2013547811 A JP2013547811 A JP 2013547811A JP 2013547811 A JP2013547811 A JP 2013547811A JP 6294076 B2 JP6294076 B2 JP 6294076B2
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peptide
amino acids
seq
gly
sequence
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Expired - Fee Related
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Japanese (ja)
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JP2014509838A5 (cg-RX-API-DMAC7.html
JP2014509838A (ja
Inventor
トネス ランゲ，エイナー
トネス ランゲ，エイナー
ソメルフェルト グロンヴォルド，マハ
ソメルフェルト グロンヴォルド，マハ
ソレンセン，ビージャー
ラウィッツ，カロリーナ
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Bionor Immuno AS
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Bionor Immuno AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
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    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/00011—Details
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    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
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  • Molecular Biology (AREA)
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  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Diabetes (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
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  • Biotechnology (AREA)
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  • AIDS & HIV (AREA)
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JP2013547811A 2011-01-06 2012-01-06 多量体ペプチド Expired - Fee Related JP6294076B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11150323.1 2011-01-06
EP11150323 2011-01-06
US201161475988P 2011-04-15 2011-04-15
US61/475,988 2011-04-15
PCT/DK2012/050010 WO2012092934A1 (en) 2011-01-06 2012-01-06 Monomeric and multimeric immunogenic peptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016216620A Division JP2017048232A (ja) 2011-01-06 2016-11-04 多量体ペプチド

Publications (3)

Publication Number Publication Date
JP2014509838A JP2014509838A (ja) 2014-04-24
JP2014509838A5 JP2014509838A5 (cg-RX-API-DMAC7.html) 2015-02-12
JP6294076B2 true JP6294076B2 (ja) 2018-03-14

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JP2013547811A Expired - Fee Related JP6294076B2 (ja) 2011-01-06 2012-01-06 多量体ペプチド
JP2016216620A Pending JP2017048232A (ja) 2011-01-06 2016-11-04 多量体ペプチド

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JP2016216620A Pending JP2017048232A (ja) 2011-01-06 2016-11-04 多量体ペプチド

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US (2) US9493514B2 (cg-RX-API-DMAC7.html)
EP (2) EP2661442A4 (cg-RX-API-DMAC7.html)
JP (2) JP6294076B2 (cg-RX-API-DMAC7.html)
KR (1) KR101993431B1 (cg-RX-API-DMAC7.html)
CN (1) CN103347892B (cg-RX-API-DMAC7.html)
AU (1) AU2012204955B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013017488A2 (cg-RX-API-DMAC7.html)
CA (1) CA2821995C (cg-RX-API-DMAC7.html)
EA (1) EA034031B1 (cg-RX-API-DMAC7.html)
MX (1) MX346475B (cg-RX-API-DMAC7.html)
WO (1) WO2012092934A1 (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2858667A1 (en) 2012-06-06 2015-04-15 Bionor Immuno AS Hiv vaccine
CN104619718A (zh) * 2012-06-06 2015-05-13 比奥诺尔免疫有限公司 源自病毒蛋白的肽用作免疫原和配药成分
EP3872097A1 (en) 2012-10-19 2021-09-01 The Council Of The Queensland Institute Of Medical Research Improved human herpesvirus immunotherapy
WO2014159931A1 (en) * 2013-03-13 2014-10-02 Washington State University Strings of epitopes useful in diagnosing and eliciting immune responses to sexually trasmitted infections
WO2015007337A1 (en) 2013-07-19 2015-01-22 Bionor Immuno As Method for the vaccination against hiv
AU2015208033B2 (en) 2014-01-27 2019-02-07 Bionor Immuno As Method for the vaccination against HIV
US10744179B2 (en) * 2014-09-18 2020-08-18 The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy Method for treatment of inflammatory skin disorders with inhibitors of IL-36 proteolytic processing
ES2959642T3 (es) * 2015-05-13 2024-02-27 The Us Secretary Of The Department Of Health And Human Services Metodos y composiciones para inducir una respuesta inmunitaria mediante construcciones con elementos conservados
KR101859223B1 (ko) * 2016-11-29 2018-06-01 단디바이오사이언스 주식회사 고병원성 인플루엔자 바이러스 검출용 마커 및 이의 용도
WO2018141089A1 (zh) * 2017-02-04 2018-08-09 中国医学科学院病原生物学研究所 广谱抑制hiv的脂肽、其衍生物、其药物组合物及其用途
US10677798B2 (en) 2017-11-22 2020-06-09 Washington State University Strings of epitopes useful in diagnosing and eliciting immune responses to sexually transmitted infections
GB201903132D0 (en) * 2019-03-08 2019-04-24 Queens Univ Of Belfast A peptide for the delivery of anionic materials
CN111221983B (zh) 2020-01-15 2023-08-04 北京百度网讯科技有限公司 时序知识图谱生成方法、装置、设备和介质
CN116832720B (zh) * 2023-06-19 2025-11-21 广州聚焦生物科技有限公司 一种发光免疫检测的冻干微球及其制备方法
CN118684745B (zh) * 2024-06-07 2025-12-09 中国医学科学院病原生物学研究所 一种抗hiv-1多肽及其衍生物和应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
JPS5896026A (ja) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
DE3380726D1 (en) 1982-06-24 1989-11-23 Japan Chem Res Long-acting composition
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4606918A (en) 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
CA1292686C (en) 1986-10-27 1991-12-03 Ze'ev Shaked Pharmaceutical compositions of recombinant interleukin-2 and formulation process
CA1294215C (en) 1986-10-27 1992-01-14 Ze'ev Shaked Pharmaceutical compositions of recombinant beta-interferon and formulation processes
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
EP0317804B1 (en) * 1987-11-24 1995-10-04 Abbott Laboratories HIV peptides and methods for detection of HIV
DE68918127D1 (de) * 1988-02-10 1994-10-20 Immulogic Pharma Corp Peptidbehandlung von hartnäckigen Infektionskrankheiten.
CA1341285C (en) * 1988-02-12 2001-08-14 Chang Yi Wang Synthetic peptides for the detection of antibodies to hiv gp120 envelope protein for diagnosis of aids and pre-aids conditions and as vaccines
MA22842A1 (fr) 1992-03-27 1993-10-01 Smithkline Beecham Biolog Procede de preparation de compositions de vaccin.
RU2160120C2 (ru) 1992-05-23 2000-12-10 Смитклайн Бичам Байолоджикалс С.А. Комбинированная вакцина на основе поверхностного антигена вируса гепатита в, способ ее получения и способ предупреждения инфекции гепатита в у человека
CA2138997C (en) 1992-06-25 2003-06-03 Jean-Paul Prieels Vaccine composition containing adjuvants
EP0812593B8 (en) 1993-03-23 2010-11-10 SmithKline Beecham Biologicals S.A. Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a
ATE415173T1 (de) 1993-09-14 2008-12-15 Pharmexa Inc Pan dr-bindeproteinen zur erhöhung der immunantwort
AU698878B2 (en) 1993-11-04 1998-11-12 Genimmune N.V. Immunodominant human T-cell epitopes of hepatitis C virus
KR100241300B1 (ko) 1993-11-16 2000-03-02 Sheldon A. Schaffer 활성물질의 조절된 방출성을 갖는 소포
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US5709995A (en) 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
ATE193893T1 (de) 1994-04-08 2000-06-15 Us Health Peptid aus dem inneren des hepatitis-c-virus brauchbar für die stimulation cytotoxischer t- lymphocyten und die diagnose des hcv-kontaktes
GB9513261D0 (en) 1995-06-29 1995-09-06 Smithkline Beecham Biolog Vaccines
JPH0950531A (ja) 1995-08-09 1997-02-18 Fuji Xerox Co Ltd 画像処理装置
JP4210735B2 (ja) 1996-03-21 2009-01-21 ファーメクサ インコーポレイテッド Ｈｌａ―ａ２．１結合ペプチド及びその使用
AU719929B2 (en) 1996-05-24 2000-05-18 Grifols Worldwide Operations Limited Multiple epitope fusion protein
US6566330B1 (en) 1996-10-22 2003-05-20 Medical University Of South Carolina Foundation Research Development Positively charged non-natural amino acids, methods of making and using thereof in peptides
CN1195702A (zh) * 1997-04-08 1998-10-14 军事医学科学院基础医学研究所 Hiv－1多表位重组膜抗原及其表达
GB9711990D0 (en) 1997-06-11 1997-08-06 Smithkline Beecham Biolog Vaccine
GB9712347D0 (en) 1997-06-14 1997-08-13 Smithkline Beecham Biolog Vaccine
ES2222728T3 (es) 1998-10-05 2005-02-01 Pharmexa A/S Procedimiento de vacunacion terapeutica.
CN1230444C (zh) * 1998-11-16 2005-12-07 德克萨斯州立大学董事会 含有hiv细胞毒t淋巴细胞表位的hiv多肽或肽或其多聚核苷酸表达构建体的用途
CA2377525A1 (en) 1999-07-19 2001-03-29 Epimmune, Inc. Inducing cellular immune responses to hepatitis c virus using peptide and nucleic acid compositions
EP1125905A1 (en) 2000-02-16 2001-08-22 Pepscan Systems B.V. Segment synthesis
GB0005703D0 (en) 2000-03-09 2000-05-03 Alpharma As Compounds
AU2000273396A1 (en) 2000-09-01 2002-03-22 Epimmune, Inc. Hla binding peptides and their uses
NO314588B1 (no) 2000-09-04 2003-04-14 Bionor Immuno As HIV-peptider, antigener, vaksinesammensetning, immunoassay- testsett og en fremgangsmåte for å påvise antistoffer indusert av HIV
EP1195381A1 (de) 2000-09-28 2002-04-10 Immusystems GmbH CD4+ T-Lymphozyten spezifische Hepatitis C Virus-Epitope
GB0026094D0 (en) 2000-10-25 2000-12-13 Imp College Innovations Ltd Methods
WO2003105058A2 (en) 2002-06-10 2003-12-18 Algonomics N.V. Method, computing routine, device for predicting properties of mhc/peptide complexes, and data and peptides produced therefrom
US7378234B2 (en) 2002-09-13 2008-05-27 Intercell Ag Method for isolating hepatitis C virus peptides
CA2513701C (en) * 2003-01-15 2013-06-18 Haruo Sugiyama Dimerized peptide
AU2005249490B2 (en) 2004-06-01 2010-07-29 Genentech, Inc. Antibody drug conjugates and methods
EP1652858A1 (en) 2004-10-28 2006-05-03 Innogenetics N.V. Peptides for inducing a CTL and/or HTL response to hepatitis C virus
EP1817341A2 (en) 2004-11-29 2007-08-15 Seattle Genetics, Inc. Engineered antibodies and immunoconjugates
TW201029663A (en) * 2008-11-12 2010-08-16 Theraclone Sciences Inc Human M2e peptide immunogens
US9066983B2 (en) * 2009-05-18 2015-06-30 National University Corporation Tokyo Medical And Dental University Peptidic antigen that induces antibody recognizing three-dimensional structure of HIV and method for synthesizing same
BR112012000032A2 (pt) * 2009-07-03 2016-03-15 Bionor Immuno As meios terapêuticos e diagnósticos inovadores
JP6069212B2 (ja) 2010-12-02 2017-02-01 ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ ペプチド骨格設計

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