JP6227523B2 - 治療の方法においておよび化合物のスクリーニングのために有用なアミロドーシスターゲット - Google Patents
治療の方法においておよび化合物のスクリーニングのために有用なアミロドーシスターゲット Download PDFInfo
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- A—HUMAN NECESSITIES
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- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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- G—PHYSICS
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- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
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| SE1150299-4 | 2011-04-05 | ||
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| PCT/SE2012/050352 WO2012138284A1 (en) | 2011-04-05 | 2012-03-30 | Amyloidosis target useful in methods of treatment and for screening of compounds |
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| JP2014516407A JP2014516407A (ja) | 2014-07-10 |
| JP2014516407A5 JP2014516407A5 (enExample) | 2015-05-14 |
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| US11077095B2 (en) * | 2017-02-24 | 2021-08-03 | Alzheon, Inc. | Methods for treating neurodegenerative disorders |
| JP7820821B2 (ja) * | 2020-01-08 | 2026-02-26 | アルファベータ・エービー | アルツハイマー病の治療のための化合物及び方法 |
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| ATE284538T1 (de) | 1998-10-30 | 2004-12-15 | Jordan L Holtzman | Komplex, bestehend aus einem chaperon und beta- amyloidprotein sowie verfahren, die diesen komplex benutzen |
| US6670195B1 (en) * | 1999-05-26 | 2003-12-30 | New York University | Mutant genes in Familial British Dementia and Familial Danish Dementia |
| US20030224982A1 (en) | 2001-07-05 | 2003-12-04 | Li Li | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US6673545B2 (en) | 2000-07-28 | 2004-01-06 | Incyte Corporation | Prostate cancer markers |
| US6716589B2 (en) | 2000-11-20 | 2004-04-06 | Alphabeta Ab | Discordant helix stabilization for prevention of amyloid formation |
| EP1387678A1 (en) * | 2001-05-03 | 2004-02-11 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. | Compounds that inhibit hsp90 and stimulate hsp70 and hsp40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation |
| MXPA04010560A (es) | 2002-04-25 | 2005-08-15 | Scripps Research Inst | Tratamiento y prevencion de condiciones pulmonares. |
| CA2507613A1 (en) | 2002-12-09 | 2004-07-08 | Jeffrey A. Whitsett | Methods of diagnosis and treatment of interstitial lung disease |
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| KR100992492B1 (ko) | 2004-04-05 | 2010-11-08 | 토쿠시마 대학 | 국소 점막 면역 유도 촉진용 항원약물 비히클, 이것을 사용하는 점막 백신, 알레르기의 예방제 또는 치료제, 약물전달 시스템, 및 점막면역의 유도방법 |
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| WO2007005672A2 (en) | 2005-06-30 | 2007-01-11 | The Scripps Research Institute | Treatment and prevention of respiratory diseases and conditions |
| CN101257919B (zh) | 2005-08-05 | 2012-08-29 | 国立大学法人德岛大学 | 可以由选择性产生IgA抗体向产生IgA和IgG两种抗体转换的抗原药物载体和使用该载体的经鼻·粘膜疫苗 |
| JP4981305B2 (ja) | 2005-11-11 | 2012-07-18 | 公益財団法人大阪バイオサイエンス研究所 | アルツハイマー病の発症リスク又はアルツハイマー病発症予後の予測方法 |
| EP2096910A4 (en) * | 2006-11-22 | 2011-11-30 | Einstein Coll Med | Transgenic mammals modified bri protein expression |
| CN101754747A (zh) | 2007-06-05 | 2010-06-23 | Paka肺部医药公司 | 用于向肺脏递送药物的方法以及组合物 |
| WO2009009396A2 (en) | 2007-07-06 | 2009-01-15 | Mayo Foundation For Medical Education And Research | Bri polypeptides and reducing ab aggregation |
| WO2010087771A1 (en) | 2009-01-30 | 2010-08-05 | Alphabeta Ab | Compound and method for treatment of alzheimer's disease |
| JP5339387B2 (ja) | 2009-08-10 | 2013-11-13 | 独立行政法人科学技術振興機構 | オートファジーの測定方法 |
| AU2010356144B2 (en) * | 2010-06-24 | 2015-06-04 | Alphabeta Ab | Compound and method for treatment of Alzheimer's disease and familial dementia |
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Also Published As
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| US9522170B2 (en) | 2016-12-20 |
| EP2694977A1 (en) | 2014-02-12 |
| WO2012138284A1 (en) | 2012-10-11 |
| US20140030274A1 (en) | 2014-01-30 |
| JP2014516407A (ja) | 2014-07-10 |
| EP2694977B1 (en) | 2016-06-29 |
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