JP5134452B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer for analyzing components contained in a liquid, and more particularly to an automatic analyzer having a cleaning function.

  The automatic analyzer targets biochemical test items, immunological test items, etc., and changes the color tone and turbidity caused by the reaction between the test sample collected from the sample and the reagent corresponding to the test item of the test sample. Optical data is measured using a photoanalyzer such as a photometer or a turbidimetric meter, thereby generating analytical data such as the component concentration and enzyme activity of each test item contained in the test sample.

  In this automatic analyzer, analysis of a test sample in which an inspection item to be inspected is set from among a large number of inspection items is performed. Then, the test sample is dispensed from the sample container to the reaction container using a sample dispensing probe. In addition, the reagent is dispensed from the reagent container to the reaction container using a reagent dispensing probe. Further, the test sample and reagent mixture dispensed into the reaction vessel are stirred using a stirrer and then measured using an optical analyzer.

  Each analysis unit of the sample dispensing probe, the reagent dispensing probe, and the stirrer is used each time the dispensing of the test sample, the dispensing of the reagent, and the stirring of the mixed solution are completed using the wash water. Washed. In addition, the reaction container is cleaned by the cleaning unit at the end of the measurement of the mixed solution using the cleaning water and the cleaning liquid having a stronger cleaning power than the cleaning water.

However, in an automatic analyzer that measures a large number of test samples over many items, a substance contained in the test sample or reagent that cannot be removed only by washing at the end of the measurement of the mixed solution during measurement, or a test sample The substance produced by the reaction between the reagent and the reagent accumulates in the reaction vessel, and there is a problem that the analysis data deteriorates. In order to avoid this problem, an automatic analyzer is known that can supply a cleaning solution to a reaction vessel after completion of measurement and perform cleaning for a longer time than cleaning at each end of measurement (for example, Patent Document 1). reference.).
JP 2001-289864 A

  However, when the reaction vessel is washed after the measurement is completed by an automatic analyzer having a plurality of reaction vessels, all the reaction vessels are washed with the washing solution, which requires a large amount of washing solution.

  The present invention has been made to solve the above-described problems, and an object of the present invention is to provide an automatic analyzer capable of reducing the consumption of cleaning liquid.

In order to achieve the above object, the automatic analyzer of the present invention comprises an analysis means for dispensing a test sample and a reagent corresponding to the inspection item of the test sample into a reaction container and measuring the mixed solution. In the automatic analyzer, inspection information storage means for storing inspection information including the container ID of the reaction container used for measurement by the analysis means, and search information included in the inspection information stored in the inspection information storage means Search information setting means for setting, search means for searching for test information having search information set by the search information setting means for the test information stored in the test information storage means, and the test searched by the search means the reaction vessel corresponding to vessel ID included in the information, characterized in that and a first cleaning means for cleaning with a cleaning liquid at other measurement by the analysis means

  According to the present invention, at the time of cleaning other than measurement, the consumption of the cleaning liquid can be reduced by determining the reaction container to be cleaned using the cleaning liquid based on preset search information.

  Hereinafter, an embodiment of an automatic analyzer according to the present invention will be described with reference to FIGS.

  FIG. 1 is a block diagram showing a configuration of an automatic analyzer according to an embodiment of the present invention. The automatic analyzer 100 generates standard data and test data by measuring each sample such as a standard sample of each test item or a test sample collected from a test sample and a mixed solution of reagents corresponding to each test item. The analysis unit 24, the analysis control unit 25 that controls each analysis unit related to the measurement of the analysis unit 24, and the standard data and test data generated by the analysis unit 24 are processed to generate calibration data and analysis data And a data processing unit 30.

  Also, a search unit 40 that determines a unit to be cleaned using a cleaning liquid at a time other than measurement by the analysis unit 24, an output unit 70 that outputs calibration data and analysis data generated by the data processing unit 30, and An operation unit 80 for inputting identification information for identifying each sample and inspection information including inspection items of the sample, and a system control unit 90 for controlling the above-described units in an integrated manner are provided.

  FIG. 2 is a perspective view showing the configuration of the analysis unit 24. The analysis unit 24 is connected to the pure water device 110, and includes a sample container 17 that stores each sample such as a standard sample and a test sample, a disk sampler 5 that stores the sample container 17, and a sample that is stored in the disk sampler 5. A reader 17a that reads identification information for identifying each sample in the sample container 17 affixed to the container 17, and a reagent container in which a first reagent that selectively reacts with a component of each inspection item included in each sample is stored. 6, a reagent container 1 having a reagent rack 1 a for holding the reagent container 6, a reagent container 7 containing a second reagent paired with a first reagent of a test item constituted by a two-reagent system, A reagent storage 2 having a reagent rack 2a for holding a reagent container 7 and a reaction disk 4 for rotatably holding a plurality of reaction containers 3 arranged on the circumference are provided.

  Further, the dispensing information in which the identification information read by the reader 17a matches or is included in the preset identification information is sucked into the sample dispensing probe 16 and discharged into the reaction container 3. A sample dispensing pump 16b, a washing tank 16a for washing the sample dispensing probe 16 with washing water such as pure water purified by the pure water device 110 at the end of dispensing of each sample, In order to perform dispensing, a sample dispensing arm 10 that holds the sample dispensing probe 16 so as to be rotatable and vertically movable is provided.

  In addition, the first reagent in the reagent container 6 stored in the reagent storage 1 is aspirated into the first reagent dispensing probe 14 and dispensed to be discharged into the reaction container 3 into which each sample has been dispensed. In order to perform the dispensing of the first reagent, the reagent dispensing pump 14b, the washing tank 14a for washing the first reagent dispensing probe 14 with the washing water of the pure water device 110 each time the dispensing of the first reagent is completed. And a first reagent dispensing arm 8 that holds the first reagent dispensing probe 14 so as to be rotatable and vertically movable.

  Moreover, the 1st stirring bar 18 for stirring the 1st liquid mixture which consists of each sample and the 1st reagent dispensed in the reaction container 3, and the 1st stirring bar 18 for every completion | finish of stirring of a 1st liquid mixture are provided. A cleaning tank 18a for cleaning using the cleaning water of the pure water apparatus 110 and a first stirring arm 20 for holding the first stirring bar 18 so as to be rotatable and vertically movable are provided.

  In addition, the second reagent in the reagent container 7 stored in the reagent storage 2 is sucked into the second reagent dispensing probe 15 and discharged into the reaction container 3 into which each sample and the first reagent are dispensed. The second reagent dispensing pump 15b for performing the cleaning, the washing tank 15a for washing the second reagent dispensing probe 15 with the washing water of the pure water device 110 every time the dispensing of the second reagent is completed, and the dispensing of the second reagent. A second reagent dispensing arm 9 is provided for holding the second reagent dispensing probe 15 so as to be pivotable and vertically movable in order to perform the injection.

  In addition, a second stirrer 19 for stirring the second mixed liquid composed of each sample, the first reagent, and the second reagent dispensed in the reaction vessel 3 and a second stirrer each time the second mixed liquid is stirred. The cleaning tank 19a which wash | cleans the 2 stirring element 19 using the washing water of the pure water apparatus 110, and the 2nd stirring arm 21 which hold | maintains the 2nd stirring element 19 so that rotation and an up-down movement are possible are provided.

  In addition, after the photometric unit 13 for optically measuring the first mixed liquid and the second mixed liquid in the reaction container 3 and the first mixed liquid and the second mixed liquid after the measurement in the reaction container 3 are sucked, A cleaning unit 12 that cleans the inside of the reaction vessel 3 using a cleaning liquid in a tank and a cleaning water in the pure water device 110 disposed in the analysis unit 24 having a stronger cleaning power than the cleaning water is provided. As the cleaning liquid, for example, an acidic cleaning liquid, an alkaline cleaning liquid, a cleaning liquid containing a surfactant, or the like is used.

  And the photometry unit 13 irradiates light to the 1st liquid mixture and 2nd liquid mixture containing the standard sample in the reaction container 3 which rotates, and detects the wavelength light of each inspection item which permeate | transmitted each liquid mixture. To generate standard data. In addition, the first mixed liquid and the second mixed liquid including the test sample in the reaction container 3 are irradiated with light, and the wavelength light of each inspection item transmitted through the mixed liquid is detected to generate test data. . Then, the generated standard data and test data are output to the data processing unit 30. Moreover, the reaction container 3 after the measurement is washed and then used again for the measurement.

  The analysis control unit 25 includes a mechanism unit 26 that drives each analysis unit of the analysis unit 24 and a control unit 27 that controls the mechanism unit 26 to activate each analysis unit of the analysis unit 24. The mechanism 26 includes a mechanism for rotating the disk sampler 5 of the analyzer 24, the reagent rack 1a of the reagent storage 1, and the reagent rack 2a of the reagent storage 2, a mechanism for rotating the reaction disk 4, and a sample dispensing arm. 10, a mechanism for rotating and vertically moving the first reagent dispensing arm 8, the second reagent dispensing arm 9, the first stirring arm 20, and the second stirring arm 21 is provided. The sample dispensing pump 16b, the first reagent dispensing pump 14b, and the second reagent dispensing pump 15b are each provided with a mechanism for driving suction and discharge, a mechanism for driving the cleaning unit 12, and the like.

  The control unit 27 includes a control circuit that controls each mechanism of the mechanism unit 26, controls each mechanism of the mechanism unit 26, and causes the analysis unit 24 to perform a measurement operation of each sample. In addition, the system control unit sets the time (dispensing time) when each sample is dispensed from the sample container 17 to the reaction container 3, and identification information for identifying the reaction container 3 used for measuring each sample, for example, the container ID. Output to 90. Further, the analyzer 24 is caused to perform an operation in the non-measurement cleaning that cleans each analysis unit before the measurement is started or after the measurement is completed.

  The data processing unit 30 in FIG. 1 is generated by a calculation unit 31 that generates calibration data and analysis data of each inspection item from the standard data and test data output from the photometry unit 13 of the analysis unit 24, and the calculation unit 31. And an inspection information storage unit 32 for storing calibration data and analysis data.

  The calculation unit 31 generates calibration data representing the relationship between the standard data output from the photometry unit 13 and the standard values of the standard samples set in advance, and the relationship between the concentration and activity value of each test item and the standard data. The calibration data is output to the examination information storage unit 32 and the output unit 70.

  In addition, the calibration data of the inspection item corresponding to the test data output from the photometry unit 13 is read from the inspection information storage unit 32. Next, using the read calibration data, analysis data expressed as a concentration or activity value is generated from the test data, and information on the inspection item is added to the generated analysis data. In addition, when the analysis data is out of a reference range that is a pre-set health diagnosis range, an abnormal data flag is added to the generated analysis data. Furthermore, a measurement abnormality flag is added to the generated analysis data when the analysis data is out of the range (measurement range) that can be analyzed by the automatic analyzer 100 set in advance. Furthermore, the dispensing time and container ID supplied from the system control unit 90 are added to the generated analysis data.

  Then, the analysis data to which the inspection information such as the abnormality data flag, the measurement abnormality flag, the analysis time, and the container ID is added is output to the inspection information storage unit 32 and the output unit 70.

  The examination information storage unit 32 includes a hard disk and stores calibration data output from the calculation unit 31. Further, the analysis data to which the examination information output from the calculation unit 31 is added is stored.

  The search unit 40 searches for test information having search information set in advance from the test information stored in the test information storage unit 32 of the data processing unit 30. And the cleaning object which wash | cleans the reaction container 3 identified by container ID contained in the searched test | inspection information using washing | cleaning liquids, such as an acidic washing liquid, an alkaline washing | cleaning liquid, and a washing | cleaning liquid containing surfactant, at the time of cleaning outside measurement The reaction container 3 is determined.

  The output unit 70 includes a printing unit 71 that prints out the calibration data output from the calculation unit 31 of the data processing unit 30 and the analysis data to which the inspection information is added, and a display unit 72 that displays the output. The printing unit 71 includes a printer or the like, and prints the calibration data output from the calculation unit 31 and the analysis data to which the inspection information is added on a printer sheet or the like according to a preset format.

  The display unit 72 includes a monitor such as a CRT or a liquid crystal panel, and displays the analytical data output from the calculation unit 31 and the analysis data added with the inspection information. Also, an analysis condition setting screen for setting analysis conditions including a reference range and a measurement range of inspection items that can be inspected by the automatic analyzer 100, search information to be searched by the search unit 40 (first to third search information) First to third search information setting screens for setting the identification information, an identification information setting screen for setting identification information of each sample to be measured, an inspection item setting screen for setting inspection items of the test sample, Displays a cleaning condition setting screen for setting cleaning conditions for non-measurement cleaning.

  The operation unit 80 includes an input device such as a keyboard, a mouse, a button, and a touch key panel, and sets inspection conditions for each inspection item, inspection information such as search information, identification information for each sample, and information on inspection items. Perform input operations to make settings.

  The system control unit 90 includes a CPU and a storage circuit 91, and stores input information such as command signals, analysis conditions, search information, identification information, and inspection item information input from the operation unit 80 in the storage circuit 91. Based on the input information, the analysis control unit 25, the data processing unit 30, the search unit 40, and the output unit 70 are controlled in an integrated manner.

  Next, referring to FIG. 1 to FIG. 7, the non-measurement cleaning performed in the analysis unit 24 will be described. FIG. 3 is a diagram illustrating an example of the configuration of the inspection information stored in the inspection information storage unit 32. FIG. 4 is a diagram illustrating an example of a first search information setting screen displayed on the display unit 72. FIG. 5 is a diagram illustrating an example of a second search information setting screen displayed on the display unit 72. FIG. 6 is a diagram illustrating an example of a third search information setting screen displayed on the display unit 72. FIG. 7 is a diagram showing a cleaning condition setting screen displayed on the display unit 72.

  In FIG. 3, analysis data and inspection information A1 to AK are stored in the inspection information storage unit 32 in time series. The analysis data and the inspection information A1 include the dispensing time a10a, the sample identification information a10b, the container IDa10c of the reaction container 3 into which the sample of the identification information a10b has been dispensed, the inspection item information a10d, the analysis data a10e, the abnormality It is composed of data flag presence / absence information a10f, measurement abnormality flag presence / absence information a10g, and the like.

  The analysis data and the inspection information A2 are the dispensing time a20a, the same identification information a10b as the analysis data and the inspection information A1, the container ID a20c, the inspection item information a20d, the analysis data a20e, the presence / absence information flag a20f, and the measurement abnormality. It consists of information a20g on the presence or absence of a flag.

  Each analysis data and inspection information A3 to A5 includes the dispensing times a30a to a50a, the same identification information a10b as the inspection information A1, each container IDa30c to a50c, each inspection item information a30d to a50d, each analysis data a30e to a50e, It includes information a30f to a50f on the presence / absence of each abnormality data flag, information a30g to a50g on the presence / absence of each measurement abnormality flag, and the like.

  The analysis data and the inspection information AK include dispensing time aK0a, identification information aK0b different from the inspection information A1, container IDaK0c, inspection item information aK0d, analysis data aK0e, presence / absence information aK0f, and measurement abnormality flag. It consists of presence / absence information aK0g.

  6 is a diagram showing an example of a first search information setting screen displayed on a display unit 72. FIG. The first search information setting screen 73 is an “item” for setting a maximum of n types of inspection items as the first search information from the items that can be inspected set on the analysis condition setting screen of the display unit 72. It consists of the columns of Then, the first search information set in the “item” column by the input operation from the operation unit 80 is stored in the storage circuit 91 of the system control unit 90.

  In the “Item” column, the first reagent or the second reagent remains in the reaction container 3 only by the cleaning during the measurement by the cleaning unit 12 of the analysis unit 24, and affects the analysis of other inspection items. A test item corresponding to a possible reagent is set as first search information. When an operation for selecting and inputting an inspection item that may affect the analysis of other inspection items is performed from the operation unit 80, the inspection item may have an influence on the dialog box 731. For example, “item A” is displayed. Further, for example, the dialog boxes 732 to 73n where no inspection item is input are blank.

  Here, when “item A” is set as the first search information, the search unit 40 is information on the inspection item from the inspection information stored in the inspection information storage unit 32 of the data processing unit 30. Search for examination information having “item A”. Next, the reaction container 3 identified by the container ID included in the searched examination information is determined as the reaction container to be cleaned.

  FIG. 5 is a diagram illustrating an example of a second search information setting screen displayed on the display unit 72. The second search information setting screen 74 includes a “measurement range” column, a “reference range” column, and a “data” column for setting the second search information. Then, the second search information set in each column by the input operation from the operation unit 80 is stored in the storage circuit 91 of the system control unit 90.

  When an input operation for setting a measurement abnormality flag as second search information is performed in the “measurement range” column from the operation unit 80, “re” is displayed in the dialog box 741. When the measurement abnormality flag is not set as the second search information, the dialog box 741 is blank.

  Here, when the measurement abnormality flag is set as the second search information, the search unit 40 searches the examination information having the measurement abnormality flag from the examination information stored in the examination information storage unit 32. Next, the reaction container 3 identified by the container ID included in the searched examination information is determined as the reaction container to be cleaned.

  When an input operation for setting an abnormal data flag as second search information is performed from the operation unit 80 in the “reference range” field, “Re” is displayed in the dialog box 742. If the abnormal data flag is not set as the second search information, the dialog box 742 is blank. Since the reference range is included in the measurement range, if the measurement abnormality flag is set as the second search information in the “measurement range” column, the abnormality data flag is also set as the second search information, and a dialog box is displayed. “Re” is displayed in 742.

  Here, when the measurement abnormality flag is set as the second search information, the search unit 40 searches the examination information having the measurement abnormality flag from the examination information stored in the examination information storage unit 32. Next, the reaction container 3 identified by the container ID included in the searched examination information is determined as the reaction container to be cleaned.

  The “data” column is composed of “1” to “p” columns and “identification information”, “item”, and “time” columns corresponding to the “1” to “p” columns. The An input operation for setting identification information of a test sample corresponding to, for example, analysis data that may be deteriorated due to factors including the reaction container 3 in the “identification information” field corresponding to the “1” field. Is performed, the input identification information is displayed in the dialog box 741a. In addition, when an operation for selecting and inputting in order to set an inspection item of analysis data that may be deteriorated due to a factor including the reaction vessel 3 in the “item” column, the inspection input in the dialog box 741b is performed. The item is displayed. Furthermore, in the “Time” column, the dispensing time when the test sample of the identification information set in the “Identification Information” column is dispensed to analyze the inspection item set in the “Item” column is set. When the input operation is performed, the dispensing time input in the dialog box 741c is displayed.

  In addition, in the “identification information”, “item”, and “time” columns corresponding to the columns “2” to “p”, the factors including the reaction container 3 are the same as in the column “1”. When the input operation for setting the identification information, the inspection item, and the dispensing time corresponding to the different analysis data that may have been deteriorated by the above is performed, the identification information input in each of the dialog boxes 742a to 74pa is Is displayed. In addition, the inspection items input in the dialog boxes 742b to 74pb are displayed. Further, the dispensing time input in each of the dialog boxes 742c to 74pc is displayed.

  Here, as the second search information, the identification information, inspection item information, and dispensing time in the “identification information”, “item”, and “time” columns corresponding to the columns “1” to “p”, respectively. Is set, the search unit 40 searches the test information stored in the test information storage unit 32 for test information having the set identification information, test item information, and dispensing time. Next, the reaction container 3 identified by the container ID included in the searched examination information is determined as the reaction container to be cleaned.

  FIG. 6 is a diagram illustrating an example of a third search information setting screen displayed on the display unit 72. The third search information setting screen 75 includes a “sample type” field for setting the sample of the identification information set on the identification information setting screen of the display unit 72 as the third search information. The third search information set in the “sample type” field by the input operation from the operation unit 80 is stored in the storage circuit 91 of the system control unit 90.

  In the column of “Sample Type”, “serum before dialysis”, which is serum obtained by processing blood collected from a specimen before dialysis in which the test sample is regularly dialyzed, Various types of samples such as “urine”, which is urine collected from a subject as a test sample, and “erythrocyte component”, which is a red blood cell component extracted from the blood of the subject, are displayed. Of the samples displayed in this column, samples that may remain in the reaction container 3 and have an influence on the analysis of each inspection item only by cleaning during measurement by the cleaning unit 12 of the analysis unit 24. Set as third search information.

  Then, when an input operation for setting from among the samples displayed in the “sample type” column is performed from the operation unit 80, “Re” is displayed in the dialog box corresponding to the sample and is not set. The sample dialog box is blank. For example, if an input operation for setting “serum before dialysis” is performed, “re” is displayed in the dialog box 751, and if not set, the dialog box 751 is blank. If an input operation for setting “urine” is performed, “re” is displayed in the dialog box 752, and if not set, the dialog box 752 is blank. Further, when an input operation for setting “red blood cell component” is performed, “re” is displayed in the dialog box 753, and if not set, the dialog box 753 becomes blank.

  Here, identification information can be set on the identification information setting screen of the display unit 72 so that each sample displayed in the “sample type” column can be identified. When a sample is set as the third search information, the search unit 40 searches the test information stored in the test information storage unit 32 for test information having the set sample identification information. Next, the reaction container 3 identified by the container ID included in the searched examination information is determined as the reaction container to be cleaned.

  FIG. 7 is a diagram showing an example of the cleaning condition setting screen displayed on the display unit 72. The cleaning condition setting screen 76 includes a column of “reaction container” for setting whether or not the reaction container 3 is cleaned using the cleaning liquid, and whether or not the sample dispensing probe 16 is cleaned using the cleaning liquid. A column for “sample dispensing probe” for setting, and a column for “reagent dispensing probe” for setting whether or not to wash the first and second reagent dispensing probes 14 and 15 using the washing liquid. And a column of “stirring bar” for setting whether or not the first and second stirring bars 18 and 19 are cleaned using the cleaning liquid. Then, information on the cleaning conditions set in each column by the input operation from the operation unit 80 is stored in the storage circuit 91 of the system control unit 90.

  In the “reaction vessel” column, “first search”, “second search”, and “third search” columns are displayed. In the “first search” field, the reaction container 3 to be cleaned using the cleaning liquid is determined based on the first search information set on the first search information setting screen 73 of FIG. When an input operation for setting this is performed, “re” is displayed in the dialog box 761, and in the case where setting based on the first search information is not set, the dialog box 761 is blank.

  Further, in the “second search” column, the reaction container 3 to be cleaned using the cleaning liquid is determined based on the second search information set on the second search information setting screen 74 of FIG. When an input operation for setting this is performed, “re” is displayed in the dialog box 762, and the dialog box 762 is blank when not determined to be determined based on the second search information.

  Further, in the “third search” column, the reaction container 3 to be cleaned using the cleaning liquid is determined based on the third search information set on the third search information setting screen 75 of FIG. When an input operation for setting this is performed, “Re” is displayed in the dialog box 763, and in the case where setting based on the third search information is not set, the dialog box 763 is blank.

  Then, the reaction container 3 to be cleaned is determined based on all the search information set in the “first search”, “second search”, and “third search” fields. Further, when the search information is not set in all the columns, the reaction container 3 is cleaned by the cleaning unit 12 by the same operation as during measurement.

  When an input operation for setting the sample dispensing probe 16 to be cleaned using the cleaning liquid is performed in the “sample dispensing probe” column, “Re” is displayed in the dialog box 764. Further, when an input operation for setting the sample dispensing probe 16 to be cleaned using the cleaning water in the cleaning tank 16a is performed, the dialog box 764 becomes blank.

  When an input operation for setting the cleaning of the first and second reagent dispensing probes 14 and 15 using the cleaning liquid is performed in the “reagent dispensing probe” column, “Re” is displayed in the dialog box 765. Is displayed. In addition, when an input operation is performed for setting the first and second reagent dispensing probes 14 and 15 to be cleaned using the cleaning water in the cleaning tanks 14a and 15a, the dialog box 765 becomes blank.

  When an input operation for setting the first and second stirring bars 18 and 19 to be cleaned using the cleaning liquid is performed in the “stirring bar” column, “L” is displayed in the dialog box 766. Further, when an input operation for setting the first and second stirrers 18 and 19 to be cleaned using the cleaning water in the cleaning tanks 18a and 19a is performed, the dialog box 766 is blanked.

  In addition, the interval of the non-measurement cleaning using the cleaning liquid of the reaction container 3 is determined according to the number of test samples and inspection items to be processed in the facility where the automatic analyzer 100 is used. In addition, the non-measurement cleaning using the cleaning liquid of each analysis unit other than the reaction vessel 3 is performed after the measurement of each sample for one day. Furthermore, in the non-measurement washing before measurement of each sample for one day, the reaction vessel 3 is washed with the washing unit 12, and each analysis unit other than the reaction vessel 3 is washed with washing water in each washing tank.

  Thus, by setting each of the first to third search information, the reaction container 3 to be cleaned using the cleaning liquid can be determined based on the set search information. In addition, the reaction container 3, the sample dispensing probe 16, the first and second reagent dispensing probes 14, 15 and the first and second stirrers 18, 19 are set to cleaning conditions for cleaning with the cleaning liquid. Therefore, it is possible to perform washing more strongly than washing during measurement or washing using washing water.

Hereinafter, an example of the operation outside the measurement in the automatic analyzer 100 will be described with reference to FIGS. 1 to 8.
FIG. 8 is a flowchart showing the operation of non-measurement cleaning in the automatic analyzer 100. In the storage circuit 91 of the system control unit 90, the first search information set on the first search information setting screen 73 in FIG. 4 and the second search information set on the second search information setting screen 74 in FIG. The search information, the third search information set on the third search information setting screen 75 in FIG. 6, and the information on the cleaning conditions for cleaning using the cleaning liquid set on the cleaning condition setting screen 76 in FIG. ing. In addition, a large number of analysis data and inspection information are stored in the inspection information storage unit 32 of the data processing unit 30.

  After the measurement of each sample is completed, the sample container 17 containing the cleaning liquid is stored in the disk sampler 5, and the reagent containers 6 and 7 containing the cleaning liquid are stored in the reagent containers 1 and 2, and then measured from the operation unit 80. When the external cleaning operation is performed, the automatic analyzer 100 starts an operation other than measurement cleaning (step S1).

  The system control unit 90 instructs the analysis control unit 25, the data processing unit 30, and the search unit 40 to perform non-measurement cleaning using a cleaning liquid. The control unit 27 of the analysis control unit 25 controls the mechanism unit 26 to operate each analysis unit of the analysis unit 24.

  The sample dispensing pump 16b sucks the cleaning liquid in the sample container 17 accommodated in the disk sampler 5 into the sample dispensing probe 16, and then discharges the sucked cleaning liquid into the cleaning tank 16a. Is cleaned (step S2).

  After the first and second reagent dispensing pumps 14b and 15b suck the cleaning liquid in the reagent containers 6 and 7 stored in the reagent containers 1 and 2 into the first and second reagent dispensing probes 14 and 15, The aspirated cleaning liquid is discharged into the cleaning tanks 14a and 15a, and the first and second reagent dispensing probes 14 and 15 are cleaned (step S3).

  The first reagent dispensing pump 14b sucks the cleaning liquid in the reagent container 6 into the first reagent dispensing probe 14, and then dispenses the sucked cleaning liquid into the two reaction containers 3. The reaction disk 4 moves the reaction vessel 3 into which the cleaning liquid has been dispensed below the first and second stirrers 18 and 19. The first and second stirrers 20 and 21 move the first and second stirrers 18 and 19 into the reaction vessel 3 containing the cleaning liquid to clean the first and second stirrers 18 and 19. (Step S4).

  The search unit 40 has inspection information having time information from when the previous non-measurement cleaning operation is performed to the current non-measurement cleaning operation from among the inspection information stored in the inspection information storage unit 32. Search for. Next, the inspection information having the first to third search information supplied from the system control unit 90 is searched from the searched inspection information. Then, the reaction container 3 identified by the container ID included in the searched inspection information is determined as the reaction container 3 to be cleaned, and the container ID is output to the control unit 27 (step S5).

  In this way, by determining the reaction containers 3 to be cleaned based on the set first to third search information, all the reaction containers 3 are cleaned using a cleaning liquid equal to or less than the amount used for cleaning. be able to.

  The control unit 27 controls the mechanism unit 26 to operate each analysis unit in order to clean the reaction container 3 with the container ID output from the search unit 40.

  The first and second reagent dispensing pumps 14b and 15b suck the cleaning liquid in the reagent containers 6 and 7 into the first and second reagent dispensing probes 14 and 15, and then the suctioned cleaning liquid is a reaction container to be cleaned. Then, the reaction vessel 3 to be cleaned is cleaned. And after the time longer than the time which the washing | cleaning unit 12 wash | cleans each reaction container 3 during measurement, the washing | cleaning unit 12 wash | cleans the reaction container 3 which accommodated the washing | cleaning liquid.

  As described above, the cleaning unit 12 is longer than the time for cleaning the reaction container 3 during measurement, and the cleaning liquid is put in the reaction container 3 to be cleaned, so that the cleaning unit 12 performs the measurement during the measurement. Can also be cleaned strongly. In addition, by cleaning only the reaction vessel 3 to be cleaned, the time required for cleaning can be shortened.

  When the cleaning unit 12 finishes cleaning the reaction container, the system control unit 90 instructs the analysis control unit 25 and the data processing unit 30 to stop the non-measurement cleaning operation. The cleaning operation is terminated (step S7).

  In addition, you may implement so that cleaning outside a measurement may be complete | finished in the state which put the washing | cleaning liquid in the reaction container 3 to be cleaned. In this case, the cleaning liquid is discharged from the reaction container 3 to be cleaned at the time of the non-measurement cleaning performed after the non-measurement cleaning operation, for example, by setting the cleaning conditions before the measurement of each sample on the next day. It will be. Thus, the reaction vessel 3 can be more strongly washed by ending off-measurement washing with the washing solution in the reaction vessel 3. In addition, the time required for cleaning can be further shortened.

  According to the embodiment of the present invention described above, the information of the inspection item can be set as the first search information. Further, the measurement abnormality flag, the abnormality data flag, the sample identification information, the inspection item information, and the dispensing time can be set as the second search information. Furthermore, sample identification information can be set as third search information. Then, based on the set first to third search information, it is possible to determine the reaction vessel 3 to be cleaned that is cleaned using the cleaning liquid at the time of cleaning outside the measurement.

  Then, when washing outside the measurement, the washing liquid is put in the reaction vessel 3 to be washed for a longer time than the washing unit 12 is washing the reaction vessel 3 during the measurement, thereby the reaction vessel to be washed. 3 can be washed more strongly than the washing performed by the washing unit 12 during the measurement.

  Thereby, it becomes possible to wash | clean using the washing | cleaning liquid below the quantity used when wash | cleaning all the reaction containers 3, and can reduce the consumption of a washing | cleaning liquid. Further, by cleaning the reaction vessel 3 to be cleaned, the time required for cleaning can be shortened, and the cleaning can be performed efficiently.

The block diagram which shows the structure of the automatic analyzer which concerns on the Example of this invention. The perspective view which shows the structure of the analysis part which concerns on the Example of this invention. The figure which shows an example of a structure of the test | inspection information preserve | saved at the test | inspection information memory | storage part which concerns on the Example of this invention. The figure which shows an example of the 1st search information setting screen displayed on the display part which concerns on the Example of this invention. The figure which shows an example of the 2nd search information setting screen displayed on the display part which concerns on the Example of this invention. The figure which shows an example of the 3rd search information setting screen displayed on the display part which concerns on the Example of this invention. The figure which shows an example of the washing | cleaning condition setting screen displayed on the display part which concerns on the Example of this invention. The flowchart which shows the operation | movement of the non-measurement washing | cleaning in the automatic analyzer which concerns on the Example of this invention.

Explanation of symbols

24 analysis unit 25 analysis control unit 26 mechanism unit 27 control unit 30 data processing unit 31 calculation unit 32 inspection information storage unit 40 search unit 70 output unit 71 printing unit 72 display unit 80 operation unit 90 system control unit 91 storage circuit 100 automatic analysis Equipment 110 Pure water equipment

Claims (6)

In an automatic analyzer equipped with an analysis means for dispensing a test sample and a reagent corresponding to the test item of the test sample into a reaction container and measuring the mixed solution,
Inspection information storage means for storing inspection information including the container ID of the reaction container used for measurement by the analysis means;
Search information setting means for setting search information included in the inspection information stored in the inspection information storage means;
Search means for searching for test information having search information set by the search information setting means for the test information stored in the test information storage means ;
A first cleaning means for cleaning the reaction container corresponding to the container ID included in the inspection information searched by the search means using a cleaning liquid at a time other than the measurement by the analysis means ;
An automatic analyzer characterized by comprising:   2. The automatic analyzer according to claim 1, wherein the search information set by the search information setting means is information on the inspection item.   2. The search information set by the search information setting means is a flag added when analysis data generated by measurement by the analysis means is out of a preset range. Automatic analyzer described in 1. 2. The automatic analyzer according to claim 1, wherein the search information set by the search information setting means is a container ID of the test sample. A second cleaning means for cleaning the reaction vessel at the time of measurement by the analysis means;
The first cleaning unit supplies the cleaning liquid into the reaction container corresponding to the container ID included in the inspection information having the search information set by the search information setting unit, and then the second cleaning unit performs cleaning. 2. The automatic analyzer according to claim 1, wherein the cleaning operation is terminated by discharging the cleaning liquid in the reaction container after a time longer than the time for performing the cleaning. The first cleaning means supplies the cleaning liquid into the reaction container corresponding to the container ID included in the inspection information having the search information set by the search information setting means, and finishes the cleaning operation. The automatic analyzer according to claim 1.

Images