JP2007315949A - Automatic analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an automatic analyzer for preventing a previous sample from being carried to a next measurement through analysis units, and implementing an accurate measurement. <P>SOLUTION: The automatic analyzer includes: a sample dispensing probe 16 for dispensing the sample; first and second reagent dispensing probes 14, 15 for dispensing first and second reagents; cleaning sections 80, 90, 100, 110, 120 for cleaning first and second stirring elements 11a1, 11b1 for stirring first and second mixed liquids; and a cleaning unit controlling section 32b for controlling the cleaning sections. The cleaning unit controlling section 32b deactivates the analysis units 16, 14, 15, 11a1, 11b1 based on measurement data from measurement sections 81d, 82c, 91d, 92c, 101d, 102c, 111d, 121d provided in the cleaning sections. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an automatic analyzer that analyzes components contained in a liquid, and more particularly to an automatic analyzer that analyzes components contained in body fluids such as human serum and urine.

  As an automatic analyzer, a change in color caused by the reaction of a mixed solution in which a test sample and a reagent are dispensed and mixed in a reaction container is measured by an absorbance method for measuring the amount of light transmitted, and the protein in the test sample is measured. -Devices that measure the concentration and activity of biochemical test item components such as nitrogen components, enzymes, and lipids are known.

  Also known is a device that measures the concentration of immunological test items such as tumor markers and virus markers by a chemiluminescence method that measures the intensity of light emitted by the reaction between a test sample and a reagent labeled with, for example, a chemiluminescent substance. It has been. Furthermore, recently, a combined type apparatus that measures a number of items by combining a first analysis unit that measures biochemical test items and the like by an absorbance method and a second analysis unit that measures immunological test items and the like. Is known (for example, see Patent Document 1).

  In these automatic analyzers, an item (measurement item) selected in accordance with an inspection is measured from among a large number of items that can be measured by setting analysis conditions for each test sample. The test sample is dispensed from the sample container to the reaction container using the sample dispensing probe, and the reagent corresponding to the measurement item is dispensed from the reagent bottle to the reaction container using the reagent dispensing probe. Next, after the mixed solution of the test sample and the reagent dispensed into the reaction container using the stir bar is stirred, the mixed solution is measured by the photometric unit to generate analysis data.

  When the test sample is measured by the first and second analysis units of the composite apparatus, the sample container containing the test sample is transported to one analysis unit, and the sample container is transferred from the sample container to the one analysis unit. A test sample is dispensed. After dispensing, the sample container is transported to the other analysis unit, and the test sample is dispensed from the sample container into the other analysis unit. After the measurement is completed, the measurement sample such as the sample to be tested, reagent, mixed solution, etc. attached to each analysis unit such as sample dispensing probe, reagent dispensing probe, and stirring bar is brought into the next measurement sample. In order to prevent the analysis data of the measurement sample from deteriorating, each analysis unit is cleaned in each cleaning tank.

  The sample dispensing probe is washed after the end of dispensing the same test sample to prevent the previously sampled test sample from being brought into the sample container containing the test sample to be dispensed next. . In addition, the reagent dispensing probe is washed every time after the dispensing of the reagent is completed in order to prevent the previously dispensed reagent from being brought into the reagent bottle or the reaction container containing the reagent to be dispensed next. Further, the stirrer is washed after the completion of stirring in order to prevent the previously stirred mixed liquid from being brought into the reaction vessel containing the mixed liquid to be stirred next.

  By the way, in dispensing a test sample or reagent, a tube is connected between a dispensing pump that performs aspiration and discharge operations and a dispensing probe, and the dispensing probe is connected via water enclosed in the tube. The sample and reagent are aspirated and discharged.

Further, in the cleaning of each analysis unit, the inner surface of each dispensing probe is washed by discharging the water from the sample dispensing probe and the reagent dispensing probe. Moreover, the sample dispensing probe, the reagent dispensing probe, and the outer surface of the stirring bar are washed using water supplied to the washing tank of each analysis unit. Then, the amount of cleaning water supplied to each analysis unit is adjusted to fall within a predetermined range at the time of installation of the apparatus or periodic inspection so that it can be cleaned strongly in a short time.
JP 2004-251797 A

  However, due to use over a long period of time or deterioration of the surrounding environment, waste materials such as scales and mold accumulate in the tube that supplies the cleaning solution, reducing the volume in the tube and supplying it to each dispensing unit during measurement. The amount of washing water may decrease. When the amount of washing water decreases in this way, the amount of the previous measurement sample brought in through each analysis unit increases, and the analysis data of the next measurement sample may be adversely affected.

  Further, in the composite apparatus, after the test sample is dispensed by the first analysis unit, the test sample is dispensed by the second analysis unit to measure the trace component of the immunological test item. When performed, the amount of the previous test sample brought in through the sample dispensing probe of the first analysis unit is increased, and the test sample in the next sample container measured by the second analysis unit is analyzed. Data may be adversely affected.

  As described above, when analysis data is adversely affected due to insufficient cleaning of each analysis unit, there is a risk of misdiagnosis without noticing the analysis data. In addition, when it is noticed, it is necessary to perform measurement again, and there is a problem of wasting a test sample, a reagent, time, and the like.

  The present invention has been made in order to solve the above-described problems. An automatic analyzer capable of preventing the previous measurement sample from being brought into the next measurement sample through the analysis unit and accurately measuring it. The purpose is to provide.

  In order to achieve the above object, the automatic analyzer of the present invention according to claim 1 is an automatic analyzer for dispensing a test sample and a reagent into a container and measuring a mixed solution thereof. Sample dispensing probe dispensed into the container, supply means for supplying a cleaning liquid for cleaning the sample dispensing probe, and measurement for measuring the supply amount of the cleaning liquid supplied from the supply means to the sample dispensing probe And a control means for controlling to stop the dispensing operation of the sample dispensing probe and / or to output warning information based on the supply amount measured by the measuring means. To do.

  The automatic analyzer of the present invention according to claim 10 is an automatic analyzer for dispensing a sample and a reagent into a container and measuring a mixed solution thereof. Measurement by means of a measuring probe, a supply means for supplying a cleaning liquid for cleaning the reagent dispensing probe, a measuring means for measuring the amount of cleaning liquid supplied from the supplying means to the reagent dispensing probe, Control means for performing control for stopping the dispensing operation of the reagent dispensing probe and / or control for outputting warning information based on the supplied amount.

  Furthermore, the automatic analyzer of the present invention according to claim 11 is an automatic analyzer for dispensing a test sample and a reagent into a container and measuring the mixed solution, and moving the mixed solution into the container. Stirring to be stirred, supply means for supplying cleaning liquid for cleaning the stirrer, measuring means for measuring the supply amount of cleaning liquid supplied from the supply means to the stirrer, and measured by the measuring means Control means for performing control to stop the movement of the stirrer into the container and / or control to output warning information based on the supply amount is provided.

  According to the present invention, the supply amount of the cleaning liquid supplied to the analysis unit is measured, and when the measured supply amount is out of the warning range, the information is output, and when the measured supply amount is out of the allowable range By stopping the operation of the analysis unit, it is possible to prevent the previous measurement sample from being brought into the next measurement sample through the analysis unit, and to measure with high accuracy.

  In the following, an embodiment of an automatic analyzer according to the present invention will be described with reference to FIGS.

  FIG. 1 is a block diagram showing a configuration of an automatic analyzer according to an embodiment of the present invention. The automatic analyzer 300 includes a first analysis unit 200a that measures a measurement item selected and input from a standard sample such as a biochemical test item or a biochemical test item for each test sample, And a second analysis unit 200b that performs measurement of a standard sample such as an immunological test item or a measurement item selected and input from among immunological test items for each test sample.

  The automatic analyzer 300 also measures the standard sample output from the transport unit 250 that transports the test sample to the first and second analysis units 200a and 200b and the first and second analysis units 200a and 200b. And a data processing unit 40 for processing the test data generated by measuring the test sample and the test data generated by measuring the test sample to create a calibration table and generate analysis data.

  Further, the automatic analyzer 300 sets an analysis condition for each measurement item measured by the output unit 50 that outputs the calibration table and analysis data from the data processing unit 40, and the first and second analysis units 200a and 200b. And an operation unit 60 for inputting measurement items for each test sample and inputting various command signals, and a system control unit 70 for controlling the above-described units in an integrated manner.

  The first analysis unit 200a includes a standard sample such as a biochemical test item, and an analysis unit 19a that measures a measurement item selected and input from biochemical test items for each test sample, and an analysis unit 19a. And an analysis control unit 30a for controlling the measurement operation.

  The analysis unit 19a includes a sample unit 20 for dispensing a sample such as a standard sample or a test sample conveyed by the conveyance unit 250, a reagent unit 21 for dispensing a reagent that reacts with a component of a measurement item in the sample, A reaction unit 22 that measures a mixture of the sample and reagent dispensed from the sample unit 20 and the reagent unit 21, and each analysis used for dispensing and measuring the sample unit 20, the reagent unit 21, and the reaction unit 22. And a cleaning unit 23 for cleaning the unit. Then, the reaction unit 22 generates standard data and test data by measuring the standard sample and the test sample, and outputs them to the data processing unit 40. In addition, a part of the immunological test items can be measured using a reagent by latex turbidimetry.

  The analysis control unit 30a includes a mechanism unit 31 having mechanisms for driving the analysis units used for measurement of the sample unit 20, the reagent unit 21, and the reaction unit 22 of the analysis unit 19a, and the mechanism unit 31 and the analysis unit 19a. And a control unit 32 for controlling the cleaning unit 23.

  The control unit 32 includes a mechanism control unit 32a that controls each mechanism of the mechanism unit 31, and a cleaning unit control unit 32b that controls the cleaning operation of the cleaning unit 23 that cleans each analysis unit of the analysis unit 19a. The cleaning unit control unit 32 b controls the cleaning operation of the cleaning unit 23 and outputs information generated during the operation to the output unit 50.

  The second analysis unit 200b includes an analysis unit 19b that measures a standard sample such as an immunological test item and a measurement item selected and input from among the immunological test items for each test sample, and an analysis unit 19b. And a control unit 30b for controlling the measurement operation and the like.

  The analysis unit 19b includes analysis units for dispensing and measuring samples and reagents in the same manner as the analysis unit 19a. Then, a standard sample of each measurement item arranged inside, a test sample conveyed by the conveyance unit 250, and a mixture mixed by dispensing an immunoreagent labeled with, for example, a chemiluminescent substance corresponding to each measurement item The intensity of light emitted by the immune reaction in the liquid is measured. By this measurement, standard data and test data of the standard sample and the test sample are generated and output to the data processing unit 40.

  The control unit 30b includes a mechanism unit that includes a mechanism that drives each analysis unit of the analysis unit 19b, and a control unit that controls the mechanism unit.

  When the measurement item selected and input of the test sample is measured by the first and second analysis units 200a, the transport unit 250 moves the sample container 17 containing the test sample placed in the standby position to the first container. The sample is transported to the vicinity of the sample unit 20 of the first analysis unit 200a and temporarily stopped. After the sample is dispensed by the sample unit 20 of the first analysis unit 200a, the sample container 17 is transported to the vicinity of the analysis unit 19b of the second analysis unit 200b. Then, after the test sample is dispensed by the analysis unit 19b of the second analysis unit 200b, the sample container 17 is transported to the measurement end position. The first analysis unit 200a performs measurement at a higher speed than the second analysis unit 200b, and usually performs measurement of more test samples and measurement items than the second analysis unit 200b.

  Further, when the measurement item selected and input for the test sample is measured only by the second analysis unit 200a, the sample container 17 disposed at the standby position is transported to the vicinity of the analysis unit 19b of the second analysis unit 200b. . And after the analysis part 19b of the 2nd analysis part 200b dispenses a test sample, the sample container 17 is conveyed to a measurement completion position.

  The data processing unit 40 creates a calibration table and generates analysis data from standard data and test data output from the reaction unit 22 of the first analysis unit 200a and the analysis unit 19b of the second analysis unit 200b. A calculation unit 41 and a storage unit 42 that stores a calibration table created by the calculation unit 41, generated analysis data, and the like are provided.

  The calculation unit 41 creates a calibration table for each measurement item from the standard data of each measurement item output from the reaction unit 22 of the first analysis unit 200a and the analysis unit 19b of the second analysis unit 200b, and outputs the calibration table. The data is output to the unit 50 and stored in the storage unit 42. For the test data in each measurement item of each test sample output from the reaction unit 22 or the analysis unit 19b, the calibration table of the measurement item is read from the storage unit 42, and then the read calibration is performed. Analytical data is calculated using a table, output to the output unit 50 and stored in the storage unit 42.

  The storage unit 42 includes a hard disk and stores the calibration table, analysis data, and the like output from the calculation unit 41 for each test sample.

  The output unit 50 includes a printing unit 51 that prints out the calibration table and analysis data output from the calculation unit 41 of the data processing unit 40, and a display unit 52 that outputs the display.

  The printing unit 51 includes a printer and prints and outputs the calibration table, analysis data, and the like output from the calculation unit 41 of the data processing unit 40 on printer paper according to a preset format.

  The display unit 52 includes a monitor such as a CRT or a liquid crystal panel, and includes an object information input screen for inputting a calibration table and analysis data output from the calculation unit 41 of the data processing unit 40, an object ID, a name, and the like. An analysis condition setting screen for setting analysis conditions for each measurement item, a measurement item setting screen for selecting and setting measurement items for each test sample, and output from the cleaning unit control unit 32b of the first analysis unit 200a Display information. Note that an audio unit may be provided, and the information output from the cleaning unit control unit 32b may be output as audio.

The operation unit 60 includes input devices such as a keyboard, a mouse, a button, and a touch key panel, sets analysis conditions for each measurement item, inputs subject information such as a subject ID and subject name of the subject, and subjects Various operations such as selection input of measurement items for each sample, standard sample measurement operation for creating a calibration table for each measurement item, and test sample measurement operation for generating analysis data are performed.
The system control unit 70 includes a CPU and a storage circuit (not shown), stores information such as a command signal supplied from the operation unit 60, analysis conditions of measurement items, subject information, measurement items for each test sample, Based on these pieces of information, the entire system is controlled.

  And the sample container 17 arrange | positioned at the conveyance part 250 is conveyed to the sample part 20 vicinity of the 1st analysis part 200a, or the analysis part 19b vicinity of the 2nd analysis part 200b. In addition, each analysis unit of the analysis units 19a and 19b in the first and second analysis units 200a and 200b is operated in a certain analysis cycle to measure a standard sample, a test sample of the transport unit 250, and the like.

  Next, with reference to FIG.2 and FIG.3, the detail of a structure of the sample part 20, the reagent part 21, and the reaction part 22 in the analysis part 19a of the 1st analysis part 200a is demonstrated.

  FIG. 2 is a perspective view showing details of the configuration of the analysis unit 19a. The sample unit 20 of the analysis unit 19a includes a disk sampler 6 that rotatably holds a sample container 17 containing a sample such as a calibrator and a test sample, and a sample in the sample container 17 that is transported to the vicinity by the transport unit 250. A sample dispensing probe 16 for sucking the sample in the sample container 17 held by the test sample or the disk sampler 6 and discharging the sample to the reaction unit 22 is provided.

  The sample unit 20 includes a sample dispensing pump 10a that sucks and discharges a sample via the sample dispensing probe 16, a sample container 17 of the transport unit 250, a sample container 17 of the disk sampler 6, a reaction unit 22, and The sample dispensing arm 10 that holds the sample dispensing probe 16 horizontally to each stop position of the cleaning unit 23 and the vertical movement at each stop position and the liquid level of the sample in each sample container 17 are detected. And a liquid level detector 18a.

  Then, the detection signal of the sample detected by the liquid level detector 18a is output to the mechanism control unit 32a of the control unit 32 in the analysis control unit 30a. Based on the detection signal from the liquid level detector 18a, the mechanism control unit 32a stops the sample dispensing arm 10 when the tip of the sample dispensing probe 16 reaches a predetermined depth from the sample liquid level. .

  The reagent unit 21 includes reagent bottles 7a and 7b containing a plurality of first reagents that selectively react with a sample and a second reagent that forms a pair with the first reagent, and a reagent rack 1a that houses the reagent bottles 7a. A reagent storage 2 that rotatably holds the reagent rack 1a that stores the reagent bottle 7a, a reagent storage 3 that rotatably holds the reagent rack 1b that stores the reagent bottle 7b, and the reagent storages 2 and 3 First and second reagent dispensing probes 14 and 15 for aspirating the first and second reagents from the reagent bottles 7a and 7b and discharging them to the reaction unit 22 are provided.

  The reagent unit 21 includes reagent dispensing pumps 8a and 9a that suck and discharge the first and second reagents via the first and second reagent dispensing probes 14 and 15, and reagent bottles in the reagent storages 2 and 3, respectively. 7a, 7b, the reaction section 22, and the first and second reagent dispensing probes 14 and 15 to the respective stop positions of the reaction section 22 and the washing section 23, and the first and second holding the upper and lower positions at the respective stop positions. Two reagent dispensing arms 8 and 9 and liquid level detectors 18b and 18c for detecting the liquid levels of the first and second reagents in the reagent bottles 7a and 7b are provided.

  And the detection signal of the 1st and 2nd reagent detected by the liquid level detectors 18b and 18c is output to the mechanism control part 32a. In the mechanism control unit 32a, based on detection signals from the liquid level detectors 18b and 18c, the distal end portions of the first and second reagent dispensing probes 14 and 15 are moved to a predetermined depth from the liquid levels of the first and second reagents. When this is reached, the first and second reagent dispensing arms 8, 9 are stopped.

  The reaction part 22 was discharged from the sample discharged from the sample dispensing probe 16 of the sample part 20, the first reagent discharged from the first reagent dispensing probe 14 of the reagent part 21, and the second reagent dispensing probe 15. A plurality of reaction vessels 4 arranged on the circumference for containing the second reagent, a reaction disk 5 for rotatably holding the reaction vessel 4, and a first mixture comprising the sample in the reaction vessel 4 and the first reagent The first stirrer 11a1 that stirs the liquid, the reaction vessel 4 containing the first mixed liquid, and the horizontal movement of the first stirrer 11a1 to each stop position of the cleaning unit 23, and the vertical movement at each stop position are possible. 1st stirring unit 11a hold | maintained in this.

  The reaction unit 22 includes a second stirrer 11b1 that stirs the second mixed liquid composed of the sample in the reaction container 4, the first reagent, and the second reagent, and the reaction container 4 that contains the second mixed liquid. And a second stirring unit 11b that holds the second stirring bar 11b1 horizontally to each stop position of the cleaning unit 23 and vertically moves at each stop position.

  Furthermore, the reaction unit 22 irradiates the reaction container 4 containing the first mixed liquid or the second mixed liquid after stirring with light, and measures the absorbance at the set wavelength from the transmitted light. A suction nozzle that cleans and dries the inside of the reaction container 4, a cleaning nozzle, and a cleaning unit 12 that holds the drying nozzle so as to move up and down are provided. .

  Each time the measurement of the first and second mixed liquids is completed, the inner surface of the reaction container 4 is washed and dried by the washing unit 12 and used again for the measurement. The photometric unit 13 outputs the standard sample of each measurement item generated by the absorbance measurement, the standard data of the test sample, and the test data to the data processing unit 40.

  FIG. 3 is a diagram showing a sample dispensing operation in the sample unit 20. The sample dispensing probe 16 is connected to the sample dispensing pump 10a and the cleaning unit 23 by a tube. This tube is made of hard, for example, polytetrafluoroethylene whose internal volume does not change due to fluctuations in internal pressure. In the following description, the same tube is used for all the tubes.

  A cleaning liquid such as water is enclosed in the tube as a pressure transmission medium for sucking and discharging the sample from the sample dispensing probe 16 in accordance with the sample suction and discharge operation of the sample dispensing pump 10a. This cleaning liquid is also used for cleaning the sample dispensing probe 16.

  Here, for example, N (N ≧ 3) measurement items are selected and input in order to measure the test sample. When the number of measurement items measured by the first analysis unit 200a is (N-1), sample samples corresponding to measurement items 1 to (N-1) in 1 to (N-1) analysis cycles. Note action is performed. First, the sample dispensing operation of the test sample corresponding to the first measurement item will be described.

  In one analysis cycle, as shown in FIG. 3A, the sample dispensing probe 16 causes the cleaning liquid in the tube to be mixed into the test sample to be sucked later by the suction operation of the sample dispensing pump 10a. Aspirate air to avoid. After the air is sucked, the tip of the sample dispensing probe 16 reaches a predetermined depth from the liquid level of the test sample in the sample container 17 of the transport unit 250 or the sample container 17 of the disk sampler 6. Move up. After the movement, a sample test for dummy corresponding to the first measurement item and a test for measurement corresponding to the first measurement item are performed by the suction operation of the sample dispensing pump 10a to prevent the cleaning liquid from being mixed into the test sample for measurement. Aspirate the sample. After this sample is aspirated, it moves into the reaction container 4 of the reaction unit 22.

  Then, as shown in FIG. 3B, the sample dispensing probe 16 discharges only the test sample for measurement in a state where the tip portion is in contact with the bottom surface in the reaction container 4, for example.

  In the second analysis cycle and thereafter, only the test sample for measurement corresponding to the second and subsequent measurement items is sucked and discharged while the air and dummy test sample are held in the sample dispensing probe 16.

  In the (N-1) analysis cycle, the test sample for measurement corresponding to the (N-1) -th measurement item is discharged to the reaction container 4 and then moved to the cleaning unit 23. The cleaning unit 23 pushes the dummy test sample and air in the sample dispensing probe 16 with the cleaning liquid, and cleans the surface in contact with the test sample inside and outside the sample dispensing probe 16. By this cleaning, the sample dispensing operation for the same test sample is completed.

  The first and second reagent dispensing probes 14 and 15 are connected to the reagent dispensing pumps 8a and 9a and the washing unit 23 by tubes, and the first reagent and the second reagent dispensing probes 14 and 15 are connected to the sample dispensing probe 16 in the same manner as the sample dispensing probe 16. The second reagent is aspirated and discharged. Then, at the end of discharge, the cleaning unit 23 pushes out the dummy reagent and air in the first and second reagent dispensing probes 14 and 15 with the cleaning liquid, and the inside and outside of the first and second reagent dispensing probes 14 and 15. The surface in contact with the first and second reagents is cleaned. The first and second reagent dispensing operations by the suction, discharge, and cleaning are performed in one analysis cycle.

  The first and second stirrers 11a1 and 11b1 are mixed with the first and second stirrers 11a1 and 11b1 at the cleaning unit 23 every time the first and second mixed liquids are stirred. Clean the surface in contact with the. The first and second stirring operations by the stirring and washing are performed in one analysis cycle.

  Next, with reference to FIG. 2 thru | or FIG. 10, the detail of a structure of the washing | cleaning part 23 in the analysis part 19a is demonstrated. FIG. 4 is a diagram illustrating a configuration of the cleaning unit 23. 5 to 10 are diagrams showing the configuration of the cleaning unit of each analysis unit of the cleaning unit 23 shown in FIG.

  FIG. 4 is a block diagram showing the configuration of the cleaning unit 23. The washing unit 23 includes a sample dispensing probe washing unit 80 for washing the sample dispensing probe 16 of the sample unit 20 every time the dispensing of the same sample is completed, and a first one of the reagent unit 21 every time dispensing of the first reagent is finished. A first reagent dispensing probe washing unit 90 for washing the reagent dispensing probe 14 and a second reagent dispensing probe washing unit for washing the second reagent dispensing probe 15 of the reagent unit 21 every time the second reagent dispensing is completed. 100.

  In addition, the cleaning unit 23 includes a first stirrer cleaning unit 110 that cleans the first stirrer 11a1 of the reaction unit 22 every time the first mixed liquid stirring is completed, and a reaction unit every time the second mixed liquid stirring ends. The second stirrer cleaning unit 120 for cleaning the 22 second stirrers 11b1 and the cleaning liquid storage unit 130 for storing the cleaning liquid supplied to each of the cleaning units described above are provided.

  FIG. 5 is a diagram showing the configuration of the sample dispensing probe cleaning unit 80 in the cleaning unit 23. The sample dispensing probe cleaning unit 80 includes an outer surface cleaning unit 81 for supplying a cleaning liquid for cleaning an outer surface (contact outer surface) of a surface (contact surface) that contacts the sample of the sample dispensing probe 16, and a sample distribution An inner surface cleaning unit 82 for supplying a cleaning liquid for cleaning the inner surface (contact inner surface) of the contact surface of the injection probe 16 and a sample dispensing probe using the cleaning liquid supplied from the outer surface cleaning unit 81 and the inner surface cleaning unit 82 And a cleaning tank 83 in which 16 cleanings are performed. And each washing | cleaning unit in the sample dispensing probe washing | cleaning part 80 is connected with the tube, and the washing | cleaning liquid is enclosed in each tube.

  The outer surface cleaning unit 81 supplies a cleaning liquid to the contact outer surface of the sample dispensing probe 16, and a three-way valve 81b that opens the cleaning liquid from the supply pump 81a to one side and the other on the cleaning liquid storage unit 130 side. And a flow rate adjustment unit 81c for adjusting the flow rate of the cleaning liquid from the three-way valve 81b opened to one side, and a measurement unit 81d that measures the flow rate of the cleaning liquid from the flow rate adjustment unit 81c as a supply amount. The cleaning units in the outer surface cleaning unit 81 are connected by tubes, and a cleaning liquid is sealed in each tube.

  As the supply pump 81a, for example, a magnet pump that continuously supplies the cleaning liquid from the cleaning liquid storage unit 130 to the three-way valve 81b is used. And when washing | cleaning the sample dispensing probe 16, the washing | cleaning liquid from the washing | cleaning liquid preservation | save part 130 is supplied to the flow volume adjustment part 81c via the three-way valve 81b opened to one side. When dispensing the sample, the cleaning liquid from the cleaning liquid storage unit 130 is returned to the cleaning liquid storage unit 130 via the three-way valve 81b opened to the other side.

  For example, a three-way solenoid valve is used as the three-way valve 81b. When cleaning the contact outer surface of the sample dispensing probe 16, the gap between the supply pump 81a and the flow rate adjusting unit 81c is opened and the other is closed. Further, when dispensing the sample, the space between the supply pump 81a and the cleaning liquid storage unit 130 is opened, and one is closed.

  The flow rate adjustment unit 81c includes, for example, a valve that adjusts the flow rate of the cleaning liquid supplied from the three-way valve 81b to the measurement unit 81d and a motor that drives the valve. Then, when cleaning the sample dispensing probe 16, the valve is adjusted so that the flow rate of the cleaning liquid from the three-way valve 81b falls within a predetermined range.

  The measurement unit 81d includes, for example, an impeller-type flow sensor that detects the flow rate of the cleaning liquid from the flow rate adjustment unit 81c, and a signal processing unit that processes a detection signal from the flow rate sensor. The signal processing unit calculates the supply amount of the cleaning liquid supplied from the supply pump 81a within the outer surface cleaning time in one analysis cycle based on the detection signal output from the flow sensor, and calculates the calculated supply amount as the first supply amount. 1 measurement data is output to the cleaning unit controller 32b.

  The inner surface cleaning unit 82 is open to the supply pump 82a for supplying the cleaning liquid to the contact inner surface of the sample dispensing probe 16, one on the supply pump 82a side and the other on the sample dispensing pump 10a side of the sample unit 20 Pressure from the sample dispensing pump 10a transmitted through the three-way valve 82b, the cleaning liquid supplied from the supply pump 82a supplied via the three-way valve 82b opened to one side, and the three-way valve 82b opened to the other side. And a measuring unit 82c for measuring. The cleaning units in the inner surface cleaning unit 82 are connected by tubes, and a cleaning liquid is sealed in each tube.

  As the supply pump 82 a, for example, a bellows pump for supplying the cleaning liquid from the cleaning liquid storage unit 130 to the contact inner surface of the sample dispensing probe 16 is used. Then, when cleaning the contact inner surface of the sample dispensing probe 16, the cleaning liquid from the cleaning liquid storage unit 130 is supplied into the sample dispensing probe 16 through the three-way valve 82b opened to one side. Also, when dispensing the sample, it is stopped.

  The tip of the sample dispensing probe 16 has a small inner diameter of, for example, about 0.3 mm so that a small amount of sample can be dispensed. For this reason, a pump capable of supplying the cleaning liquid into the sample dispensing probe 16 at a higher pressure than the outer surface cleaning unit 81 is used.

  For example, a three-way solenoid valve is used as the three-way valve 82b. When cleaning the contact inner surface of the sample dispensing probe 16, the gap between the supply pump 81a and the sample dispensing probe 16 is opened, and the other is closed. Further, when dispensing a sample, the space between the sample dispensing pump 10a and the sample dispensing probe 16 is opened, and one is closed.

  The measuring unit 82c is configured by, for example, a semiconductor pressure sensor for detecting the pressure of the cleaning liquid from the three-way valve 82b, and a signal processing unit that processes a detection signal from the pressure sensor. The signal processing unit calculates a pressure value from the detection signal from the pressure sensor, and further calculates the supply amount of the cleaning liquid supplied from the supply pump 82a within the inner surface cleaning time of one analysis cycle based on the calculated pressure value. . Then, the calculated pressure value and supply amount are output to the cleaning unit controller 32b as second measurement data.

  Further, when a sample is dispensed using the sample dispensing probe 16, a second sample for detecting clogging of the sample dispensing probe 16 due to components such as fibrin contained in serum when the sample is aspirated or discharged. The measurement data is output to the cleaning unit controller 32b.

  As described above, by providing the pressure sensor in the measuring unit 82c, the supply amount of the cleaning liquid for cleaning the contact inner surface of the sample dispensing probe 16 is measured, and the sample dispensing probe 16 when the sample is sucked or discharged is measured. Can be detected.

  As shown in FIG. 6, the cleaning tank 83 has a discharge port 83a for discharging the cleaning liquid from the outer surface cleaning unit 81, and a drain port for discharging the cleaning liquid discharged from the discharge port 83a and the sample dispensing probe 16 to the outside. 83b. After the dispensing of the same sample is completed, the contact outer surface of the sample dispensing probe 16 is washed with the cleaning liquid indicated by the parabolic arrow shown in FIG. 6A discharged from the discharge port 83a. Further, the dummy sample remaining in the sample dispensing probe 16 and the sample adhering to the contact inner surface are washed with the cleaning liquid indicated by the arrow in FIG. 6B discharged from the tip of the sample dispensing probe 16. .

  Here, the inner diameter and length of each tube connected to each cleaning unit have predetermined dimensions, and when the automatic analyzer 300 is installed, the supply amount of the cleaning liquid is set to fall within the normal range. After that, in the outer surface cleaning unit 81 and the cleaning tank 83, when an unnecessary object such as scale adheres or accumulates in each tube between the supply pump 81a and the cleaning tank 83, the supply amount of the cleaning liquid decreases from the normal range. Even if, for example, the cleaning liquid leaks between the supply pump 81a and the measuring unit 81d, the supply amount of the cleaning liquid decreases from the normal range.

  Further, in the inner surface cleaning unit 82 and the sample dispensing probe 16, if an unnecessary object such as scale adheres or accumulates in each tube between the supply pump 82 a and the sample dispensing probe 16, the pressure value in the second measurement data. Becomes higher and the supply amount of the cleaning liquid decreases from the normal range. Further, for example, when the cleaning liquid leaks between the supply pump 82a and the sample dispensing probe 16, the pressure value decreases and the supply amount of the cleaning liquid decreases from the normal range.

  When the supply amount of the cleaning liquid supplied from the outer surface cleaning unit 81 to the cleaning tank 83 is within the allowable range even if it is out of the normal range, the cleaning liquid discharged from the discharge port 83a has the parabola of FIG. 6 (a). It is drawn and dropped so that it contacts the entire contact outer surface from the vicinity of the contact outer surface of the sample dispensing probe 16. Thereby, almost all of the sample adhering to the contact outer surface of the sample dispensing probe 16 can be washed out within the outer surface cleaning time in one analysis cycle.

  Further, when the supply amount of the cleaning liquid from the outer surface cleaning unit 81 is smaller than the allowable range, the cleaning liquid discharged from the discharge port 83a lacks momentum and reaches a part of the contact outer surface of the sample dispensing probe 16. Just do it.

  Furthermore, when the supply amount of the cleaning liquid from the outer surface cleaning unit 81 is excessive than the allowable range at the time of installation, the cleaning liquid discharged from the discharge port 83a draws a parabola indicated by a broken-line arrow in FIG. The sample drops, and only a part of the contact outer surface of the sample dispensing probe 16 or the upper part of the sample dispensing probe 16 is applied.

  As described above, when the supply amount of the cleaning liquid from the outer surface cleaning unit 81 is out of the allowable range, a part of the previous sample remains on the contact outer surface of the sample dispensing probe 16, and the disc sampler 6 containing the next sample is stored. A previous sample of an allowable limit amount or more that adversely affects the analysis data of the next test sample is brought into the sample container 17 or the sample container 17 of the transport unit 250 containing the next test sample. .

  On the other hand, when the supply amount of the cleaning liquid from the inner surface cleaning unit 82 is within the allowable range, the dummy sample in the sample dispensing probe 16 shown in FIG. 3B is pushed out and the sample adhered to the contact inner surface. Can wash out almost everything.

  Further, if the supply amount of the cleaning liquid from the inner surface cleaning unit 82 is smaller than the allowable range, the dummy sample remains in the sample dispensing probe 16. Even if the dummy sample is pushed out of the sample dispensing probe 16, a part of the sample adhered to the contact inner surface remains.

  As a result, when the next sample is discharged into the reaction container 4, a previous sample of an allowable limit amount or more that adversely affects the analysis data of the next test sample is brought into the reaction container 4.

  FIG. 7 is a diagram showing the configuration of the first reagent dispensing probe cleaning unit 90 in the cleaning unit 23. FIG. 8 is a diagram showing details of the configuration of the second reagent dispensing probe cleaning unit 100 in the cleaning unit 23. The first and second reagent dispensing probe cleaning units 90 and 100 are configured in the same manner as the sample dispensing probe cleaning unit 80 of FIG.

  The first and second reagent dispensing probe cleaning units 90 and 100 are outer surface cleaning units 91 and 101 for supplying a cleaning liquid for cleaning the contact outer surfaces of the first and second reagent dispensing probes 14 and 15 of the reagent unit 21. And inner surface cleaning units 92 and 102 for supplying cleaning liquid for cleaning the contact inner surfaces of the first and second reagent dispensing probes 14 and 15, and the outer surface cleaning units 91 and 101 and the inner surface cleaning units 92 and 102. And cleaning tanks 93 and 103 in which the first and second reagent dispensing probes 14 and 15 are cleaned using a cleaning liquid. Each cleaning unit is connected by a tube, and a cleaning liquid is sealed in each tube.

  The outer surface cleaning units 91 and 101 include supply pumps 91a and 101a for supplying cleaning liquid to the first and second reagent dispensing probes 14 and 15, and one of the cleaning liquids from the supply pumps 91a and 101a and a cleaning liquid storage unit 130. The three-way valves 91b and 101b that are open to the other side, the flow rate adjusting parts 91c and 101c that adjust the flow rate of the cleaning liquid from the three-way valves 91b and 101b that are open to the one side, and the cleaning liquid from the flow rate adjusting parts 91c and 101c It is configured by measuring units 91d and 101d that measure the flow rate as a supply amount and generate first measurement data. The cleaning units in the outer surface cleaning units 91 and 101 are connected to each other by a tube, and a cleaning liquid is sealed in each tube.

  The inner surface cleaning units 92 and 102 are provided with supply pumps 92 a and 102 a for supplying cleaning liquid into the first and second reagent dispensing probes 14 and 15, one of the supply pumps 92 a and 102 a side, and the reagent unit 21. The first and second reagent dispensing probes 14 are supplied from the supply pumps 92a and 102a through the three-way valves 92b and 102b opened to the other side of the reagent dispensing pumps 8a and 9a and the three-way valves 92b and 102b opened to the other side. , 15 and the pressure of the cleaning liquid transmitted from the reagent dispensing pumps 8a, 9a to the first and second reagent dispensing probes 14, 15 via the three-way valves 92b, 102b opened to the other. The measuring units 92c and 102c are configured to measure the supply amount and the pressure value to generate second measurement data. The cleaning units in the inner surface cleaning units 92 and 102 are connected by a tube, and a cleaning liquid is sealed in each tube.

  The cleaning tanks 93 and 103 are configured to discharge the cleaning liquid from the discharge ports 93a and 103a for discharging the cleaning liquid from the outer surface cleaning units 91 and 101, and the discharge ports 93a and 103a and the first and second reagent dispensing probes 14 and 15, respectively. And drainage ports 93b and 103b for discharging.

  Here, when the supply amount of the cleaning liquid supplied from the outer surface cleaning units 91 and 101 to the cleaning tanks 93 and 103 is within an allowable range, the cleaning liquid discharged from the discharge ports 93a and 103a is divided into the first and second reagent amounts. The contact is made over the entire contact outer surface from the vicinity of the contact outer surface of the probe 14 or 15. Thereby, almost all of the first and second reagents adhering to the contact outer surfaces of the first and second reagent dispensing probes 14 and 15 can be washed away.

  Further, when the supply amount of the cleaning liquid from the outer surface cleaning units 91 and 101 is smaller than the allowable range, the cleaning liquid discharged from the discharge ports 93a and 103a lacks momentum and only hits a part of the contact outer surface. .

  Furthermore, if the supply amount of the cleaning liquid from the outer surface cleaning units 91 and 101 is more than the allowable range during installation, the cleaning liquid discharged from the discharge ports 93a and 103a will stagnate and hit the upper end of the contact outer surface or above. Only.

  As described above, when the supply amount of the cleaning liquid from the outer surface cleaning units 91 and 101 is out of the allowable range, the previous first and second reagents adhering to the contact outer surfaces of the first and second reagent dispensing probes 14 and 15 are removed. In the reagent bottles 7a and 7b in which a part remains and the next first and second reagents are accommodated, the previous first and second reagents exceeding the allowable limit amount that adversely affects the analysis data of the next measurement item are present. Will be brought in.

  On the other hand, when the supply amount of the cleaning liquid from the inner surface cleaning units 92 and 102 is within the allowable range, the dummy first and second reagents are pushed out from the first and second reagent dispensing probes 14 and 15 and contact inner surfaces are contacted. Almost all of the first and second reagents adhering to can be washed away.

  If the supply amount of the cleaning liquid from the inner surface cleaning units 92 and 102 is smaller than the allowable range, the first and second dummy reagents remain in the first and second reagent dispensing probes 14 and 15. Even if the dummy first and second reagents are pushed out from the first and second reagent dispensing probes 14 and 15, a part of the first and second reagents before adhering to the contact inner surface remains.

  As a result, when the next first and second reagents are discharged into the reaction vessel 4, the previous first and second reagents exceeding the allowable limit amount that adversely affects the analysis data of the next measurement item are brought in. become.

  FIG. 9 is a diagram illustrating details of the configuration of the first stirrer cleaning unit 110 in the cleaning unit 23. FIG. 10 is a diagram showing details of the configuration of the second stirring bar cleaning unit 120 in the cleaning unit 23. The first and second stirring bar cleaning units 110 and 120 are configured in the same manner as the outer surface cleaning unit 81 and the cleaning tank 83 of the sample dispensing probe cleaning unit 80 of FIG.

  The first and second stirrer cleaning units 110 and 120 are surfaces (contact outer surfaces) of the first and second stirrers 11a1 and 11b1 that are in contact with the first and second mixed liquids in the reaction vessel 4 of the reaction unit 22. The outer surface cleaning units 111 and 121 for supplying a cleaning liquid for cleaning, and the cleaning tank 113 for cleaning the first and second stirring bars 11a1 and 11b1 using the cleaning liquid supplied from the outer surface cleaning units 111 and 121, 123. Each cleaning unit is connected by a tube, and a cleaning liquid is sealed in each tube.

  The outer surface cleaning units 111 and 121 include supply pumps 111a and 121a for supplying the cleaning liquid to the first and second stirrers 11a1 and 11b1, and the cleaning liquid from the supply pumps 111a and 121a on one side and the cleaning liquid storage unit 130 side. The three-way valves 111b and 121b that are open to the other side, the flow rate adjustment units 111c and 121c that adjust the flow rate of the cleaning liquid from the three-way valves 111b and 121b that are open to the other side, and the flow rate of the cleaning liquid from the flow rate adjustment units 111c and 121c The measuring units 111d and 121d measure the supply amount and generate the first measurement data. And each cleaning unit in each outer surface washing | cleaning part 111,121 is connected with the tube, and the washing | cleaning liquid is enclosed in each tube.

  The cleaning tanks 113 and 123 include discharge ports 113a and 123a for discharging the cleaning liquid from the outer surface cleaning units 111 and 121, and drainage ports 113b and 123b for discharging the cleaning liquid from the discharge ports 113a and 123a to the outside. Have. Then, after the stirring of the first and second mixed liquids is completed, the contact outer surfaces of the first and second stirring bars 11a1 and 11b1 are cleaned with the cleaning liquid from the external cleaning units 111 and 121 discharged from the discharge ports 113a and 123a. Is done.

  Here, when the supply amount of the cleaning liquid from the outer surface cleaning units 111 and 121 is within an allowable range, the cleaning liquid discharged from the discharge ports 113a and 123a is in the vicinity of the contact outer surface of the first and second stirrers 11a1 and 11b1. To the entire contact outer surface. Thereby, almost all of the first and second mixed liquids adhering to the contact outer surfaces of the first and second stirring bars 11a1 and 11b1 can be washed away.

  Further, when the supply amount of the cleaning liquid from the outer surface cleaning units 111 and 121 is smaller than the allowable range, the cleaning liquid discharged from the discharge ports 113a and 123a lacks momentum, and the first and second stirrers 11a1 and 11a1. It only reaches a part of the contact outer surface of 11b1.

  Furthermore, if the supply amount of the cleaning liquid from the outer surface cleaning units 111 and 121 is excessive than the allowable range at the time of installation, the cleaning liquid discharged from the discharge ports 113a and 123a excessively hits the upper and upper end portions of the contact outer surface. Only.

  Thus, when the supply amount of the cleaning liquid from the outer surface cleaning units 111 and 121 is out of the permissible range, the previous first and second mixed liquids adhering to the contact outer surfaces of the first and second stirring bars 11a1 and 11b1 In the reaction vessel 4 in which a part of the reaction mixture 4 contains the next first and second mixed liquids, the previous first amount exceeding the allowable limit amount that adversely affects the analysis data of the next first and second mixed liquids. The 1st and 2nd liquid mixture will be brought in.

Next, the configuration of the analysis control unit 30a will be described in detail with reference to FIGS.
The mechanism unit 31 of the analysis control unit 30a in FIG. 2 includes a mechanism for rotating the disk sampler 6, the reagent storage 2 and the reagent storage 3 of the analysis unit 19a, a mechanism for rotating the reaction disk 5, a sample dispensing arm 10, A mechanism for rotating and vertically moving the first reagent dispensing arm 8, the second reagent dispensing arm 9, the first stirring unit 11a, and the second stirring unit 11b, a mechanism for vertically moving the washing unit 12, and sample dispensing A mechanism for driving the pump 10a, the reagent dispensing pump 8a, and the reagent dispensing pump 9a is provided.

  Further, the mechanism unit 31 includes a reaction vessel 4 via a mechanism that drives the first and second stirrers 11a1 and 11b1 of the first and second stirring units 11a and 11b, and a cleaning nozzle and a drying nozzle of the cleaning unit 12, respectively. A cleaning pump for sucking, cleaning, and drying the liquid mixture therein, a mechanism for driving the drying pump, and the like are provided.

  The mechanism control unit 32a of the control unit 32 includes the disk sampler 6 of the mechanism unit 31, the reagent storages 2 and 3, the reaction disk 5, the sample dispensing arm 10, the first and second reagent dispensing arms 8, 9, the first and the second. The second stirring units 11a and 11b, the first and second stirring bars 11a1 and 11b1, the cleaning unit 12, the sample dispensing pump 10a, the reagent dispensing pumps 8a and 9a, and the cleaning pump and the drying pump of the cleaning unit 12 are driven. To control each mechanism.

  The cleaning unit control unit 32b controls the operation of each cleaning unit in the cleaning unit 23 of the analysis unit 19a.

  11 and 12 are diagrams for explaining details of control of the outer surface cleaning unit 81 and the inner surface cleaning unit 82 of the sample dispensing probe cleaning unit 80 in the cleaning unit control unit 32b.

  A curve A represented on the x and y axes in FIG. 11 indicates the supply amount of the cleaning liquid supplied from the outer surface cleaning unit 81 to the sample dispensing probe 16 via the cleaning tank 83, and the sample container 17 containing the next sample. It shows the relationship with the amount of sample brought in before being brought in.

  This curve A indicates that when the cleaning liquid is set to various supply amounts, and the sample dispensing probe 16 is cleaned with the set supply amount, the previous sample brought into the sample container 17 containing the next sample is brought in. It is obtained by measuring the quantity.

  Here, the normal range is defined between the supply amount NL and the supply amount NH larger than the supply amount NL. The allowable range is between the supply amount LiL smaller than the supply amount NL and the supply amount LiH larger than the supply amount NH. The warning ranges are between the supply amount LiL and the supply amount NL and between the supply amount NH and the supply amount LiH.

  The cleaning unit control unit 32b, based on the first measurement data output from the measurement unit 81d of the outer surface cleaning unit 81 at the time of cleaning, sets the flow rate adjustment unit 81c of the outer surface cleaning unit 81 in order to keep the supply amount within the normal range. To control. Also, a determination is made when the supply amount is outside the normal range.

  When the supply amount is out of the normal range and within the warning range, for example, the component of the predetermined measurement item measured by the analysis unit 19a or 19b of the first or second analysis unit 200a or 200b has a predetermined concentration. It is determined that the adjusted carry-in amount of the previous sample is less than the allowable limit amount, and the analysis data of the predetermined measurement item in the next sample falls within the allowable error range. Further, it is determined that, for example, a small amount of unnecessary material is accumulated in the tube between the outer surface cleaning unit 81 and the cleaning tank 83, and S probe outer surface cleaning warning information for urging cleaning in the tube is sent via the system control unit 70. To the output unit 50.

  When the supply amount is out of the allowable range, it is determined that the carry-in amount exceeds the allowable limit amount and the analysis data of the predetermined measurement item in the next sample is out of the allowable error range. Further, for example, a large amount of unnecessary material accumulates in the tube between the outer surface cleaning unit 81 and the cleaning tank 83, and it is determined that the flow rate adjustment by the flow rate adjustment unit 81c is impossible.

  Then, the S probe outer surface cleaning error information is output to the mechanism control unit 32 a and also output to the output unit 50 via the system control unit 70. The mechanism control unit 32a stops the next sample dispensing operation by the sample dispensing probe 16 based on the error information.

  The cleaning unit control unit 32b is set according to the outer surface cleaning units 91 and 101 of the first and second reagent dispensing probe cleaning units 90 and 100 and the first and second stirring bar cleaning units 110 and 120. Based on the normal range, the warning range, and the allowable range, each cleaning unit and each analysis unit are controlled in the same manner as the outer surface cleaning unit 81. Each information is output to the output unit 50.

  A curve B represented on the x and y axes in FIG. 12 indicates the supply amount of the cleaning liquid supplied from the inner surface cleaning unit 82 of the sample dispensing probe cleaning unit 80 to the sample dispensing probe 16 and before being brought into the next sample. This represents the relationship with the amount of sample brought in.

  This curve B shows, for example, after the sample dispensing probe 16 is washed with the supply amount of the washing liquid when each tube between the supply pump 82a and the sample dispensing probe 16 is set to various dimensions, and before the next sample is washed. It is obtained by actually measuring the amount of sample brought in. Here, the supply amount NL1 or more of the cleaning liquid is set to a normal range. A supply amount LiL1 or more smaller than the supply amount NL1 is set as an allowable range. A warning range is set between the supply amount LiL1 and the supply amount NL1.

  The cleaning unit control unit 32b determines when the supply amount is out of the normal range based on the second measurement data output from the measurement unit 82c of the inner surface cleaning unit 82 at the time of cleaning.

  When the supply amount is out of the normal range and within the allowable range, for example, the component of the predetermined measurement item measured by the analysis unit 19a or 19b of the first or second analysis unit 200a or 200b has a predetermined concentration. It is determined that the adjusted carry-in amount of the previous sample is less than the allowable limit amount, and the analysis data of the predetermined measurement item in the next sample falls within the allowable error range. Further, it is determined that, for example, a small amount of unnecessary material is accumulated in the tube between the inner surface cleaning unit 82 and the sample dispensing probe 16, and S probe inner surface cleaning warning information for prompting cleaning in the tube is sent to the system control unit. The data is output to the output unit 50 via 70.

  When the supply amount is out of the allowable range, it is determined that the carry-in amount exceeds the allowable limit amount and the analysis data of the next sample is out of the allowable error range. Then, the S probe inner surface cleaning error information is output to the mechanism control unit 32 a and also output to the output unit 50 via the system control unit 70. Based on this error information, the mechanism control unit 32a stops the sample dispensing operation for dispensing the next sample by the sample dispensing probe 16.

  As in the case of the inner surface cleaning unit 82, the cleaning unit control unit 32b sets the normal range and warning set according to the inner surface cleaning units 92 and 102 of the first and second reagent dispensing probe cleaning units 90 and 100. Based on the range and the allowable range, the analysis units of the inner surface cleaning units 92 and 102 and the analysis unit 19a are controlled in the same manner as the inner surface cleaning unit 82. Each information is output to the output unit 50.

  Further, based on the second measurement data output from the measurement unit 82c at the time of sample suction and discharge, when the pressure value is higher than the allowable limit value, fibrin contained in, for example, serum at the tip of the sample dispensing probe 16 The clogging information is output to the mechanism control unit 32a and the output unit 50. Based on the clogging information, the mechanism control unit 32a stops the sample dispensing operation for dispensing the next sample by the sample dispensing probe 16.

Hereinafter, an example of the operation of the automatic analyzer 300 will be described with reference to FIGS. 1 to 20.
13 to 16 are flowcharts showing the operation of the automatic analyzer 300. FIG. 13 shows a sample dispensing operation corresponding to the measurement item measured by the first analysis unit 200a among the measurement items selected and input from the measurement item setting screen. FIG. 14 shows the first reagent dispensing operation corresponding to the measurement item measured by the first analyzer 200a. FIG. 15 shows a first stirring operation corresponding to a measurement item measured by the first analysis unit 200a. FIG. 16 shows the second reagent dispensing operation and the second stirring operation corresponding to the measurement item measured by the first analysis unit 200a, and the measurement item measurement operation measured by the second analysis unit 200b. .
FIG. 17 shows an example of a measurement item setting screen displayed on the display unit 52.
Further, FIG. 18 shows the timing of the sample dispensing operation corresponding to the flowchart of FIG. FIG. 19 shows the timing of the first reagent dispensing operation and the first stirring operation corresponding to the flowcharts of FIGS. 14 and 15. FIG. 20 shows the timing of the second reagent dispensing and second stirring operation of the measurement items measured by the first analyzer 200a corresponding to the flowchart of FIG.

  FIG. 13 is a flowchart showing the sample dispensing operation corresponding to the measurement items measured by the first analysis unit 200a among the measurement items selected and input from the measurement item setting screen of FIG.

  A calibration table for each measurement item is stored in advance in the storage unit 42 of the data processing unit 40 by a calibration operation from the operation unit 60. In addition, the measurement item selected and input for each test sample is stored in the internal storage circuit of the system control unit 70 by the measurement item selection input from the operation unit 60.

  FIG. 17 is a diagram illustrating an example of a measurement item setting screen that is selectively input and displayed on the display unit 52. The measurement item setting screen 53 includes an “ID” column for displaying the ID of the subject input on the subject information input screen, an “item” column for displaying the item name in an abbreviated name, and an “ID” column. The measurement item setting area 53a for setting the measurement item of the item name displayed in the “item” column for each subject ID displayed in FIG.

  In the “ID” column, for example, “1” and “2” IDs of subjects input in advance are displayed. In the “item” column, item names such as “GOT”, “GPT”, “Ca” measured by the first analysis unit 200a, and “HBsAg” measured by the second analysis unit 200b are displayed. It is displayed.

  In the measurement item setting area 53a, “◯” is displayed when the item name in the “item” column corresponding to the ID of each subject in the “ID” column is set, and “0” is displayed when the item name is not set.・ ”Is displayed. For example, when “GOT” and “Ca” are set for “1” displayed in the “ID” column from the operation unit 60, one test corresponding to “GOT” is set in the measurement item setting area 53a. And “◯” of two tests corresponding to “Ca” is displayed. When “GPT” and “HBsAg” are set for “2” displayed in the “ID” column, “○” of 3 tests corresponding to “GPT” and 4 tests corresponding to “HBSAg” are set. Is displayed.

  Measurement item setting information selected and input from the measurement item setting screen 53 is stored in an internal storage circuit of the system control unit 70. The measurement of the test sample is performed based on the input information, and the selected measurement items to the left of the ID of each test object are sequentially selected from the test sample corresponding to “1” at the top of “ID”. The measurement is performed in order from “GOT”.

  First, the sample container 17 containing the test samples with the subject IDs “1” and “2” is arranged in the transport unit 250. And if measurement start operation of a test sample is performed from the operation part 60, the automatic analyzer 300 will start operation | movement (step S1 of FIG. 13).

  The system control unit 70 measures the measurement items for each test sample stored in the internal storage circuit in the first and second analysis units 200a and 200b, the transport unit 250, the data processing unit 40, and the output unit 50. Instruct. The analysis control units 30a and 30b of the first and second analysis units 200a and 200b temporarily move the analysis units of the analysis units 19a and 19b to their home positions. Further, the transport unit 250 transports the sample container 17 containing the test sample having the subject ID “m” (m = 1) to the vicinity of the sample unit 20 of the analysis unit 19a (step S2 in FIG. 13).

  The sample dispensing probe 16 of the sample unit 20 includes the m test measurement item of the subject ID “m” selected and input on the measurement item setting screen 53 in the m analysis cycle shown in FIG. 18, and (m + 1) analysis cycle. (M + 1) A test sample for measuring the measurement items of the test is dispensed (step S3 in FIG. 13). It is assumed that the test sample for m test is accommodated in the reaction vessel 4Tm by this sample dispensing operation.

  Then, the outer surface cleaning unit 81 and the inner surface cleaning unit 82 of the sample dispensing probe cleaning unit 80 in the cleaning unit 23 of the analysis unit 19a are moved to the cleaning tank 83 in the (m + 1) analysis cycle of FIG. The dummy test sample with the subject ID “m” and the air are pushed out, and cleaning is performed to wash out the test sample adhering to the contact outer surface and the contact inner surface of the sample dispensing probe 16 (step S4 in FIG. 13). ).

  In this cleaning operation, the measurement unit 81d of the outer surface cleaning unit 81 and the measurement unit 82c of the inner surface cleaning unit 82 measure the supply amount of the cleaning liquid to be supplied to the sample dispensing probe 16, and generate the first and second. The measurement data is output to the cleaning unit controller 32b of the analysis controller 30a.

  When the supply amount of the cleaning liquid supplied to the cleaning tank 83 is within the normal range (Yes in step S5 in FIG. 13), it is determined that the cleaning is performed normally, and the process proceeds to step S6. If the normal range is not reached (No in step S5 in FIG. 13), the process proceeds to step S7.

  Next, when the supply amount of the cleaning liquid supplied to the cleaning tank 83 is within the warning range (Yes in step S7 in FIG. 13), S probe outer surface warning information for prompting the cleaning in the tube is displayed on the output unit 50, for example, the display unit. 52 (step S8 in FIG. 13).

  If the warning range is not reached (No in step S7 in FIG. 13), the S probe outer surface cleaning error information for stopping the dispensing of the next test sample at that time is sent to the mechanism control unit 32a of the analysis control unit 30a. And output to the output unit 50. The mechanism control unit 32a stops the sample dispensing operation based on the S probe outer surface cleaning error information from the cleaning unit control unit 32b (step 9 in FIG. 13). Thereafter, the process proceeds to the steps of FIGS.

  After “Yes” in Step S5, when the supply amount of the cleaning liquid supplied into the sample dispensing probe 16 is within the normal range (Yes in Step S6 in FIG. 13), it is determined that the cleaning is performed normally. Then, the process proceeds to step S13. If the normal range is not reached (No in step S6 in FIG. 13), the process proceeds to step S10.

  When the supply amount of the cleaning liquid is within the warning range (Yes in step S10 in FIG. 13), S probe inner surface warning information for prompting cleaning of the tube is output to the output unit 50 (step S11 in FIG. 13). ). If the supply amount of the cleaning liquid is out of the warning range (No in step S10 in FIG. 13), the mechanism control unit displays S probe inner surface cleaning error information for stopping the dispensing of the next test sample at that time. 32a and the output unit 50. The mechanism control unit 32a stops the sample dispensing operation based on the S probe inner surface cleaning error information from the cleaning unit control unit 32b (step 12 in FIG. 13). Thereafter, the process proceeds to the steps of FIGS.

  When “yes” in step S6, or after step S8 or step S11, m is 2 (yes in step S13 in FIG. 13), the process proceeds to the steps in FIG. 14 and FIG. If m is 1 (No in step S13 in FIG. 13), the process returns to step S2.

  Here, an example of the operation when the S probe outer surface and S probe inner surface cleaning errors of steps S9 and S12 do not occur in the sample dispensing operation of the test sample corresponding to the first test to the third test will be described below. To do.

FIG. 14 is a flowchart showing the first reagent dispensing operation corresponding to the measurement item measured by the first analysis unit 200a.
The first reagent dispensing probe 14 in the reagent unit 21 of the analysis unit 19a is configured to supply the first reagent of the measurement item of the test (n-5) in the n analysis cycle (n = 6) shown in FIG. Dispensing (step S21 in FIG. 14).

  Note that the first reagent is not dispensed into the reaction vessel 4Ti (1 ≦ i ≦ 3) of the test in which the S probe outer surface and inner surface cleaning errors of steps S9 and S12 occurred in the sample dispensing operation of FIG. ing.

  The outer surface cleaning unit 91 and the inner surface cleaning unit 92 of the first reagent dispensing probe cleaning unit 90 in the cleaning unit 23 are air and dummy in the first reagent dispensing probe 14 that has moved to the cleaning tank 93 in the n analysis cycle. The first reagent is pushed out, and cleaning is performed to wash out the test sample adhering to the contact outer surface and the contact inner surface of the first reagent dispensing probe 14 (step S22 in FIG. 14).

  In this cleaning operation, the measuring unit 91d of the outer surface cleaning unit 91 and the measuring unit 92c of the inner surface cleaning unit 92 measure the supply amount of the cleaning liquid supplied to clean the first reagent dispensing probe 14, and generate the first The second measurement data is output to the cleaning unit controller 32b.

  If the supply amount of the cleaning liquid supplied to the cleaning tank 93 is within the normal range (Yes in step S23 in FIG. 14), it is determined that the cleaning is performed normally, and the process proceeds to step S24. On the other hand, if it is out of the normal range (No in step S23 in FIG. 14), the process proceeds to step S25.

  Next, when the supply amount of the cleaning liquid is within the warning range (Yes in step S25 in FIG. 14), R1 probe outer surface warning information for prompting cleaning in the tube is output to the output unit 50 (step S26 in FIG. 14). ). Thereafter, the process proceeds to step S31.

  Further, when the supply amount of the cleaning liquid is out of the warning range (No in step S25 in FIG. 14), at that time (n-4) the R1 probe for stopping the dispensing of the first reagent of the measurement item of the test The external surface cleaning error information is output to the mechanism control unit 32a and the output unit 50. The mechanism control unit 32a stops the first reagent dispensing operation based on the R1 probe outer surface cleaning error information from the cleaning unit control unit 32b (step 27 in FIG. 14). Thereafter, the process proceeds to the step of FIG.

  If the supply amount of the cleaning liquid supplied into the first reagent dispensing probe 14 is within the normal range after “Yes” in Step S23 (Yes in Step S24 in FIG. 14), it is determined that the supply amount is normal. Then, the process proceeds to step S31. On the other hand, if it is out of the normal range (No in step S24 in FIG. 14), the process proceeds to step S28.

  When the supply amount of the cleaning liquid is within the warning range (Yes in step S28 in FIG. 14), R1 probe inner surface warning information for prompting cleaning in the tube is output to the output unit 50 (step S29 in FIG. 14). ). Thereafter, the process proceeds to step S31.

  Further, when the supply amount of the cleaning liquid is out of the warning range (No in step S28 in FIG. 14), at that time (n-4) the R1 probe for stopping the dispensing of the first reagent of the measurement item of the test The inner surface cleaning error information is output to the mechanism control unit 32a and the output unit 50. The mechanism control unit 32a stops the first reagent dispensing operation based on the R1 probe inner surface cleaning error information from the cleaning unit control unit 32b (step 30 in FIG. 14). Thereafter, the process proceeds to the step of FIG.

  When “yes” in step S24, or after step S26 or step S29, n is 8 (yes in step S31 in FIG. 14), the process proceeds to the step in FIG. If n is less than 8 (No in step S31 in FIG. 14), the process returns to step S21.

  Here, in the first reagent dispensing operation corresponding to the first test to the third test, an example of the operation when the R1 probe outer surface and inner surface cleaning errors do not occur in steps S27 and S30 will be described below.

FIG. 15 is a flowchart showing a first stirring operation corresponding to a measurement item measured by the first analysis unit 200a.
The first stirring bar 11a1 in the reaction unit 22 of the analysis unit 19a is accommodated in the reaction vessel 4T (p-6) in the p analysis cycle (p = 7) shown in FIG. 19B (p-6). ) The first mixed liquid composed of the test sample to be tested and the first reagent is stirred (step S41 in FIG. 15).

  In the sample dispensing operation of FIG. 13, the S probe outer surface and inner surface cleaning error occurred in steps S9 and S12, and the R1 probe outer surface and inner surface cleaning error of steps S27 and S30 in the first reagent dispensing operation of FIG. The first agitation is not performed in the reaction vessel 4Ti (1 ≦ i ≦ 3) of the test in which the above occurred.

  Then, the outer surface cleaning unit 111 of the first stirrer cleaning unit 110 in the cleaning unit 23 is for washing away the first mixed liquid adhering to the contact outer surface of the first stirrer 11a1 moved to the cleaning tank 113 in the p analysis cycle. (Step S42 in FIG. 15).

  In this cleaning operation, the measurement unit 111d of the outer surface cleaning unit 111 outputs the first measurement data generated by measuring the supply amount of the cleaning liquid supplied to the first stirrer 11a1 to the cleaning unit control unit 32b.

  Then, when the supply amount of the cleaning liquid supplied to the cleaning tank 113 is within the normal range (Yes in step S43 in FIG. 15), the process proceeds to step S47. If the normal range is not reached (No in step S43 in FIG. 15), the process proceeds to step S44.

  Next, when the supply amount of the cleaning liquid is within the warning range (Yes in step S44 in FIG. 15), the first stirrer surface warning information for prompting cleaning in the tube is output to the output unit 50 (in FIG. 15). Step S45). Thereafter, the process proceeds to step S47.

  When the supply amount of the cleaning liquid is out of the warning range (No in step S44 in FIG. 15), the first stirrer 11a1 is moved to the reaction container 4T (p-5) of the test (p-5) and the first stirring bar 11a1 is moved. The first stirrer surface cleaning error information for stopping the first stirring / stirring operation for stirring the first mixed liquid is output to the mechanism control unit 32a and the output unit 50. The mechanism control unit 32a stops the first stirring operation of the test (p-5) based on the first stirrer surface cleaning error information from the cleaning unit control unit 32b (step 46 in FIG. 15). Thereafter, the process proceeds to the step of FIG.

  If “yes” in step S43 or p is 9 after step S45 (yes in step S47 in FIG. 15), the process proceeds to the step in FIG. If p is less than 9 (No in step S47 in FIG. 15), the process returns to step S41.

  Here, an example of the operation in which the first stirrer surface cleaning error in step S46 has not occurred in the first stirring operation corresponding to the first to third tests will be described below.

  FIG. 16 shows the second reagent dispensing and second stirring operation corresponding to the measurement item measured by the first analysis unit 200a and the measurement operation of the measurement item measured by the second analysis unit 200b. It is a flowchart.

  In step S51, the second reagent dispensing probe 15 of the reagent unit 21 dispenses the second reagent of the measurement item of one test in the k analysis cycle (9 <k) shown in FIG.

  In the sample dispensing operation shown in FIG. 13, the S probe outer surface and inner surface cleaning error occurred in steps S9 and S12. In the first reagent dispensing operation shown in FIG. 14, the R1 probe outer surface and inner surface cleaning error occurred in steps S27 and S30. The second reagent dispensing operation is not performed on the reaction container 4Ti of the test that has occurred and the test that has caused the first stirrer surface cleaning error in step S46 in the first stirring operation of FIG.

  Then, the second reagent dispensing probe washing unit 100 in the washing unit 23 performs washing for washing off the second reagent adhering to the contact surface of the second reagent dispensing probe 15 moved to the washing tank 103 in the k analysis cycle. Do.

  The cleaning unit control unit 32b, based on the first and second measurement data output from the second reagent dispensing probe cleaning unit 100 in this cleaning operation, similarly to steps S23 to S30 in the first reagent dispensing operation. Operate.

  Then, when the R2 probe outer surface and inner surface cleaning error does not occur in the second reagent dispensing operation in the k analysis cycle, the second reagent of the measurement items of the two tests is dispensed in the (k + 1) analysis cycle. . In addition, if no error in cleaning the outer surface and the inner surface of the R2 probe occurs during the second reagent dispensing operation in the (k + 1) analysis cycle, the second reagent of the three test items is dispensed in the (k + 2) analysis cycle. Note.

  Here, an example of the operation when the R2 probe outer surface and inner surface cleaning errors do not occur in the second reagent dispensing operation corresponding to the first to third tests will be described below.

  In step S52, the second stirrer 11b1 of the reaction unit 22 includes the test sample, the first reagent, and the test sample stored in the reaction vessel 4T1 in, for example, the (k + 1) analysis cycle illustrated in FIG. The second mixed liquid composed of the second reagent is stirred.

  In the sample dispensing operation shown in FIG. 13, the S probe outer surface and inner surface cleaning error occurred in steps S9 and S12. In the first reagent dispensing operation shown in FIG. 14, the R1 probe outer surface and inner surface cleaning error occurred in steps S27 and S30. The test that occurred, the test that the first stirrer surface cleaning error in step S46 occurred in the first stirring operation of FIG. 15, and the test that the R2 probe outer surface and inner surface cleaning error occurred in the second reagent dispensing operation in step S51. The second stirring is not performed on the reaction vessel 4Ti.

  And the outer surface washing | cleaning part 121 of the 2nd stirring element washing | cleaning part 120 in the washing | cleaning part 23 removes the 2nd liquid mixture adhering to the contact outer surface of the 2nd stirring element 11b1 which moved to the washing tank 123 in the (k + 1) analysis cycle. Wash to wash off.

  The cleaning unit controller 32b operates in the same manner as Steps S43 to S46 in the first stirring operation based on the first measurement data output from the second stirring bar cleaning unit 120 in this cleaning operation.

  If the second stirrer surface cleaning error does not occur in the second stirring operation in the (k + 1) analysis cycle, the second mixed liquid of the measurement items of the two tests is stirred in the (k + 2) analysis cycle. To do. In addition, if no second stirrer surface cleaning error occurs in the second stirring operation in the (k + 2) analysis cycle, the second mixed liquid of the measurement items of the three tests is stirred in the (k + 3) analysis cycle. To do.

  Here, an example of the operation when the second stirring element surface cleaning error does not occur in the second stirring operation corresponding to the first test to the third test will be described below.

  After step S52, the photometric unit 13 of the reaction unit 22 irradiates the reaction container 4Ti containing the second mixed liquid with light, and measures the absorbance at the set wavelength from the transmitted light. Then, test data of each measurement item of the test samples with the test subject IDs “1” and “2” is generated and output to the calculation unit 41 of the data processing unit 40 (step S53 in FIG. 16).

  The calculation unit 41 generates analysis data of each measurement item of each test sample from the test data output from the photometry unit 13, stores it in the storage unit 42, and outputs it to the output unit 50 (step of FIG. 16). S54).

  After “Yes” in step S15, the transport unit 250 transports the sample container 17 containing the test sample with the subject ID “2” to the vicinity of the analysis unit 19b of the second analysis unit 200b (FIG. 13). Step S61).

  The analysis unit 19b measures the intensity of light emitted by the immune reaction of the mixture obtained by dispensing the test sample with the subject ID “2” and the immunoreagent with “HBsAg” corresponding to the three tests. The test data generated by this measurement is output to the calculation unit 41 (step S62 in FIG. 16).

  It should be noted that the test sample in which the S probe outer surface and inner surface cleaning errors in steps S9 and S12 occurred in the sample dispensing operation of FIG. 13 is not dispensed by the second analyzer 200b.

  The calculation unit 41 generates analysis data from the test data output from the analysis unit 19b, stores it in the storage unit 42, and outputs it to the output unit 50 (step S63 in FIG. 16).

  When the analysis units 19a and 19b finish cleaning of all the analysis units and the analysis data of all the measurement items of the subject IDs “1” and “2” are output, the automatic analyzer 300 performs the measurement. The operation is terminated (step S71 in FIG. 16).

  According to the embodiment of the present invention described above, the cleaning liquid supplied to the contact outer surface of the sample dispensing probe 16, the first and second reagent dispensing probes 14, 15 and the first and second stirring bars 11a1, 11b1. Based on the first measurement data generated by measuring the supply amount, the supply amount of the cleaning liquid supplied to each analysis unit can be adjusted to the normal range. Further, when the supply amount of the cleaning liquid supplied to each analysis unit is out of the normal range and within the warning range, the warning information can be output to the output unit 50.

  Then, based on the second measurement data generated by measuring the supply amount of the cleaning liquid supplied to the contact inner surface of the sample dispensing probe 16 and the first measurement data, the contact inner surface of the sample dispensing probe 16 and / or When the supply amount of the cleaning liquid supplied to the contact outer surface is out of the allowable range, the sample dispensing operation in the analysis units 19a and 19b for dispensing the next test sample can be stopped.

  The contact of the first reagent dispensing probe 14 based on the second measurement data generated by measuring the supply amount of the cleaning liquid supplied to the contact inner surface of the first reagent dispensing probe 14 and the first measurement data. When the supply amount of the cleaning liquid supplied to the inner surface and / or the contact outer surface is out of the allowable range, the first reagent dispensing operation in the analysis unit 19a for dispensing the next first reagent can be stopped. Further, based on the second measurement data generated by measuring the supply amount of the cleaning liquid supplied to the contact inner surface of the second reagent dispensing probe 15 and the first measurement data, the contact of the second reagent dispensing probe 15 is performed. When the supply amount of the cleaning liquid supplied to the inner surface and / or the contact outer surface is out of the allowable range, the second reagent dispensing operation in the analysis unit 19a for dispensing the next second reagent can be stopped.

  Further, based on the first measurement data of the first stirring bar 11a1, the next first mixed liquid is stirred when the supply amount of the cleaning liquid supplied to the contact outer surface of the first stirring bar 11a1 is out of the allowable range. Therefore, the first stirring operation in the analysis unit 19a can be stopped. Further, based on the first measurement data of the second stirring bar 11b1, when the supply amount of the cleaning liquid supplied to the contact outer surface of the second stirring bar 11b1 is out of the allowable range, the next second liquid mixture is stirred. Therefore, the second stirring operation in the analyzing unit 19a can be stopped.

  Thereby, it is possible to prevent the measurement sample such as the previous test sample, the reagent, and the mixed solution from being brought into the next measurement sample through each analysis unit, and perform measurement with high accuracy.

The block diagram which shows the structure of the automatic analyzer which concerns on the Example of this invention. The figure which shows the detail of a structure of the analysis part in the 1st analysis part which concerns on the Example of this invention. The figure which shows the sample dispensing operation | movement in the sample part which concerns on the Example of this invention. The block diagram which shows the detail of a structure of the washing | cleaning part which concerns on the Example of this invention. The figure which shows the structure of the sample dispensing probe washing | cleaning part which concerns on the Example of this invention. The figure which shows the structure of the washing tank which concerns on the Example of this invention. The figure which shows the structure of the 1st reagent dispensing probe washing | cleaning part which concerns on the Example of this invention. The figure which shows the structure of the 2nd reagent dispensing probe washing | cleaning part which concerns on the Example of this invention. The figure which shows the structure of the 1st stirring element washing | cleaning part which concerns on the Example of this invention. The figure which shows the structure of the 2nd stirring element washing | cleaning part which concerns on the Example of this invention. The figure for demonstrating the detail of control of the outer surface washing | cleaning part of the sample dispensing probe washing | cleaning part in the washing | cleaning unit control part which concerns on the Example of this invention. The figure for demonstrating the detail of control of the inner surface washing | cleaning part of the sample dispensing probe washing | cleaning part in the washing | cleaning unit control part which concerns on the Example of this invention. The flowchart which shows an example of the sample dispensing operation | movement of the measurement item measured by the 1st analysis part which concerns on the Example of this invention. The flowchart which shows an example of the 1st reagent dispensing operation | movement of the measurement item measured by the 1st analysis part which concerns on the Example of this invention. The flowchart which shows an example of the 1st stirring operation | movement of the measurement item measured by the 1st analysis part which concerns on the Example of this invention. The flowchart which shows an example of 2nd reagent dispensing and 2nd stirring operation of the measurement item measured by the 1st analysis part which concerns on the Example of this invention, and the measurement operation of the measurement item measured by the 2nd analysis part. . The figure which shows an example of the measurement item setting screen which concerns on the Example of this invention. The figure which shows an example of the sample dispensing operation | movement timing corresponding to the flowchart of FIG. 13 which concerns on the Example of this invention. The figure which shows an example of the 1st reagent dispensing and 1st stirring operation timing corresponding to the flowchart of FIG.14 and FIG.15 which concerns on the Example of this invention. The figure which shows an example of the 2nd reagent dispensing of the measurement item measured by the 1st analysis part corresponding to the flowchart of FIG. 16 which concerns on the Example of this invention, and a 2nd stirring operation timing.

Explanation of symbols

19a, 19b Analysis unit 20 Sample unit 21 Reagent unit 22 Reaction unit 23 Cleaning unit 30a, 30b Analysis control unit 31 Mechanism unit 32 Control unit 32a Mechanism control unit 32b Cleaning unit control unit 40 Data processing unit 41 Calculation unit 42 Storage unit 50 Output Unit 51 printing unit 52 display unit 60 operation unit 70 system control unit 200a first analysis unit 200b second analysis unit 250 transport unit 300 automatic analyzer

Claims (11)

In an automatic analyzer that dispenses test samples and reagents into containers and measures the mixture,
A sample dispensing probe for dispensing the test sample into the container;
Supply means for supplying a cleaning solution for cleaning the sample dispensing probe;
Measuring means for measuring the supply amount of the cleaning liquid supplied from the supply means to the sample dispensing probe;
An automatic analysis comprising: control means for controlling to stop the dispensing operation of the sample dispensing probe and / or to output warning information based on the supply amount measured by the measuring means apparatus.   The control unit is configured to stop the operation of the sample dispensing probe when the supply amount of the cleaning liquid supplied from the supply unit to the sample dispensing probe is out of an allowable range. Item 2. The automatic analyzer according to Item 1. An output means for outputting the measurement result of the mixed liquid;
The control means outputs the warning information to the output means when the supply amount of the cleaning liquid supplied from the supply means to the sample dispensing probe is within a warning range. Item 2. The automatic analyzer according to Item 1.   2. The automatic analyzer according to claim 1, wherein the control unit controls a supply amount of a cleaning liquid supplied from the supply unit to the sample dispensing probe.   The automatic analyzer according to claim 1, wherein the measuring unit measures a flow rate of a cleaning liquid for cleaning an outer surface of the sample dispensing probe that is in contact with the test sample.   The automatic analyzer according to claim 1, wherein the measuring unit measures a pressure of a cleaning liquid for cleaning an inner surface of the sample dispensing probe that is in contact with the test sample.   The measurement means measures the pressure at the time of suction or discharge of the test sample in the dispensing of the sample dispensing probe, and detects clogging of the sample dispensing probe. 6. The automatic analyzer according to 6. Transport means for transporting the test sample;
A first analysis means for measuring the test sample transported by the transport means by dispensing it into the container with the sample dispensing probe;
Second analysis means for measuring by dispensing the test sample transported by the transport means,
2. The automatic analyzer according to claim 1, wherein the transport unit transports the test sample to the first analysis unit, and then transports the sample to the second analysis unit.   9. The automatic analyzer according to claim 8, wherein the second analyzing unit measures the intensity of light emitted from a mixture of a trace component contained in the test sample and the reagent that reacts with the component. . In an automatic analyzer that dispenses test samples and reagents into containers and measures the mixture,
A reagent dispensing probe for dispensing the reagent into the container;
Supply means for supplying a cleaning solution for cleaning the reagent dispensing probe;
Measuring means for measuring the supply amount of the cleaning liquid supplied from the supply means to the reagent dispensing probe;
An automatic analysis comprising: control means for controlling to stop the dispensing operation of the reagent dispensing probe and / or to output warning information based on the supply amount measured by the measuring means apparatus. In an automatic analyzer that dispenses test samples and reagents into containers and measures the mixture,
A stir bar that moves into the vessel and stirs the mixture;
Supply means for supplying a cleaning liquid for cleaning the stirring bar;
Measuring means for measuring the supply amount of the cleaning liquid supplied from the supply means to the stirrer;
And automatic control means for performing control for stopping movement of the stirrer into the container and / or control for outputting warning information based on the supply amount measured by the measuring means. Analysis equipment.

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