JP6286358B2 - プロテアソーム阻害剤に応答するバイオマーカー - Google Patents

プロテアソーム阻害剤に応答するバイオマーカー Download PDF

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Publication number
JP6286358B2
JP6286358B2 JP2014541346A JP2014541346A JP6286358B2 JP 6286358 B2 JP6286358 B2 JP 6286358B2 JP 2014541346 A JP2014541346 A JP 2014541346A JP 2014541346 A JP2014541346 A JP 2014541346A JP 6286358 B2 JP6286358 B2 JP 6286358B2
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marker
tumor
nras
sample
patient
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JP2014533114A (ja
JP2014533114A5 (https=
Inventor
アリソン バーガー，
アリソン バーガー，
ヒューズ バーナード，
ヒューズ バーナード，
ニベディタ チャットパディヤイ，
ニベディタ チャットパディヤイ，
エリック エム． コーニグ，
エリック エム． コーニグ，
ジョージ ジェイ． マリガン，
ジョージ ジェイ． マリガン，
マシュー シー． シュー，
マシュー シー． シュー，
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2014541346A 2011-11-11 2012-11-09 プロテアソーム阻害剤に応答するバイオマーカー Expired - Fee Related JP6286358B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161558470P 2011-11-11 2011-11-11
US61/558,470 2011-11-11
PCT/US2012/064520 WO2013071163A2 (en) 2011-11-11 2012-11-09 Biomarkers of response to proteasome inhibitors

Related Child Applications (1)

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JP2017230701A Division JP2018033467A (ja) 2011-11-11 2017-11-30 プロテアソーム阻害剤に応答するバイオマーカー

Publications (3)

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JP2014533114A JP2014533114A (ja) 2014-12-11
JP2014533114A5 JP2014533114A5 (https=) 2015-12-24
JP6286358B2 true JP6286358B2 (ja) 2018-02-28

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JP2014541346A Expired - Fee Related JP6286358B2 (ja) 2011-11-11 2012-11-09 プロテアソーム阻害剤に応答するバイオマーカー
JP2017230701A Pending JP2018033467A (ja) 2011-11-11 2017-11-30 プロテアソーム阻害剤に応答するバイオマーカー

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US (1) US20150184246A1 (https=)
EP (1) EP2776586B1 (https=)
JP (2) JP6286358B2 (https=)
CN (1) CN104126017A (https=)
CA (1) CA2855368A1 (https=)
WO (1) WO2013071163A2 (https=)

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EP3099332A4 (en) * 2014-01-29 2017-06-21 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
JP6576942B6 (ja) * 2014-03-03 2019-11-27 マドリガル ファーマシューティカルズ インコーポレイテッド 標的治療薬
AU2016363113A1 (en) * 2015-12-03 2018-06-07 Alfred Health Monitoring treatment or progression of myeloma
US11312991B2 (en) * 2016-01-27 2022-04-26 Kabushiki Kaisha Dnaform Method for decoding base sequence of nucleic acid corresponding to end region of RNA and method for analyzing DNA element
CN107151255A (zh) * 2016-03-06 2017-09-12 复旦大学 硼酸类化合物及其制备方法和用途
TWI599571B (zh) * 2017-04-14 2017-09-21 中化合成生技股份有限公司 伊克薩姆畢（Ｉｘａｚｏｍｉｂ）檸檬酸中間體之製造方法以及使用其製造之伊克薩姆畢檸檬酸
CN112795651B (zh) * 2021-01-22 2023-04-14 中国医科大学附属盛京医院 Muc20作为诊断多发性套细胞淋巴瘤蛋白酶体抑制剂耐药的标志物及其应用
CN113092209B (zh) * 2021-04-02 2023-10-27 复旦大学附属肿瘤医院 一种富集、鉴定待测病样中分子标志物的方法

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Also Published As

Publication number Publication date
US20150184246A1 (en) 2015-07-02
EP2776586A2 (en) 2014-09-17
WO2013071163A2 (en) 2013-05-16
CA2855368A1 (en) 2013-05-16
EP2776586A4 (en) 2015-09-16
WO2013071163A3 (en) 2014-08-28
EP2776586B1 (en) 2018-03-07
JP2014533114A (ja) 2014-12-11
JP2018033467A (ja) 2018-03-08
CN104126017A (zh) 2014-10-29

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