JP6289084B2 - Automatic analyzer - Google Patents

Description

  Embodiments described herein relate generally to an automatic analyzer.

  The automatic analyzer is intended for test items such as biochemical test items and immunological test items, and the color tone produced by the reaction of a mixture of test samples such as blood and urine collected from the test sample and reagents for each test item. Changes in turbidity are measured optically with a measuring unit such as a spectrophotometer or a turbidimetric meter. In response to the result obtained by the measurement by the measurement unit, the automatic analyzer generates analysis data represented by the concentration of various test item components in the test sample, the activity of the enzyme, and the like.

  The automatic analyzer cleans the probe and reaction vessel used for measurement and repeatedly uses them. Cleaning of the probe is performed by moving the probe to a predetermined probe cleaning position, and then sucking and discharging a certain amount of detergent with this probe. To clean the reaction container, after moving the reaction container to a predetermined reaction container cleaning position, suction of the mixed liquid, discharge of cleaning liquid such as detergent into the reaction container, suction of the discharged cleaning liquid, and drying in the reaction container, etc. Is done.

  A detergent for washing the probe and the reaction container is stored in a dedicated detergent tank according to the washing application. When the remaining amount of detergent stored in the detergent tank decreases while the measurement is repeatedly performed, the user needs to replace the detergent tank with a new detergent tank at a certain replacement timing. For example, the automatic analyzer notifies the user of the replacement timing of the detergent by detecting whether the remaining amount of the detergent is equal to or less than a predetermined amount with a liquid level detection sensor.

  However, when detecting whether or not the remaining amount of the detergent is equal to or less than a predetermined amount using the liquid level detection sensor, it is necessary to immerse the liquid level detection sensor in the detergent stock solution. Therefore, chemical resistance to strong acid or strong alkali is required for the liquid level detection sensor, or the configuration for providing the liquid level detection sensor in the detergent tank becomes complicated. Therefore, there is a problem that the method using the liquid level detection sensor is expensive.

JP 2010-133784 A Japanese Patent No. 3264545

  As a method for detecting whether or not the remaining amount of the detergent is equal to or less than a predetermined amount, a method using a weight sensor that obtains a detection result corresponding to the weight of the detergent tank can be considered. When the weight sensor is used, it is not necessary to immerse the weight sensor in the detergent stock solution, so that the weight sensor is not required to have chemical resistance. Therefore, the method using the weight sensor can be realized at a low cost, and the configuration can be simplified.

  However, in the method using the weight sensor, it is necessary to stop the automatic analyzer when detecting that the detergent tank is lifted based on the detection result obtained from the weight sensor. The reason is that the detergent is not supplied when the detergent tank is replaced, so that the reaction container is not sufficiently washed, and the possibility of causing a poor measurement result is excluded. Therefore, in the method using the weight sensor, there is a problem that the working efficiency is lowered when the detergent is replaced during the analysis process.

  The present invention has been made to solve the above problems, and an object of the present invention is to provide an automatic analyzer capable of replacing a detergent even during an analysis process and improving work efficiency.

Automatic analyzer embodiment performs an analysis process of measuring the mixture of each reaction vessel by dispensing a sample and a reagent amount in each of a plurality of reaction vessels, an automatic analyzer for cleaning a reaction vessel after analysis process A cleaning means for cleaning a plurality of reaction containers using a detergent stored in a detergent storage means configured to be replaceable, and a detection result corresponding to the remaining amount of detergent stored in the detergent storage means. When the remaining amount detection means to output and the detection result output from the remaining amount detection means detect that the remaining amount of the detergent is equal to or less than a predetermined amount, the analysis processing for the plurality of reaction containers is continued, and After the measurement of the number of reaction containers corresponding to the volume of the detergent flow path connecting between the detergent storage means and the cleaning means, the number of reaction containers corresponding to the replacement time of the detergent storage means scheduled to be measured is unwashed. Control means specified as .

The block diagram of the structural example of the automatic analyzer which concerns on 1st Embodiment. The functional block diagram of the structural example of the control part of FIG. 1, and an analysis part. The perspective view of schematic structure of the analysis part of FIG. 1 or FIG. The figure which shows typically the structural example of the washing | cleaning part which concerns on 1st Embodiment. The flowchart of the example of detergent replacement | exchange processing in the automatic analyzer which concerns on 1st Embodiment. The flowchart of the example of detergent replacement | exchange processing in the automatic analyzer which concerns on 1st Embodiment. Explanatory drawing of the reaction container information which concerns on 1st Embodiment. The flowchart of the sample dispensing process example in the automatic analyzer which concerns on 1st Embodiment. The flowchart of the reagent dispensing process example in the automatic analyzer which concerns on 1st Embodiment. The flowchart of the example of a stirring process in the automatic analyzer which concerns on 1st Embodiment. The flowchart of the example of a measurement process in the automatic analyzer which concerns on 1st Embodiment. The figure which shows an example of the operation | movement sequence of the automatic analyzer which concerns on 1st Embodiment. Explanatory drawing of operation | movement of the automatic analyzer which concerns on 1st Embodiment. The figure which shows typically the structural example of the washing | cleaning part which concerns on 2nd Embodiment. Operation | movement explanatory drawing of the suction pressure sensor which concerns on 2nd Embodiment. The figure which shows an example of the operation | movement sequence of the automatic analyzer which concerns on 2nd Embodiment. The flowchart of the example of an apparatus stop process in the automatic analyzer which concerns on 3rd Embodiment. Operation | movement explanatory drawing of the automatic analyzer which concerns on 3rd Embodiment.

  Hereinafter, embodiments will be described with reference to the drawings.

[First Embodiment]
The automatic analyzer according to the first embodiment performs a predetermined analysis process for each of a plurality of reaction containers, and cleans the reaction container after the analysis process. In this embodiment, the analysis process is a series of processes for measuring a mixed solution after dispensing and stirring a sample and a reagent.

  In the automatic analyzer according to the first embodiment, the detergent stored in the detergent storage means is used for washing the reaction container. The automatic analyzer is configured to allow replacement of the detergent storage means, obtains a detection result corresponding to the remaining amount of detergent stored in the detergent storage means from the remaining amount detection means, and based on the obtained detection result, the detergent The replacement timing of the storage means is detected. Even when this replacement timing is detected, the automatic analyzer continues the analysis process while identifying an unwashed container. For specified unwashed containers, by providing control such as prohibiting the use of analysis processing, it is possible to replace detergents even during analysis processing, and to provide an automatic analyzer that improves work efficiency Can do.

  In the following, the automatic analyzer according to the embodiment skips measurement or the like for an unwashed container by providing skip information in association with the reaction container in order to prohibit the use of the reaction container specified as an unwashed container. To prevent measurement results from being defective. In addition, the “unwashed container” means that the detergent is not sufficiently supplied by the replacement of the detergent storage means in addition to the reaction container that has not been substantially cleaned due to the unsupply of the detergent accompanying the replacement of the detergent storage means. Includes a reaction vessel with the potential for inadequate cleaning. In the following embodiments, a “bulk detergent” in which the container for containing the detergent is replaced will be described as an example. However, the present invention is not limited to the bulk detergent. In the following embodiments, “detergent tank replacement” may be referred to as “detergent replacement”.

<Configuration>
(Automatic analyzer)
FIG. 1 shows a functional block diagram of a configuration example of the automatic analyzer according to the first embodiment.

  The automatic analyzer 1 according to the first embodiment includes an analysis unit 10, a data processing unit 30, an operation unit 40, an output control unit 50, an output unit 60, a control unit 70, and a storage unit 80. It consists of The output control unit 50 includes a display control unit 51 and a print control unit 52. The output unit 60 includes a display unit 61 and a printing unit 62. The control unit 70 includes a specifying unit 71 and a time measuring unit 72.

  The analysis unit 10 measures a liquid mixture of a test sample (sample) and a reagent for each inspection item (measurement item) set in advance. The analysis unit 10 dispenses a sample and a reagent into each of a plurality of reaction vessels, stirs them, and drives various units for measuring a mixed liquid in each reaction vessel and these units. And a mechanism unit. The analysis unit 10 will be described later.

  The data processing unit 30 generates analysis data and the like for each inspection item based on the measurement data obtained by the measurement of the analysis unit 10.

  The operation unit 40 accepts an input for setting analysis parameters and an input for instructing execution of various operations to the automatic analyzer 1. The function of the operation unit 40 includes input devices such as a keyboard, a mouse, a button, and a touch key panel. The operation unit 40 is an example of an “operation unit”.

  The output control unit 50 causes the output unit 60 to output analysis data and various information generated by the data processing unit 30. That is, the display control unit 51 causes the display unit 61 to output analysis data and various types of information generated by the data processing unit 30. The print control unit 52 causes the printing unit 62 to output analysis data and various types of information generated by the data processing unit 30. The output control unit 50, the display control unit 51, or the print control unit 52 is an example of an “output control unit”.

  The output unit 60 outputs analysis data, various types of information, and the like that are output-controlled by the output control unit 50. For example, the display unit 61 includes a display device such as a CRT (Cathode Ray Tube) or a liquid crystal display, and displays and outputs a setting screen for setting analysis parameters, analysis data, and the like. The printing unit 62 includes a printer device, and prints out analysis data and the like on a printer sheet in a predetermined format. The output unit 60, the display unit 61, or the printing unit 62 is an example of an “output unit”.

  The control unit 70 controls the analysis unit 10, the data processing unit 30, and the output control unit 50. The identification unit 71 identifies an unwashed container when the detergent storage means is replaced. In this embodiment, the specifying unit 71 specifies an unwashed container based on the replacement time of the detergent storage means. In this embodiment, the replacement time of the detergent storage means is the time required for replacement of the detergent storage means. The timer 72 measures the replacement time of the detergent storage means. The specifying unit 71 and the time measuring unit 72 will be described later. The control unit 70 includes a CPU (Central Processing Unit). The CPU controls each unit constituting the automatic analyzer 1 by reading the control program stored in the storage unit 80 and executing processing corresponding to the control program. The control unit 70 is an example of a “control unit”, and the timer unit 72 is an example of a “timer unit”.

  The storage unit 80 stores a control program for controlling each unit of the automatic analyzer 1, analysis data generated by the data processing unit 30, and the like. In addition, the storage unit 80 stores reaction container information for performing process management of analysis processing for each of the plurality of reaction containers. The storage unit 80 is an example of a “storage unit”.

(Analysis Department)
FIG. 2 shows a functional block diagram of a configuration example of the control unit and the analysis unit in FIG. In FIG. 2, the same parts as those in FIG.
FIG. 3 shows a perspective view of a schematic configuration of the analysis unit of FIG. 1 or FIG. In FIG. 3, the same parts as those in FIG. 1 or FIG.

  The analysis unit 10 includes a sample disk 11, a sample dispensing unit 12, a reaction disk 13, a first reagent storage 14, a first reagent dispensing unit 15, a second reagent storage 16, and a second reagent dispensing. The unit 17, the stirring unit 18, the measuring unit 19, and the cleaning unit 20 are included. The analysis unit 10 includes a rotation mechanism unit 11c, 13c, 14c, 16c, a dispensing mechanism unit 12c, 15c, 17c, and a stirring mechanism unit 18e.

  The sample disk 11 holds a plurality of sample containers 111 each containing a test sample. At least one of the plurality of sample containers 111 may contain a standard sample for calibration. The rotation mechanism unit 11 c rotates the sample disk 11 around a vertical rotation axis in accordance with control from the control unit 70. That is, the sample disk 11 is configured to be rotatable.

  As shown in FIG. 3, the sample dispensing unit 12 includes a sample probe 12a and a sample arm 12b. The sample probe 12 a performs dispensing to suck the sample in the sample container 111 held on the sample disk 11 and discharge it into the reaction container 131. Dispensing of the sample into the reaction vessel 131 is performed every cycle. The sample arm 12b holds the sample probe 12a. The dispensing mechanism unit 12c rotates the sample arm 12b or moves it up and down in accordance with the control from the control unit 70. That is, the sample probe 12a is configured to be rotatable and configured to be movable in the vertical direction.

  The reaction disk 13 rotatably holds a plurality of reaction vessels 131 arranged in the circumferential direction. The rotation mechanism unit 13 c rotates the reaction disk 13 around a vertical rotation axis in accordance with control from the control unit 70. That is, the reaction disk 13 is configured to be rotatable.

  The first reagent storage 14 stores a plurality of reagent containers 141 that store the first reagent in a circumferential direction. The rotation mechanism unit 14 c rotates the first reagent storage 14 around the vertical rotation axis in accordance with control from the control unit 70. That is, the first reagent storage 14 is configured to be rotatable.

  As shown in FIG. 3, the first reagent dispensing unit 15 includes a first reagent dispensing probe 15a and a first reagent dispensing arm 15b. The first reagent dispensing probe 15a performs dispensing by sucking the first reagent in the reagent container 141 held in the first reagent container 14 and discharging it into the reaction container 131 from which the sample has been discharged. Dispensing the first reagent into the reaction vessel 131 is performed every cycle. The first reagent dispensing arm 15b holds the first reagent dispensing probe 15a. The dispensing mechanism unit 15c rotates the first reagent dispensing arm 15b or moves it up and down according to the control from the control unit 70. That is, the first reagent dispensing probe 15a is configured to be rotatable and configured to be movable in the vertical direction.

  The second reagent storage 16 stores a plurality of reagent containers 161 that store the second reagent side by side in the circumferential direction. The rotation mechanism unit 16 c rotates the second reagent storage 16 around a vertical rotation axis in accordance with control from the control unit 70. That is, the second reagent storage 16 is configured to be rotatable.

  As shown in FIG. 3, the second reagent dispensing unit 17 includes a second reagent dispensing probe 17a and a second reagent dispensing arm 17b. The second reagent dispensing probe 17a performs dispensing to aspirate the second reagent in the reagent container 161 held in the second reagent storage 16 and to discharge it into the reaction container 131 from which the sample and the first reagent have been discharged. . Dispensing the second reagent into the reaction vessel 131 is performed every cycle. The second reagent dispensing arm 17b holds the second reagent dispensing probe 17a. The dispensing mechanism unit 17c rotates the second reagent dispensing arm 17b or moves it up and down in accordance with the control from the control unit 70. That is, the second reagent dispensing probe 17a is configured to be rotatable and configured to be movable in the vertical direction.

  As shown in FIG. 3, the stirring unit 18 includes a first stirring bar 18a, a first stirring arm 18b, a second stirring bar 18c, and a second stirring arm 18d. The first stirring arm 18b holds the first stirring bar 18a. The stirring mechanism unit 18e rotates the first stirring bar 18a or moves it up and down in accordance with the control from the control unit 70. That is, the first stirring bar 18a is configured to be rotatable and configured to be movable in the vertical direction. The first stirrer 18 a agitates the mixed solution of the sample and the first reagent discharged to the reaction container 131 for each cycle in accordance with control from the control unit 70. The second stirring arm 18d holds the second stirring bar 18c. The agitation mechanism 18e rotates the second agitator 18c or moves it up and down in accordance with the control from the controller 70. That is, the second stirring bar 18c is configured to be rotatable and configured to be movable in the vertical direction. The second stirring bar 18c stirs the mixed solution of the sample, the first reagent, and the second reagent discharged to the reaction container 131 for each cycle in accordance with the control from the control unit 70.

  The measurement unit 19 measures the mixed liquid in the reaction vessel 131. The measurement unit 19 irradiates the mixed liquid in the reaction container 131 that rotates and detects light that has passed through the mixed liquid. The measurement unit 19 generates measurement data based on the detected light. The measurement unit 19 sends the generated measurement data to the data processing unit 30 according to the control from the control unit 70.

  The cleaning unit 20 cleans the inside of the reaction container 131 after the measurement by the measurement unit 19. The cleaning unit 20 cleans the inside of the reaction vessel 131 using the detergent stored in the detergent tank as the detergent storage unit according to the control from the control unit 70.

(Washing part)
FIG. 4 schematically illustrates a configuration example of the cleaning unit 20 according to the first embodiment. In FIG. 4, it is assumed that a series of cleaning is performed by sequentially arranging reaction vessels 131 for each cycle at the cleaning positions P1 to P8 where the cleaning operation is defined for each position.

  Among the holding positions of the reaction vessel 131 held by the reaction disk 13, a plurality of predetermined holding positions are determined in advance as cleaning positions P1 to P8. Each reaction container held by the reaction disk 13 is measured by the measuring unit 19 and then arranged in order from the cleaning positions P1 to P8 every cycle, and is cleaned at each cleaning position.

  The cleaning unit 20 includes a pure water tank 21, an alkaline detergent tank 22, an acidic detergent tank 23, and a plurality of nozzles 24. Each nozzle 24 is provided at each cleaning position and is held so as to be movable in the vertical direction. The nozzle 24 is used for suction and discharge of pure water and detergent by a suction means and discharge means (not shown) and suction of waste liquid.

  The pure water tank 21 stores pure water for cleaning. A pure water passage 211 stored in the pure water tank 21 is connected to the pure water tank 21. The flow path 211 connects between the pure water tank 21 and the four nozzles 24 provided at each of the cleaning positions P1, P4, P5, and P6. Actually, an open / close valve or the like may be appropriately provided between the pure water tank 21 and the nozzle 24.

  The alkaline detergent tank 22 stores an alkaline detergent for cleaning. The alkaline detergent tank 22 is configured such that the tank itself can be replaced. The cleaning unit 20 has a weight sensor 222. The weight sensor 222 can output a detection result corresponding to the remaining amount of the alkaline detergent by outputting a detection result corresponding to the weight of the alkaline detergent stored in the alkaline detergent tank 22. Therefore, the replacement timing of the alkaline detergent tank 22 can be detected based on the detection result output from the weight sensor 222. The alkaline detergent tank 22 is connected to a flow path 221 of an alkaline detergent stored in the alkaline detergent tank 22. The flow path 221 connects between the alkaline detergent tank 22 and the nozzle 24 provided at the cleaning position P2. Actually, an open / close valve or the like may be appropriately provided between the alkaline detergent tank 22 and the nozzle 24.

  The acidic detergent tank 23 stores an acidic detergent for cleaning. The acid detergent tank 23 is configured so that the tank itself can be replaced. The cleaning unit 20 includes a weight sensor 232. The weight sensor 232 can output the detection result corresponding to the remaining amount of the acid detergent by outputting the detection result corresponding to the weight of the acid detergent stored in the acid detergent tank 23. Accordingly, it is possible to detect the replacement timing of the acidic detergent tank 23 based on the detection result output from the weight sensor 232. The acid detergent tank 23 is connected to a flow path 231 for the acid detergent stored in the acid detergent tank 23. The flow path 231 connects between the acidic detergent tank 23 and the nozzle 24 provided at the cleaning position P3. Actually, an open / close valve or the like may be appropriately provided between the acidic detergent tank 23 and the nozzle 24.

  Further, the waste liquid channel 213 connects between the nozzle 24 provided at the cleaning position P1 and a high concentration waste liquid tank (not shown). The waste liquid flow path 223 connects between the nozzles 24 provided at the cleaning positions P2, P3, P4, P5, and P6 and a low concentration waste liquid tank (not shown). The suction channel 233 connects between the nozzles 24 provided at the cleaning positions P7 and P8 and a waste liquid tank (not shown). Actually, an open / close valve or the like may be provided between the waste liquid tank and the nozzle 24 as appropriate.

  At the cleaning position P1, pure water is injected into the reaction vessel 131, and high-concentration waste liquid is discharged from the reaction vessel 131 using the waste liquid channel 213 as a waste channel. At the washing position P2, the inside (inner wall) of the reaction vessel 131 is washed with an alkaline detergent, and low-concentration waste liquid is discharged from the reaction vessel 131 using the waste liquid passage 223 as a waste liquid passage. At the washing position P3, the inside (inner wall) of the reaction vessel 131 is washed with an acidic detergent, and low-concentration waste liquid is discharged from the reaction vessel 131 using the waste liquid channel 223 as a waste liquid channel. At the washing position P4, the reaction vessel 131 is washed with pure water, and the low-concentration waste liquid is discharged from the reaction vessel 131 using the waste liquid passage 223 as a waste liquid passage. At the washing position P5, the reaction vessel 131 is washed with pure water, and low-concentration waste liquid is discharged from the reaction vessel 131 using the waste liquid passage 223 as a waste liquid passage. At the washing position P6, the reaction vessel 131 is washed with pure water, and low-concentration waste liquid is discharged from the reaction vessel 131 using the waste liquid passage 223 as a waste liquid passage. At the cleaning position P7, a solution such as pure water is sucked from the reaction vessel 131 using the suction channel 233 as a channel. At the cleaning position P8, a solution such as pure water is sucked from the reaction vessel 131 using the suction flow path 233 as a flow path, and drying by the drying chip 132 is performed.

  The cleaning unit 20 is an example of a “cleaning unit”. The alkaline detergent tank 22 or the acidic detergent tank 23 is an example of “detergent storage means”. The weight sensor 222 or the weight sensor 232 is an example of a “remaining amount detection unit” or a “weight sensor”.

  In the automatic analyzer 1 having the above-described configuration, for example, the control unit 70 starts a sequence in which each process of sample dispensing, reagent dispensing, stirring, measurement, and washing is executed every cycle. Analyze the plurality of reaction vessels.

  The automatic analyzer 1 according to the first embodiment is configured such that the operation mode can be switched to either the normal mode or the detergent replacement mode. The normal mode is an operation mode set when the automatic analyzer 1 is activated. In the normal mode, when it is detected that the remaining amount of the detergent stored in the alkaline detergent tank 22 or the acidic detergent tank 23 has become a predetermined amount or less, the apparatus is stopped in order to maintain the reliability of the measurement result ( Analysis process is stopped). The detergent replacement mode is an operation mode that shifts from the normal mode according to an instruction from the user when it is detected that the remaining amount of the detergent stored in the alkaline detergent tank 22 or the acidic detergent tank 23 has become a predetermined amount or less. . In the detergent replacement mode, even when the remaining amount of the detergent stored in the alkaline detergent tank 22 or the acidic detergent tank 23 is equal to or less than a predetermined amount, the analysis process is continued and the number corresponding to the detergent tank replacement time is set. An unwashed container is identified. By shifting the operation mode of the automatic analyzer 1 to the detergent replacement mode, even when the alkaline detergent tank 22 or the acidic detergent tank 23 is replaced, the user can prevent measurement results from being defective and improve work efficiency. it can.

<Operation>
Hereinafter, an operation example of the automatic analyzer 1 according to the first embodiment will be described. When the automatic analyzer 1 replaces the alkaline detergent tank 22 or the acidic detergent tank 23, the automatic analyzer 1 performs a detergent replacement process, which will be described later, and identifies an unwashed container. The automatic analyzer 1 prevents the specified unwashed container from being used for the analysis process, so that even when the detergent tank is replaced, the apparatus is not stopped and the measurement result is prevented from being defective. . In the following, in order to simplify the description, the alkaline detergent tank 22 and the weight sensor 222 will be described as an example, but the same applies to the acidic detergent tank 23 and the weight sensor 232.

  The storage unit 80 stores in advance a program corresponding to each step of the flow of the processing example described below. The CPU built in the control unit 70 reads out the program stored in the storage unit 80 and executes processing corresponding to the read program, thereby realizing processing of each flow.

[Detergent replacement]
FIG. 5 and FIG. 6 show flowcharts of examples of detergent replacement processing in the automatic analyzer 1 according to the first embodiment.

(S01, S02)
The automatic analyzer 1 is set by the control unit 70 so as to operate in the normal mode when activated. In the normal mode, the function of the weight sensor 222 is set to ON. That is, the detection function of the weight sensor 222 is validated, and the weight sensor 222 outputs a detection result corresponding to the remaining amount of the tank. Thereby, the automatic analyzer 1 can detect the detergent replacement timing in S03.

(S03)
The controller 70 operates in the normal mode until the detergent replacement timing is detected (S03: N). In this embodiment, the automatic analyzer 1 detects the detergent replacement timing by detecting that the remaining amount of the detergent has become a predetermined amount or less based on the detection result obtained from the weight sensor 222. When the detergent timing is detected (S03: Y), the processing of the automatic analyzer 1 proceeds to S04.

(S04)
When it is detected based on the detection result obtained from the weight sensor 222 that the remaining amount of the detergent is equal to or less than the predetermined amount, the timer unit 72 starts measuring time. The time measuring unit 72 is used for measuring the replacement time of the detergent.

(S05)
The control unit 70 performs error display. As a specific example, the display control unit 51 that receives control from the control unit 70 causes the display unit 61 to display information on the content prompting the replacement of the detergent tank, such as “Please replace the detergent tank”. At this time, the display control unit 51 causes the display unit 61 to display information on the content urging replacement of the alkaline detergent tank 22 according to the control from the control unit 70. In addition, the display control unit 51 causes the display unit 61 to display information on the content for inquiring the user whether or not to replace the detergent tank according to the control from the control unit 70.

(S06)
When the user instructs not to replace the detergent tank via the operation unit 40 (S06: N), the process of the control unit 70 proceeds to S07. On the other hand, when the user instructs to replace the detergent tank via the operation unit 40 (S06: Y), the process of the control unit 70 proceeds to S10.

(S07)
When the user instructs not to replace the detergent tank through the operation unit 40, the control unit 70 monitors whether or not the remaining amount of the detergent stored in the alkaline detergent tank 22 is exhausted (S07). . The control unit 70 detects whether or not the remaining amount of the detergent stored in the detergent tank is exhausted by detecting whether or not the remaining amount of the detergent is equal to or less than the threshold level less than S03 by the weight sensor 222. When it is detected that the remaining amount of the detergent stored in the alkaline detergent tank 22 is exhausted (S07: Y), the processing of the control unit 70 proceeds to S08.

(S08)
The control unit 70 performs error display. As a specific example thereof, the display control unit 51 causes the display unit 61 to display information on the content for notifying the occurrence of an abnormality such as “no more detergent” in accordance with the control from the control unit 70. At this time, the display control unit 51 causes the display unit 61 to display information on the content indicating the detergent tank of the alkaline detergent tank 22 or the acidic detergent tank 23 in which the remaining amount of detergent is detected. In S08, the time measuring unit 72 may end the time measurement started in S04.

(S09)
When the remaining amount of detergent is exhausted, it becomes impossible to wash the reaction container and the like, and if the analysis process is continued as it is, the reliability is lowered due to the poor measurement result. Therefore, the control unit 70 stops the apparatus and ends a series of processes (end).

(S10, S11)
When the user gives an instruction to replace the detergent tank via the operation unit 40 (S06: Y), the control unit 70 shifts the operation mode to the detergent replacement mode. In the detergent replacement mode, the function of the weight sensor 222 is set to off. That is, the detection function of the weight sensor 222 is invalidated, and the weight sensor 222 outputs a predetermined fixed value without outputting a detection result corresponding to the remaining amount of the detergent tank. As a result, the automatic analyzer 1 does not stop the analysis process even if the remaining amount of the detergent tank becomes a predetermined amount or less.

(S12)
The controller 70 waits until the replacement of the detergent tank is completed (S12: N). In this embodiment, the control unit 70 detects the completion of the replacement of the detergent tank when the user receives an instruction to complete the replacement of the detergent tank through the operation unit 40. When the replacement of the detergent tank is completed (S12: Y), the process of the control unit 70 proceeds to S13.

(S13)
When the completion of the replacement of the detergent tank is detected, the time measuring unit 72 ends the time measurement. The time measured by the time measuring unit 72 from S04 to S13 corresponds to the detergent tank replacement time described later. That is, the timer 72 starts timing when it is detected from the detection result output from the weight sensor 222 that the remaining amount of the detergent is equal to or less than the predetermined amount. When the completion of the exchange is instructed, the timing is ended. The control unit 70 acquires the time measured by the time measuring unit 72 as the replacement time of the detergent tank.

(S14, S15)
The controller 70 shifts the operation mode to the normal mode. In the normal mode, the function of the weight sensor 222 is set to ON. As a result, the automatic analyzer 1 stops the analysis process when the remaining amount of the detergent tank falls below a predetermined amount.

(S16)
The specifying unit 71 specifies an unwashed container. That is, the specific unit 71 continues the analysis process for the plurality of reaction containers when the detection result output from the weight sensor 222 detects that the remaining amount of the detergent is equal to or less than the predetermined amount, and is not washed. Identify the container. As a specific example, the specifying unit 71 specifies an unwashed container based on the replacement time of the detergent tank. The replacement time of the detergent tank corresponds to the time measured by the time measuring unit 72 from S04 to S13. The replacement time of the detergent tank corresponds to the time when the supply of detergent is insufficient. Therefore, there is a possibility that the measurement result of the reaction container cleaned by the cleaning unit 20 during the replacement time of the detergent tank may be poor.

  Actually, as shown in FIG. 4, a flow path 221 between the alkaline detergent tank 22 and the nozzle 24 of the cleaning unit 20 and a flow path 231 between the acidic detergent tank 23 and the nozzle 24 of the cleaning unit 20 are provided. Exists. Therefore, even if the detergent tank is replaced when it is detected by the weight sensors 222 and 232 that the remaining amount of the detergent is equal to or less than the predetermined amount, the reaction container is sufficiently filled with the detergent remaining in the flow paths 221 and 231. It is possible to wash. The diameters and lengths of the flow paths 221 and 231 and the amount of detergent used for one reaction container in the cleaning unit 20 are known. That is, since the volumes of the flow paths 221 and 231 are known, the specifying unit 71 is used for the amount of detergent remaining in the flow paths 221 and 231 and one reaction container even when the detergent tank is replaced. Based on the amount of detergent used, the number of reaction vessels in which the analysis process can be continued is known. Thereafter, air or the like may be mixed into the flow paths 221 and 231 during the replacement operation of the detergent tank, and the detergent may not be continuously supplied in the same manner as before the replacement of the detergent tank. Therefore, the specific unit 71 is a detergent tank that is scheduled to be measured after measuring the number of reaction containers corresponding to the volume of the detergent flow path connecting the alkaline detergent tank 22 (acidic detergent tank 23) and the washing unit 20. The number of reaction containers according to the exchange time is identified as unwashed containers.

  For example, when it is detected that the remaining amount of the detergent stored in the alkaline detergent tank 22 has become a predetermined amount or less, the volume of the alkaline detergent flow path 221 is set to B, and the washing unit 20 is used for washing the reaction container. When the volume (amount) of the detergent to be used is C, [B / C] ([x] indicates the maximum integer not exceeding x) of the detergent remaining in the flow path 221. Is possible. Therefore, even during the replacement of the detergent tank, [B / C] reaction containers can be cleaned.

  For example, when the replacement time of the detergent tank is T0 and the time of one cycle is t, the specifying unit 71 sets the number of unwashed containers to [T0 / t] (when (T0 / t) is an integer) or ([T0 / t] +1) (when (T0 / t) is a non-integer)

  Therefore, the specifying unit 71 sets [T0 / t] or ([T0 / t] +1) reaction containers in which the measurement of the mixed solution is performed following the [B / C] reaction containers to the unwashed container. As specified. That is, the specific unit 71 is a detergent that connects between the alkaline detergent tank 22 and the cleaning unit 20 when it is detected from the detection result output from the weight sensor 222 that the remaining amount of the detergent is equal to or less than a predetermined amount. The number of reaction containers corresponding to the replacement time of the detergent tank scheduled to be measured after the measurement of the number of reaction containers corresponding to the volume of each of the flow paths can be specified as unwashed containers.

(S17)
The control unit 70 gives the skip information to the reaction vessel information corresponding to the reaction vessel specified as the unwashed vessel in S16 among the reaction vessels in which the analysis process is performed, and the reaction vessel information newly given the skip information. Is stored in the storage unit 80. The skip information is information indicating whether or not to skip the analysis process. In this embodiment, the control unit 70 performs process management for each of a plurality of reaction containers in which different analysis processes are performed based on the reaction container information set for each reaction container. Thereafter, the processing of the control unit 70 proceeds to S01.

  The normal mode is an example of a “first operation mode”, and the detergent replacement mode is an example of a “second operation mode”.

  As described above, in the automatic analyzer 1, in the normal mode, the control unit 70 detects that the remaining amount of the detergent is equal to or less than the predetermined amount based on the detection result output from the weight sensor 222, and the operation unit. When the replacement of the detergent is instructed via 40, the detection function of the weight sensor 222 is invalidated and the operation mode is shifted to the detergent replacement mode. Further, in the automatic analyzer 1, in the detergent replacement mode, the control unit 70 specifies the unwashed container by the specifying unit 71, and disables the detection function of the weight sensor 222 when the replacement of the detergent tank is completed. The mode is canceled and the operation mode is shifted to the normal mode.

  Furthermore, in the automatic analyzer 1, in the normal mode, the control unit 70 detects that the remaining amount of the detergent is equal to or less than a predetermined amount based on the detection result output from the weight sensor 222 or from the weight sensor 222. When it is detected from the output detection result that the remaining amount of the detergent is equal to or less than the predetermined amount and no replacement of the detergent is instructed via the operation unit 40, the apparatus is stopped.

  About the reaction container specified as an unwashed container, it is possible to reflect in analysis processing as follows by giving skip information to reaction container information.

  In FIG. 7, explanatory drawing of the reaction container information which concerns on 1st Embodiment is shown.

  The memory | storage part 80 memorize | stores the reaction container information containing the skip information which shows whether the analysis process after dispensing of a sample is skipped for every reaction container, for example. The reaction container information includes a reaction container ID, analysis process information, and skip information. The reaction container ID is information for identifying the reaction container. The analysis process information is information indicating the content of the analysis process of the reaction container (sample number, reagent number, measurement item, measurement parameter, etc.). The skip information is information that specifies whether or not to skip each process constituting the analysis process. The skip information may be information that specifies whether or not to skip at least sample dispensing in the analysis process.

  The control unit 70 refers to the reaction container information stored in the storage unit 80, so that each process (sample dispensing process, reagent dispensing process, stirring process, measurement process) constituting the analysis process is performed for each reaction container. Can be controlled.

[Sample dispensing process]
FIG. 8 shows a flowchart of a sample dispensing process example in the automatic analyzer 1 according to the first embodiment. The sample dispensing process is a process that is activated by the control unit 70 for each cycle and dispenses a sample into the washed reaction container.

(S21)
The control unit 70 detects whether or not there is a reaction container to be measured at a predetermined sample dispensing position. When it is detected that there is a reaction container at a predetermined sample dispensing position (S21: Y), the processing of the control unit 70 proceeds to S22. On the other hand, when it is not detected that there is a reaction container to be measured at a predetermined sample dispensing position (S21: N), the control unit 70 ends a series of processes (end).

(S22)
When it is detected that there is a reaction container at a predetermined sample dispensing position, the control unit 70 determines whether or not to dispense a sample from the reaction container information corresponding to the reaction container. As a specific example, the control unit 70 identifies the reaction container ID by reading identification information (for example, a barcode) attached to the reaction container, and analyzes the reaction container information corresponding to the identified reaction container ID. It is determined whether or not to dispense the sample with reference to the information. When it is determined that the sample is to be dispensed (S22: Y), the process of the control unit 70 proceeds to S23. On the other hand, when it is determined that the sample is not to be dispensed (S22: N), the control unit 70 ends the series of processes (end).

(S23)
When it is determined that the sample is to be dispensed, the control unit 70 determines whether or not to skip the dispensing of the sample from the skip information of the reaction container information corresponding to the reaction container. When it is determined that the dispensing of the sample is to be skipped (S23: Y), the control unit 70 ends the series of processes (end). On the other hand, when it is determined not to skip dispensing of the sample (S23: N), the process of the control unit 70 proceeds to S24.

(S24-S28)
When it is determined that the sample dispensing is not skipped, the control unit 70 moves the sample arm 12b as appropriate by the dispensing mechanism unit 12c (rotation or vertical movement; the same applies hereinafter). The sample probe 12a is stopped at a predetermined sample position where a desired sample container is accommodated (S24). Next, the control unit 70 causes the sample probe 12a to suck a predetermined amount of sample (S25). Next, the control unit 70 appropriately moves the sample arm 12b by the dispensing mechanism unit 12c to stop the sample probe 12a at a predetermined sample dispensing position (S26). Next, the control unit 70 causes the sample sucked in S25 to be discharged into the reaction container, thereby causing the sample to be dispensed. Subsequently, the control unit 70 appropriately moves the sample arm 12b by the dispensing mechanism unit 12c, stops the sample probe 12a at a predetermined home position (S28), and ends a series of processing (end).

  As described above, the automatic analyzer 1 can skip the dispensing of the sample for each reaction container based on the skip information.

(Reagent dispensing process)
FIG. 9 shows a flowchart of a reagent dispensing process example in the automatic analyzer 1 according to the first embodiment. The reagent dispensing process is a process for dispensing the reagent into the reaction container after the sample is dispensed by the control unit 70 every cycle. FIG. 9 illustrates the case where the first reagent is dispensed into the reaction container, but the same applies to the case where the second reagent is dispensed into the reaction container.

(S31)
The control unit 70 detects whether there is a reaction container to be measured at a predetermined first reagent dispensing position. When it is detected that there is a reaction container to be measured at a predetermined first reagent dispensing position (S31: Y), the process of the control unit 70 proceeds to S32. On the other hand, when it is not detected that there is a reaction container to be measured at the predetermined first reagent dispensing position (S31: N), the control unit 70 ends a series of processes (end).

(S32)
When it is detected that there is a reaction container to be measured at a predetermined first reagent dispensing position, the control unit 70 determines whether or not to dispense the first reagent from the reaction container information corresponding to the reaction container. Is determined. As a specific example thereof, the control unit 70 identifies the reaction container ID by reading the identification information attached to the reaction container, and refers to the analysis process information of the reaction container information corresponding to the identified reaction container ID. It is determined whether or not to dispense the first reagent. When it is determined that the first reagent is to be dispensed (S32: Y), the process of the control unit 70 proceeds to S33. On the other hand, when it is determined that the first reagent is not dispensed (S32: N), the control unit 70 ends the series of processes (end).

(S33)
When it is determined that the first reagent is to be dispensed, the control unit 70 determines whether or not to skip the dispensing of the first reagent from the skip information of the reaction container information corresponding to the reaction container. When it is determined that the dispensing of the first reagent is to be skipped (S33: Y), the control unit 70 ends the series of processes (end). On the other hand, when it is determined that the dispensing of the first reagent is not skipped (S33: N), the process of the control unit 70 proceeds to S34.

(S34-S38)
When it is determined that the dispensing of the first reagent is not to be skipped, the control unit 70 moves the first reagent dispensing arm 15b as appropriate by the dispensing mechanism unit 15c, and the desired reagent container is placed in the first reagent storage 14. The first reagent dispensing probe 15a is stopped at the stored predetermined first reagent position (S34). Next, the control unit 70 causes the first reagent dispensing probe 15a to aspirate a predetermined amount of the first reagent (S35). Next, the controller 70 appropriately moves the first reagent dispensing arm 15b by the dispensing mechanism 15c, and stops the first reagent dispensing probe 15a at a predetermined first reagent dispensing position (S36). Next, the control unit 70 causes the first reagent aspirated in S35 to be discharged into the reaction container, thereby causing the first reagent to be dispensed. Subsequently, the control unit 70 appropriately moves the first reagent dispensing arm 15b by the dispensing mechanism unit 15c, stops the first reagent dispensing probe 15a at a predetermined home position (S38), and performs a series of processes. End (end).

  As described above, the automatic analyzer 1 can skip dispensing of the first reagent for each reaction container based on the skip information. Similarly, the automatic analyzer 1 can skip dispensing of the second reagent for each reaction container based on the skip information.

[Agitation treatment]
FIG. 10 shows a flowchart of an example of the stirring process in the automatic analyzer 1 according to the first embodiment. The agitation process is a process of agitating the mixed solution in the reaction container after the sample and the first reagent or the sample, the first reagent, and the second reagent are dispensed by being started by the control unit 70 every cycle.

(S41)
The controller 70 detects whether or not there is a reaction vessel to be measured at a predetermined stirring position. When it is detected that there is a reaction container to be measured at the predetermined stirring position (S41: Y), the processing of the control unit 70 proceeds to S42. On the other hand, when it is not detected that there is a reaction vessel to be measured at the predetermined stirring position (S41: N), the control unit 70 ends the series of processes (end).

(S42)
When it is detected that there is a reaction container to be measured at a predetermined stirring position, the control unit 70 determines whether to perform stirring from the reaction container information corresponding to the reaction container. As a specific example thereof, the control unit 70 identifies the reaction container ID by reading the identification information attached to the reaction container, and refers to the analysis process information of the reaction container information corresponding to the identified reaction container ID. It is determined whether or not stirring is performed. When it is determined that stirring is performed (S42: Y), the process of the control unit 70 proceeds to S43. On the other hand, when it is determined that stirring is not performed (S42: N), the control unit 70 ends a series of processing (end).

(S43)
When it is determined that stirring is performed, the control unit 70 determines whether or not stirring is skipped from the skip information of the reaction container information corresponding to the reaction container. When it is determined that stirring is to be skipped (S43: Y), the control unit 70 ends a series of processes (end). On the other hand, when it is determined that the stirring is not skipped (S43: N), the process of the control unit 70 proceeds to S44.

(S44-S46)
When it is determined that the stirring is not skipped, the control unit 70 moves the first stirring arm 18b and the second stirring arm 18d appropriately by the stirring mechanism unit 18e, and moves the first stirring bar 18a and the second stirring arm 18d to the stirring position of the reaction vessel. The second stirring bar 18c is stopped (S44). Next, the control unit 70 causes the stirring mechanism 18e to stir the reaction vessel using the first stirring bar 18a and the second stirring bar 18c (S45). Subsequently, the control unit 70 appropriately moves the first stirring arm 18b and the second stirring arm 18d by the stirring mechanism unit 18e to stop the first stirring bar 18a and the second stirring bar 18c at a predetermined home position ( S46), a series of processing ends (end).

  As described above, the automatic analyzer 1 can skip stirring for each reaction container based on skip information.

[Measurement processing]
FIG. 11 shows a flowchart of a measurement processing example in the automatic analyzer 1 according to the first embodiment. The measurement process is a process that is started for each cycle by the control unit 70 and measures the mixed liquid in the reaction vessel after stirring.

(S51)
The control unit 70 detects whether there is a reaction container to be measured at a predetermined measurement position. When it is detected that there is a reaction container to be measured at a predetermined measurement position (S51: Y), the processing of the control unit 70 proceeds to S52. On the other hand, when it is not detected that there is a reaction container to be measured at a predetermined measurement position (S51: N), the control unit 70 ends a series of processes (end).

(S52)
When it is detected that there is a reaction container to be measured at a predetermined measurement position, the control unit 70 determines whether or not to perform measurement from the reaction container information corresponding to the reaction container. As a specific example thereof, the control unit 70 identifies the reaction container ID by reading the identification information attached to the reaction container, and refers to the analysis process information of the reaction container information corresponding to the identified reaction container ID. Determine whether or not to make a measurement. When it is determined that measurement is to be performed (S52: Y), the process of the control unit 70 proceeds to S53. On the other hand, when it is determined that the measurement is not performed (S52: N), the control unit 70 ends the series of processes (end).

(S53)
When it is determined that the measurement is to be performed, the control unit 70 determines whether or not to skip the measurement from the skip information of the reaction container information corresponding to the reaction container. When it is determined that the measurement is to be skipped (S53: Y), the control unit 70 ends the series of processes (end). On the other hand, when it is determined not to skip the measurement (S53: N), the process of the control unit 70 proceeds to S54.

(S54)
When it is determined that the measurement is not skipped, the control unit 70 causes the measurement unit 19 to measure the mixed liquid in the reaction container. The measurement unit 19 irradiates the mixed liquid in the reaction container with light, and generates measurement data based on the light transmitted through the mixed liquid. Thereafter, the control unit 70 ends the series of processes (end).

  As described above, the automatic analyzer 1 can skip the measurement for each reaction container based on the skip information.

[Operation sequence example]
FIG. 12 shows an example of an operation sequence of the automatic analyzer 1 according to the first embodiment. FIG. 12 is a sequence diagram that represents the flow of temporal processing in the analysis unit 10, the weight sensor 222, the time measurement unit 72, the display unit 61, and the operation unit 40 in the vertical direction. FIG. 12 shows the weight sensor 222 as an example, but the same applies to the weight sensor 232.

  When the weight sensor 222 detects that the remaining amount of the detergent stored in the alkaline detergent tank 22 is less than or equal to a predetermined amount (SQ1), the timer 72 starts timing (SQ2), while the measuring unit 19 The analysis process using etc. is continued. Moreover, the display control part 51 displays the information of the content which urges replacement | exchange of a detergent tank on the display part 61 (SQ3).

  When the user who sees the information displayed on the display unit 61 in SQ3 instructs the replacement of the detergent tank via the operation unit 40 (SQ4), the function of the weight sensor 222 is turned off (SQ5). In addition, the display control unit 51 causes the display unit 61 to display information on content that prompts the user to instruct the completion of replacement of the detergent tank via the operation unit 40 (SQ6).

  When the user who replaced the detergent tank looks at the information displayed on the display unit 61 in SQ6 and instructs the completion of the replacement of the detergent tank via the operation unit 40 (SQ7), the function of the weight sensor 222 is turned on. Then (SQ8), the time measurement unit 72 ends the time measurement (SQ9).

  According to the first embodiment, [B / C] reaction containers are measured from when the weight sensor 222 detects that the remaining amount of the detergent stored in the alkaline detergent tank 22 is equal to or less than a predetermined amount. The analysis process including is continued. Then, the subsequent [T0 / t] or ([T0 / t] +1) reaction containers are identified as unwashed containers due to air mixing into the flow path, etc., and skip the analysis process including the next measurement. Is possible.

  FIG. 13 shows an operation explanatory diagram of the automatic analyzer 1 according to the first embodiment. FIG. 13 shows an example in which [B / C] is 50, the number of measurement tests is 50, T0 is 45 seconds, t is 4.5 seconds, and the total number of reaction vessels is 60. .

  For example, when it is detected that the remaining amount of the detergent stored in the alkaline detergent tank 22 is equal to or less than a predetermined amount during the measurement of the reaction container having the reaction container ID “1”, the automatic analyzer 1 (specification unit 71). ) Stores “1” which is the reaction container ID as the reaction container of the base point 1. Even if the remaining amount of the alkaline detergent is equal to or less than the predetermined amount, the detergent remains in the flow path as described above, and therefore, the detergent in the flow path is used for 50 (= [B / C]) reaction containers. It is washed using. Therefore, the automatic analyzer 1 specifies the reaction container having the reaction container ID “50” as the reaction container of the end point 1 and stores “50” which is the reaction container ID of the specified reaction container.

  Subsequently, the automatic analyzer 1 identifies the reaction container whose reaction container ID is “51” following the reaction container ID “50” as the reaction container of the base point 2, and is the reaction container ID of the reaction container of the base point 2. “51” is stored. Since 10 (= T0 / t) reaction vessels from the base point 2 are not sufficiently washed, the automatic analyzer 1 uses the reaction vessel whose reaction vessel ID is “60” as the reaction vessel of the end point 2 Specify “60”, which is the reaction container ID of the identified reaction container. As a result, skip information is assigned to the reaction container information of reaction containers having reaction container IDs “51” to “60”. Thereby, the automatic analyzer 1 can skip analysis processing such as measurement for the reaction containers having the reaction container IDs of “51” to “60”. In addition, about the reaction container whose reaction container ID is "61" or more, since the detergent after detergent tank replacement | exchange is supplied, washing | cleaning using detergent is performed and analysis processes, such as a measurement, are performed.

  As described above, according to the first embodiment, the detergent replacement mode in which the function of the weight sensor is set to OFF is provided, and the analysis process is performed even when it is detected that the remaining amount of the detergent is equal to or less than the predetermined amount. Since the number of unwashed containers corresponding to the detergent tank replacement time is specified while continuing, the efficiency of the detergent tank replacement work is improved, and the measurement results due to insufficient cleaning are prevented. Is possible.

[Second Embodiment]
In the first embodiment, it has been described that the detergent replacement time is received from the user via the operation unit 40 and the detergent replacement time is measured. On the other hand, in 2nd Embodiment, the replacement time detection means for detecting the replacement time of a detergent tank is provided, and a control part specifies an unwashed container based on the replacement time detected by the replacement time detection means. . This makes it possible to accurately measure the replacement time of the detergent tank regardless of the user's completion instruction timing, thereby reducing the number of uncleaned containers specified according to the replacement time and improving the throughput of the apparatus. Can be achieved.

  In the automatic analyzer according to the second embodiment, a suction pressure sensor is provided in the cleaning unit, and the control unit acquires the replacement time of the detergent tank based on the detection result obtained by the suction pressure sensor. Hereinafter, the automatic analyzer according to the second embodiment will be described focusing on differences from the first embodiment.

  FIG. 14 schematically shows a configuration example of the cleaning unit according to the second embodiment. In FIG. 14, the same parts as those in FIG. 4 are denoted by the same reference numerals, and description thereof will be omitted as appropriate.

  The cleaning unit 20a according to the second embodiment includes a first suction means (not shown) that guides the alkaline detergent stored in the alkaline detergent tank 22 to the nozzle 24, and an acidic detergent stored in the acidic detergent tank 23. Second suction means (not shown) for guiding the detergent to the nozzle 24 by sucking the detergent is included. Further, the cleaning unit 20a includes a suction pressure sensor 224 that detects a suction pressure when the alkaline detergent stored in the alkaline detergent tank 22 is sucked by the first suction means, and the acidic detergent stored in the acidic detergent tank 23. And a suction pressure sensor 234 that detects the suction pressure when suctioned by the two suction means. The suction pressure sensors 224 and 234 are an example of “suction pressure detection means”.

  FIG. 15 is a diagram for explaining the operation of the suction pressure sensor 224. In FIG. 15, the horizontal axis represents time, and the vertical axis represents suction pressure. FIG. 15 describes the suction pressure sensor 224, but the same applies to the suction pressure sensor 234.

  The suction pressure sensor 224 outputs a detection result corresponding to the air suction pressure pr0 when the replacement of the alkaline detergent tank 22 is not completed. The suction pressure sensor 224 outputs a detection result corresponding to the suction pressure pr1 of the alkaline detergent after the replacement of the alkaline detergent tank 22 is completed. Therefore, the control unit 70a according to the second embodiment obtains the replacement completion timing of the alkaline detergent tank 22 by obtaining the time ta when the suction pressure pr0 is changed to the suction pressure pr1 from the detection result obtained by the suction pressure sensor 224. Can be detected.

  Similarly, the suction pressure sensor 234 outputs a detection result corresponding to the air suction pressure pr0 ′ when the replacement of the acidic detergent tank 23 is not completed. The suction pressure sensor 234 outputs a detection result corresponding to the suction pressure pr1 ′ of the acidic detergent after the replacement of the acidic detergent tank 23 is completed. Therefore, the control unit 70a according to the second embodiment obtains the time ta ′ when the suction pressure pr0 ′ is changed to the suction pressure pr1 ′ from the detection result obtained by the suction pressure sensor 234, thereby replacing the acidic detergent tank 23. Completion timing can be detected.

  In the control unit 70a, the timing unit 72 starts timing when the weight sensors 222 and 232 detect that the remaining amount of the detergent is equal to or less than a predetermined amount. The timing unit 72 ends timing at the replacement completion timing detected as described above. That is, the time measuring unit 72 can end the time counting based on the suction pressure detected by the suction pressure sensors 224 and 234 after the replacement of the alkaline detergent tank 22 or the acidic detergent tank 23. The control unit 70a acquires the time measured by the time measuring unit 72 as the detergent tank replacement time.

  In the second embodiment, the time measuring unit 72, the first suction unit and the suction pressure sensor 224, or the time measuring unit 72, the second suction unit and the suction pressure sensor 234 are examples of “exchange time detection unit”.

  FIG. 16 shows an example of an operation sequence of the automatic analyzer according to the second embodiment. FIG. 16 is a sequence diagram showing the flow of processing in the analysis unit 10, the weight sensor 222, the time measuring unit 72, the display unit 61, the operation unit 40, and the suction pressure sensor 224 in the vertical direction. In FIG. 16, the same parts as those in FIG.

  In the second embodiment, the automatic analyzer detects completion of replacement of the alkaline detergent tank 22 based on the suction pressure of the alkaline detergent detected by the suction pressure sensor 224 after shifting to the detergent replacement mode (SQ10). Upon receiving this detection, the function of the weight sensor 222 is turned on (SQ11), and the time measuring unit 72 ends the time measurement (SQ12).

  As described above, according to the second embodiment, the detergent replacement time can be accurately measured without depending on the user instruction timing. As a result, it is possible to reduce the number of unwashed containers according to the replacement time of the detergent and improve the throughput of the apparatus without wasting samples and reagents.

  In addition, a timing unit, a suction unit, and a suction pressure sensor are provided as replacement time detection units, and a first suction pressure (suction pressure pr0 in FIG. 15) when air is sucked by the suction pressure sensor during a suction period by the suction unit. The detergent replacement time (T1 in FIG. 15) may be obtained from the detection timing of the second suction pressure (the suction pressure pr1 in FIG. 15) when the detergent is sucked.

[Third Embodiment]
In the third embodiment, when there is a reaction container specified as an unwashed container in any of the above-described embodiments, when there is a stop instruction from the user, the apparatus is stopped after washing. Note that “stop of the apparatus” in this embodiment is to stop the analysis processing. As a result, it is possible to reliably avoid a measurement result failure due to insufficient cleaning in the next measurement.

  Hereinafter, the automatic analyzer according to the third embodiment will be described focusing on differences from the first embodiment. The configuration of the automatic analyzer according to the third embodiment is the same as the configuration of the automatic analyzer according to the first embodiment. Hereinafter, for convenience of explanation, the third embodiment will be described using the configuration of the automatic analyzer 1 according to the first embodiment.

  FIG. 17 shows a flowchart of an apparatus stop processing example in the automatic analyzer according to the third embodiment. The CPU built in the control unit according to the third embodiment reads the program stored in the storage unit and executes the process corresponding to the read program, thereby realizing the process of each flow.

(S61)
The control unit 70 stands by until an instruction to stop the apparatus is issued from the user via the operation unit 40 (S61: N). When the apparatus is instructed to stop (S61: Y), the process of the control unit 70 proceeds to S62.

(S62, S63)
When the user gives an instruction to stop the apparatus, the control unit 70 searches the reaction vessel information stored in the storage unit 80 in order to determine whether or not there is a reaction vessel to which skip information is assigned (S62). As a result of searching the reaction container information, when there is a reaction container to which skip information is given (S63: Y), the processing of the control unit 70 proceeds to S64. When there is no reaction container to which the skip information is assigned (S63: N), the process of the control unit 70 proceeds to S67.

(S64)
As a result of searching the reaction container information, when there is a reaction container to which skip information is given, the control unit 70 rotates the reaction disk 13 by the rotation mechanism unit 13c, and selects the reaction container to which skip information is given in S63. Stop at a predetermined cleaning position.

(S65)
The control unit 70 causes the cleaning unit 20 to perform a series of cleaning processes on the reaction vessel stopped at a predetermined cleaning position as described in FIG.

(S66)
The control unit 70 deletes the skip information given to the reaction container information corresponding to the reaction container. Thereafter, the processing of the control unit 70 proceeds to S63. That is, S64 to S66 are repeated until there is no reaction container information to which skip information is assigned.

(S67)
As a result of searching the reaction container information, when there is no reaction container to which the skip information is added, the control unit 70 stops the apparatus according to a predetermined apparatus stop sequence. Thereafter, the control unit 70 ends the series of processes (end).

  FIG. 18 is an operation explanatory diagram of the automatic analyzer according to the third embodiment. FIG. 18 shows an example in which [B / C] is 50, the number of measurement tests is 45, T0 is 45 seconds, t is 4.5 seconds, and the total number of reaction vessels is 50. .

  For example, when it is detected that the remaining amount of the detergent stored in the detergent tank has become a predetermined amount or less during the measurement of the reaction container having the reaction container ID “1”, the automatic analyzer 1 (specification unit 71) , “1” which is the reaction container ID is stored as the reaction container of the base point 1. Even if the remaining amount of the detergent is less than the predetermined amount, the detergent remains in the flow path as described above, so the detergent in the flow path is not used for 50 (= [B / C]) reaction containers. To be washed. In this case, the entire reaction vessel is washed with the detergent in the flow path. The automatic analyzer 1 identifies the reaction container with the reaction container ID “50” as the reaction container of the end point 1, and stores “50” which is the reaction container ID of the identified reaction container.

  Subsequently, the automatic analyzer 1 identifies the reaction container whose reaction container ID is “51” following the reaction container ID “50” as the reaction container of the base point 2, and is the reaction container ID of the reaction container of the base point 2. “51” is stored. Since 10 (= T0 / t) reaction vessels from the base point 2 are not sufficiently washed, the automatic analyzer 1 uses the reaction vessel whose reaction vessel ID is “60” as the reaction vessel of the end point 2 Specify “60”, which is the reaction container ID of the identified reaction container. As a result, skip information is assigned to the reaction container information of reaction containers having reaction container IDs “51” to “60”.

  Here, when the user gives an instruction to stop the apparatus, the apparatus is stopped after washing the reaction container IDs “51” to “60” even when they are not used for measurement.

  As described above, according to the third embodiment, when the user gives an instruction to stop the automatic analyzer, the apparatus is stopped after cleaning. Defects can be reliably avoided.

  In the first embodiment, the reaction vessel specified as an unwashed vessel is not used for measurement or the like, but is not limited to this. For example, the automatic analyzer may present information indicating a reaction container specified as an unwashed container to the user. That is, the automatic analyzer may include an output control unit 50 that causes the output unit 60 to output information indicating a reaction container identified as an unwashed container.

  The above embodiment is not limited to the configuration of the cleaning unit. Moreover, said embodiment is not limited to the structure of an analysis part.

  The above embodiment is not limited to the content of the analysis process. That is, the analysis processing in the above embodiment may be one in which at least one of sample dispensing, reagent dispensing, stirring, and measurement is omitted. In addition, the analysis processing in the above embodiment may further include measurement by an ion selective electrode method using an ion selective electrode, calibration, and the like.

  In the above embodiment, instead of turning on the function of the weight sensor, the detection result obtained from the weight sensor is judged, and instead of turning off the function of the weight sensor, the result obtained from the weight sensor is obtained. The detection result may not be determined.

  In the above embodiment, the automatic analyzer capable of switching the operation mode to the normal mode or the detergent replacement mode has been described as an example, but the present invention is not limited to this. What is necessary is just an automatic analyzer provided with the function in detergent replacement | exchange mode which concerns on said embodiment.

  Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the spirit of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, and are included in the invention described in the claims and the equivalent scope thereof.

DESCRIPTION OF SYMBOLS 1 Automatic analyzer 10 Analysis part 11 Reaction disk 11c, 13c, 14c, 16c Rotation drive part 12 Sample dispensing part 12c, 15c, 17c Dispensing mechanism part 13 Reaction disk 14 1st reagent storage 15 1st reagent dispensing part 16 Second reagent storage 17 Second reagent dispensing unit 18e Stirring mechanism unit 19 Measuring unit 20, 20a Washing unit 21 Pure water tank 22 Alkaline detergent tank 23 Acidic detergent tank 30 Data processing unit 40 Operation unit 50 Output control unit 51 Display control Unit 52 Print control unit 60 Output unit 61 Display unit 62 Printing unit 70, 70a Control unit 71 Identification unit 72 Timing unit 80 Storage units 211, 221, 231 Channel 213, 223 Waste fluid channel 222, 232 Weight sensors 224, 234 Suction Pressure sensor 233 Suction channel

Claims (11)

An automatic analyzer that dispenses a sample and a reagent into each of a plurality of reaction containers, performs an analysis process to measure a mixed solution in each reaction container, and cleans the reaction container after the analysis process,
A cleaning means for cleaning the plurality of reaction vessels using a detergent stored in a replaceable detergent storage means;
A remaining amount detection means for outputting a detection result corresponding to the remaining amount of the detergent stored in the detergent storage means;
When it is detected from the detection result output from the remaining amount detection means that the remaining amount of the detergent is equal to or less than a predetermined amount, the analysis processing for the plurality of reaction containers is continued, and the detergent storage After the measurement of the number of reaction containers corresponding to the volume of the detergent flow path connecting between the cleaning means and the cleaning means, the number of reaction containers corresponding to the replacement time of the detergent storage means scheduled to be measured is not cleaned. and control means for identifying as a container,
The automatic analyzer characterized by including. The time measurement is started when it is detected that the remaining amount of the detergent has become a predetermined amount or less based on the detection result, and when the completion of replacement of the detergent storage means is instructed via the operation means, the time measurement is started. Including a timing means to terminate,
The control means obtains the time measured by the time measuring means as the replacement time;
The automatic analyzer according to claim 1 . Including an exchange time detecting means for detecting the exchange time;
The control means identifies the unwashed container based on the replacement time detected by the replacement time detection means;
The automatic analyzer according to claim 1 or 2 , characterized by the above. The replacement time detection means includes
Timing means for starting timing when it is detected by the detection result that the remaining amount of the detergent is equal to or less than a predetermined amount;
Suction means for sucking detergent stored in the detergent storage means;
Suction pressure detection means for detecting suction pressure when suctioning the detergent by the suction means,
The timing means is
Based on the suction pressure detected by the suction pressure detection means after replacement of the detergent storage means, the time counting is terminated,
The control means obtains the time measured by the time measuring means as the replacement time;
The automatic analyzer according to claim 3 . An automatic analyzer that dispenses a sample and a reagent into each of a plurality of reaction containers, performs an analysis process to measure a mixed solution in each reaction container, and cleans the reaction container after the analysis process,
A cleaning means for cleaning the plurality of reaction vessels using a detergent stored in a replaceable detergent storage means;
A remaining amount detection means for outputting a detection result corresponding to the remaining amount of the detergent stored in the detergent storage means;
When it is detected from the detection result output from the remaining amount detection means that the remaining amount of the detergent is equal to or less than a predetermined amount, the analysis processing for the plurality of reaction containers is continued, and the detergent storage Control means to identify as an unwashed container based on the replacement time of the means;
Suction means for sucking detergent stored in the detergent storage means;
Suction pressure detection means for detecting suction pressure when the detergent is sucked by the suction means;
Time measurement is started when it is detected from the detection result that the remaining amount of the detergent is equal to or less than a predetermined amount, and based on the suction pressure detected by the suction pressure detection means after replacement of the detergent storage means, A timing means for terminating the timing,
Obtaining the time measured by the time measuring means as the replacement time;
An automatic analyzer characterized by that . Storage means for storing at least skip information indicating whether or not to skip dispensing of the sample,
The control means gives the skip information to the reaction container specified as the unwashed container and stores it in the storage means.
The automatic analyzer according to any one of claims 1 to 5 , wherein: The control means causes at least dispensing of the sample to be skipped for the reaction container specified as the unwashed container by the skip information stored in the storage means.
The automatic analyzer according to claim 6 . Including output control means for causing the output means to output information indicating the reaction container identified as the unwashed container,
The automatic analyzer according to any one of claims 1 to 7 , wherein the automatic analyzer is provided. The control unit, when instructed to stop the analysis process via the operation unit, stops the analysis process after washing the reaction container specified as the unwashed container by the cleaning unit,
The automatic analyzer according to any one of claims 1 to 8 , wherein: The operation mode can be switched to the first operation mode or the second operation mode.
The first operation mode is an operation mode in which the analysis process is stopped when it is detected from the detection result output from the remaining amount detecting means that the remaining amount of the detergent is equal to or less than a predetermined amount,
In the first operation mode, the control means detects that the remaining amount of the detergent is equal to or less than a predetermined amount based on the detection result output from the remaining amount detection means, and the detergent is provided via the operation means. When the replacement is instructed, the detection function of the remaining amount detecting means is invalidated and the operation mode is shifted to the second operation mode,
In the second operation mode, the control means specifies the unwashed container, and when the replacement of the detergent storage means is completed, cancels the invalidation of the detection function and sets the operation mode to the first operation mode. Shift to operation mode,
The automatic analyzer according to any one of claims 1 to 9 , wherein the automatic analyzer is provided. The automatic analyzer according to any one of claims 1 to 10 , wherein the remaining amount detection means is a weight sensor that outputs a detection result corresponding to the weight of the detergent storage means.

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