JP6242696B2 - 腸管免疫賦活剤 - Google Patents
腸管免疫賦活剤 Download PDFInfo
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- JP6242696B2 JP6242696B2 JP2014008648A JP2014008648A JP6242696B2 JP 6242696 B2 JP6242696 B2 JP 6242696B2 JP 2014008648 A JP2014008648 A JP 2014008648A JP 2014008648 A JP2014008648 A JP 2014008648A JP 6242696 B2 JP6242696 B2 JP 6242696B2
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- ganoderma
- spore
- intestinal
- cells
- peyer
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Description
<処方>
成分 配合量(%)
1.霊芝破壁胞子 30.0
2.米胚芽油 60.0
3.ミツロウ 7.0
4.ビタミンE 3.0
<製造方法>
成分1〜4を混合し、ゼラチン、グリセリン、カラメル色素で構成される被膜に、250mg充填し、乾燥後、軟カプセル剤を得る。
<用法>
1日当り4粒摂取する。
<処方>
成分 配合量(%)
1.霊芝超臨界胞子抽出物 30.0
2.ひまわり油 60.0
3.ミツロウ 7.0
4.ビタミンE 3.0
<製造方法>
成分1〜4を混合し、ゼラチン、グリセリン、カラメル色素で構成される被膜に、250mg充填し、乾燥後、軟カプセル剤を得る。
<用法>
1日当り4粒摂取する。
<処方>
成分 配合量(%)
1.霊芝破壁胞子 10.0
2.コーンスターチ 87.0
3.ショ糖脂肪酸エステル 3.0
<製造方法>
成分1〜3を混合し、2号硬カプセルに250mg充填して硬カプセル剤を得る。
<用法>
1日当り4粒摂取する。
<処方>
成分 配合量(%)
1.霊芝破壁胞子 10.0
2.乳糖 60.0
3.還元麦芽糖水飴 26.0
4.ショ糖脂肪酸エステル 4.0
<製造方法>
成分1〜4を混合して打錠成型し、0.3gの錠剤を得る。
<用法>
1日当り3粒摂取する。
<処方>
成分 配合量(%)
1.霊芝超臨界胞子抽出物 2.0
2.乳糖 60.0
3.還元麦芽糖水飴 34.0
4.ショ糖脂肪酸エステル 4.0
<製造方法>
成分1〜4を混合して打錠成型し、0.3gの錠剤を得る。
<用法>
1日当り3粒摂取する。
<処方>
成分 配合量(%)
1.霊芝破壁胞子 5.0
2.乳糖 90.0
3.セルロース 5.0
<製造方法>
成分1〜3を乾式法により造粒し、顆粒剤を得る。
<用法>
1日当り2g摂取する。
<処方>
成分 配合量(%)
1.霊芝超臨界胞子抽出物 1.0
2.乳糖 94.0
3.セルロース 5.0
<製造方法>
成分1〜3を乾式法により造粒し、顆粒剤を得る。
<用法>
1日当り2g摂取する。
<処方>
成分 配合量(%)
1.カラギーナン 1.0
2.ゼラチン 0.5
3.砂糖 20.0
4.霊芝超臨界胞子抽出物 0.01
5.精製水 78.49
<製造方法>
成分1〜5を混合し、加熱しながら煮詰める。冷却後、ゼリーの型10個に流し込んで冷却し、1個100gのゼリーを得る。
<用法>
1日1個を摂取する。
BALB/c系マウスに、霊芝破壁胞子、あるいは霊芝超臨界胞子抽出物を粉末飼料に4%となるように添加し10日間、摂取させた。投与最終日に小腸よりパイエル板を摘出し、細胞数を計測した。尚、比較として、霊芝(Ganoderma lucidum)の子実体の熱水抽出物について同時に試験を行った。
実験例1のマウスのパイエル板より採取した細胞を1×107個/mLとなるように0.1%BSA含有PBBSに浮遊させ、その100μLをエッペンチューブに添加し、ヘルパーT細胞の細胞表面抗原であるCD4を添加して、4℃、30分間反応させた。氷冷した0.1%BSA含有PBBSを添加することにより、反応を停止し、遠心処理した後に、上清を吸引除去し、得られた細胞ペレットに0.1%BSA含有PBBSを添加した。再度遠心処理後に上清を吸引除去し、得られた細胞ペレットに0.1%BSA含有PBBSを添加して、細胞浮遊液を調製した。フローサイトメトリーにて、細胞浮遊液中のヘルパーT細胞数を計測した。
実験例1のマウスのパイエル板より採取した細胞を1×107個/mLとなるように0.1%BSA含有PBBSに浮遊させ、その100μLをエッペンチューブに添加し、B細胞の細胞表面抗原であるCD19を添加して、4℃、30分間反応させた。氷冷した0.1%BSA含有PBBSを添加することにより、反応を停止し、遠心処理した後に、上清を吸引除去し、得られた細胞ペレットに0.1%BSA含有PBBSを添加した。再度遠心処理後に上清を吸引除去し、得られた細胞ペレットに0.1%BSA含有PBBSを添加して、細胞浮遊液を調製した。フローサイトメトリーにて、細胞浮遊液中のB細胞数を計測した。
実験例1のマウスのパイエル板より採取した細胞を1×106個で播種し、5μg/mLとなるようにConA(コンカナバリンA)を含有する牛胎児血清含有RPMI1640培地中で、5日間培養した。培養上清を回収し、上清中に含まれるインターフェロンγをELISA法により測定した。
Claims (3)
- 霊芝の超臨界胞子抽出物を含有することを特徴とする腸管免疫賦活剤。
- 腸管パイエル板に含まれる細胞を増殖させることを特徴とする請求項1記載の腸管免疫賦活剤。
- 腸管パイエル板に含まれるヘルパーT細胞及び/又はB細胞を増殖させることを特徴とする請求項1記載の腸管免疫賦活剤。
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