JP2009288052A - Automatic analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an automatic analyzer capable of reducing work for filling and storing a cleaning liquid. <P>SOLUTION: The automatic analyzer includes: an inspection item setting screen 75 for setting inspection items for each sample to be inspected; a sample dispensation probe 16 for performing dispensation by sucking from a sample vessel 17 to be inspected for discharging to a reaction vessel 3; and a reaction vessel cleaning section 12 for supplying and discharging the cleaning liquid into the reaction vessel 3 and cleaning the inside of the reaction vessel 3 for storing a mixed liquid. Based on inspection items set on the inspection item setting screen 75, the reaction vessel 3 for storing the cleaning liquid supplied by the reaction vessel cleaning section 12 is moved to a sample discharge position Pa capable of discharging a sample to be inspected into the reaction vessel 3 by the sample dispensation probe 16 to clean the sample dispensation probe 16 by the cleaning liquid in the reaction vessel 3. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an automatic analyzer for analyzing components contained in a liquid, and more particularly to an automatic analyzer having a cleaning function.

  The automatic analyzer is intended for biochemical test items, immunological test items, etc., and changes in color tone and turbidity caused by the reaction of the test sample collected from the test sample and the reagent mixture corresponding to each test item are spectrophotometric. The concentration of various components in the test sample and the activity of the enzyme are determined by optical measurement using an optical analyzer such as a meter or a turbidimetric meter.

  In this automatic analyzer, analysis of a test sample in which an inspection item to be inspected is set from among a large number of inspection items is performed. Then, the test sample is dispensed from the sample container stored in the sampler to the reaction container using the sample dispensing probe. In addition, the reagent is dispensed from the reagent container housed in the reagent container to the reaction container using a reagent dispensing probe. Further, the test sample and reagent mixture dispensed into the reaction vessel are stirred using a stirrer and then measured using an optical analyzer.

  Each analysis unit of the sample dispensing probe, the reagent dispensing probe, and the stirrer is used each time the dispensing of the test sample, the dispensing of the reagent, and the stirring of the mixed solution are completed using the wash water. Washed. In addition, the reaction container is washed every time the measurement of the mixed solution is performed using washing water or a washing liquid having a stronger washing power than the washing water.

  However, a small amount of the test sample dispensed previously through the sample dispensing probe is brought into the sample container that contains the next test sample, and is subject to the specific settings that are easily affected by the next test sample. There is a problem that analysis data of immunological test items deteriorates. In addition, a small amount of reagent dispensed previously through the reagent dispensing probe is brought into the reagent to be dispensed next, and the analysis data of the test item of a specific reagent that is easily affected by the previous reagent deteriorates. There's a problem.

In order to avoid problems due to cross-contamination between test samples and reagents, a sample container containing a cleaning liquid with stronger cleaning power than cleaning water was stored in the sampler, and the affected test items were set. Before dispensing the test sample, the method of washing the sample dispensing probe using the washing solution of the sample container, or storing the reagent container containing the washing solution in the reagent store and dispensing the affecting reagent, A method is known in which a reagent dispensing probe is washed using a washing solution in a reagent container before dispensing a reagent affected by the reagent (see, for example, Patent Document 1).
JP-A-6-207944

  However, it is necessary to store each container that contains the cleaning solution before analyzing the test sample, or check the amount of cleaning solution in each stored container and replenish the cleaning solution if it is insufficient Therefore, there is a problem that work related to the cleaning liquid is time-consuming.

  The present invention has been made to solve the above-described problems, and an object of the present invention is to provide an automatic analyzer that can reduce the work of replenishing and storing cleaning liquid.

  In order to achieve the above object, the automatic analyzer of the present invention according to claim 1 dispenses a test sample and a reagent corresponding to a test item of the test sample into a reaction container, In an automatic analyzer for measuring, an inspection item setting means for setting an inspection item of the test sample, a dispensing probe for performing dispensing for sucking and discharging the test sample or the reagent, and the reaction container A reaction container cleaning means for supplying and discharging a cleaning liquid into the reaction container and cleaning the inside of the reaction container in which the liquid mixture is stored, and the reaction container cleaning means based on the inspection item set by the inspection item setting means The reaction container containing the cleaning solution supplied by the above is moved to a discharge position where the dispensing probe can discharge the sample or the reagent, and the dispensing probe is cleaned using the cleaning liquid in the reaction container. Dispensing to do Characterized in that a lobe cleaning means.

  Further, the automatic analyzer of the present invention according to claim 5 is an automatic analyzer for dispensing a test sample and a reagent corresponding to an inspection item of the test sample into a reaction container and measuring the mixed solution. Test item setting means for setting test items of the test sample, a stirrer for stirring the liquid mixture in the reaction container, and supplying and discharging a cleaning liquid into the reaction container, and the liquid mixture is accommodated A reaction container cleaning means for cleaning the reaction container, and a reaction container containing the cleaning liquid supplied by the reaction container cleaning means based on the inspection item set by the inspection item setting means. And a stirrer cleaning means for cleaning the stirrer using the cleaning liquid in the reaction vessel.

  According to the present invention, by using the cleaning liquid used for cleaning the reaction container, the work of replenishing the cleaning liquid or storing the container containing the cleaning liquid can be reduced.

  Hereinafter, an embodiment of an automatic analyzer according to the present invention will be described with reference to FIGS.

  FIG. 1 is a block diagram showing a configuration of an automatic analyzer according to an embodiment of the present invention. This automatic analyzer 100 obtains standard data and test data by measuring a standard sample of each test item and a test sample collected from the test using a reagent corresponding to each test item in order to test the test sample. An analysis unit 24 to be generated and an analysis control unit 25 that controls each analysis unit related to the measurement of the analysis unit 24 are provided.

  Further, the standard data and test data generated by the analysis unit 24 are processed to generate calibration data and analysis data, and the output of the calibration data and analysis data generated by the data processing unit 60 is output. A unit 70, an operation unit 80 for inputting various command signals and the like, and a system control unit 90 for controlling the above-described units in an integrated manner.

  FIG. 2 is a perspective view showing the configuration of the analysis unit 24. The analysis unit 24 is connected to the pure water apparatus 110, and includes a sample container 17 that stores each sample such as a standard sample and a test sample, a disk sampler 5 that holds the sample container 17, and each test included in each sample. A reagent container 6 containing a first reagent that selectively reacts with the component of the item, a reagent container 1 having a reagent rack 1a for holding the reagent container 6, and a first inspection item constituted by a two-reagent system A reagent container 7 containing a second reagent paired with a reagent, a reagent container 2 having a reagent rack 2a for holding the reagent container 7, and a plurality (m pieces) arranged at equal intervals on the circumference. And a reaction disk 4 that rotatably holds the reaction vessel 3.

  Further, the sample dispensing probe 16 for performing dispensing for sucking the sample in the sample container 17 and discharging it into the reaction container 3, and the sample dispensing probe 16 is purified by the pure water device 110 every time the sample dispensing is completed. A cleaning tank 16a for cleaning using the cleaning water such as pure water, and a sample dispensing pump for performing dispensing to suck the sample in the sample container 17 into the sample dispensing probe 16 and discharge it into the reaction container 3 16 b and a sample dispensing arm 10 that holds the sample dispensing probe 16 so as to be rotatable and vertically movable in order to dispense the sample.

  In addition, a first reagent dispensing probe 14 for dispensing the first reagent in the reagent container 6 and discharging it into the reaction container 3 into which the test sample has been dispensed, and the dispensing of the first reagent. A washing tank 14a for washing the first reagent dispensing probe 14 with the washing water of the deionized water device 110 at each end, and a reaction by sucking the first reagent in the reagent container 6 into the first reagent dispensing probe 14 A first reagent dispensing pump 14b for dispensing into the container 3 and a first reagent dispensing for holding the first reagent dispensing probe 14 to be rotatable and vertically movable in order to dispense the first reagent. A note arm 8 is provided.

  In addition, the first stirrer 18 for agitating the first mixed liquid composed of the sample and the first reagent discharged into the reaction vessel 3 and the first stirrer 18 for each time the stirring of the first mixed liquid is completed are purified water. The cleaning tank 18a which wash | cleans using the washing water of the apparatus 110, and the 1st stirring arm 20 which hold | maintains the 1st stirring element 18 so that rotation and a vertical movement are possible are provided.

  In addition, a second reagent dispensing probe 15 for aspirating the second reagent in the reagent container 7 and discharging it into the reaction container 3 from which the test sample and the first reagent are discharged, and a second reagent When the second reagent dispensing probe 15 is finished, the second reagent dispensing probe 15 is washed with the washing water of the pure water device 110 and the second reagent in the reagent container 7 is sucked into the second reagent dispensing probe 15. Then, the second reagent dispensing pump 15b for dispensing the test sample and the first reagent discharged into the reaction container 3, and the second reagent dispensing probe 15 for dispensing the second reagent. Is provided with a second reagent dispensing arm 9 that can be rotated and moved up and down.

  In addition, a second stirrer 19 for stirring the second mixed liquid composed of the sample, the first reagent, and the second reagent discharged into the reaction container 3, and the second stirring each time the second mixed liquid is stirred. A washing tank 19a for washing the child 19 with the washing water of the pure water device 110 and a second stirring arm 21 for holding the second stirring bar 19 so as to be rotatable and vertically movable are provided.

  In addition, after the photometric unit 13 for optically measuring the first mixed liquid and the second mixed liquid in the reaction container 3 and the first mixed liquid and the second mixed liquid after the measurement in the reaction container 3 are sucked, Reaction that cleans the inside of the reaction vessel 3 using the cleaning water of the pure water device 110, the first cleaning liquid having a stronger cleaning power than the cleaning water, and the second cleaning liquid different from the first cleaning liquid. And a container cleaning unit 12. As the first cleaning liquid and the second cleaning liquid, for example, an acidic cleaning liquid, an alkaline cleaning liquid, a cleaning liquid containing a surfactant, or the like is used.

  And the photometry unit 13 irradiates light to the 1st liquid mixture and 2nd liquid mixture containing the standard sample in the reaction container 3 which rotates, and detects the wavelength light of each inspection item which permeate | transmitted each liquid mixture. To generate standard data. In addition, the first mixed liquid and the second mixed liquid including the test sample in the reaction container 3 are irradiated with light, and the wavelength light of each inspection item transmitted through the mixed liquid is detected to generate test data. . The generated standard data and test data are output to the data processing unit 60. Moreover, the reaction container 3 after the measurement is washed and then used again for the measurement.

  The analysis control unit 25 includes a mechanism unit 26 that drives each analysis unit of the analysis unit 24 and a control unit 27 that controls the mechanism unit 26. The mechanism 26 includes a mechanism for rotating the disk sampler 5 of the analyzer 24, the reagent rack 1a of the reagent storage 1, and the reagent rack 2a of the reagent storage 2, a mechanism for rotating the reaction disk 4, and a sample dispensing arm. 10, a mechanism for rotating and vertically moving the first reagent dispensing arm 8, the second reagent dispensing arm 9, the first stirring arm 20, and the second stirring arm 21 is provided.

  In addition, a mechanism for aspirating and discharging the sample dispensing pump 16b, the first reagent dispensing pump 14b, and the second reagent dispensing pump 15b, and a mechanism for driving each washing unit of the reaction container washing unit 12 are provided. ing.

  The control unit 27 includes a control circuit that controls each mechanism of the mechanism unit 26, and controls each mechanism of the mechanism unit 26 to operate each analysis unit of the analysis unit 24 and each cleaning unit of the reaction container cleaning unit 12. Measure the sample.

  Further, the sample dispensing probe 16 that contacts each sample accommodated in the sample container 17 of the analysis unit 24, the first reagent dispensing probe 14 that contacts the first reagent accommodated in the reagent container 6, and the reagent container 7 are accommodated. The second reagent dispensing probe 15 in contact with the second reagent, the first stirrer 18 in contact with the first mixed solution accommodated in the reaction vessel 3, and the second mixed solution accommodated in the reaction vessel 3. Each analysis target analysis unit of the second stirring bar 19 to be cleaned is cleaned using a cleaning solution for cleaning the reaction container 3 in the reaction container cleaning unit 12.

  A data processing unit 60 in FIG. 1 generates a calibration data and analysis data for each inspection item from standard data and test data output from the photometry unit 13 of the analysis unit 24, and a calculation unit 61 generates the data. And a data storage unit 62 for storing the calibration data and analysis data.

  The calculation unit 61 generates calibration data representing the relationship between the standard data output from the photometric unit 13 and the standard values of preset standard samples, and the relationship between the concentration and activity value of each test item and the standard data. The calibration data is output to the output unit 70 and stored in the data storage unit 62.

  Further, calibration data of the inspection item corresponding to the test data output from the photometry unit 13 is read from the data storage unit 62. Next, using the read calibration data, analysis data expressed as a concentration or activity value is generated from the test data, and the generated analysis data is output to the output unit 70 and stored in the data storage unit 62.

  The data storage unit 62 includes a hard disk or the like, stores calibration data output from the calculation unit 61 for each inspection item, and stores analysis data for each test sample.

  The output unit 70 includes a printing unit 71 that prints out the calibration data and analysis data output from the calculation unit 61 of the data processing unit 60 and a display unit 72 that displays the output. The printing unit 71 includes a printer or the like, and prints the calibration data and analysis data output from the calculation unit 61 on printer paper or the like according to a preset format.

  The display unit 72 includes a monitor such as a CRT or a liquid crystal panel, and displays calibration data and analysis data output from the calculation unit 61. Also, an analysis condition setting screen for setting analysis conditions for inspection items that can be inspected by the automatic analyzer 100 is displayed. Further, an influence item setting screen for setting the cleaning conditions for cleaning the sample dispensing probe 16 of the analysis unit 24 using the cleaning liquid of the reaction container cleaning unit 12, the first and second reagent dispensing probes 14, 15 and an influence reagent setting screen for setting a cleaning condition for cleaning each of the first and second stirrers 18 and 19 using the cleaning liquid of the reaction container cleaning unit 12 is displayed. Furthermore, an inspection item setting screen for setting inspection items for each test sample, a subject information setting screen for setting subject information for identifying the test sample, and the like are displayed.

The operation unit 80 includes input devices such as a keyboard, a mouse, a button, and a touch key panel. The operation unit 80 sets each cleaning condition for cleaning each cleaning target analysis unit of the analysis unit 24, sets inspection items for each sample, An input operation for setting sample information and the like is performed.
The system control unit 90 includes a CPU and a storage circuit 91, and stores input information such as a command signal input from the operation unit 80, each cleaning condition, an inspection item for each test sample, and the like in the storage circuit 91. Based on the input information, the analysis control unit 25, the data processing unit 60, and the output unit 70 are collectively controlled.

  Next, an example of the operation of the reaction container 3 of the analysis unit 24 will be described with reference to FIGS. 1 to 3. FIG. 3 is a diagram illustrating a stop position of the reaction vessel 3 in the analysis unit 24. FIG. 4 is a diagram showing the rotational movement of the reaction vessel 3.

  In FIG. 3, m reaction vessels 3 in the analysis unit 24 are rotated by the rotation of the angle θ in the direction of arrow R1 by the reaction disk 4 every analysis cycle, as shown in FIG. Stop at each stop position. At each stop position, there are a cleaning position W (first to fifth cleaning positions W1 to W5) where the reaction container 3 is cleaned, and a position where a sample is discharged into the reaction container 3 by the sample dispensing probe 16. There is a sample discharge position Pa and a first reagent discharge position Pa1 which is a position where the first reagent is discharged in the reaction container 3 from which the sample has been discharged by the first reagent dispensing probe 14.

  Further, the first stirring position Pa2, which is a position where the first mixed solution in the reaction vessel 3 is stirred by the first stirring bar 18, and the inside of the reaction vessel 3 containing the first mixed solution by the second reagent dispensing probe 15. The second reagent discharge position Pb is a position where the second reagent is discharged, the second stirring position Pb1 is the position where the second mixed liquid in the reaction vessel 3 is stirred by the second stirrer 19, and the like. .

  The reaction vessel 3 stopped at the first washing position W1 of the washing position W in the first analysis cycle after the operation of measuring the standard sample or the operation of measuring the test sample from the operation unit 80 is performed as follows. In the second analysis cycle, it stops at the second cleaning position W2, and in the third analysis cycle, it stops at the third cleaning position W3. Further, in the a-th analysis cycle (m> a> 5), it stops at the sample discharge position Pa, and in the (a + 1) -th analysis cycle, it stops at the first reagent discharge position Pa1, and further in the (a + 2) -th analysis cycle. Then, it stops at the first stirring position Pa2. Furthermore, in the b-th analysis cycle {m> b> (a + 2)}, it stops at the second reagent discharge position Pb, and in the (b + 1) -th analysis cycle, it stops at the second stirring position Pb1. Furthermore, in the (m + 1) th analysis cycle, the operation is stopped again at the first cleaning position W1, and the same operation as in the first to mth analysis cycles is repeated until the measurement of the sample is completed.

  Next, with reference to FIG. 1 thru | or FIG. 7, the detail of the structure of the reaction container washing | cleaning 12 in the analysis part 24 is demonstrated. FIG. 5 is a diagram illustrating a configuration of the reaction container cleaning unit 12. 6 and 7 are diagrams showing a configuration of a part of the cleaning unit of the reaction container cleaning unit 12. FIG.

  In FIG. 5, the reaction container cleaning unit 12 includes a cleaning nozzle unit 41 for discharging and sucking cleaning water and cleaning liquid, and tubes connected to the first to fifth nozzles 411 to 415 of the cleaning nozzle unit 41. And a cleaning pump unit 42 for supplying and discharging cleaning water and cleaning liquid. When the reaction disk 4 is rotating, the reaction disk 4 is held at the upper stop position above the reaction vessel 3 at the cleaning position W. When the reaction disk 4 stops, the reaction disk 4 moves downward and stops at the cleaning position W. The reaction vessel 3 was washed.

  The cleaning nozzle unit 41 includes five types of first to fifth nozzles 411 to 415 corresponding to the first to fifth cleaning positions W1 to W5 of the cleaning position W.

  The first nozzle 411 is a suction nozzle that sucks the first mixed solution in the reaction vessel 3 stopped at the first washing position W1 and each mixed solution of the second mixed solution and the washing water used for washing the reaction vessel 3, In addition, it is configured by a discharge nozzle that discharges cleaning water into the reaction vessel 3 after sucking the first mixed solution or the second mixed solution. Then, the inside of the reaction vessel 3a is washed with the washing water by a series of washing operations including the discharge of each liquid mixture, the supply of the washing water, and the discharge of the supplied washing water performed by the washing pump unit 42.

  The second nozzle 412 includes a discharge nozzle that discharges the first cleaning liquid into the reaction container 3 stopped at the second cleaning position W2, and a suction nozzle that sucks the first cleaning liquid discharged into the reaction container 3. Is done. Then, the reaction container 3 cleaned at the first cleaning position W1 is subjected to the first cleaning operation by a series of cleaning operations including discharge performed by the cleaning pump unit 42, supply of the first cleaning liquid, and discharge of the supplied first cleaning liquid. Wash with the cleaning solution.

  In addition, the series of first cleaning liquid supply operations including the discharge performed by the cleaning pump unit 42 and the supply of the first cleaning liquid causes the sample dispensing probe 16 and each of the first dispensing probe 16 and the first cleaning liquid to be placed in the reaction container 3 stopped at the second cleaning position W2. The 1st and 2nd reagent dispensing probe 14,15 and the 1st washing | cleaning liquid used for washing | cleaning of each washing | cleaning object analysis unit of each 1st and 2nd stirring element 18 and 19 are supplied.

  And the reaction container 3 which accommodated the 1st washing | cleaning liquid is rotationally moved to each stop position of each washing | cleaning object analysis unit, and each washing | cleaning object analysis unit is used using the 1st washing | cleaning liquid in the reaction container 3 stopped at each stop position. Cleaning is performed. After cleaning with the first cleaning liquid, cleaning is performed to wash off the first cleaning liquid adhering to each cleaning target analysis unit using the cleaning water in the cleaning tank of each cleaning target analysis unit. The reaction vessel 3 containing the first cleaning liquid stopped at each stop position is rotationally moved to the third cleaning position W3.

  Here, when the cleaning target analysis unit is the sample dispensing probe 16, the reaction container 3 containing the first cleaning liquid stops at the sample discharge position Pa. The sample dispensing pump 16b cleans the sample dispensing probe 16 by sucking the first cleaning liquid in the reaction vessel 3 into the sample dispensing probe 16 and discharging the suctioned first cleaning liquid into the cleaning tank 16a. To do. After cleaning with the first cleaning liquid, the cleaning tank 16a cleans the sample dispensing probe 16 using cleaning water.

  Further, when the analysis target analysis units are the first and second reagent dispensing probes 14 and 15, the reaction container 3 containing the first cleaning liquid stops at the first and second reagent discharge positions Pa1 and Pb. To do. Each of the first and second reagent dispensing pumps 14b and 15b sucks the first cleaning liquid in the reaction container 3 into the first and second reagent dispensing probes 14 and 15, and the sucked first cleaning liquid. The first and second reagent dispensing probes 14 and 15 are washed by being discharged into the washing tanks 14a and 15a. After washing with the first washing liquid, the washing tanks 14a and 15a wash the first and second reagent dispensing probes 14 and 15 using washing water.

  Further, when the analysis target analysis units are the first and second stirrers 18 and 19, the reaction vessel 3 containing the first cleaning liquid stops at the first and second stirring positions Pa2 and Pb1. Each first and second stirring arm 20, 21 immerses each first and second stirring bar 18, 19 in the first cleaning liquid of the reaction vessel 3, thereby allowing each first and second stirring bar 18, 19 is washed. After washing with the first washing liquid, the washing tanks 18a and 19a wash the first and second stirrers 18 and 19 using washing water.

  Thus, the 1st washing | cleaning liquid used for washing | cleaning of the reaction container 3 can be used for washing | cleaning of each washing | cleaning object analysis unit. Thereby, the operation | work which accommodates the sample container 17 which accommodates the 1st washing | cleaning liquid in the disk sampler 5, and the operation | work which replenishes the 1st washing | cleaning liquid to the sample container 17 can be reduced. Moreover, the operation | work which accommodates the reagent containers 6 and 7 which accommodate a 1st washing | cleaning liquid in the reagent storages 1 and 2, and the operation | work which replenishes the 1st washing | cleaning liquid to the reagent containers 6 and 7 can be reduced.

  In addition, the sample container 17 that accommodates a large number of test samples can be accommodated in the disk sampler 5, and a large number of test samples can be measured simultaneously. In addition, the reagent containers 6 and 7 that store a large number of first reagents and second reagents can be stored in the reagent containers 1 and 2, and a large number of test items can be tested at the same time.

  The third nozzle 413 includes a discharge nozzle that discharges the second cleaning liquid into the reaction container 3 stopped at the third cleaning position W3, and a suction nozzle that sucks the second cleaning liquid discharged into the reaction container 3. The Then, the reaction vessel 3 cleaned at the second cleaning position W2 is subjected to a first cleaning operation by a series of cleaning operations including discharge performed by the cleaning pump unit 42, supply of the second cleaning liquid, and discharge of the supplied second cleaning liquid. Wash with 2 washing solution.

  In addition, by a series of second cleaning liquid supply operations including discharge and supply of the second cleaning liquid performed by the cleaning pump unit 42, the respective analysis target analysis units are cleaned in the reaction vessel 3 stopped at the third cleaning position W3. A second cleaning liquid to be used is supplied. And the reaction container 3 which accommodated the 1st washing | cleaning liquid is rotationally moved to each stop position of each washing | cleaning object analysis unit, and each washing | cleaning object analysis unit is used using the 2nd washing | cleaning liquid in the reaction container 3 stopped at each stop position. Cleaning is performed. After washing with the second washing liquid, washing is performed to wash off the second washing liquid adhering to each washing target analysis unit using washing water in the washing tank of each washing target analysis unit. The reaction container 3 containing the second cleaning liquid stopped at each stop position is rotationally moved to the fourth cleaning position W4.

  Thus, the 2nd washing | cleaning liquid used for washing | cleaning of the reaction container 3 can be used for washing | cleaning of each washing | cleaning object analysis unit. Thereby, the operation | work which accommodates the sample container 17 which accommodates the 2nd washing | cleaning liquid in the disk sampler 5, and the operation | work which replenishes the 2nd washing | cleaning liquid to the sample container 17 can be reduced. Moreover, the operation | work which accommodates the reagent containers 6 and 7 which accommodate a 2nd washing | cleaning liquid in the reagent storages 1 and 2, and the operation | work which replenishes the reagent containers 6 and 7 with a 2nd washing | cleaning liquid can be reduced.

  In addition, the sample container 17 that accommodates a large number of test samples can be accommodated in the disk sampler 5, and a large number of test samples can be measured simultaneously. In addition, the reagent containers 6 and 7 that store a large number of first reagents and second reagents can be stored in the reagent containers 1 and 2, and a large number of test items can be tested at the same time.

  The fourth nozzle 414 includes a discharge nozzle that discharges cleaning water into the reaction container 3 stopped at the fourth cleaning position W4, and a suction nozzle that sucks the cleaning water discharged into the reaction container 3. Then, the inside of the reaction vessel 3 cleaned at the third cleaning position W3 is cleaned with the cleaning water by a series of cleaning operations including the discharge performed by the cleaning pump unit 42, the supply of the cleaning water, and the discharge of the supplied cleaning water. .

  The fifth nozzle 415 is constituted by a suction nozzle that dries the inside of the reaction vessel 3 stopped at the fifth cleaning position W5. Then, the inside of the reaction vessel 3 cleaned at the fourth cleaning position W4 is dried by a series of drying operations including discharge and discharge performed by the cleaning pump unit 42.

  The cleaning pump unit 42 includes a cleaning water supply pump 43 that supplies cleaning water to the discharge nozzles of the first and fourth nozzles 411 and 414 in the cleaning nozzle unit 41, and a first discharge nozzle of the second nozzle 412. A first supply pump 44 that supplies the cleaning liquid, a second supply pump 45 that supplies the second cleaning liquid to the discharge nozzle of the third nozzle 413, and suction nozzles of the first to fifth nozzles 411 to 415 Each liquid mixture, washing water, and a drainage pump unit 46 for discharging each washing liquid.

  In addition, the first detergent bottle 47 containing the concentrate of the first cleaning liquid, the second detergent bottle 48 storing the concentrate of the second cleaning liquid, and the suction nozzle of the first nozzle 411 were discharged. The first drainage tank 49 for storing each liquid mixture and the cleaning water, and the cleaning water discharged from the suction nozzles of the second to fifth nozzles 412 to 415, the first cleaning liquid, and the second cleaning liquid are stored. And a second drainage tank 50.

  FIG. 6 is a diagram showing the configuration of the first supply pump 44. The first supply pump 44 is sucked by the detergent pump 443 for sucking the concentrated liquid of the first washing liquid from the first detergent bottle 47 through the three-way valve 441 and the first branch pipe 442, and the detergent pump 443. A supply pump 444 that dilutes the concentrated liquid to generate a first cleaning liquid and supplies the first cleaning liquid to the discharge nozzle of the second nozzle 412 is provided.

  The three-way valve 441 is constituted by, for example, a three-way electromagnetic valve having first to third opening / closing parts that can be opened and closed. When the concentrated liquid is sucked from the first detergent bottle 47 by the detergent pump 443, the first opening / closing part connected to the first detergent bottle 47 and the second opening / closing part connected to the first branch pipe 442 are provided. The third opening / closing part connected to the discharge nozzle of the first nozzle 411 is closed. Further, when the first cleaning liquid is supplied to the first nozzle 411 by the supply pump 444, the second and third opening / closing parts are opened, and the first opening / closing part is closed.

  The first branch pipe 442 has three first to third openings, and the openings communicate with each other inside. The first opening is connected to the second opening / closing part of the three-way valve 441. The second opening is connected to the detergent pump 443, and the third opening is connected to the supply pump 444.

  The detergent pump 443 sucks the concentrated liquid in the first detergent bottle 47 between the second opening / closing part of the three-way valve 441 and the first opening part of the first branch pipe 442.

  The supply pump 444 is connected to the pure water device 110 and the first branch pipe 442, sucks cleaning water from the pure water device 110, and opens the first branch pipe 442 and the second and second opening / closing sections. The concentrated solution sucked by the detergent pump 443 is supplied to the discharge nozzle of the second nozzle 412 through the three-way valve 441. By this supply, the first cleaning liquid obtained by diluting the concentrated liquid with the cleaning water is supplied to the discharge nozzle of the second nozzle 412.

  In this way, since the concentrated liquid is diluted with the cleaning water to generate the first cleaning liquid, the first detergent bottle 47 does not require a large storage space and can be downsized.

  FIG. 7 is a diagram showing the configuration of the second supply pump 45. The second supply pump 45 is connected to the second detergent bottle 48 via a three-way valve 451 having first and third openable / closable portions and a first branch pipe 452 having first to third openings. The detergent pump 453 for sucking the concentrate of the cleaning liquid 2 and the second cleaning liquid diluted with the cleaning water that sucked the concentrate sucked by the detergent pump 453 and sucked the cleaning water from the pure water device 110 And a supply pump 454 that supplies the discharge nozzle of the nozzle 413. Since each cleaning unit of the second supply pump 45 operates in the same manner as each cleaning unit of the first supply pump 44, the description thereof is omitted.

  In this way, since the concentrated liquid is diluted with the cleaning water to generate the second cleaning liquid, the second detergent bottle 48 does not require a large storage space and can be downsized.

  The drainage pump unit 46 of FIG. 5 is supplied into the reaction vessel 3 and the first drainage pump 461 that discharges the first mixed solution and the second mixed solution in the reaction vessel 3 into the first drainage tank 49. The cleaning water, the first cleaning liquid, and the second cleaning liquid are put into the second drainage tank 50 through the two branch valves 462 and 463 and the third branch pipe 464 having the first to fifth openings. And a second drainage pump 465 for discharging.

  The first drain pump 461 has one end connected to the suction nozzle of the first nozzle 411 and the other end connected to the first drain tank 49. Then, the first mixed solution or the second mixed solution in the reaction vessel 3 stopped at the first washing position W1 and the washing water supplied into the reaction vessel 3 are sucked by the suction nozzle of the first nozzle 411. The liquid is discharged to the first drainage tank 49.

  The two-way valve 462 is configured by a two-way electromagnetic valve having first and second opening / closing portions that can be opened and closed between the suction nozzle of the second nozzle 412 and the first opening of the third branch pipe 464. The first opening / closing part is connected to the suction nozzle of the second nozzle 412, and the second opening / closing part is connected to the first opening of the third branch pipe 464. When the first cleaning liquid is sucked from the reaction container 3 at the second cleaning position W2 by the second drainage pump 465, the space between the suction nozzle of the second nozzle 412 and the first opening of the third branch pipe 464 is used. Is open.

  Further, when the first cleaning liquid used for cleaning each analysis target analysis unit is supplied to the reaction vessel 3 at the second cleaning position W2, the space between the suction nozzle of the second nozzle 412 and the first opening of the third branch pipe 464 is used. Is open.

  The two-way valve 463 is constituted by a two-way electromagnetic valve having first and second opening / closing portions that can be opened and closed between the suction nozzle of the third nozzle 413 and the second opening of the third branch pipe 464. The first opening / closing part is connected to the suction nozzle of the third nozzle 413, and the second opening / closing part is connected to the second opening of the third branch pipe 464. When the second cleaning liquid is sucked from the reaction container 3 at the third cleaning position W3 by the second drainage pump 465, the space between the suction nozzle of the third nozzle 413 and the second opening of the third branch pipe 464 is used. Is open.

  Further, when the second cleaning liquid used for cleaning each analysis target analysis unit is supplied to the reaction container 3 at the third cleaning position W3, between the suction nozzle of the third nozzle 413 and the second opening of the third branch pipe 464. Is closed.

  In the third branch pipe 464, the first to fifth openings communicate with each other inside, and the third opening is connected to the suction nozzle of the fourth nozzle 414. The fourth opening is connected to the suction nozzle of the fifth nozzle 415, and the fifth opening is connected to one end of the second drainage pump 465.

  The second drainage pump 465 has the other end connected to the second drainage tank 50. Then, the first cleaning liquid supplied to the reaction vessel 3 at the second cleaning position W2 is sucked by the suction nozzle of the second nozzle 412 through the two-way valve 462 and the third branch pipe 464 and sucked first. Is discharged to the second drainage tank 50.

  Further, the second cleaning liquid supplied to the reaction container 3 at the third cleaning position W3 is sucked by the suction nozzle of the third nozzle 413 through the two-way valve 463 and the third branch pipe 464, and is sucked. Is discharged to the second drainage tank 50.

  Further, the washing water supplied into the reaction vessel 3 at the fourth washing position W4 is sucked by the suction nozzle of the fourth nozzle 414 via the third branch pipe 464, and the sucked washing water is sucked into the second drainage tank. To 50.

  Furthermore, the inside of the reaction vessel 3 at the fifth cleaning position W5 is dried by the suction nozzle of the fifth nozzle 415 via the third branch pipe 464.

  Hereinafter, an example of the operation of the automatic analyzer 100 will be described with reference to FIGS. 1 to 11. FIG. 8 is a diagram illustrating an example of the influence item setting screen displayed on the display unit 72. FIG. 9 is a diagram illustrating an example of the influence reagent setting screen displayed on the display unit 72. FIG. 10 is a diagram illustrating an example of an inspection item setting screen displayed on the display unit 72. FIG. 11 is a flowchart showing the operation of the automatic analyzer 100.

  In FIG. 8, the influence item setting screen 73 is used for the “item” column for displaying inspection items set as inspection items that can be inspected on the analysis condition setting screen of the display unit 72 and for cleaning the sample dispensing probe 16. The column is composed of a “cleaning liquid” column for displaying the type of the cleaning liquid and an influence item setting area 73a for setting the cleaning liquid for the sample dispensing probe 16 suitable for cleaning the affected inspection item.

  In the column of “cleaning liquid”, the “first liquid” that is the first cleaning liquid used for cleaning the reaction container 3 of the analysis unit 24, the “second liquid” that is the second cleaning liquid, and the first “First and second liquids” which are the cleaning liquid and the second cleaning liquid are displayed. In the “item” column, for example, “GOT”, “GPT”, “Ca”, “HBsAg”, and the like, which are inspection items set on the analysis condition setting screen of the display unit 72, are displayed.

  In the influence item setting area 73a, the inspection item affected by the “item” column is selected, and the “first liquid” or “second liquid” in the “cleaning liquid” column corresponding to the selected inspection item is selected. Alternatively, when “first and second liquids” is selected, “◯” is displayed in the area corresponding to the cleaning liquid of the selected inspection item, and “•” is displayed in the non-selected area.

  Here, for example, “HBsAg” is selected as the inspection item affected by the operation unit 80, and “first liquid” is selected as the cleaning liquid suitable for cleaning “HBsAg”, for example. “O” is displayed in the area 73b corresponding to “HBsAg” and “first liquid”. The information on the inspection item to be affected and the cleaning condition of the cleaning liquid set on the influence item setting screen 73 is stored in the storage circuit 91 of the system control unit 90. The cleaning conditions are set in accordance with the determination of inspection items that can be inspected by the automatic analyzer 100 installed.

  FIG. 9 is a diagram showing an example of the influence reagent setting screen displayed on the display unit 72. The influential reagent setting screen 74 includes columns of “influenced first reagent” and “influenced first reagent” for displaying the inspection items set in the analysis condition setting screen of the display unit 72, and “influenced by The first reagent that affects the test item displayed in the columns of “first reagent” and “affected first reagent”, the setting of the first reagent that is affected by the first reagent, and the first reagent that affects the first reagent The first reagent dispensing probe 14 and the first reagent setting area 74a for setting the cleaning liquid for the first stirring bar 18 are suitable.

  In addition, columns of “influenced second reagent” and “influenced second reagent” for displaying test items configured by two-reagent reagents set on the analysis condition setting screen of the display unit 72, and “ The setting of the second reagent affected by the second reagent that affects the test item displayed in the columns of the “second reagent that affects” and the “second reagent affected”, and the second reagent that is affected by this second reagent, and the influence The second reagent dispensing probe 15 suitable for cleaning the second reagent and the second reagent setting area 74b for setting the cleaning liquid for the second stirring bar 19 are configured.

  In the columns “Influenced first reagent” and “Affected first reagent”, the inspection items “GOT” and “GPT” displayed in the “Item” column of the affected item setting screen 73 in FIG. "," Ca ", and" HBsAg "are displayed.

  In the first reagent setting area 74a, the test item of the first reagent that has an influence displayed in the columns of “the first reagent to be affected” and “the first reagent that is affected”, and the first reagent are affected. A test item for the first reagent is selected. In addition, a first cleaning solution and / or a second cleaning solution suitable for cleaning the influential first reagent is selected. For example, “1” corresponding to the first cleaning liquid selected in the area corresponding to the selected first reagent, “2” corresponding to the second cleaning liquid, or “3” corresponding to the first and second cleaning liquids. Is displayed. In addition, “•” is displayed in the area that is not selected, and “−” is displayed in the area that cannot be selected.

  In the columns of “second reagent to be affected” and “second reagent to be affected”, an examination composed of two-reagent reagents displayed in the “item” column of the influence item setting screen 73 in FIG. Items such as “GOT”, “GPT”, “Ca”, and “HBsAg” are displayed.

  In the second reagent setting area 74b, the test item of the second reagent that has an influence displayed in the columns of “the second reagent to be affected” and “the second reagent that is affected”, and the second reagent are affected. The inspection item for the second reagent is selected. In addition, a first cleaning liquid and / or a second cleaning liquid suitable for cleaning the second reagent having an influence is selected. For example, “1” corresponding to the first cleaning liquid selected in the area corresponding to the selected second reagent, “2” corresponding to the second cleaning liquid, or “3” corresponding to the first and second cleaning liquids. Is displayed. In addition, “•” is displayed in the area that is not selected, and “−” is displayed in the area that cannot be selected.

  Here, “GPT” is selected from the operation unit 80 as the test item of the first reagent to be affected in the columns of “Affecting first reagent” and “Affected first reagent”, and the influence from this first reagent is selected. “Ca” is selected as the inspection item of the first reagent to be received. In addition, by selecting the first cleaning solution, “Ca” in the “Affected first reagent” column corresponding to “GPT” in the “Influencing first reagent” column in the first reagent setting area 74a. "1" is displayed in the area 74c. The information on the cleaning conditions of the cleaning solution suitable for cleaning the first reagent that affects the first reagent that is set on the affecting reagent setting screen 74, the first reagent that is affected by the first reagent, and the first reagent that affects the It is stored in the storage circuit 91 of the system control unit 90.

  The cleaning conditions are set based on the experimental results between the reagents applied to the inspection items that can be inspected by the automatic analyzer 100.

  FIG. 10 is a diagram illustrating an example of an inspection item setting screen displayed on the display unit 72. The examination item setting screen 75 includes, for example, an “ID” field for displaying the subject ID that is the subject information set on the subject information setting screen displayed on the display unit 72, and the influence item setting in FIG. The “item” column for displaying the examination item displayed in the “item” column of the screen 73 and the examination item displayed in the “item” column for each subject ID displayed in the “ID” column. It comprises a measurement item setting area 75a for setting. Note that when analysis of a test sample collected from the subject is performed according to the diagnosis result for each subject, the inspection items of the test sample of the subject are set.

  In the “ID” column, for example, “1” and “2” which are subject IDs are displayed. In the “item” column, inspection items such as “GOT”, “GPT”, “Ca”, and “HBsAg” are displayed.

  In the measurement item setting area 75a, the inspection item in the “item” column for inspecting the subject with the ID in the “ID” column is selected. “◯” is displayed in the selected area, and “•” is displayed in the non-selected area.

  Here, for example, by selecting “GOT” for “1” displayed in the “ID” column from the operation unit 80, one test corresponding to “1” and “GOT” in the measurement item setting area 75a. “◯” is displayed in the area of “2”, and “○” is displayed in the area of 2 tests by selecting “GPT”. Further, by selecting “Ca” for “2” displayed in the “ID” column, “◯” is displayed in the area of 3 tests corresponding to “2” and “Ca” in the measurement item setting area 75a. When “HBsAg” is selected, “◯” is displayed in the four test areas.

  Information on the inspection item for each test sample set on the inspection item setting screen 75 is stored in the storage circuit 91 of the system control unit 90. The measurement of the test sample in the analysis unit 24 is performed in the order of tests set on the inspection item setting screen 75.

  FIG. 11 is a flowchart showing the operation of the automatic analyzer 100. Calibration data for each inspection item is stored in the data storage unit 62 of the data processing unit 60. Further, in the storage circuit 91 of the system control unit 90, the cleaning conditions set on the influence item setting screen 73 in FIG. 8 and the influence reagent setting screen 74 in FIG. 9 and the inspection item setting screen 75 in FIG. 10 are set. Information on inspection items for each test sample is stored.

  A sample container 17 containing test samples corresponding to “1” and “2” that are IDs of the test set on the test item setting screen 75 is stored in the disk sampler 5 of the analysis unit 24. . And if operation which starts the measurement of a test sample is performed from the operation part 80, the automatic analyzer 100 will start the analysis of a test sample (step S1).

  The system control unit 90 instructs the analysis control unit 25, the data processing unit 60, and the output unit 70 to analyze the test sample based on the information on the test items for each test sample stored in the storage circuit 91. In addition, the analysis control unit 25 causes the sample dispensing probe 16, the first reagent dispensing probe 14, the second reagent dispensing probe 15, the first stirrer 18, and the second agitation of the analyzing unit 24 associated with the measurement of the test sample. Instruct the cleaning of each analysis target analysis unit of the child 19.

  The control unit 27 of the analysis control unit 25 controls the mechanism unit 26 based on the cleaning conditions supplied from the system control unit 90 and the information of the inspection items for each test sample, and each analysis unit and reaction of the analysis unit 24. Each cleaning unit of the container cleaning unit 12 is operated.

  In the first analysis cycle, the reaction disk 4 of the analysis unit 24 stops at an angle θ rotation. The reaction container 3 stopped at the first cleaning position W1 of the cleaning position W in this analysis cycle is set as the reaction container 3 corresponding to one test set on the inspection item setting screen 75. The reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W.

  In each of the second to (a-1) analysis cycles, the reaction disk 4 rotates at an angle θ and stops. The reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W.

  In the a-th analysis cycle, the reaction disk 4 rotates at an angle θ and stops. The sample dispensing probe 16 sucks the test sample corresponding to one test from the sample container 17 with the subject ID “1” of the disk sampler 5 and stops the sucked test sample at the sample discharge position Pa. Discharge into the reaction vessel 3. The reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W.

  In the (a + 1) th analysis cycle, the reaction disk 4 rotates at an angle θ and stops. The sample dispensing probe 16 sucks the test sample corresponding to the second test from the sample container 17 with the subject ID “1”, and the reaction container corresponding to the second test in which the sucked test sample is stopped at the sample discharge position Pa. 3 is discharged. The first reagent dispensing probe 14 sucks the first reagent corresponding to one test from the reagent container 6 of the reagent container 1, and the reaction container 3 of one test in which the sucked first reagent is stopped at the first reagent discharge position Pa1. Discharge inside.

  Then, since the test sample with the subject ID “2” to be dispensed next includes “HBsAg” which is an affected test item, the reaction container cleaning unit 12 stops the reaction at the cleaning position W. While washing | cleaning the container 3, the 1st washing | cleaning liquid used for washing | cleaning of the sample dispensing probe 16 is supplied to the reaction container 3 stopped to the 2nd washing position W2 (step S2).

  In the (a + 2) th analysis cycle, the reaction disk 4 rotates and moves the reaction container 3 at the second cleaning position W2 to the sample discharge position Pa. Then, the sample dispensing pump 16b cleans the sample dispensing probe 16 using the first cleaning liquid in the reaction container 3 stopped at the sample discharge position Pa (step S3). Subsequently, the washing tank 16a wash | cleans the sample dispensing probe 16 wash | cleaned with the 1st washing | cleaning liquid using washing water.

  As described above, the sample dispensing probe 16 can be washed with the washing liquid before dispensing the test sample in which the affected test item is set. Thereby, it is possible to prevent the analysis data of the affected test item from deteriorating and to analyze the test sample with high accuracy.

  In the (a + 3) th analysis cycle, the reaction disk 4 rotates and moves the reaction container 3 at the sample discharge position Pa to the third cleaning position W3. The sample dispensing probe 16 sucks the test sample corresponding to the three tests from the sample container 17 with the subject ID “2”, and the reaction container corresponding to the three tests where the suctioned test sample is stopped at the sample discharge position Pa. 3 is discharged. The first reagent dispensing probe 14 sucks the first reagent corresponding to the two tests from the reagent container 6, and discharges the sucked first reagent into the two-test reaction container 3 stopped at the first reagent discharge position Pa1. . The first stirring bar 18 stirs the first mixed liquid in the reaction vessel 3 of one test stopped at the first stirring position Pa2.

  The first reagent to be dispensed next is the first reagent of “Ca” to be affected, and the first reagent dispensed before this first reagent affects the first reagent of “Ca”. Since it is the first reagent of “GPT”, the reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W and also adds the first reagent dispensing probe to the reaction container 3 stopped at the second cleaning position W2. The first cleaning liquid used for cleaning 14 is supplied (step S4).

  In the (a + 4) th analysis cycle, the reaction disk 4 rotates and moves the reaction container 3 at the second cleaning position W2 to the first reagent discharge position Pa1. And the 1st reagent dispensing pump 14b wash | cleans the 1st reagent dispensing probe 14 using the 1st washing | cleaning liquid in the reaction container 3 stopped in 1st reagent discharge position Pa1 (step S5). Subsequently, the washing tank 14a wash | cleans the 1st reagent dispensing probe 14 wash | cleaned with the 1st washing | cleaning liquid using washing water.

  As described above, after dispensing the influential first reagent, the first reagent dispensing probe 14 can be washed with the washing liquid before dispensing the first reagent affected by the first reagent. . Thereby, it is possible to prevent the analysis data of the test item of the affected first reagent from being deteriorated, and to analyze the test sample with high accuracy.

  In the (a + 5) th analysis cycle, the reaction disk 4 rotates and moves the reaction container 3 at the first reagent discharge position Pa1 to the third cleaning position W3. The sample dispensing probe 16 sucks the test sample corresponding to the four tests from the sample container 17 with the subject ID “2”, and the reaction container corresponding to the four tests in which the sucked test sample is stopped at the sample discharge position Pa. 3 is discharged. The first reagent dispensing probe 14 sucks the first reagent corresponding to the three tests from the reagent container 6, and discharges the sucked first reagent into the three-test reaction container 3 stopped at the first reagent discharge position Pa1. . The first stirring bar 18 stirs the first mixed liquid in the reaction container 3 of the two tests stopped at the first stirring position Pa2.

  The first mixed liquid to be stirred next contains the first reagent of “Ca” to be affected, and the first mixed liquid stirred before this first mixed liquid has an influence on the first reagent of “Ca”. Since it is the first mixed liquid containing the first reagent of “GPT”, the reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W and also adds the reaction container 3 stopped at the second cleaning position W2 to the reaction container 3 stopped. A first cleaning liquid used for cleaning the first stirring bar 18 is supplied (step S6).

  In the (a + 6) th analysis cycle, the reaction disk 4 rotates and moves the reaction vessel 3 at the second cleaning position W2 to the first stirring position Pa2. And the 1st stirring arm 20 wash | cleans the 1st stirring element 18 using the 1st washing | cleaning liquid in the reaction container 3 stopped in 1st stirring position Pa2 (step S7). Next, the cleaning tank 18a cleans the first stirrer 18 cleaned with the first cleaning liquid using cleaning water.

  Thus, after stirring the 1st liquid mixture containing the 1st reagent which influences, it stirs using the washing | cleaning liquid before stirring the 1st liquid mixture containing the 1st reagent affected by the 1st reagent. The child 18 can be cleaned. Thereby, it is possible to prevent the analysis data of the test item of the affected first reagent from being deteriorated, and to analyze the test sample with high accuracy.

  In the (a + 7) th analysis cycle, the reaction disk 4 rotates and moves the reaction vessel 3 at the first stirring position Pa2 to the third cleaning position W3. The first reagent dispensing probe 14 sucks the first reagent corresponding to the four tests from the reagent container 6, and discharges the sucked first reagent into the four-test reaction container 3 stopped at the first reagent discharge position Pa1. . The first stirrer 18 stirs the first mixed solution in the three-test reaction vessel 3 stopped at the first stirring position Pa2. The reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W.

  In the (a + 8) th analysis cycle, the reaction disk 4 rotates by an angle θ and stops. The first stirring bar 18 stirs the first mixed solution in the 4-test reaction vessel 3 stopped at the first stirring position Pa2. The reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W.

  In each of the (a + 9) th to (b + 2) th analysis cycles, the reaction disk 4 rotates at an angle θ and stops. The reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W.

  In the (b + 3) th analysis cycle, the reaction disk 4 stops at an angle θ. The second reagent dispensing probe 15 sucks the second reagent corresponding to one test from the reagent container 7 of the reagent storage 2 and stops the sucked second reagent at the second reagent discharge position Pb. Discharge inside.

  In the (b + 4) th analysis cycle, the reaction disk 4 stops at an angle θ. The second reagent dispensing probe 15 sucks the second reagent corresponding to the two tests from the reagent container 7, and discharges the sucked second reagent into the two-test reaction container 3 stopped at the second reagent discharge position Pb. . The 2nd stirring element 19 stirs the 2nd liquid mixture in the reaction container 3 of 1 test stopped at the 2nd stirring position Pb1.

  In the (b + 5) th analysis cycle, the reaction disk 4 stops at an angle θ. The second reagent dispensing probe 15 sucks the second reagent corresponding to the three tests from the reagent container 7 and discharges the sucked second reagent into the three-test reaction container 3 stopped at the second reagent discharge position Pb. . The 2nd stirring element 19 stirs the 2nd liquid mixture in the reaction container 3 of 2 tests stopped in the 2nd stirring position Pb1.

  And the 2nd liquid mixture stirred next contains the 1st reagent of "Ca" which is affected, and the 2nd liquid mixture stirred before this 2nd liquid mixture affects the 1st reagent of "Ca" Since it is the second mixed solution containing the first reagent of “GPT”, the reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W and adds the reaction container 3 stopped at the second cleaning position W2. A first cleaning liquid used for cleaning the second stirring bar 19 is supplied (step S8).

  In the (b + 6) th analysis cycle, the reaction disk 4 rotates and moves the reaction vessel 3 at the second cleaning position W2 to the second stirring position Pb1. And the 2nd stirring arm 21 wash | cleans the 2nd stirring element 19 using the 1st washing | cleaning liquid in the reaction container 3 stopped in the 2nd stirring position Pb1 (step S9). Subsequently, the washing tank 19a wash | cleans the 2nd stirring element 19 wash | cleaned with the 1st washing | cleaning liquid using washing water.

  In this way, after the second mixed liquid containing the first reagent having an influence is stirred, the second mixed liquid containing the first reagent affected by the first reagent is stirred using the cleaning liquid before the second mixed liquid is stirred. The child 19 can be washed. Thereby, it is possible to prevent the analysis data of the test item of the affected first reagent from being deteriorated, and to analyze the test sample with high accuracy.

  In the (b + 7) th analysis cycle, the reaction disk 4 rotates and moves the reaction vessel 3 at the second stirring position Pb1 to the third cleaning position W3. The second reagent dispensing probe 15 sucks the second reagent corresponding to the four tests from the reagent container 7 and discharges the sucked second reagent into the four-test reaction container 3 stopped at the second reagent discharge position Pb. . The 2nd stirring element 19 stirs the 2nd liquid mixture in the reaction container 3 of 3 tests stopped in the 2nd stirring position Pb1. The reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W.

  In the (b + 8) th analysis cycle, the reaction disk 4 stops at an angle θ. The second stirring bar 19 stirs the second mixed liquid in the 4-test reaction vessel 3 stopped at the second stirring position Pb1. The reaction container cleaning unit 12 cleans the reaction container 3 stopped at the cleaning position W.

  The photometric unit 13 outputs each test data generated by measuring the second mixed solution in the reaction container 3 of the n test (1 ≦ n ≦ 4) to the calculation unit 61 of the data processing unit 60. The calculation unit 61 generates analysis data from the test data output by the photometry unit 13 and outputs the analysis data to the output unit 70.

  When all the reaction vessels 3 used for the measurement are washed by the reaction vessel washing unit 12 and each analysis data is generated and output to the output unit 70, the system control unit 90, the analysis control unit 25, the data processing By causing the unit 60 and the output unit 70 to stop the test sample analysis operation, the automatic analyzer 100 ends the test sample analysis (step S10).

  According to the embodiment of the present invention described above, the reaction container 3 supplied with the cleaning liquid used for cleaning the reaction container 3 is moved to the stop position of each analysis target analysis unit, and the cleaning liquid in the moved reaction container 3 is used. Each analysis target analysis unit can be cleaned. Thereby, the operation | work which accommodates the sample container 17 which accommodates cleaning liquid in the disk sampler 5, and the operation | work which replenishes the sample liquid to the sample container 17 can be reduced. Moreover, the operation | work which accommodates the reagent containers 6 and 7 which accommodate a washing | cleaning liquid in the reagent storages 1 and 2, and the operation | work which replenishes the washing | cleaning liquid to the reagent containers 6 and 7 can be reduced.

  In addition, the sample container 17 that accommodates a large number of test samples can be accommodated in the disk sampler 5, and a large number of test samples can be measured simultaneously. In addition, the reagent containers 6 and 7 that store a large number of first reagents and second reagents can be stored in the reagent containers 1 and 2, and a large number of test items can be tested at the same time.

  Then, the sample dispensing probe 16 can be washed with a washing solution before dispensing the test sample in which the test item to be affected is set. Thereby, it is possible to prevent the analysis data of the affected test item from deteriorating and to analyze the test sample with high accuracy.

  In addition, after dispensing the affecting reagent, the first and second reagent dispensing probes 14 and 15 can be washed using a washing solution before dispensing the reagent affected by the reagent. Thereby, it is possible to prevent the analysis data of the test item of the affected reagent from deteriorating and to analyze the test sample with high accuracy.

  Further, after the mixed solution containing the affecting reagent is stirred, the first and second stirrers 18 and 19 are washed with the cleaning solution before the mixed solution containing the reagent affected by the reagent is stirred. Can do. Thereby, it is possible to prevent the analysis data of the test item of the affected reagent from deteriorating and to analyze the test sample with high accuracy.

  In addition, this invention is not limited to the said Example, The 1st supply pump which can supply the 1st washing | cleaning liquid connected to the 1st detergent bottle 47 and the pure water apparatus 110, and this 1st The first discharge nozzle connected to the supply pump and capable of discharging the first cleaning liquid, and the second supply capable of supplying the second cleaning liquid connected to the second detergent bottle 48 and the pure water device 110. A pump and a second discharge nozzle connected to the second supply pump and capable of discharging the second cleaning liquid are added, and the first and second discharge nozzles are disposed above the stop position of the reaction vessel 3. . Then, the reaction container 3 to be supplied with the cleaning liquid is rotationally moved to the positions of the first and second discharge nozzles, and the first and second cleaning liquids are supplied to the reaction container 3, respectively. It is also possible to carry out such that each of the cleaning object analysis units is cleaned by rotating and moving the reaction container 3 containing the above to the stop position of each of the cleaning object analysis units.

The block diagram which shows the structure of the automatic analyzer which concerns on the Example of this invention. The perspective view which shows the structure of the analysis part which concerns on the Example of this invention. The figure which shows the stop position of the reaction container which concerns on the Example of this invention. The figure which shows an example of the rotational movement of the reaction container which concerns on the Example of this invention. The figure which shows the structure of the reaction container washing | cleaning part which concerns on the Example of this invention. The figure which shows the structure of the 1st supply pump which concerns on the Example of this invention. The figure which shows the structure of the 2nd supply pump which concerns on the Example of this invention. The figure which shows an example of the influence item setting screen displayed on the display part which concerns on the Example of this invention. The figure which shows an example of the influence reagent setting screen displayed on the display part which concerns on the Example of this invention. The figure which shows an example of the test | inspection item setting screen displayed on the display part which concerns on the Example of this invention. The flowchart which shows operation | movement of the automatic analyzer which concerns on the Example of this invention.

Explanation of symbols

W cleaning position W1 first cleaning position W2 second cleaning position W3 third cleaning position W4 fourth cleaning position W5 fifth cleaning position 3 reaction vessel 4 reaction disk 12 reaction vessel cleaning unit 25 analysis control unit 26 mechanism unit 27 control unit 41 Cleaning nozzle unit 42 Cleaning pump unit 43 Cleaning water supply pump 44 First supply pump 45 Second supply pump 46 Drain pump unit 47 First detergent bottle 48 Second detergent bottle 49 First drain tank 50 Second Drainage tank 110 Pure water device 411 1st nozzle 412 2nd nozzle 413 3rd nozzle 414 4th nozzle 415 5th nozzle 461 1st drainage pump 462, 463 2 way valve 464 3rd branch pipe 465 Second drainage pump

Claims (6)

In an automatic analyzer that dispenses a test sample and a reagent corresponding to the test item of the test sample into a reaction container and measures the mixture,
Inspection item setting means for setting inspection items of the test sample;
A dispensing probe for performing dispensing for sucking and discharging the test sample or the reagent;
A reaction container cleaning means for supplying and discharging a cleaning liquid into the reaction container, and cleaning the reaction container in which the mixed liquid is stored;
Based on the inspection item set by the inspection item setting means, a reaction container that contains the cleaning liquid supplied by the reaction container cleaning means, and a dispensing position at which the dispensing probe can discharge the test sample or the reagent. And a dispensing probe cleaning means for cleaning the dispensing probe using the cleaning liquid in the reaction vessel.   A cleaning liquid tank is provided for cleaning the dispensing probe with a cleaning liquid having a weaker cleaning power than the cleaning liquid used for cleaning the reaction container every time when dispensing of the test sample or the reagent is completed. The automatic analyzer according to claim 1.   The dispensing probe cleaning means cleans the dispensing probe before dispensing a test sample including a test item affected by a preset setting among the test items set by the test item setting means. The automatic analyzer according to claim 1, wherein   The dispensing probe cleaning means is influenced by the influential reagent after the dispensing of the reagent having a preset influence among the reagents of the inspection item set by the inspection item setting means. 2. The automatic analyzer according to claim 1, wherein the dispensing probe is washed before the reagent is dispensed. In an automatic analyzer that dispenses a test sample and a reagent corresponding to the test item of the test sample into a reaction container and measures the mixture,
Inspection item setting means for setting inspection items of the test sample;
A stirrer for stirring the mixed solution in the reaction vessel;
A reaction container cleaning means for supplying and discharging a cleaning liquid into the reaction container, and cleaning the reaction container in which the mixed liquid is stored;
Based on the inspection item set by the inspection item setting means, the reaction container containing the cleaning liquid supplied by the reaction container cleaning means is moved to a stirring position where the stirring bar can be stirred, An automatic analyzer comprising: a stir bar cleaning means for cleaning the stir bar using a cleaning liquid.   6. The cleaning liquid used for cleaning the reaction vessel is at least one of an alkaline cleaning liquid, an acidic cleaning liquid, or a cleaning liquid containing a surfactant, according to any one of claims 1 to 5. The automatic analyzer described.

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