JP6240626B2 - 抗アトピー性皮膚炎用組成物 - Google Patents
抗アトピー性皮膚炎用組成物 Download PDFInfo
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- JP6240626B2 JP6240626B2 JP2015033450A JP2015033450A JP6240626B2 JP 6240626 B2 JP6240626 B2 JP 6240626B2 JP 2015033450 A JP2015033450 A JP 2015033450A JP 2015033450 A JP2015033450 A JP 2015033450A JP 6240626 B2 JP6240626 B2 JP 6240626B2
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- atopic dermatitis
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- nariltin
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Description
そのうち、花粉症やアレルギー性鼻炎は、別名、即時型過敏とも呼ばれるI型アレルギーであることが分かっている。なお、I型アレルギーは、アレルギーの原因となるアレルゲンに特異的に反応するIgEや一部のIgG4などの免疫グロブリン等が関与する液性免疫である(非特許文献1を参照。)。
(1)じゃばら果実
この発明で使用するじゃばら果実は、特に限定することなく使用できる。中でも、単位重量当たりのナリルチンの含有量が多いことから、摘果された果実や果皮が黄変する以前の未成熟段階の果実が好ましい。ここで、未成熟段階の果実とは、具体的には、着果から3月〜4月後に摘果した果実が好ましい。なお、じゃばらは、一般的に6月ごろに着果することから、9月〜10月ごろに収穫された果実が好ましい。
じゃばら果皮は、じゃばら果実から手で剥いたもの、公知の自動皮むき機により剥いたもの、果汁圧搾機により果汁を搾った後に残る残渣などが使用できるが、手間を考えると果汁圧搾機の残渣が好ましい。
じゃばら乾燥果皮末は、フリーズドライ法で乾燥したのち、熱乾燥法によって乾燥することによって製造したものであり、中でも、80℃で熱乾燥したものが好ましい。このようにして製造したじゃばら乾燥果皮は、高いナリルチン濃度を維持したまま、酸化されるとアレルギー誘発物質になるリモネンが完全に除去されている。そのため、この発明の抗アトピー性皮膚炎用組成物自身によるアレルギー等が発症する可能性をほぼ完全に無くすことができる。
じゃばら乾燥果皮は、ボールミル等を使用する公知の粉砕方法により果皮末に加工して使用する。なお、果皮末に加工する際の粉末の大きさは、200〜1000メッシュのものである。粉末が200メッシュの篩を通らないほど大きければ、乾燥果皮末から溶出するナリルチン量が限定され、粉末が1000メッシュの篩を通り抜けるほど小さければ粉砕に手間が掛かるからである。
抗アトピー性皮膚炎用組成物におけるじゃばら乾燥果皮末の含有量は、0.01〜10%(重量%、特に記載がなければ以下同じ。)であり、1〜5%が好ましい。1%以上であれば充分な効果が得られ、5%以下であれば塗り心地、安定性、色味がよいからである。
この発明の抗アトピー性皮膚炎用組成物は、この発明の効果を損なわない範囲において、一般に化粧料、医薬部外品、医薬品等の抗アトピー性皮膚炎用組成物に使用される公知の任意成分を必要に応じて加えてもよい。
この発明の抗アトピー性皮膚炎用組成物は、化粧料、医薬部外品、医薬品等を調製する公知の方法により調製できる。具体的には、高速ホモミキサー、プラネタリーミキサー、流動式混合機などにより、抗アトピー性皮膚炎用組成物の構成成分を混合することによって調製することができる。なお、加える成分に応じて、加温や冷却しながら混合してもよい。
この発明の抗アトピー性皮膚炎用組成物は、皮膚に使用するものであれば特に限定しない。具体的には、溶液系、可溶化系、乳化系、粉末分散系、水―油二層系、水―油―粉末系、水―油―シリコーン系の三層系や親水性軟膏や吸水性軟膏、ゲル系、エアゾール系など任意の剤型でよい。
この発明の抗アトピー性皮膚炎用組成物は、外皮に使用される化粧料、医薬部外品、医薬品等に広範囲に使用できる。具体的には、洗顔料、乳液、クリーム、化粧水、パック、美容液等のスキンケア化粧料、ファンデーションなどのベースメイクアップや口紅、アイシャドウ、アイライナーなどのポイントメークやシャンプー、リンス、コンディショナーや頭皮ケア剤などを含むヘアケア製品、浴用剤、芳香性化粧料等にも使用でき、分野別では、サンケア商品、ボディケア商品、美白商品や抗老化用商品にも使用できる。
(1)じゃばら乾燥果皮末の調製
和歌山県和歌山市松江北のじゃばら果樹からじゃばら果実を10月末頃に採取して、その果皮を手で剥ぎ取った。剥ぎ取った果皮を-70℃のフリーズドライ法で乾燥したのち、80℃で8時間熱乾燥して乾燥果皮を得た。乾燥果皮をボールミルで粉砕して、200メッシュの篩に掛け、200メッシュの篩を通過したじゃばら乾燥果皮末を得た。
この発明に係る抗アトピー性皮膚炎用組成物を調製した。具体的には、表1に記載の成分をビーカーに入れ、ホモミキサーや攪拌機で攪拌して調製した。
(2)で製造した抗アトピー性皮膚炎用組成物を、成人男女各10名(20代〜50代)の顔及び皮膚に塗布して、その性能を「使用感試験」、「刺激試験」、「肌質改善試験」により評価した。その結果を表2から表4に示す。
(2)で製造した抗アトピー性皮膚炎用組成物をアトピー性皮膚炎の患者10人の患部に朝晩2回塗布して、症状の変化を目視により調べた。なお、患者の年齢、性別、及び症状の変化を表5に示す。
じゃばら乾燥果皮末に含まれるナリルチンA及びナリルチンBが、抗アレルギー・抗炎症に関与する遺伝子の転写量に与える影響を、実験動物を使用して調べた。その詳細を以下に示す。
ナリルチンは、大阪薬科大学生薬学教室谷口教授が精製したものを使用した。なお、ナリルチンは、分子式C27H32O14のS体の化合物であり、立体構造的に区別する場合、2S-ナリルチンと表記される。また、精製法によっては、ナリルチン(2S-ナリルチン)の単離過程で、R体に異性化した2R-ナリルチンが20重量%程含まれる。
アレルギーモデルマウスは、Yamamoto(下記の参考文献1を参照。)らの方法に従って作製した。)。具体的には、まずNC/Ngaマウスの背部及び耳介部をバリカン、電気シェーバーにて毛刈りしたのち、除毛剤エピラットを適量塗布し除毛した。除毛剤をふき取ったのち、ビオスタAD(株式会社ビオスタ製)100mgをマイクロピペットのチップ裏部で背部及び耳介部に均一に塗布した(初回惹起)。
アレルギーモデルマウスの白血球でしている細胞性免疫関連遺伝子のmRNA転写量をex vivo simulation法により測定した。具体的には、以下のようにして測定した。
ダニアレルゲンDer f1及びDer f2(アサヒフードアンドヘルスケア株式会社製)を、それぞれ濃度が100μg/mlとなるように溶解・懸濁してアレルゲン混合溶液を調製した。また、ナリルチンAとナリルチンBを、血液との反応時の濃度が100μM、10μM、1μMになるようにDMSOにて溶解し、ナリルチン溶液を調製した。なお、ナリルチンを含まない溶液を実験対照として使用するため調製した。
ヘパリン採血したマウス全血60μlに、アレルゲン混合溶液1.2μl、及びナリルチン溶液1.2μlを添加し、37℃で4時間反応させた。このナリルチン添加マウス全血中の各遺伝子のmRNAの転写量を、Mitsuhashiの方法(下記の参考文献2を参照。)に従って測定した。具体的には次のようにして行った。
図1は、ナリルチンの投与量が、ケモカインCXCL1遺伝子の転写量に与える影響を示すグラフである。また、図2は、ナリルチンの投与量が、ケモカインCCL4遺伝子の転写量に与える影響を示すグラフである。さらに、図3は、ナリルチンの投与量が、インターロイキンIL-16遺伝子の転写量に与える影響を示すグラフである。加えて、図4は、ナリルチンの投与量がL-ヒスチジン脱炭酸酵素HDC遺伝子の転写量に与える影響を示すグラフである。
Claims (2)
- フリーズドライ法によって乾燥して、熱乾燥法により乾燥したのち、粉末に粉砕して、200〜1000メッシュの篩を通過したじゃばら乾燥果皮末を有効成分として含む抗アトピー性皮膚炎用組成物。
- 80℃で熱乾燥する請求項1に記載の抗アトピー性皮膚炎用組成物。
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