JP6277126B2 - ホスホリルコリン（ｐｃ）および／またはｐｃコンジュゲートに結合する抗体 - Google Patents
ホスホリルコリン（ｐｃ）および／またはｐｃコンジュゲートに結合する抗体 Download PDFInfo
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- JP6277126B2 JP6277126B2 JP2014525119A JP2014525119A JP6277126B2 JP 6277126 B2 JP6277126 B2 JP 6277126B2 JP 2014525119 A JP2014525119 A JP 2014525119A JP 2014525119 A JP2014525119 A JP 2014525119A JP 6277126 B2 JP6277126 B2 JP 6277126B2
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- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
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- Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161521607P | 2011-08-09 | 2011-08-09 | |
| US61/521,607 | 2011-08-09 | ||
| PCT/US2012/049990 WO2013022968A1 (en) | 2011-08-09 | 2012-08-08 | Antibodies binding to phosphorylcholine (pc) and/or pc conjugates |
Publications (3)
| Publication Number | Publication Date |
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| JP2014529398A JP2014529398A (ja) | 2014-11-13 |
| JP2014529398A5 JP2014529398A5 (enExample) | 2015-10-01 |
| JP6277126B2 true JP6277126B2 (ja) | 2018-02-07 |
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| US (3) | US9796786B2 (enExample) |
| EP (1) | EP2741770A4 (enExample) |
| JP (1) | JP6277126B2 (enExample) |
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| AU (1) | AU2012294431B2 (enExample) |
| CA (1) | CA2843960C (enExample) |
| WO (1) | WO2013022968A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| HRP20190988T1 (hr) | 2011-08-09 | 2019-09-20 | Athera Biotechnologies Ab | Nova protutijela protiv fosforilkolina |
| CN103906532B (zh) * | 2011-08-09 | 2018-01-26 | 阿瑟拉生物技术公司 | 结合磷酰胆碱（pc）和/或pc结合物的抗体 |
| US20150376268A1 (en) * | 2013-02-25 | 2015-12-31 | The Regents Of The University Of California | Antibodies to oxidized phospholipids |
| AR103442A1 (es) | 2015-01-16 | 2017-05-10 | Juno Therapeutics Inc | Anticuerpos y receptores de antígenos quiméricos específicos de ror1 |
| MX2018009011A (es) | 2016-02-02 | 2018-11-19 | Hutchinson Fred Cancer Res | Anticuerpos anti receptor 1 transmembrana de tirosina-proteina cinasa (ror1) y usos de los mismos. |
| KR20250173600A (ko) | 2023-03-17 | 2025-12-10 | 옥시토프 파마 비.브이. | 항-포스포콜린 항체 및 그 사용 방법 |
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| FR2402664A1 (fr) | 1977-09-07 | 1979-04-06 | Agronomique Inst Nat Rech | Produits de couplage phosphorylcholine, composes amines procede d'obtention et applications |
| US5955584A (en) | 1986-03-31 | 1999-09-21 | Charter Ventures | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
| DE3751182T2 (de) | 1986-08-06 | 1995-10-26 | Scripps Clinic Res | Monoklonale Antikörper, B-spezifisch für Apolipoprotein, die von zwei Hybridomen erzeugt werden. |
| JPH02188532A (ja) | 1989-01-17 | 1990-07-24 | Otsuka Pharmaceut Co Ltd | リポソームワクチン |
| AU5522390A (en) | 1989-04-19 | 1990-11-16 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Process for removing c-reactive protein and anti-phosphorylcholine antibodies from biological fluids |
| JP3283041B2 (ja) | 1990-07-13 | 2002-05-20 | 学校法人藤田学園 | 人工抗体 |
| EP0562020A4 (en) | 1990-12-10 | 1993-11-18 | Alving, Carl L. | A vaccine against cholesterol to prevent hypercholesterolemia and atherosclerosis |
| JPH07504817A (ja) | 1992-03-03 | 1995-06-01 | ザ ロックフェラー ユニヴァーシティ | Ｂ２９（Ｉｇ‐βまたはＩｇ−γ）を含むレセプタ複合体およびその利用 |
| WO1994014454A1 (en) | 1992-12-29 | 1994-07-07 | Entremed, Inc. | Vaccines against sterols |
| DE69411154T2 (de) | 1993-02-22 | 1998-10-22 | Alza Corp., Palo Alto, Calif. | Mittel zur oralen gabe von wirkstoffen |
| US5455032A (en) | 1993-07-29 | 1995-10-03 | The United States Of America As Represented By The Department Of Health And Human Services | Use of phosphocholine hapten conjugates in vaccines |
| AU1159497A (en) | 1996-11-08 | 1998-06-03 | Regents Of The University Of California, The | Methods and reagents for non-invasive imaging of atherosclerotic plaque |
| US6375925B1 (en) | 1996-11-08 | 2002-04-23 | The Regents Of The University Of California | Methods and reagents for non-invasive imaging of atherosclerotic plaque |
| US6225070B1 (en) | 1997-08-07 | 2001-05-01 | The Regents Of The University Of California | Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma |
| US20040185039A1 (en) | 2002-08-30 | 2004-09-23 | Heinz Kohler | Therapeutic applications of noncovalent dimerizing antibodies |
| US6300308B1 (en) | 1997-12-31 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions for inducing autoimmunity in the treatment of cancers |
| DE69911417T2 (de) | 1998-07-03 | 2004-06-17 | Athera Biotechnologies Ab | Verfahren zur diagnose von gefässerkrankungen und früher atheriosklerose |
| SE9802402D0 (sv) | 1998-07-03 | 1998-07-03 | Karolinska Innovations Ab | Method of diagnosing cardiovascular disease and early atherosclerosis |
| DE60045869D1 (de) | 1999-10-26 | 2011-06-01 | Univ California | Reagenzien und verfahren für diagnose, 'imaging' und behandlung von atherosklerotischen krankheiten |
| SE0000855D0 (sv) | 2000-03-15 | 2000-03-15 | Karolinska Innovations Ab | Antigenic composition useful as a vaccine against atherosclerosis |
| AU2001259730A1 (en) | 2000-05-12 | 2001-11-26 | The Regents Of The University Of California | Standardized oxidized ldl assay |
| MXPA02012434A (es) * | 2000-06-16 | 2004-09-06 | Cambridge Antibody Tech | Anticuerpos que se unen inmunoespecificamente a estimulador de linfocitos ii. |
| DE10041515A1 (de) | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
| US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| SE0103754L (sv) | 2001-04-05 | 2002-10-06 | Forskarpatent I Syd Ab | Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid |
| US20070122419A1 (en) | 2003-04-11 | 2007-05-31 | The Regents Of The University Of California | Methods and compositions for treating atherosclerosis |
| WO2005100405A2 (en) | 2004-04-15 | 2005-10-27 | Athera Biotechnologies Ab | Phosphorylcholine conjugates and corresponding antibodies |
| WO2006017538A2 (en) | 2004-08-03 | 2006-02-16 | Dyax Corp. | Hk1-binding proteins |
| ATE462802T1 (de) | 2004-09-08 | 2010-04-15 | Eisai R&D Man Co Ltd | Verfahren zur bildung eines signalsondenpolymers |
| NZ561218A (en) * | 2005-02-07 | 2011-04-29 | Univ California | Methods for reducing the symptoms of autoimmunity and inflammation using binding proteins against antigens exposed on dead or dying cells |
| EP1868651A4 (en) | 2005-04-12 | 2010-10-06 | Univ Duke | METHOD FOR INDUCTION OF NEUTRALIZING ANTIBODIES TO THE HIV VIRUS |
| CA2631212A1 (en) | 2005-11-28 | 2007-07-05 | Medimmune, Llc | Antagonists of hmgb1 and/or rage and methods of use thereof |
| US20090258005A1 (en) | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
| JP5122908B2 (ja) | 2007-10-17 | 2013-01-16 | 日泉化学株式会社 | 自動車の内装用部材の取り付け構造 |
| CN102124342A (zh) | 2008-07-07 | 2011-07-13 | 阿瑟拉生物技术公司 | 阿尔茨海默病新的治疗和诊断方法 |
| WO2010028306A2 (en) * | 2008-09-05 | 2010-03-11 | The Regents Of The University Of California Office Of The President | Antibodies with mannose binding lectin effector function for inhibiting pathologic inflammatory conditions |
| WO2012010291A1 (en) | 2010-07-21 | 2012-01-26 | Athera Biotechnologies Ab | Diagnostic and therapeutic methods and compositions for metabolic disease |
| IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | Plasma kallikrein binding proteins |
| HRP20190988T1 (hr) | 2011-08-09 | 2019-09-20 | Athera Biotechnologies Ab | Nova protutijela protiv fosforilkolina |
| CN103906532B (zh) * | 2011-08-09 | 2018-01-26 | 阿瑟拉生物技术公司 | 结合磷酰胆碱（pc）和/或pc结合物的抗体 |
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- 2012-08-08 EP EP12821512.6A patent/EP2741770A4/en not_active Withdrawn
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| US20210230310A1 (en) | 2021-07-29 |
| CA2843960A1 (en) | 2013-02-14 |
| EP2741770A1 (en) | 2014-06-18 |
| EP2741770A4 (en) | 2014-12-31 |
| WO2013022968A1 (en) | 2013-02-14 |
| US20180086847A1 (en) | 2018-03-29 |
| CN103906532A (zh) | 2014-07-02 |
| US20140193413A1 (en) | 2014-07-10 |
| US9796786B2 (en) | 2017-10-24 |
| CA2843960C (en) | 2020-09-15 |
| HK1199409A1 (en) | 2015-07-03 |
| CN103906532B (zh) | 2018-01-26 |
| AU2012294431B2 (en) | 2017-03-30 |
| AU2012294431A1 (en) | 2014-02-20 |
| JP2014529398A (ja) | 2014-11-13 |
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