JP6290918B2 - 免疫原性組成物 - Google Patents

免疫原性組成物 Download PDF

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Publication number
JP6290918B2
JP6290918B2 JP2015545783A JP2015545783A JP6290918B2 JP 6290918 B2 JP6290918 B2 JP 6290918B2 JP 2015545783 A JP2015545783 A JP 2015545783A JP 2015545783 A JP2015545783 A JP 2015545783A JP 6290918 B2 JP6290918 B2 JP 6290918B2
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seq
toxin
fragment
repeat
adjuvant
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JP2016502551A5 (cg-RX-API-DMAC7.html
JP2016502551A (ja
Inventor
ボウトリュー，ドミニク
マリー ジェーン バレンタイン ジャーメイン，ソフィー
マリー ジェーン バレンタイン ジャーメイン，ソフィー
ウォールマック，ヒューグース
Original Assignee
グラクソスミスクライン バイオロジカルズ ソシエテ アノニム
グラクソスミスクライン バイオロジカルズ ソシエテ アノニム
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2015545783A 2012-12-05 2013-12-03 免疫原性組成物 Active JP6290918B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201221875 2012-12-05
GB1221875.6 2012-12-05
PCT/EP2013/075405 WO2014086787A1 (en) 2012-12-05 2013-12-03 Immunogenic composition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018020900A Division JP6626521B2 (ja) 2012-12-05 2018-02-08 免疫原性組成物

Publications (3)

Publication Number Publication Date
JP2016502551A JP2016502551A (ja) 2016-01-28
JP2016502551A5 JP2016502551A5 (cg-RX-API-DMAC7.html) 2017-01-19
JP6290918B2 true JP6290918B2 (ja) 2018-03-07

Family

ID=49724573

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015545783A Active JP6290918B2 (ja) 2012-12-05 2013-12-03 免疫原性組成物
JP2018020900A Active JP6626521B2 (ja) 2012-12-05 2018-02-08 免疫原性組成物

Family Applications After (1)

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JP2018020900A Active JP6626521B2 (ja) 2012-12-05 2018-02-08 免疫原性組成物

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US (2) US9694064B2 (cg-RX-API-DMAC7.html)
EP (2) EP3513806B1 (cg-RX-API-DMAC7.html)
JP (2) JP6290918B2 (cg-RX-API-DMAC7.html)
CN (2) CN112807422A (cg-RX-API-DMAC7.html)
AR (1) AR093712A1 (cg-RX-API-DMAC7.html)
AU (1) AU2013354186A1 (cg-RX-API-DMAC7.html)
BR (1) BR112015012841B1 (cg-RX-API-DMAC7.html)
CA (1) CA2893435C (cg-RX-API-DMAC7.html)
CY (1) CY1121560T1 (cg-RX-API-DMAC7.html)
DK (2) DK3513806T5 (cg-RX-API-DMAC7.html)
ES (2) ES2939307T3 (cg-RX-API-DMAC7.html)
FI (1) FI3513806T3 (cg-RX-API-DMAC7.html)
HR (2) HRP20190711T1 (cg-RX-API-DMAC7.html)
HU (2) HUE061273T2 (cg-RX-API-DMAC7.html)
LT (2) LT3513806T (cg-RX-API-DMAC7.html)
PL (2) PL2928489T3 (cg-RX-API-DMAC7.html)
PT (2) PT2928489T (cg-RX-API-DMAC7.html)
SG (1) SG11201503861UA (cg-RX-API-DMAC7.html)
SI (2) SI2928489T1 (cg-RX-API-DMAC7.html)
TR (1) TR201905272T4 (cg-RX-API-DMAC7.html)
WO (1) WO2014086787A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201503927B (cg-RX-API-DMAC7.html)

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BR112013027229B1 (pt) 2011-04-22 2020-10-27 Wyeth Llc polipeptídeo imunogênico isolado e seu uso, composição imunogênica e seu uso, célula recombinante ou progênie da mesma, e método de produção de uma toxina de clostridium difficile mutante
BR122016023101B1 (pt) * 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
CN112807422A (zh) * 2012-12-05 2021-05-18 葛兰素史密丝克莱恩生物有限公司 免疫原性组合物
PL3160500T3 (pl) * 2014-06-25 2020-02-28 Glaxosmithkline Biologicals S.A. Immunogenna kompozycja clostridium difficile
HUE038212T2 (hu) * 2014-07-25 2018-10-29 Biosynth Srl Többszörös beépített epitópokat kifejezõ molekuláris konstrukt bázikus egységeket tartalmazó glikokonjugátum vakcinák enteropatogén baktériumok által okozott fertõzések elleni szélesspektrumú vakcina elõállításához
WO2016131157A1 (en) 2015-02-19 2016-08-25 Immune Biosolutions Inc Clostridium difficile toxins a and/or b antigen and epitope antibody, and pharmaceutical uses thereof
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WO2017165398A1 (en) 2016-03-21 2017-09-28 Children's Medical Center Corporation Compositions and methods for inhibiting wnt signaling
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CN107397956A (zh) * 2017-08-08 2017-11-28 南开大学 一种铜绿假单胞菌外膜蛋白疫苗的制备方法及应用
US12252515B2 (en) 2018-01-16 2025-03-18 Children's Medical Center Corporation Compositions and methods for inhibiting Wnt signaling
GB201804092D0 (en) * 2018-03-14 2018-04-25 Imperial Innovations Ltd Methods and compositions
US10933126B2 (en) 2018-05-03 2021-03-02 The Board Of Regents Of The University Of Oklahoma Clostridium difficile immunogenic compositions and methods of use
MX2021014097A (es) * 2019-05-21 2022-03-11 Univ California Composiciones de vacunas para clostridium difficile.
US20230218735A1 (en) * 2020-06-19 2023-07-13 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
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Publication number Publication date
LT3513806T (lt) 2023-04-11
TR201905272T4 (tr) 2019-05-21
US20170340719A1 (en) 2017-11-30
PT3513806T (pt) 2023-03-02
LT2928489T (lt) 2019-04-10
JP2018104446A (ja) 2018-07-05
US9694064B2 (en) 2017-07-04
CA2893435C (en) 2024-11-12
ZA201503927B (en) 2017-11-29
EP3513806B1 (en) 2023-01-25
US10130694B2 (en) 2018-11-20
BR112015012841B1 (pt) 2022-05-03
HRP20230359T1 (hr) 2023-06-09
US20150313984A1 (en) 2015-11-05
EP2928489A1 (en) 2015-10-14
CA2893435A1 (en) 2014-06-12
FI3513806T3 (fi) 2023-04-26
JP6626521B2 (ja) 2019-12-25
ES2721930T3 (es) 2019-08-06
HRP20190711T1 (hr) 2019-05-31
HUE043091T2 (hu) 2019-08-28
EP2928489B1 (en) 2019-02-27
PL2928489T3 (pl) 2019-07-31
DK3513806T3 (da) 2023-02-27
CN112807422A (zh) 2021-05-18
JP2016502551A (ja) 2016-01-28
CY1121560T1 (el) 2020-05-29
DK2928489T3 (en) 2019-04-23
PL3513806T3 (pl) 2023-05-15
BR112015012841A2 (pt) 2017-09-26
ES2939307T3 (es) 2023-04-20
CN104884081A (zh) 2015-09-02
AU2013354186A1 (en) 2014-06-12
SI3513806T1 (sl) 2023-04-28
HUE061273T2 (hu) 2023-06-28
DK3513806T5 (da) 2024-09-02
SI2928489T1 (sl) 2019-05-31
WO2014086787A1 (en) 2014-06-12
PT2928489T (pt) 2019-05-28
AR093712A1 (es) 2015-06-17
SG11201503861UA (en) 2015-06-29
EP3513806A1 (en) 2019-07-24

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