JP2020052014A - Sample analysis device, sample analysis method, and program - Google Patents

Abstract

To provide sample analysis device, sample analysis method, and program, which enhance reliability of analysis results even if a cleaning liquid used for cleaning is unknown.SOLUTION: A sample analysis device 30 is provided, comprising a reader unit 335 configured to read "read information" from an identification member 21 provided on an exterior surface of a cleaning liquid container 20 having a cleaning liquid therein; a cleaning unit 100 configured to clean a suction unit 451 in the sample analysis device 30 using the cleaning liquid; and a control unit 331 configured to switch between operating conditions of the cleaning unit 100 according to the read information.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a sample analyzer, a sample analysis method, and a program.

  Patent Literature 1 discloses a sample analyzer that determines whether or not a reagent is appropriate at the time of reagent replacement. As shown in FIG. 16, in this sample analyzer, the user inputs the 27-digit Reagent Code attached to the reagent on the reagent replacement screen 610, and presses the execution button 611. If the entered Reagent Code is incorrect, a Reagent Code warning screen 620 is displayed. The Reagent Code warning screen 620 displays a warning that the Reagent Code has not been correctly entered and that the analysis result cannot be guaranteed, and also confirms with the user whether to execute reagent replacement. Is displayed.

JP 2013-190446 A

  In the above-described sample analyzer, a predetermined portion in the device is cleaned using a cleaning liquid. In this case, in order to obtain an appropriate analysis result, it is necessary for the apparatus manufacturer to perform sufficient cleaning using a cleaning liquid in which components and the like are set. However, there is a case where a cleaning liquid in which a component other than a device manufacturing company sets components and the like, in other words, an unknown cleaning liquid whose components and expiration dates cannot be grasped is used for cleaning. When an unknown cleaning solution is used in this way, even if a screen as shown in FIG. 16 is displayed, if the analysis proceeds as it is, the reliability of the analysis result decreases.

  The first aspect of the present invention relates to a sample analyzer that measures a measurement sample prepared by mixing a sample and a reagent, and analyzes the sample based on the measurement result. The sample analyzer (30) according to this aspect includes a reading unit (335) that reads read information from a container (20) containing a cleaning liquid, and a predetermined part (451) in the apparatus (30) using the cleaning liquid. And a control unit (331) that switches operating conditions of the cleaning unit (100) based on the read information.

  If a cleaning liquid in which components are set by a company other than the manufacturer of the sample analyzer is used, there is a possibility that proper cleaning cannot be performed because the components of the cleaning liquid and the expiration date are unknown. According to the sample analyzer of this aspect, the operating conditions of the cleaning unit are switched based on the read information. Therefore, when it is considered that the cleaning liquid in which the components and the like are set by a company other than the manufacturing company of the sample analyzer based on the read information is stored in the cleaning liquid container, by changing the operating conditions, for example, the cleaning time is extended. As a result, highly reliable cleaning can be performed. Therefore, even when the cleaning is performed using an unknown cleaning liquid whose component, expiration date, and the like cannot be determined, the reliability of the analysis result can be improved.

  In the sample analyzer (30) according to this aspect, when the cleaning unit (100) acquires the cleaning liquid information on the cleaning liquid contained in the container (20) from the read information, the cleaning unit (100) performs the predetermined operation using the cleaning liquid according to the first operating condition. If the part (451) is cleaned and the cleaning liquid information is not obtained from the read information, the predetermined part (451) may be cleaned using the cleaning liquid according to the second operation condition different from the first operation condition. At this time, when the cleaning liquid information is obtained from the read information, it can be assumed that the cleaning liquid in which the manufacturer of the sample analyzer has set the components and the like is contained in the container, and when the cleaning liquid information is not obtained from the read information, Further, it can be assumed that a cleaning liquid in which components other than the manufacturer of the sample analyzer are set is stored in the container. Therefore, for example, by performing more reliable cleaning under the second operating condition than under the first operating condition, the reliability of the analysis result can be enhanced even when an unknown cleaning liquid is used.

  In this case, the sample analyzer (30) according to this aspect may be configured to include the control unit (331) that determines whether the cleaning liquid information has been acquired from the read information.

  In the sample analyzer (30) according to this aspect, the cleaning time under the second operating condition may be set longer than the cleaning time under the first operating condition. In this case, even if an unknown cleaning liquid is used, reliable cleaning can be performed.

  In the sample analyzer (30) according to this aspect, the number of times of washing under the second operating condition may be set to be larger than the number of times of washing under the first operating condition. In this case, even if an unknown cleaning liquid is used, reliable cleaning can be performed.

  In the sample analyzer (30) according to this aspect, the time required for one cycle of operation including the cleaning operation of the predetermined portion (451) when the cleaning is performed under the second operation condition is as follows. In this case, the time may be an integral multiple of the time required for one cycle of operation including the cleaning operation of the predetermined portion (451). With this configuration, the operation under the first operation condition and the operation under the second operation condition can be easily switched.

  The sample analyzer (30) according to the present aspect is configured such that when the number of washings performed according to the first operation condition reaches a number obtained by subtracting the first number from the number of washable times set for the container (20), the container ( The notification for prompting the replacement of 20) is performed, and the number of times of cleaning performed in accordance with the second operation condition is reduced to the number of times obtained by subtracting the second number greater than the first number from the settable number of cleanings set for the container (20). When it arrives, it can be configured to provide a notification to prompt the replacement of the container (20). In the case of a cleaning liquid in which a component other than the manufacturer of the sample analyzer is set, the cleaning liquid may be inadvertently exhausted because the remaining amount of the container containing the cleaning liquid is unknown. According to the sample analyzer of the present aspect, when cleaning is performed under the second operating condition, replacement of the container is prompted earlier than under the first operating condition. In addition, measurement and analysis with low reliability can be prevented.

  The sample analyzer (30) according to this aspect, when cleaning is performed according to the second operating condition, when the date and time that has advanced the expiration date set for the container (20) by a predetermined number of days has arrived, 20) It can be configured to notify that the expiration date has arrived. In the case of a cleaning solution in which components other than the manufacturer of the sample analyzer are set, the deterioration of the cleaning solution may proceed unintentionally. According to the sample analyzer of this aspect, when washing is performed under the second operating condition, a date and time that is earlier than the original expiration date by a predetermined number of days is set as a new expiration date. Thereby, unintended deterioration of the cleaning liquid can be prevented, and measurement and analysis with low reliability can be prevented.

  In the sample analyzer (30) according to this aspect, the reading unit (335) may be configured to be a barcode reader for reading read information from a barcode of the container (20). The barcode provided on the container is a one-dimensional code having information in one direction, a two-dimensional code such as a QR code (registered trademark), or the like. In this case, the read information can be smoothly acquired from the container.

  In the sample analyzer (30) according to this aspect, the reading unit (335) may be configured to be an RFID reader for reading read information from the RF tag of the container (20). In this case, the read information can be smoothly acquired from the container.

  The sample analyzer (30) according to this aspect may be configured to notify that the analysis result cannot be guaranteed if the cleaning liquid information regarding the cleaning liquid contained in the container (20) is not obtained from the read information. In this way, the operator can grasp that the reliability of the analysis result may be low as a result of using the unknown cleaning liquid based on the notification contents.

  In this case, the sample analyzer (30) according to this aspect includes a display unit (333) that displays an analysis result list screen (210) showing a list of analysis results for each sample, and acquires cleaning liquid information from the read information. If not, the analysis result list screen (210) may indicate that the analysis result cannot be guaranteed for the display of the corresponding sample. This allows the operator to visually grasp the analysis result with low reliability when the analysis result list screen is displayed.

  In addition, the sample analyzer (30) according to the present embodiment includes the display unit (333) that displays the analysis result detail screen (220) indicating the details of the analysis result of the sample, and the cleaning liquid information is not obtained from the read information. In this case, a message that the analysis result cannot be guaranteed may be displayed on the analysis result detail screen (220). Thus, the operator can visually grasp the reliability of the analysis result of the sample when the analysis result detail screen is displayed.

  Further, the sample analyzer (30) according to this aspect includes a display unit (333) for displaying a reagent list screen (230) showing a list of reagents. On the screen (230), a mark (232a) indicating that the analysis result cannot be guaranteed for the display of the corresponding cleaning liquid may be added. In this way, the operator can visually grasp the cleaning liquid that may reduce the reliability of the analysis result when the reagent list screen is displayed.

  The sample analyzer (30) according to the present embodiment includes a receiving unit (334) for receiving an input of cleaning liquid information on the cleaning liquid contained in the container (20), and the cleaning unit (100) converts the reading information into the cleaning liquid information. Is acquired, and when the cleaning liquid information received by the receiving unit (334) is the predetermined cleaning liquid information, the predetermined part (451) is cleaned using the cleaning liquid according to the first operation condition, and the read information is read. When the cleaning liquid information is not acquired and the cleaning liquid information received by the receiving unit (334) is not the predetermined cleaning liquid information, the predetermined part (451) is cleaned using the cleaning liquid according to the second operation condition different from the first operation condition. It can be configured to: The receiving unit is, for example, a touch panel, a keyboard, a mouse, and the like. In this case, even though the cleaning liquid in which the manufacturing company of the sample analyzer has set the components and the like is stored in the container, even if the cleaning liquid information is not obtained from the read information, based on the cleaning liquid information received by the receiving unit, The first operating condition can be set appropriately.

  In this case, the sample analyzer (30) according to this aspect is configured to include the control unit (331) that determines whether the cleaning liquid information received by the receiving unit (334) is predetermined cleaning liquid information. obtain.

  The sample analyzer (30) according to this aspect includes a reagent dispensing section (450) for dispensing a reagent, and a predetermined portion (451) in the apparatus (30) is provided with a nozzle of the reagent dispensing section (450). And In this case, the measurement sample can be properly prepared by washing the nozzle.

  In this case, the reagent dispensing unit (450) may be configured to dispense a reagent according to the measurement item among the plurality of reagents via the nozzle. Even when a plurality of reagents are used in this way, by mixing the nozzles, the reagents can be prevented from being mixed with each other, and the measurement sample can be appropriately prepared.

  In the sample analyzer (30) according to the present aspect, the washing liquid information may be configured to include at least one of a lot number, an expiration date, a type of the washing liquid, a washable number of times, and a capacity. Thus, the quality of the cleaning liquid can be determined based on the cleaning liquid information.

  A second aspect of the present invention relates to a sample analysis method for measuring a measurement sample prepared by mixing a sample and a reagent, and analyzing the sample based on the measurement result. In the sample analysis method according to this aspect, read information is read from a container (20) containing a cleaning liquid, and operating conditions for cleaning a predetermined portion (451) in the device (30) are switched based on the read information, and the read information is read. A predetermined portion (451) is cleaned with a cleaning liquid according to the operating conditions based on the above.

  According to the sample analysis method according to this aspect, the same effect as in the first aspect can be obtained.

  A third aspect of the present invention relates to a program. The program (332a) according to the present embodiment includes a computer (30) for analyzing a sample based on a measurement result of a measurement sample prepared by mixing a sample and a reagent, and a computer (30) for storing a cleaning liquid. Based on the read information read from (20), a process of switching operating conditions for cleaning a predetermined portion (451) in the device (30) is executed.

  According to the program of the present aspect, the same effect as in the first aspect can be obtained.

  ADVANTAGE OF THE INVENTION According to this invention, even if it wash | cleans using an unknown washing | cleaning liquid, the reliability of an analysis result can be improved.

FIG. 1 is a schematic diagram illustrating an outline of a configuration of the sample analyzer according to the first embodiment. FIG. 2 is a schematic diagram illustrating a procedure in which the sample analyzer according to the first embodiment acquires cleaning liquid information on the cleaning liquid. FIG. 3 is a plan view schematically illustrating a configuration when the transport unit and the measurement unit according to the first embodiment are viewed from above. FIG. 4A is a cross-sectional view schematically illustrating a configuration of the suction unit and the cleaning tank according to the first embodiment. FIG. 4B is a diagram schematically illustrating a configuration of the cleaning unit according to the first embodiment. FIG. 5 is a block diagram illustrating a configuration of the sample analyzer according to the first embodiment. FIG. 6 is a flowchart illustrating a process for acquiring cleaning liquid information and determining an operation condition relating to cleaning according to the first embodiment. FIG. 7A is a schematic diagram illustrating a configuration of a reading start screen displayed on the display unit according to the first embodiment. FIG. 7B is a schematic diagram illustrating a configuration of a confirmation screen displayed on the display unit according to the first embodiment. FIGS. 7C and 7D are schematic diagrams illustrating a configuration of a screen displayed on the display unit in the reception process according to the first embodiment. FIGS. 8A to 8C are schematic diagrams illustrating a configuration of a screen displayed on the display unit in the reception process according to the first embodiment. FIG. 9A is a schematic diagram for explaining the operation of the suction unit when the first operation condition according to the first embodiment is set. FIG. 9B is a schematic diagram for explaining the operation of the suction unit when the second operation condition according to the first embodiment is set. FIG. 9C is a schematic diagram for explaining the operation of the suction unit when the second operation condition according to the modification of the first embodiment is set. FIG. 10A is a schematic diagram for explaining a notification timing for prompting replacement of the cleaning liquid container when the first operation condition according to the first embodiment is set. FIG. 10B is a schematic diagram for explaining a notification timing for urging replacement of the cleaning liquid container when the second operation condition according to the first embodiment is set. FIG. 10C is a schematic diagram for explaining a newly set expiration date when the second operation condition according to the first embodiment is set. FIG. 11 is a schematic diagram illustrating a configuration of an analysis result list screen displayed on the display unit according to the first embodiment. FIG. 12 is a schematic diagram illustrating a configuration of an analysis result detail screen displayed on the display unit according to the first embodiment. FIG. 13 is a schematic diagram illustrating a configuration of a reagent list screen displayed on the display unit according to the first embodiment. FIG. 14 is a flowchart illustrating a process for acquiring cleaning liquid information and determining operation conditions related to cleaning according to the second embodiment. FIG. 15A is a flowchart illustrating a process for acquiring cleaning liquid information and determining an operation condition relating to cleaning according to the third embodiment. FIG. 15B is a schematic diagram illustrating a configuration of a reception start screen displayed on the display unit according to the third embodiment. FIG. 16 is a schematic diagram for explaining a configuration according to the related art.

<First embodiment>
As shown in FIG. 1, the sample analyzer 30 measures a measurement sample prepared by mixing a sample and a reagent, and analyzes the sample based on the measurement result. The sample analyzer 30 includes the cleaning unit 100, a control unit 331, a reading unit 335, and a suction unit 451. A reagent container 441 is provided inside the sample analyzer 30. The cleaning liquid container 20 is provided outside the sample analyzer 30. The reagent container 441 contains a reagent used for preparing a measurement sample. The cleaning liquid container 20 contains a cleaning liquid. The cleaning liquid container 20 and the cleaning unit 100 are connected via a flow path. The detailed configuration of the sample analyzer 30 will be described later with reference to FIGS.

  When the analysis of the sample is started, the sample container 11 containing the sample is provided to the sample analyzer 30. The sample in the sample container 11 is dispensed into the reaction container 422 in the sample analyzer 30. The suction unit 451 is a nozzle for dispensing a reagent. The suction unit 451 sucks the reagent in the reagent container 441, and discharges the sucked reagent to the reaction container 422. Thus, the sample and the reagent are mixed in the reaction container 422, and a measurement sample is prepared. Thereafter, the sample analyzer 30 obtains a measurement result by measuring the measurement sample by the detection unit 480 described later, and analyzes the sample based on the measurement result. The reaction container 422 having completed the measurement is discarded.

  The cleaning unit 100 cleans the suction unit 451 using the cleaning liquid in the cleaning liquid container 20 each time the reagent is dispensed by the suction unit 451. The cleaning liquid container 20 includes an identification member 21 on the outer surface. The identification member 21 is a barcode label on which a barcode is printed. The barcode printed on the identification member 21 is a one-dimensional code having information in one direction. The reading unit 335 is used to acquire cleaning liquid information on the cleaning liquid. The reading unit 335 of the first embodiment is a barcode reader for reading read information from a barcode of the identification member 21 set in the cleaning liquid container 20.

  Note that the barcode printed on the identification member 21 may be a two-dimensional code such as a QR code (registered trademark). Further, the identification member 21 is not limited to a barcode label, and may be an RF tag. In this case, the reading unit 335 is an RFID reader for reading read information from the RF tag of the identification member 21 installed in the cleaning liquid container 20.

  Here, it is preferable that the cleaning liquid contained in the cleaning liquid container 20 is a cleaning liquid in which components and the like are set by the manufacturer of the sample analyzer 30 so that correct analysis results can be obtained. The cleaning liquid container 20 containing such a cleaning liquid is called, for example, a genuine product or a regular product. On the other hand, the cleaning liquid contained in the cleaning liquid container 20 may be, for example, a cleaning liquid in which a component other than the manufacturer of the sample analyzer 30 has set components and the like. The cleaning liquid container 20 containing such a cleaning liquid is referred to as, for example, a non-genuine product.

  With reference to FIG. 2, a procedure in which the sample analyzer 30 acquires the cleaning liquid information on the cleaning liquid when a new cleaning liquid container 20 is connected to the sample analyzer 30 will be described.

  When the cleaning liquid container 20 includes the identification member 21, the operator uses the reading unit 335 to read read information from the barcode of the identification member 21 included in the cleaning liquid container 20. The read information is bar code information composed of numbers and the like. Here, the identification member 21 installed in the cleaning liquid container 20 that stores the cleaning liquid in which the component of the sample analyzer 30 is set can obtain the cleaning liquid information by performing a predetermined decoding process on the read information. Is configured. On the other hand, in the case where the identification member 21 is installed in the cleaning liquid container 20 containing the cleaning liquid in which the components and the like are set by a company other than the manufacturing company of the sample analyzer 30, even if the read information is subjected to a predetermined decoding process, No cleaning liquid information is obtained.

  When the manufacturing company of the sample analyzer 30 is the cleaning liquid container 20 that stores the cleaning liquid in which the components and the like are set, the control unit 331 illustrated in FIG. 1 performs a predetermined decoding process on the read information to obtain the cleaning liquid information. I do. The cleaning liquid information acquired in this case includes the lot number, the expiration date, and the type of the cleaning liquid. The type of the cleaning liquid is, for example, a product code or a product name. The cleaning liquid information includes, in addition to the above, the number of times that cleaning can be performed using the cleaning liquid in the cleaning liquid container 20, the volume of the cleaning liquid in the cleaning liquid container 20, the manufacturer or distributor, and the manufacturer or distributor. And an address. The cleaning liquid information does not necessarily need to include all of the information, and may include at least one of the information.

  On the other hand, in the case of a cleaning liquid container 20 that stores a cleaning liquid in which a component or the like is set by a company other than the manufacturing company of the sample analyzer 30, the control unit 331 stores the cleaning liquid information even if a predetermined decoding process is performed on the read information. can not get. In this case, the operator inputs cleaning liquid information by manual input. That is, the operator inputs the cleaning liquid information using the receiving unit 334 of the sample analyzer 30 described later. Further, the cleaning liquid container 20 that stores the cleaning liquid in which the components and the like are set by a company other than the manufacturer of the sample analyzer 30 may not include the identification member 21 in some cases. Also in this case, the operator manually inputs the cleaning liquid information.

  Returning to FIG. 1, the control unit 331 determines whether the cleaning liquid information has been acquired from the read information of the reading unit 335. When the cleaning liquid information is acquired from the read information, that is, when the cleaning liquid in which the manufacturer of the sample analyzer 30 sets the components and the like is stored in the cleaning liquid container 20, the control unit 331 sets the operating conditions of the cleaning unit 100 as First operating conditions are set. Then, the cleaning unit 100 cleans the suction unit 451 using the cleaning liquid in the cleaning liquid container 20 according to the first operation condition. On the other hand, when the cleaning liquid information is not acquired from the read information, that is, when the cleaning liquid in which the components and the like are set by a company other than the manufacturer of the sample analyzer 30 is stored in the cleaning liquid container 20, the control unit 331 controls the cleaning unit 100 Is set as a second operation condition different from the first operation condition. Then, the cleaning unit 100 cleans the suction unit 451 using the cleaning liquid in the cleaning liquid container 20 according to the second operation condition.

  As described above, the control unit 331 switches the operating condition of the cleaning unit 100 based on the read information. Then, the cleaning unit 100 cleans a predetermined part using the cleaning liquid according to the operating conditions based on the read information. When a cleaning liquid in which components are set by a company other than the manufacturer of the sample analyzer 30 is used, there is a possibility that proper cleaning cannot be performed because the components of the cleaning liquid and the expiration date are unknown. However, in the first embodiment, the predetermined part, that is, the suction part 451 is cleaned in accordance with the operating conditions based on the information read by the reading unit 335. Therefore, if a company other than the manufacturer of the sample analyzer 30 considers that the cleaning liquid in which the components and the like are set is stored in the cleaning liquid container 20 based on the read information, the cleaning time is increased by changing the operating conditions, for example. Thus, highly reliable cleaning can be performed. Therefore, even when the cleaning is performed using an unknown cleaning liquid whose component, expiration date, and the like cannot be determined, the reliability of the analysis result can be improved.

  Further, when the cleaning liquid information is obtained from the read information, the cleaning unit 100 cleans the suction unit 451 according to the first operation condition. When the cleaning liquid information is not obtained from the read information, the cleaning unit 100 cleans the suction unit 451 according to the second operation condition. I do. Accordingly, by performing more reliable cleaning under the second operating condition than under the first operating condition, the reliability of the analysis result can be improved even when an unknown cleaning liquid is used.

  The reading unit 335 is a barcode reader for reading read information from the barcode of the cleaning liquid container 20. Thereby, the read information can be smoothly acquired from the container. Note that even when the reading unit 335 is an RFID reader for reading read information from the RF tag of the cleaning liquid container 20, the read information can be smoothly acquired from the container.

  Further, the cleaning liquid information includes at least one of a lot number, an expiration date, a type of the cleaning liquid, the number of times of cleaning, and a capacity. Thus, the quality of the cleaning liquid and the like can be determined based on the cleaning liquid information.

  The object to be cleaned with the cleaning liquid in the cleaning unit 100 is not limited to the suction unit 451, but may be any predetermined part in the sample analyzer 30. For example, suction units 411 and 491 described below for dispensing the sample in the sample container 11 into the reaction container 422 may be washed with the cleaning liquid in the cleaning liquid container 20. Also in this case, when the cleaning liquid information is not obtained from the read information, if the suction units 411 and 491 are cleaned in accordance with the second operation condition, a situation in which different samples are mixed can be prevented and a measurement sample can be appropriately prepared. Therefore, the reliability of the analysis result can be improved.

  As shown in FIG. 3, the sample analyzer 30 includes a transport unit 31 and a measurement unit 32. The measurement unit 32 is disposed behind the transport unit 31. The measurement unit 32 performs measurement related to a blood coagulation test. Therefore, in the first embodiment, the sample contained in the sample container 11 is plasma. In FIG. 3, the XYZ axes are orthogonal to each other, and the X axis direction and the Y axis direction correspond to directions parallel to the horizontal plane. The X-axis positive direction corresponds to the left direction, the Y-axis positive direction corresponds to the rearward direction, and the Z-axis positive direction corresponds to the vertically downward direction.

  The liquid stored as a sample in the sample container 11 is not limited to plasma. That is, the sample contained in the sample container 11 is not limited to plasma, but may be whole blood, serum, urine, lymph, body cavity fluid, or the like. For example, when a measurement related to a blood cell test is performed on the sample by the measurement unit 32, the sample may be whole blood. For example, when the measurement unit 32 performs a measurement related to a blood coagulation test, an immunological test, or a biochemical test on the sample, the sample may be plasma. For example, when a measurement related to an immunological test or a biochemical test is performed on the sample by the measurement unit 32, the sample may be serum.

  The transport unit 31 includes a rack storage unit 311, a rack transport unit 312, and a rack collection unit 313. The rack storage unit 311 and the rack collection unit 313 are connected to the right end and the left end of the rack transport unit 312, respectively. The operator sets the sample rack 12 on which the sample container 11 is set in the rack storage unit 311.

  The transport unit 31 sends the sample rack 12 set in the rack storage unit 311 to the right end of the rack transport unit 312. Subsequently, the transport unit 31 transports the sample rack 12 to the left, and sequentially positions the sample containers 11 at the suction position 312a or the suction position 312b. The suction position 312a is a position for the sample dispensing unit 410 described later to aspirate the sample, and the suction position 312b is a position for the sample dispensing unit 490 described later to aspirate the sample. The transport unit 31 transports the sample rack 12 to the rack collection unit 313 when the suction of the samples into all the sample containers 11 held in the sample rack 12 is completed.

  The measuring unit 32 includes a sample dispensing unit 410, a reaction container table 420, a heating table 430, a reagent table 440, two reagent dispensing units 450, two cleaning tanks 460, a transfer unit 470, A detection unit 480 and a sample dispensing unit 490 are provided. Two cleaning liquid containers 20 are connected to the measuring section 32. The two cleaning liquid containers 20 contain an acidic cleaning liquid and an alkaline cleaning liquid, respectively. When the suction unit 451 of the reagent dispensing unit 450 is washed, the two types of cleaning liquids are used properly according to the type of the reagent that the suction unit 451 dispensed immediately before.

  The sample dispensing unit 410 includes a suction unit 411, an arm 412, and a mechanism unit 413. The suction unit 411 is installed at the tip of the arm 412. The suction unit 411 is a nozzle. The mechanism unit 413 is configured to rotate the arm 412 in the circumferential direction and to move the arm 412 in the vertical direction. Thereby, the suction unit 411 can move in the circumferential direction and the vertical direction. The sample dispensing section 410 lowers the suction section 411 from above with respect to the sample container 11 positioned at the suction position 312a, and penetrates the stopper that seals the sample container 11. Then, the sample dispensing unit 410 sucks the sample from the sample container 11 via the suction unit 411, and discharges the sucked sample to the reaction container 422 held in the holding hole 421 of the reaction container table 420.

  The sample dispensing unit 490 includes a suction unit 491, an arm 492, and a mechanism unit 493, like the sample dispensing unit 410. The suction unit 491 is provided at the tip of the arm 492. The suction unit 491 is a nozzle. The mechanism unit 493 is configured to rotate the arm 492 in the circumferential direction and to move the arm 492 in the vertical direction. Thereby, the suction part 491 can move in the circumferential direction and the vertical direction. The sample dispensing section 490 inserts the sample container 11 positioned at the suction position 312b by lowering the suction section 411 from the upper side. Then, the sample dispensing unit 490 aspirates the sample from the sample container 11 via the suction unit 491, and discharges the aspirated sample to the reaction container 422 held in the holding hole 421 of the reaction container table 420.

  The reaction container table 420 has a ring shape in a plan view, and is arranged outside the reagent table 440. The reaction container table 420 is configured to be rotatable in the circumferential direction. The reaction container table 420 has a plurality of holding holes 421 for holding the reaction container 422.

  The heating table 430 includes a plurality of holding holes 431 for holding the reaction container 422 and a transfer unit 432 for transferring the reaction container 422. The heating table 430 has a circular contour in a plan view, and is configured to be rotatable in a circumferential direction. The heating table 430 heats the reaction container 422 set in the holding hole 431 to 37 ° C.

  When the sample is discharged to the reaction container 422 held by the reaction container table 420, the reaction container table 420 is rotated, and the reaction container 422 containing the sample is transferred to the vicinity of the heating table 430. Then, the transfer unit 432 of the heating table 430 grasps the reaction container 422 and sets it in the holding hole 431 of the heating table 430.

  The reagent table 440 is configured such that a reagent container 441 containing a reagent used for measurement relating to a blood coagulation test can be installed. The reagent table 440 is configured to be rotatable in the circumferential direction. The reagent table 440 is provided with a plurality of reagent containers 441 each containing a reagent used in measurement of a measurement item.

  The reagent dispensing section 450 includes a suction section 451 and a mechanism section 452. The mechanism unit 452 is configured to move the suction unit 451 in the horizontal direction so as to cross the reagent table 440 and to move the suction unit 451 in the vertical direction. The suction unit 451 is provided with a heating unit (not shown) for heating the reagent sucked by the suction unit 451. The two reagent dispensing units 450 are installed below the upper surface of the housing of the measuring unit 32.

  The reagent dispensing section 450 dispenses the reagent into the reaction container 422 heated by the heating table 430. When dispensing the reagent, the transfer unit 432 or the transfer unit 470 takes out the reaction container 422 from the holding hole 431 of the heating table 430 and positions the reaction container 422 just above the washing tank 460 installed near the heating table 430. Then, the reagent dispensing unit 450 sucks the reagent from the reagent container 441 via the suction unit 451, heats the sucked reagent, and discharges the heated reagent to the reaction container 422. Thereby, the reagent is mixed with the sample, and the measurement sample is prepared. After that, the transfer unit 470 sets the reaction container 422 in the holding hole 481 of the detection unit 480. The two reagent dispensing sections 450 are selectively used so as to enable a smooth measurement of the sample.

  The two cleaning tanks 460 are respectively arranged within the movement range of the two suction units 451. The suction unit 451 is moved to the washing tank 460 each time the dispensing of the reagent is completed, and is washed in the washing tank 460 with the washing liquid. Further, the suction unit 451 is cleaned with the cleaning liquid in the cleaning tank 460 even after the sample analyzer 30 is started.

  As described above, the predetermined portion to be cleaned is the suction unit 451 of the reagent dispensing unit 450, and the suction unit 451 is a nozzle. The measurement sample can be properly prepared by washing the nozzle. In addition, the reagent dispensing unit 450 prepares a measurement sample by mixing a reagent according to a measurement item among a plurality of reagents with a sample via the suction unit 451. Even when a plurality of reagents are used in this way, by washing the suction unit 451, mixing of the reagents can be prevented, and a measurement sample can be appropriately prepared.

  The measurement principle of the detection unit 480 includes, for example, a coagulation method, a synthetic substrate method, an immunoturbidimetry, and an agglutination method. The detection unit 480 includes a plurality of holding holes 481. The detection unit 480 irradiates the reaction container 422 set in the holding hole 481 with light, receives the light transmitted through the measurement sample, and outputs a signal corresponding to the received light intensity.

  As shown in FIG. 4A, the cleaning tank 460 is a container whose upper part is opened upward through an opening 461. The cleaning tank 460 is made of resin, metal, or the like. An inlet 462 is formed at the lower part of the cleaning tank 460, and an outlet 463 is formed at the upper part of the cleaning tank 460. The inlet 462 is connected to the outside of the cleaning tank 460 by an injection path 464. The discharge port 463 is connected to the outside of the cleaning tank 460 by a discharge path 465. The tip 451a of the suction part 451 has a bent shape. Thus, when the reagent sucked by the suction unit 451 is discharged to the reaction container 422, the discharged reagent flows along the inner side wall of the reaction container 422, so that bubbles are not easily generated in the reaction container 422. The flow path 451b in the suction part 451 extends in the up-down direction.

  When the cleaning of the suction unit 451 is performed, the suction unit 451 is inserted into the cleaning tank 460 from above through the opening 461. Then, the cleaning liquid is injected into the cleaning tank 460 through the injection port 462, and is discharged through the discharge port 463. Thereby, the outer peripheral surface of the suction unit 451 is cleaned. In addition, the RO water flows downward in the flow path 451b of the suction unit 451. The RO water flowing into the flow path 451b is discharged from the outlet of the flow path 451b provided at the tip 451a. Thereby, the inner peripheral surface of the suction part 451, that is, the flow path 451b is cleaned. Thus, at least the inner peripheral surface and the outer peripheral surface of the suction section 451 that have come into contact with the reagent are washed with the washing liquid and the RO water.

  As shown in FIG. 4B, the measurement unit 32 includes a cleaning unit 100 that cleans the suction unit 451. The cleaning unit 100 includes a flow path and a mechanism for flowing the cleaning liquid through the cleaning tank 460, and a flow path and a mechanism for flowing the RO water through the flow path 451b of the suction unit 451.

  The cleaning liquid in the two cleaning liquid containers 20 is taken into the measuring unit 32 by a flow path (not shown) and stored in the chambers 101 and 102, respectively. The chambers 101 and 102 are connected to a pump 105 via a flow path via electromagnetic valves 103 and 104, respectively. The pump 105 is configured by a syringe that can send a cleaning liquid. The liquid supply side of the pump 105 is connected to the injection path 464 of the cleaning tank 460 by the flow path 107 via the electromagnetic valve 106. The discharge path 465 of the cleaning tank 460 is connected to the pump 109 via the flow path 108. The pump 109 is configured by a syringe that can apply a negative pressure to the flow path 108. The liquid sending side of the pump 109 is connected to a flow path for discarding the cleaning liquid.

  On the other hand, RO water is supplied to the pump 111. The pump 111 is constituted by a syringe capable of sending RO water at high pressure. The liquid sending side of the pump 111 is connected to a fixed amount syringe 113 through an electromagnetic valve 112 by a flow path. The liquid sending side of the fixed amount syringe 113 is connected to the flow path 451b of the suction unit 451 by the flow path 114.

  When the reagent is dispensed by the suction unit 451, the quantitative syringe 113 takes in the reagent into the flow channel 451b by applying a negative pressure to the flow channel 114, and applies a positive pressure to the flow channel 114, The reagent taken in the channel 451b is discharged.

  When the outer peripheral surface of the suction unit 451 is cleaned by the cleaning liquid in the chamber 101, the pump 105 takes in the cleaning liquid from the chamber 101 with the electromagnetic valves 104 and 106 closed. Subsequently, in a state where the electromagnetic valves 103 and 104 are closed and the electromagnetic valve 106 is opened, the pump 105 transfers the taken cleaning liquid from the inlet 462 through the electromagnetic valve 106 and the flow path 107 into the cleaning tank 460. Pour into When the level of the cleaning liquid in the cleaning tank 460 is positioned above the discharge port 463, the driving of the pump 105 is stopped. Thereby, the outer peripheral surface of the suction part 451 is in a state of being immersed.

  After a lapse of a predetermined time, the pump 109 is driven, the cleaning liquid is drawn into the flow path 108 from the discharge port 463, and the cleaning liquid is discharged from the cleaning tank 460. The pump 109 flows the cleaning liquid drawn into the flow path 108 to a flow path for disposal. Thus, the cleaning of the outer peripheral surface of the suction unit 451 with the cleaning liquid in the chamber 101 is completed.

  On the other hand, when the outer peripheral surface of the suction unit 451 is cleaned by the cleaning liquid in the chamber 102, the pump 105 takes in the cleaning liquid from the chamber 102 with the electromagnetic valves 103 and 106 closed. After that, as in the case of the cleaning liquid in the chamber 101, each part of the cleaning unit 100 is driven, so that the cleaning liquid in the chamber 102 fills the cleaning tank 460 and flows through the flow path for disposal. Thus, the cleaning of the outer peripheral surface of the suction unit 451 with the cleaning liquid in the chamber 102 is completed.

  When the flow path 451b of the suction unit 451 is washed with the RO water, the pump 111 takes in the RO water with the electromagnetic valve 112 closed. Subsequently, in a state where the electromagnetic valve 112 is opened, the pump 111 causes the taken RO water to flow through the electromagnetic valve 112, the fixed amount syringe 113, and the flow path 114 to the flow path 451 b of the suction unit 451. The RO water flowing through the flow path 451b is discharged to the cleaning tank 460. The RO water discharged into the cleaning tank 460 is flown into a flow path for disposal by driving the pump 109. Thus, the cleaning of the flow path 451b of the suction unit 451 with the RO water is completed.

  The cleaning unit 100 cleans the flow channel 451b of the suction unit 451 using RO water, but is not limited thereto. The cleaning unit 100 may clean the flow channel 451b using the cleaning liquid in the chamber 101 or the cleaning liquid in the chamber 102. It may be configured. Further, the configuration of the cleaning unit 100 is not limited to the configuration illustrated in FIG.

  In one cleaning operation of the suction unit 451, the outer peripheral surface of the suction unit 451 is cleaned using the cleaning liquid in the chamber 101 or the cleaning liquid in the chamber 102, and the flow path 451b of the suction unit 451 is cleaned using RO water. Is performed.

  As shown in FIG. 5, the sample analyzer 30 includes a transport unit 31, a measurement unit 32, and an analysis unit 33.

  The measurement unit 32 includes a control unit 321, a storage unit 322, the cleaning unit 100, and various mechanism units illustrated in FIGS. 3 to 4B. Control unit 321 is, for example, a CPU. The storage unit 322 is, for example, a ROM, a RAM, and a hard disk. The control unit 321 controls each unit in the measuring unit 32 and the transport unit 31 according to programs and data stored in the storage unit 322. The control unit 321 performs measurement related to the blood coagulation test on the sample, stores the signal output from the detection unit 480 as the measurement result, and transmits the measurement result to the analysis unit 33. Further, the control unit 321 operates the cleaning unit 100 according to the operation conditions of the cleaning unit 100 set by the control unit 331 of the analysis unit 33.

  The analysis unit 33 is configured by, for example, a personal computer. The analysis unit 33 includes a control unit 331, a storage unit 332, a display unit 333, a reception unit 334, and a reading unit 335. The control unit 331 is, for example, a CPU. The storage unit 332 is, for example, a ROM, a RAM, or a hard disk. The storage unit 332 stores a program 332a for causing the analysis unit 33 to execute a predetermined process. The control unit 331 controls each unit in the analysis unit 33 and the measurement unit 32 according to the program 332a and data stored in the storage unit 332.

  6 and 9 are performed by the control unit 331 executing the program 332a. 6 and 9 is performed by the control unit 321 of the measurement unit 32, the control unit 321 performs the processing described below with reference to FIGS. This is performed by executing a program stored in H.322.

  The display unit 333 is, for example, a liquid crystal display. The receiving unit 334 is used when an operator manually inputs an instruction. The receiving unit 334 is, for example, a mouse or a keyboard. The display unit 333 and the reception unit 334 may be integrally configured by a touch panel display or the like.

  The control unit 331 performs an analysis on the blood coagulation test on the sample based on the measurement result received from the measurement unit 32. Specifically, the control unit 331 includes PT, APTT, Fbg, extrinsic coagulation factor, endogenous coagulation factor, coagulation factor XIII, HpT, TTO, FDP, D dimer, PIC, FM, ATIII, Plg, APL, Analysis is performed on measurement items such as PC, VWF: Ag, VWF: RCo, ADP, collagen, and epinephrine.

  Next, with reference to the flowchart shown in FIG. 6, a description will be given of a process of acquiring cleaning liquid information and determining operating conditions relating to cleaning when replacing the cleaning liquid container 20.

  The process in FIG. 6 is started when the operator inputs an instruction to change the cleaning liquid via the reception unit 334. 6 is performed for each cleaning liquid container 20 connected to the measuring unit 32. 6 is executed by the control unit 331 of the analysis unit 33, but may be executed by the control unit 321 of the measurement unit 32, or may be executed jointly by both the control units 331 and 321. Good. A part of the processing in FIG. 6 may be executed by the control unit 331, and the other part may be executed by the control unit 321. Hereinafter, the screens shown in FIGS. 7A and 7B will be appropriately referred to in the description of FIG.

  In step S11, the control unit 331 causes the display unit 333 to display the reading start screen 510, and in step S12, drives the reading unit 335 to start the reading process. As shown in FIG. 7A, the reading start screen 510 includes a button 511. The operator brings the reading unit 335 close to the identification member 21 of the new cleaning liquid container 20 and reads the barcode with the reading unit 335. When the identification member 21 is not provided on the cleaning liquid container 20 or when the identification member 21 of the cleaning liquid container 20 is damaged, the operator inputs cleaning liquid information manually. In this case, the operator operates the button 511.

  In step S13, the control unit 331 determines whether the reading unit 335 has read the barcode. When the reading by the reading unit 335 is performed, in step S14, the control unit 331 performs a decoding process on the information read by the reading unit 335, that is, the barcode information. Subsequently, the control unit 331 determines whether or not the cleaning liquid information has been acquired as a result of the decryption processing in step S14. When the cleaning liquid information is acquired by the decryption process, it is considered that the new cleaning liquid container 20 contains the cleaning liquid in which the component of the sample analyzer 30 is installed by the manufacturer of the sample analyzer 30. Therefore, in step S16, the control unit 331 stores the acquired cleaning liquid information in the storage unit 332, and sets the first operation condition as an operation condition relating to cleaning of the suction unit 451. Details of the first operation condition will be described later with reference to FIG.

  On the other hand, when the button 511 is operated on the reading start screen 510 in FIG. 7A and when the cleaning liquid information is not obtained by the decryption processing in step S15, the control unit 331 advances the processing to step S17.

  In steps S14 and S15, other processing may be performed instead of determining whether or not the cleaning liquid information has been acquired by the decryption processing. For example, the read information may include cleaning liquid information that does not require a decoding process and a predetermined number, and in step S15, it may be determined whether the read information includes the predetermined number. In this case, if it is determined that the read information includes the predetermined number, the process proceeds to step S16. If it is determined that the read information does not include the predetermined number, the process proceeds to step S17. In addition, the read information may include cleaning liquid information that does not require decryption, and it may be determined in step S15 whether the cleaning liquid information has a predetermined format or content. In this case, if it is determined that the cleaning liquid information has the predetermined format or content, the process proceeds to step S16. If it is determined that the cleaning liquid information does not have the predetermined format or content, the process proceeds to step S17.

  In step S17, the control unit 331 displays a confirmation screen 520 on the display unit 333, and determines whether or not an exchange instruction has been received. As shown in FIG. 7B, the confirmation screen 520 includes buttons 521 and 522. The operator operates the button 521 when manually inputting the cleaning liquid information, that is, when inputting the cleaning liquid information via the reception unit 334. The operator operates the button 522 to end the processing in FIG. When the button 522 is operated, the control unit 331 terminates the processing in FIG.

  If the barcode has not been read, and if the cleaning liquid information has not been obtained by the decoding process, the new cleaning liquid container 20 contains the cleaning liquid in which a component other than the manufacturer of the sample analyzer 30 has set the components and the like. it seems to do. Therefore, when the button 521 is operated, in step S18, the control unit 331 performs a reception process and receives the cleaning liquid information via the reception unit 334. In the reception process, the control unit 331 displays the screens shown in FIGS. 7C to 8C on the display unit 333 in order, receives the cleaning liquid information, and stores the received cleaning liquid information in the storage unit 332. Then, in step S19, the control unit 331 sets a second operation condition different from the first operation condition as the operation condition relating to the cleaning of the suction unit 451. Details of the second operation condition will be described later with reference to FIG.

  Thus, when the processing illustrated in FIG. 6 ends, the control unit 331 transmits the operation conditions set in step S16 or step S19 to the control unit 321 of the measurement unit 32. The control unit 321 of the measurement unit 32 drives the cleaning unit 100 according to the received operating conditions to clean the suction unit 451.

  The screen displayed in the reception process will be described with reference to FIGS. 7C to 8C.

  When the reception process is started, a screen 530 shown in FIG. 7C is displayed. As shown in FIG. 7C, the screen 530 includes an input area 531 and a button 532. The operator inputs the new lot number of the cleaning liquid container 20 into the input area 531 via the reception unit 334. When the input is completed and the button 532 is operated, a screen 540 shown in FIG. 7D is displayed.

  As shown in FIG. 7D, the screen 540 includes an input area 541 and a button 542. The operator inputs the expiration date of the new cleaning liquid container 20 into the input area 541 via the reception unit 334. When the input is completed and the button 542 is operated, a screen 550 shown in FIG. 8A is displayed.

  As shown in FIG. 8A, the screen 550 includes an input area 551 and a button 552. The operator inputs the product code or the product name of the new cleaning liquid container 20 into the input area 551 via the reception unit 334. The product code and product name correspond to the type of cleaning solution. When the input is completed and the button 552 is operated, a screen 560 shown in FIG. 8B is displayed.

  As shown in FIG. 8B, the screen 560 includes an input area 561 and a button 562. The operator inputs the manufacturer or seller of the new cleaning liquid container 20 into the input area 561 via the reception unit 334. When the input is completed and the button 562 is operated, a screen 570 shown in FIG. 8C is displayed.

  As shown in FIG. 8C, the screen 570 includes an input area 571 and a button 572. The operator inputs the address of the manufacturer or seller of the new cleaning liquid container 20 into the input area 571 via the reception unit 334. When the input is completed and the button 572 is operated, the control unit 331 stores the cleaning liquid information input via the screens illustrated in FIGS. 7C to 8C in the storage unit 332. Thus, the reception process ends.

  When each item of the cleaning liquid information is received one by one on the screens shown in FIGS. 7C to 8C, the operator is prevented from inputting another item by mistake, and the cleaning liquid information can be reliably acquired. .

  The operation of the suction unit 451 under the first operation condition and the second operation condition will be described with reference to FIGS.

  As illustrated in FIGS. 9A and 9B, the operation of the suction unit 451 includes a dispensing operation of dispensing a reagent from the reagent container 441 to the reaction container 422 and a cleaning performed by the cleaning unit 100 with the cleaning liquid. Operation. In the dispensing operation, the suction unit 451 is positioned right above the reagent container 441, inserted into the reagent container 441, aspirates the reagent in the reagent container 441, rises above the reagent container 441, and rises above the reagent container 441. The reagent aspirated by is heated by a heating unit provided in the suction unit 451. Then, the suction unit 451 is positioned right above the reaction container 422 positioned right above the cleaning tank 460, is inserted into the reaction container 422, and discharges the sucked reagent into the reaction container 422. In the cleaning operation, the suction unit 451 is positioned right above the cleaning tank 460, inserted into the cleaning tank 460, immersed in the cleaning liquid filled in the cleaning tank 460, and placed in the channel 451 b of the suction unit 451. Water is washed away.

  The cleaning operation is performed immediately after the dispensing operation. An operation in one cycle is an operation including a cleaning operation. Specifically, the operation includes one dispensing operation including a plurality of steps as described above and a cleaning operation following one dispensing operation. Become. The time required for the dispensing operation is T0 regardless of the cleaning operation conditions.

  The cleaning unit 100 performs a cleaning operation on the suction unit 451 according to the operation conditions regarding cleaning set by the processing in FIG.

  Specifically, when the first operation condition is set as the operation condition relating to the cleaning when the new cleaning liquid container 20 is connected, as shown in FIG. The cleaning operation is performed so that the time required for the cleaning operation using the cleaning liquid in the inside becomes T1. In this case, the time T0 + T1 required for the dispensing operation and the cleaning operation is set to 8 seconds. That is, the cleaning unit 100 performs the cleaning operation such that the time required for one cycle of operation including the cleaning operation using the cleaning liquid in the newly connected cleaning liquid container 20 is 8 seconds.

  On the other hand, when the second operation condition is set as the operation condition relating to the cleaning when the new cleaning liquid container 20 is connected, as shown in FIG. 9B, the cleaning unit 100 cleans the cleaning liquid in the newly connected cleaning liquid container 20. The cleaning operation is performed such that the time required for the cleaning operation using is T2. In this case, the time T0 + T2 required for the dispensing operation and the cleaning operation is set to 16 seconds. That is, the cleaning unit 100 performs the cleaning operation such that the time required for one cycle of operation including the cleaning operation using the cleaning liquid in the newly connected cleaning liquid container 20 is 16 seconds, which is twice the first operation condition. Execute. In this case, for example, the time during which the suction unit 451 is immersed in the cleaning liquid in the cleaning tank 460 is set longer than the first operation condition, so that the time of the cleaning operation under the second operation condition is set longer.

  As described above, in the first embodiment, the cleaning time T2 under the second operation condition is set longer than the cleaning time T1 under the first operation condition. Thereby, even if a cleaning liquid in which components and the like are set by a company other than the manufacturer of the sample analyzer 30 is used, reliable cleaning can be performed.

  Further, as shown in FIGS. 9A and 9B, the time T0 + T2 required for one cycle of operation of the suction unit 451 when the second operation condition is set is equal to the time when the first operation condition is set. Is twice the time T0 + T1 required for one cycle of operation of the suction unit 451 in FIG. Thereby, the operation under the first operation condition and the operation under the second operation condition can be easily switched. It should be noted that the time T0 + T2 is not limited to twice the time T0 + T1, but the same effect can be obtained if it is an integral multiple.

  The second operating condition is not limited to being set as shown in FIG. 9B, but may be set as shown in FIG. 9C. In the example shown in FIG. 9C, the number of times of cleaning under the second operation condition is set to be larger than the number of times of cleaning under the first operation condition. Specifically, the time required for one cycle of operation is set to 16 seconds as in FIG. 9B, but the cleaning operation requiring time T3 is performed twice during time T2. In this case, the cleaning unit 100 discards the cleaning liquid in the cleaning tank 460 after the first cleaning, and newly fills the cleaning tank 460 with the cleaning liquid in the second cleaning. That is, in a continuous cleaning operation within one cycle of operation, the cleaning liquid supplied to the cleaning tank 460 is replaced. Thereby, even if a cleaning liquid in which components and the like are set by a company other than the manufacturer of the sample analyzer 30 is used, reliable cleaning can be performed.

  Further, in the first embodiment, as shown in FIGS. 10A and 10B, the notification timing for prompting the replacement of the cleaning liquid container 20 is determined when the cleaning is performed according to the first operation condition and when the cleaning is performed according to the second operation condition. And the case where the washing is performed according to the above. In the first embodiment, the number N of times of cleaning using the cleaning liquid container 20 is stored in the storage unit 332 in advance. The control unit 331 causes the display unit 333 to display a message prompting replacement as a notification for prompting replacement of the cleaning liquid container 20 when the number of times of cleaning reaches a number obtained by subtracting a predetermined number of times from the number N of times of cleaning. .

  Specifically, as illustrated in FIG. 10A, the control unit 331 subtracts the first number n1 from the number N of possible cleanings set in the cleaning liquid container 20 for the number of cleanings performed according to the first operation condition. When the number of times N-n1 has been reached, notification for prompting replacement of the cleaning liquid container 20 is performed. On the other hand, as illustrated in FIG. 10B, the control unit 331 determines that the number of times of cleaning performed in accordance with the second operation condition is greater than the first number of times n1 from the number N of times of cleaning set in the cleaning liquid container 20. When the number of times N−n2, which is obtained by subtracting the number of times n2, is reached, a notification for prompting replacement of the cleaning liquid container 20 is issued. The first number n1 and the second number n2 are stored in the storage unit 322 in advance.

  In the case of a cleaning liquid in which components other than the manufacturer of the sample analyzer 30 are set, the cleaning liquid may be inadvertently exhausted because the remaining amount of the cleaning liquid container 20 is unknown. However, when the cleaning is performed under the second operating condition, the replacement of the cleaning liquid container 20 is promoted earlier than in the case of the first operating condition. Analysis can be prevented from being performed.

  Although FIG. 10A illustrates a case where the first number n1 is 1 or more, the first number n1 may be 0. Further, the number N of times of cleaning is not limited to being stored in the storage unit 332 in advance. For example, when the cleaning liquid information includes the number N of times of cleaning, the number N of times of cleaning may be obtained from the cleaning liquid information, and when the information of cleaning liquid includes a capacity, the number N of times of cleaning is based on the volume obtained from the cleaning liquid information. May be calculated.

  Further, in the first embodiment, as shown in FIG. 10C, when the cleaning is performed according to the second operation condition, the date and time when the expiration date set in the cleaning liquid container 20 is advanced by a predetermined number of days d has come. At times, a notification that the expiration date of the cleaning liquid container 20 has arrived is issued. In the first embodiment, the expiration date of the cleaning liquid container 20 is acquired based on the cleaning liquid information. The predetermined number of days d is stored in the storage unit 322 in advance. When the expiration date has expired, the control unit 331 causes the display unit 333 to display a message prompting replacement as a notification that the expiration date of the cleaning liquid container 20 has expired.

  Specifically, as shown in FIG. 10C, when the cleaning is performed according to the second operation condition, the control unit 331 sets the original expiration date set based on the cleaning liquid information by a predetermined number of days d. Set an earlier date as the new expiration date. Then, when the newly set expiration date has come, the control unit 331 notifies that the expiration date of the cleaning liquid container 20 has come. On the other hand, when the cleaning is performed in accordance with the first operation condition, the control unit 331 notifies that the expiration date of the cleaning liquid container 20 has expired when the expiration date set based on the cleaning liquid information has expired.

  In the case of a cleaning liquid in which components other than the manufacturer of the sample analyzer 30 are set, the deterioration of the cleaning liquid may proceed unintentionally. However, when cleaning is performed under the second operation condition, a date and time obtained by advancing the predetermined number of days d from the preset original expiration date is set as a new expiration date. Thereby, unintended deterioration of the cleaning liquid can be prevented, and measurement and analysis with low reliability can be prevented.

  Next, with reference to FIGS. 11 to 13, it will be described that the screen displayed on the display unit 333 is notified that the analysis result cannot be guaranteed.

  When the operator inputs an instruction to display a list of analysis results for each sample via the reception unit 334, the control unit 331 causes the display unit 333 to display the analysis result list screen 210 illustrated in FIG.

  As shown in FIG. 11, the analysis result list screen 210 includes a list 211 and a detail display button 212. The list 211 displays information for each sample. The display items of the list 211 include a state, a sample number, an end time, a start time, a date, and an analysis result for each measurement item. For example, “Review” is displayed in the status display item. “Review” indicates that in the measurement of the corresponding sample, a reagent other than the manufacturer of the sample analyzer 30 dispenses the reagent by the suction unit 451 washed with the washing liquid in which the components and the like are set.

  Here, when a sample other than the manufacturer of the sample analyzer 30 is washed with the cleaning liquid in which the components and the like are set when the sample is measured, there is a possibility that the sample is not properly cleaned. In this case, the reliability of the obtained analysis result decreases. Therefore, when the cleaning liquid information is not obtained from the read information, the control unit 331 of the analysis unit 33 displays “Review” indicating that the analysis result cannot be guaranteed on the analysis result list screen 210, and displays “Review” indicating the state of the corresponding sample. Attach to display item. This allows the operator to visually grasp the analysis result with low reliability when the analysis result list screen 210 is displayed. Note that a character string such as “*” or a mark may be added instead of the “Review” display.

  When confirming the detailed information on the sample, the operator selects a row of the corresponding sample in the list 211 via the reception unit 334. As a result, a frame 211a is added to the row of the corresponding sample. Then, the operator operates the detail display button 212 via the reception unit 334. Thereby, the control unit 331 causes the display unit 333 to display the analysis result detail screen 220 including the detailed information on the selected sample.

  As shown in FIG. 12, the analysis result detail screen 220 includes a sample number display area 221, a list 222, a graph display area 223, and a comment area 224.

  The sample number display area 221 displays the sample number of the sample displayed on the analysis result detail screen 220. The list 222 displays the analysis results of all the measurement items performed on the sample displayed on the analysis result detail screen 220. The list 222 is provided with a scroll bar extending vertically so that all analysis results can be displayed. When displaying the detailed information on the analysis result, the operator selects a row of the corresponding measurement item in the list 222. Thereby, the frame 222a is added to the row of the corresponding measurement item. When the row of the measurement item in the list 222 is selected, detailed information on the corresponding measurement item is displayed in the graph display area 223.

  The graph display area 223 displays a graph obtained by measurement on the measurement item selected in the list 222. In the example illustrated in FIG. 12, “PT” is selected as the measurement item, and thus the coagulation curve obtained by the measurement regarding the measurement item “PT” is displayed in the graph display area 223.

  The comment area 224 displays information on the analysis result of the sample. In the example shown in FIG. 12, the reliability of the analysis result of the sample shown on the analysis result detail screen 220 is low because the suction unit 451 is washed with the cleaning liquid in which the components and the like are set by a company other than the manufacturer of the sample analyzer 30. Is displayed in the comment area 224. That is, when the cleaning liquid information is not obtained from the read information, the control unit 331 displays a warning message in the comment area 224.

  As described above, when the cleaning liquid information is not obtained from the read information, the control unit 331 displays on the analysis result detail screen 220 that the analysis result cannot be guaranteed. Thereby, the operator can visually grasp the reliability of the analysis result of the sample when the analysis result detail screen 220 is displayed.

  When the operator inputs an instruction to display the state of the reagent in a list via the reception unit 334, the control unit 331 causes the display unit 333 to display the reagent list screen 230 shown in FIG.

  As shown in FIG. 13, the reagent list screen 230 includes a reagent table image 231 and two cleaning liquid images 232. The reagent table image 231 shows the state of the plurality of reagent containers 441 installed on the reagent table 440. The cleaning liquid image 232 shows the state of the cleaning liquid container 20 connected to the measuring unit 32. The type of the cleaning liquid included in the cleaning liquid information acquired in the processing of FIG. 6 is displayed in the cleaning liquid image 232. Further, a mark 232a is added to the cleaning liquid image 232 when the cleaning liquid information is not obtained from the read information in the processing of FIG. The mark 232a is, for example, an icon.

  As described above, when the cleaning liquid information is not obtained from the read information, the control unit 331 attaches the mark 232a indicating that the analysis result cannot be guaranteed for the display of the corresponding cleaning liquid on the reagent list screen 230. Thus, when the reagent list screen 230 is displayed, the operator can visually grasp the cleaning liquid that may reduce the reliability of the analysis result.

  As described above, the control unit 331 notifies each screen shown in FIGS. 11 to 13 that the analysis result cannot be guaranteed if the cleaning liquid information is not acquired from the read information. That is, when the cleaning liquid information is not acquired from the read information, “Review” is displayed on the analysis result list screen 210 in FIG. 11, and the reliability of the analysis result is low in the comment area 224 on the analysis result detail screen 220 in FIG. Is displayed, and a mark 232a is added to the cleaning liquid image 232 on the reagent list screen 230 of FIG. That is, the display unit 333 and the screens shown in FIGS. 11 to 13 are notification units for notifying that the analysis result cannot be guaranteed. Thereby, the operator can grasp that the reliability of the analysis result may be low as a result of using the cleaning liquid in which the components and the like are set by a company other than the manufacturer of the sample analyzer 30 based on the notification contents.

  The notification that the analysis result cannot be guaranteed may be made by displaying a warning message on a display unit such as a liquid crystal panel provided in the sample analyzer 30. Further, the notification that the analysis result cannot be guaranteed may be notified by sound from a speaker provided in the sample analyzer 30.

<Embodiment 2>
In the second embodiment, the processing of the first embodiment shown in FIG. 6 is changed to FIG. 14, a step S21 is added between steps S18 and S19 as compared with FIG. Other configurations of the second embodiment are the same as those of the first embodiment.

  14 is also executed by the control unit 331 of the analysis unit 33, but may be executed by the control unit 321 of the measurement unit 32, or may be executed jointly by both the control units 331 and 321. A part of the processing in FIG. 14 may be executed by the control unit 331, and the other part may be executed by the control unit 321.

  With reference to FIG. 14, processing different from the first embodiment will be described.

  In step S21, the control unit 331 determines whether the cleaning liquid information received in step S18 is predetermined cleaning liquid information. If the received cleaning liquid information is the predetermined cleaning liquid information, the control unit 331 advances the process to step S16 as in the case where the cleaning liquid information is decoded from the read information of the reading unit 335. Then, in step S16, the control unit 331 sets a first operation condition as an operation condition relating to cleaning of the suction unit 451. On the other hand, when the received cleaning liquid information is not the predetermined cleaning liquid information, the control unit 331 advances the process to Step S19. Then, in step S19, the control unit 331 sets a second operation condition as an operation condition relating to cleaning of the suction unit 451.

  Here, despite the fact that the cleaning liquid container 20 containing the cleaning liquid in which the components and the like are set by the manufacturer of the sample analyzer 30 is prepared, the reading is performed due to the stain or damage of the identification member 21 or the failure of the reading unit 335. It is also conceivable that a situation may occur in which the cleaning liquid information cannot be obtained from the information. In such a case, according to the processing of the first embodiment shown in FIG. 6, even if the cleaning liquid container 20 contains the cleaning liquid in which the manufacturer of the sample analyzer 30 sets the components and the like, this cleaning liquid container 20 is It is determined that a company other than the manufacturing company of the sample analyzer 30 contains the cleaning liquid in which the components and the like are set.

  In contrast, in the second embodiment, in step S21, the control unit 331 determines whether the cleaning liquid information received by the receiving unit 334 is predetermined cleaning liquid information. For example, the control unit 331 determines whether or not the lot number included in the received cleaning liquid information is a lot number specific to the cleaning liquid container 20 containing the cleaning liquid in which the manufacturer of the sample analyzer 30 sets the components and the like. judge. Note that the control unit 331 may determine whether the received cleaning liquid information includes a predetermined character string. When such a determination is made, it can be correctly grasped that the cleaning liquid container 20 contains the cleaning liquid in which the manufacturer of the sample analyzer 30 sets the components and the like.

  As described above, in the second embodiment, the control unit 331 sets the operation condition as the first condition when the cleaning liquid information is acquired from the read information and when the cleaning liquid information received by the reception unit 334 is the predetermined cleaning liquid information. 1 Set operating conditions. When the cleaning liquid information is not acquired from the read information and the cleaning liquid information received by the reception unit 334 is not the predetermined cleaning liquid information, the control unit 331 sets the second operation condition as the operation condition. Accordingly, even when the cleaning liquid in which the manufacturing company of the sample analyzer 30 sets the components and the like is stored in the cleaning liquid container 20, the cleaning liquid information received by the reception unit 334 is received even when the cleaning liquid information is not acquired from the read information. , The first operation condition can be appropriately set.

<Embodiment 3>
In the third embodiment, the processing of the first embodiment shown in FIG. 6 is changed to FIG. Other configurations of the third embodiment are the same as those of the first embodiment.

  The processing in FIG. 15A is also executed by the control unit 331 of the analysis unit 33, but may be executed by the control unit 321 of the measurement unit 32, and is executed jointly by both the control units 331 and 321. Is also good. A part of the processing in FIG. 15A may be executed by the control unit 331, and the other part may be executed by the control unit 321.

  As shown in FIG. 15A, in step S31, the control unit 331 causes the display unit 333 to display the reception start screen 580. As shown in FIG. 15B, the reception start screen 580 includes buttons 581 and 582. The operator operates the button 581 when manually inputting the cleaning liquid information relating to the new cleaning liquid container 20, that is, when inputting the cleaning liquid information via the reception unit 334. The operator operates the button 582 when ending the processing of FIG.

  In step S32, the control unit 331 determines whether an exchange instruction has been received based on which of the buttons 581 and 582 has been operated. When the button 582 is operated, the control unit 331 terminates the processing in FIG. When the button 581 is operated, the cleaning liquid information is received in the reception processing of step S33, similarly to step S18 of the first embodiment shown in FIG. In step S34, the control unit 331 determines whether the cleaning liquid information received in step S33 is predetermined cleaning liquid information. The determination in step S34 is the same as that in step S21 of the second embodiment shown in FIG. When determining that the received cleaning liquid information is the predetermined cleaning liquid information, the control unit 331 advances the process to step S35, and when determining that the received cleaning liquid information is not the predetermined cleaning liquid information, the processing proceeds to step S36. Steps S35 and S36 are the same as steps S16 and S19 of the first embodiment shown in FIG.

  As described above, in the third embodiment, the operating condition is set based on the reception information of the cleaning liquid information by the reception unit 334. Then, similarly to the first embodiment, the suction unit 451 is cleaned according to the set operating conditions. As a result, as in the first embodiment, the reliability of the analysis result can be improved even when cleaning is performed using an unknown cleaning liquid.

20 Cleaning liquid container (container)
30 Sample analyzer 100 Washing unit 210 Analysis result list screen 220 Analysis result detailed screen 230 Reagent list screen 232a Mark 331 Control unit 332a Program 333 Display unit 334 Reception unit 335 Reading unit 450 Reagent dispensing unit 451 Suction unit (predetermined part, nozzle)

Claims (21)

A sample analyzer for measuring a measurement sample prepared by mixing a sample and a reagent, and analyzing the sample based on the measurement result,
A reading unit that reads read information from a container containing the cleaning liquid;
A cleaning unit that cleans a predetermined part in the apparatus using the cleaning liquid,
A sample analyzer, comprising: a controller configured to switch an operation condition of the cleaning unit based on the read information. The washing unit includes:
When cleaning liquid information on the cleaning liquid contained in the container is obtained from the read information, the predetermined portion is cleaned using the cleaning liquid according to a first operation condition,
2. The sample analyzer according to claim 1, wherein when the cleaning liquid information is not obtained from the read information, the predetermined part is cleaned using the cleaning liquid according to a second operation condition different from the first operation condition.   The sample analyzer according to claim 2, further comprising a control unit that determines whether the cleaning liquid information has been acquired from the read information.   4. The sample analyzer according to claim 2, wherein the cleaning time under the second operation condition is longer than the cleaning time under the first operation condition. 5.   The sample analyzer according to any one of claims 2 to 4, wherein the number of washings under the second operating condition is larger than the number of washings under the first operating condition.   The time required for one cycle of operation including the cleaning operation of the predetermined part when the cleaning is performed under the second operation condition is the same as the time required for the cleaning operation of the predetermined part when the cleaning is performed under the first operation condition. The sample analyzer according to any one of claims 2 to 5, wherein the sample analyzer is an integral multiple of a time required for one cycle of operation.   When the number of times of cleaning performed in accordance with the first operation condition reaches a number obtained by subtracting the first number of times from the settable number of times of cleaning for the container, notification for prompting replacement of the container is performed, and When the number of washings performed in accordance with the operating condition reaches a number obtained by subtracting a second number greater than the first number from the number of washings that can be set for the container, a notification for prompting replacement of the container is issued. The sample analyzer according to any one of claims 2 to 6.   When cleaning is performed in accordance with the second operation condition, when a date and time that advance the expiration date set for the container by a predetermined number of days has arrived, a notification that the expiration date of the container has arrived is issued. Item 8. The sample analyzer according to any one of Items 2 to 7.   The sample analyzer according to claim 1, wherein the reading unit is a barcode reader for reading the read information from a barcode of the container.   The sample analyzer according to claim 1, wherein the reading unit is an RFID reader for reading the read information from an RF tag of the container.   The sample analyzer according to any one of claims 1 to 10, wherein when the cleaning liquid information relating to the cleaning liquid contained in the container is not obtained from the read information, it is notified that an analysis result cannot be guaranteed. A display unit that displays an analysis result list screen showing a list of analysis results for each sample,
12. The sample analyzer according to claim 11, wherein when the cleaning liquid information is not obtained from the read information, a message indicating that an analysis result cannot be guaranteed for a display of the corresponding sample is given on the analysis result list screen. . A display unit that displays an analysis result detail screen showing details of the analysis result of the sample,
13. The sample analyzer according to claim 11, wherein when the washing liquid information is not obtained from the read information, a message indicating that the analysis result cannot be guaranteed is displayed on the analysis result detail screen. A display unit for displaying a reagent list screen showing a list of the reagents,
14. The reagent list screen according to claim 11, wherein, if the cleaning liquid information is not obtained from the read information, a mark indicating that the analysis result cannot be guaranteed for the display of the corresponding cleaning liquid is added to the reagent list screen. The sample analyzer according to claim 1. A receiving unit for receiving an input of cleaning liquid information regarding the cleaning liquid contained in the container,
The washing unit includes:
When the cleaning liquid information is acquired from the read information, and when the cleaning liquid information received by the reception unit is predetermined cleaning liquid information, the predetermined part is cleaned using the cleaning liquid according to a first operation condition. And
If the cleaning liquid information is not obtained from the read information and the cleaning liquid information received by the reception unit is not the predetermined cleaning liquid information, the predetermined cleaning liquid is used by using the cleaning liquid according to a second operation condition different from the first operation condition. The sample analyzer according to any one of claims 1 to 14, wherein the part is washed.   The sample analyzer according to claim 15, further comprising: a control unit that determines whether the cleaning liquid information received by the receiving unit is predetermined cleaning liquid information. A reagent dispensing unit for dispensing the reagent,
The sample analyzer according to any one of claims 1 to 16, wherein the predetermined portion in the device is a nozzle of the reagent dispensing unit.   The sample analyzer according to claim 17, wherein the reagent dispensing unit dispenses the reagent according to a measurement item among the plurality of reagents via the nozzle.   19. The sample analyzer according to claim 1, wherein the cleaning liquid information includes at least one of a lot number, an expiration date, a type of a cleaning liquid, the number of times of cleaning, and a capacity. A sample analysis method for measuring a measurement sample prepared by mixing a sample and a reagent, and analyzing the sample based on the measurement result,
Read the read information from the container containing the cleaning liquid,
Switching the operating conditions related to cleaning of a predetermined portion in the apparatus based on the read information,
A sample analysis method for cleaning the predetermined portion using the cleaning liquid according to the operating condition based on the read information; A computer in the sample analyzer that analyzes the sample based on the measurement result of the measurement sample prepared by mixing the sample and the reagent,
A program for executing a process of switching operating conditions related to cleaning of a predetermined portion in the apparatus based on read information read from a container containing a cleaning liquid.

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