JP6290100B2 - ビロキサジンの緩和放出製剤 - Google Patents

ビロキサジンの緩和放出製剤 Download PDF

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Publication number
JP6290100B2
JP6290100B2 JP2014556658A JP2014556658A JP6290100B2 JP 6290100 B2 JP6290100 B2 JP 6290100B2 JP 2014556658 A JP2014556658 A JP 2014556658A JP 2014556658 A JP2014556658 A JP 2014556658A JP 6290100 B2 JP6290100 B2 JP 6290100B2
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Prior art keywords
viloxazine
formulation
release
sustained release
drug
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JP2014556658A
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English (en)
Japanese (ja)
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JP2015506980A (ja
JP2015506980A5 (enExample
Inventor
エル． ビエイラ，マイケル
エル． ビエイラ，マイケル
ピー． バート，パッドマナブー
ピー． バート，パッドマナブー
ビー． ファン，オースティン
ビー． ファン，オースティン
Original Assignee
スパーナス ファーマシューティカルズ インコーポレイテッド
スパーナス ファーマシューティカルズ インコーポレイテッド
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Application filed by スパーナス ファーマシューティカルズ インコーポレイテッド, スパーナス ファーマシューティカルズ インコーポレイテッド filed Critical スパーナス ファーマシューティカルズ インコーポレイテッド
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Publication of JP2015506980A5 publication Critical patent/JP2015506980A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
JP2014556658A 2012-02-08 2013-02-07 ビロキサジンの緩和放出製剤 Active JP6290100B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261596458P 2012-02-08 2012-02-08
US61/596,458 2012-02-08
PCT/US2013/025121 WO2013119794A1 (en) 2012-02-08 2013-02-07 Modified release formulations of viloxazine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018018946A Division JP6510093B2 (ja) 2012-02-08 2018-02-06 ビロキサジンの緩和放出製剤

Publications (3)

Publication Number Publication Date
JP2015506980A JP2015506980A (ja) 2015-03-05
JP2015506980A5 JP2015506980A5 (enExample) 2016-01-21
JP6290100B2 true JP6290100B2 (ja) 2018-03-07

Family

ID=47741312

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014556658A Active JP6290100B2 (ja) 2012-02-08 2013-02-07 ビロキサジンの緩和放出製剤
JP2018018946A Active JP6510093B2 (ja) 2012-02-08 2018-02-06 ビロキサジンの緩和放出製剤
JP2019066455A Active JP6832973B2 (ja) 2012-02-08 2019-03-29 ビロキサジンの緩和放出製剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2018018946A Active JP6510093B2 (ja) 2012-02-08 2018-02-06 ビロキサジンの緩和放出製剤
JP2019066455A Active JP6832973B2 (ja) 2012-02-08 2019-03-29 ビロキサジンの緩和放出製剤

Country Status (8)

Country Link
US (9) US9358204B2 (enExample)
EP (2) EP2812074B1 (enExample)
JP (3) JP6290100B2 (enExample)
AU (4) AU2013217013B2 (enExample)
CA (1) CA2864088C (enExample)
ES (1) ES2950875T3 (enExample)
MX (2) MX356727B (enExample)
WO (1) WO2013119794A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2735934C (en) 2008-09-05 2014-01-07 Supernus Pharmaceuticals, Inc. Method of treatment of attention deficit/hyperactivity disorder (adhd)
AU2013217013B2 (en) 2012-02-08 2017-04-20 Supernus Pharmaceuticals, Inc. Modified release formulations of viloxazine
IT201800011125A1 (it) * 2018-12-14 2020-06-14 Dpl Pharma S P A Composizioni farmaceutiche orali solide comprendenti matrici monolitiche complesse per la somministrazione cronotropica di medicamenti nel tratto gastroenterico
US20240041893A1 (en) 2023-10-03 2024-02-08 Innovate Therapeutics Llc An Extended-Release Pharmaceutical Formulation of Viloxazine And Process For Preparation Thereof
WO2025135797A1 (ko) * 2023-12-18 2025-06-26 주식회사 아스트로젠 (s)-빌록사진 또는 이의 염의 개선된 제조 방법

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138405A (en) 1966-12-28 1969-01-01 Ici Ltd Morpholine derivatives
FR2453639A1 (fr) * 1979-04-09 1980-11-07 Sanofi Sa Composition medicamenteuse a liberation programmee immediate-retard a base de naftidrofuryl
US4260606A (en) 1979-07-19 1981-04-07 A. H. Robins Company, Inc. 3-Methyleneazetidine derivatives
US5658590A (en) 1995-01-11 1997-08-19 Eli Lilly And Company Treatment of attention-deficit/hyperactivity disorder
US5558879A (en) * 1995-04-28 1996-09-24 Andrx Pharmaceuticals, Inc. Controlled release formulation for water soluble drugs in which a passageway is formed in situ
US6262115B1 (en) * 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
DE19830201A1 (de) 1998-07-07 2000-01-13 Boehringer Ingelheim Pharma Mittel mit antidepressiver Wirkung
WO2000006162A1 (de) 1998-07-27 2000-02-10 Boehringer Ingelheim Pharma Kg Mittel mit antidepressiver wirkung, mit pramipexol und einem weiteren antidepressivum
MXPA03006003A (es) 2001-01-02 2005-09-08 Upjohn Co Nuevas combinaciones de farmacos.
WO2002087549A1 (fr) * 2001-04-25 2002-11-07 Taisho Pharmaceutical Co., Ltd. Comprimes a liberation prolongee du type a unites multiples
SE0102887D0 (sv) * 2001-08-29 2001-08-29 Astrazeneca Ab New formulation
WO2004073695A1 (en) * 2003-02-21 2004-09-02 Lek Pharmaceuticals D.D Therapeutic system comprising amoxicillin and clavulanic acid
DE10353196A1 (de) 2003-11-13 2005-06-16 Röhm GmbH & Co. KG Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix
US7119031B2 (en) * 2004-06-28 2006-10-10 Micron Technology, Inc. Methods of forming patterned photoresist layers over semiconductor substrates
DE102004035938A1 (de) * 2004-07-23 2006-02-16 Röhm GmbH & Co. KG Verfahren zur Herstellung von überzogenen Arzneiformen mit stabilem Wirkstofffreigabeprofil
US7288347B2 (en) 2004-08-31 2007-10-30 Xerox Corporation Method of applying spot varnish to xerographic image and emulsion aggregation toners for use therein
MX2007012947A (es) * 2005-04-18 2008-04-09 Rubicon Res Pvt Ltd Composiciones biomejoradas.
US9161918B2 (en) * 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
WO2007026219A2 (en) 2005-08-31 2007-03-08 Pfizer Products Inc. Combinations of a 5-ht1b antagonist with a noradrenalin re-uptake inhibitor or a serotonin noradrenalin reutake inhibitor for treating cns conditions
US20090041844A1 (en) * 2006-02-10 2009-02-12 Boehringer Ingelheim International Gmbh Modified Release Formulation
EP2457563B1 (en) * 2006-05-09 2017-03-22 Mallinckrodt LLC Zero-order modified release solid dosage forms
EP1973528B1 (en) * 2006-11-17 2012-11-07 Supernus Pharmaceuticals, Inc. Sustained-release formulations of topiramate
WO2008122019A1 (en) * 2007-04-02 2008-10-09 Cypress Biosciences, Inc. Improving the tolerability of both mirtazapine and reboxetine by using them in combination
EP2167096A4 (en) * 2007-06-13 2010-07-14 Cypress Bioscience Inc IMPROVING TOLERANCE TO MIRTAZAPINE AND A SECOND ACTIVE INGREDIENT BY THE COMBINED USE OF THEM
CA2706651A1 (en) * 2007-12-04 2009-06-11 Merck Sharp & Dohme Corp. Tryptamine sulfonamides as 5-ht6 antagonists
CA2735934C (en) 2008-09-05 2014-01-07 Supernus Pharmaceuticals, Inc. Method of treatment of attention deficit/hyperactivity disorder (adhd)
MX2011011579A (es) * 2009-04-30 2012-01-27 Supernus Pharmaceuticals Inc Metodo de tratamiento contra la depresion.
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CN102548544B (zh) * 2009-10-09 2015-01-21 永进药品工业株式会社 同时具有速效特性和长效特性的药物组合物
AU2013217013B2 (en) * 2012-02-08 2017-04-20 Supernus Pharmaceuticals, Inc. Modified release formulations of viloxazine

Also Published As

Publication number Publication date
WO2013119794A1 (en) 2013-08-15
JP2018090601A (ja) 2018-06-14
JP2015506980A (ja) 2015-03-05
AU2013217013A1 (en) 2014-08-28
EP2812074B1 (en) 2023-05-10
AU2017206245A1 (en) 2017-08-10
AU2019216707A1 (en) 2019-09-05
AU2013217013B2 (en) 2017-04-20
ES2950875T3 (es) 2023-10-16
US9603853B2 (en) 2017-03-28
EP4233915A2 (en) 2023-08-30
US20160256465A1 (en) 2016-09-08
AU2020233746A1 (en) 2020-10-08
US20170258801A1 (en) 2017-09-14
MX2014009528A (es) 2014-11-25
US9358204B2 (en) 2016-06-07
JP6510093B2 (ja) 2019-05-08
US20230381191A1 (en) 2023-11-30
JP2019123736A (ja) 2019-07-25
JP6832973B2 (ja) 2021-02-24
US20250222004A1 (en) 2025-07-10
US20190201407A1 (en) 2019-07-04
EP2812074A1 (en) 2014-12-17
AU2019216707B2 (en) 2020-10-22
AU2020233746B2 (en) 2023-09-14
US20160279136A1 (en) 2016-09-29
MX2023003000A (es) 2023-04-05
US9662338B2 (en) 2017-05-30
US20250367208A1 (en) 2025-12-04
US20250228859A1 (en) 2025-07-17
CA2864088A1 (en) 2013-08-15
MX356727B (es) 2018-06-12
CA2864088C (en) 2020-04-28
US10265319B2 (en) 2019-04-23
AU2017206245B2 (en) 2019-05-16
US20130202661A1 (en) 2013-08-08
EP4233915A3 (en) 2023-09-20

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