JP6224455B2 - ｍｉＲＮＡ−２９発現のアンタゴニスト、並びに大動脈瘤の予防及び治療におけるその使用 - Google Patents

ｍｉＲＮＡ−２９発現のアンタゴニスト、並びに大動脈瘤の予防及び治療におけるその使用 Download PDF

Info

Publication number
JP6224455B2
JP6224455B2 JP2013501865A JP2013501865A JP6224455B2 JP 6224455 B2 JP6224455 B2 JP 6224455B2 JP 2013501865 A JP2013501865 A JP 2013501865A JP 2013501865 A JP2013501865 A JP 2013501865A JP 6224455 B2 JP6224455 B2 JP 6224455B2
Authority
JP
Japan
Prior art keywords
mirna
antisense
expression
aortic aneurysm
oligonucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013501865A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013523696A5 (enExample
JP2013523696A (ja
Inventor
ザイハー，アンドレアス
ディメラー，ステファニー
ブーン，レイニー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goethe Universitaet Frankfurt am Main
Original Assignee
Goethe Universitaet Frankfurt am Main
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goethe Universitaet Frankfurt am Main filed Critical Goethe Universitaet Frankfurt am Main
Publication of JP2013523696A publication Critical patent/JP2013523696A/ja
Publication of JP2013523696A5 publication Critical patent/JP2013523696A5/ja
Application granted granted Critical
Publication of JP6224455B2 publication Critical patent/JP6224455B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2013501865A 2010-04-01 2011-04-01 ｍｉＲＮＡ−２９発現のアンタゴニスト、並びに大動脈瘤の予防及び治療におけるその使用 Active JP6224455B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10003675.5 2010-04-01
EP10003675A EP2371370A1 (en) 2010-04-01 2010-04-01 Antagonists of miRNA-29 expression and their use in the prevention and treatment of aortic aneurysms and atherosclerotic plaque destabilization
PCT/EP2011/055122 WO2011121120A1 (en) 2010-04-01 2011-04-01 ANTAGONISTS OF miRNA-29 EXPRESSION AND THEIR USE IN THE PREVENTION AND TREATMENT OF AORTIC ANEURYSMS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016060073A Division JP2016193888A (ja) 2010-04-01 2016-03-24 ｍｉＲＮＡ−２９発現のアンタゴニスト、並びに大動脈瘤の予防及び治療におけるその使用

Publications (3)

Publication Number Publication Date
JP2013523696A JP2013523696A (ja) 2013-06-17
JP2013523696A5 JP2013523696A5 (enExample) 2014-05-15
JP6224455B2 true JP6224455B2 (ja) 2017-11-01

Family

ID=42269707

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013501865A Active JP6224455B2 (ja) 2010-04-01 2011-04-01 ｍｉＲＮＡ−２９発現のアンタゴニスト、並びに大動脈瘤の予防及び治療におけるその使用
JP2016060073A Pending JP2016193888A (ja) 2010-04-01 2016-03-24 ｍｉＲＮＡ−２９発現のアンタゴニスト、並びに大動脈瘤の予防及び治療におけるその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016060073A Pending JP2016193888A (ja) 2010-04-01 2016-03-24 ｍｉＲＮＡ−２９発現のアンタゴニスト、並びに大動脈瘤の予防及び治療におけるその使用

Country Status (9)

Country Link
US (1) US9062307B2 (enExample)
EP (2) EP2371370A1 (enExample)
JP (2) JP6224455B2 (enExample)
CN (1) CN102939090A (enExample)
AU (1) AU2011234453B2 (enExample)
CA (1) CA2795164C (enExample)
ES (1) ES2690198T3 (enExample)
RU (1) RU2012146518A (enExample)
WO (1) WO2011121120A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US8618073B2 (en) 2010-07-22 2013-12-31 The University Of North Carolina At Chapel Hill Use of miR-29 for cell protection
JP2015518475A (ja) * 2012-04-10 2015-07-02 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラルシェルシェ メディカル）Ｉｎｓｅｒｍ（Ｉｎｓｔｉｔｕｔ Ｎａｔｉｏｎａｌ Ｄｅｌａ Ｓａｎｔｅ Ｅｔｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｍｅｄｉｃａｌｅ） 非アルコール性脂肪性肝炎の治療方法
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY
US9828603B2 (en) 2012-08-13 2017-11-28 Cedars Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
RU2712511C2 (ru) * 2014-09-08 2020-01-29 Мираген Терапеутикс, Инк. Миметики mir-29 и пути их применения
US11357799B2 (en) 2014-10-03 2022-06-14 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
EP3247716A4 (en) 2015-01-20 2018-10-17 Miragen Therapeutics, Inc. Mir-92 inhibitors and uses thereof
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
WO2017214949A1 (zh) * 2016-06-16 2017-12-21 毛侃琅 一种抑制 miRNA-29a 表达的慢病毒载体的构建及其应用
WO2017219170A1 (zh) * 2016-06-19 2017-12-28 毛侃琅 特异抑制人 miRNA-29a 和 miR-424 表达的慢病毒载体的构建及其应用
WO2017219169A1 (zh) * 2016-06-19 2017-12-28 毛侃琅 一种抑制 miRNA-29a 和 miR-185 表达的慢病毒载体及其应用
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
US11759482B2 (en) 2017-04-19 2023-09-19 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
CN109762883B (zh) * 2019-01-31 2020-01-21 温州医科大学 血浆/血清外泌体hsa-miRNA-29-3p作为青光眼诊断标志物中的应用
CN110511930B (zh) * 2019-06-11 2023-01-10 河北医科大学 Sal-miR-58及其在抑制血管炎性反应和动脉瘤形成中的用途
CN117979975A (zh) * 2021-05-07 2024-05-03 加利福尼亚大学董事会 用于预防和治疗动脉瘤、高血压、ards和其他与内皮功能障碍相关联的疾病的mirna抑制剂
US20250304956A1 (en) * 2021-08-06 2025-10-02 Leadermed Champion Limited miRNA-BASED COMPOSITIONS AND METHODS OF USE THEREOF
CN114432453B (zh) * 2022-02-25 2022-10-14 上海大学 敲低或抑制clec4d的试剂在制备心肌缺血再灌注损伤药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008042231A2 (en) 2006-09-29 2008-04-10 Children's Medical Center Corporation Compositions and methods for evaluating and treating heart failure
ES2621161T3 (es) 2007-07-31 2017-07-03 The Board Of Regents Of The University Of Texas System Familia de micro-ARN que modula la fibrosis y usos de la misma
CL2008003699A1 (es) * 2007-12-13 2009-10-09 Takeda Pharmaceuticals Co Nanopartícula que comprende pioglitazona y un polímero biocompatible, preparación farmacéutica que la contiene; stent (endoprótesis vascular) que la porta; y su uso en la profilaxis o tratamiento de enfermedades arterioescleróticas.
CA2716343A1 (en) * 2008-02-21 2009-08-27 The Board Of Regents Of The University Of Texas System Micro-rnas that modulate smooth muscle proliferation and differentiation and uses thereof

Also Published As

Publication number Publication date
US9062307B2 (en) 2015-06-23
CN102939090A (zh) 2013-02-20
EP2552454A1 (en) 2013-02-06
US20130116303A1 (en) 2013-05-09
ES2690198T3 (es) 2018-11-19
CA2795164A1 (en) 2011-10-06
EP2371370A1 (en) 2011-10-05
RU2012146518A (ru) 2014-05-10
JP2016193888A (ja) 2016-11-17
CA2795164C (en) 2019-06-18
EP2552454B1 (en) 2018-07-11
AU2011234453A1 (en) 2012-10-18
WO2011121120A1 (en) 2011-10-06
JP2013523696A (ja) 2013-06-17
AU2011234453B2 (en) 2015-01-22

Similar Documents

Publication Publication Date Title
JP6224455B2 (ja) ｍｉＲＮＡ−２９発現のアンタゴニスト、並びに大動脈瘤の予防及び治療におけるその使用
JP5898843B2 (ja) 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法
US7994150B2 (en) Micro-RNAs that modulate smooth muscle proliferation and differentiation and uses thereof
CN104011208B (zh) 作为治疗靶的miRNA-212/132家族
JP2013523696A5 (enExample)
CN103210085A (zh) 用于治疗或诊断骨障碍和/或心血管障碍的组合物
WO2011064354A2 (en) Micro-rna and tissue repair
WO2010120969A1 (en) Targeting of the mir-30 family and let-7 family as a treatment for heart disease
JP2014504857A (ja) ロックドヌクレオチドを含むｍｉｃｒｏＲＮＡ阻害剤
JP2013511964A (ja) ｍｉＲＮＡ−１００を含む医薬組成物ならびに血管増殖および内皮炎症を調節するためのその使用
Guedes et al. High fat diet reduces the expression of miRNA‐29b in heart and increases susceptibility of myocardium to ischemia/reperfusion injury
Latsios et al. MicroRNAs in the diagnosis and treatment of unstable angina
JP5522435B2 (ja) Ｍｘｄ３遺伝子の発現阻害による肥満の抑制
CN102266569B (zh) miR-199a及其抑制剂的应用
Preethi et al. Therapeutic aspect of microRNA inhibition in various types of hypertension and hypertensive complications
EP4603586A1 (en) Inhibitory oligonucleotides against adamts7
US20250161398A1 (en) Design and development of a novel messenger rna therapeutic to treat atherosclerosis
WO2019139351A1 (en) Pharmaceutical composition for preventing or treating muscular disease or cachexia comprising, as active ingredient, mirna located in dlk1 -dio3 cluster or variant thereof
KR20150078074A (ko) microRNA-365 활성화제를 포함하는 혈관평활근세포 증식 또는 이동 억제용 약학적 조성물
WO2024165603A1 (en) Pharmaceutical composition for use in treatment of venous thromboembolism
EP3546578A1 (en) Ap-1 binding polynucleotides
Simmons MIR-744 Modulation by Disturbed Flow and its Role in Endothelial Inflammation and Atherosclerosis
KR20150074426A (ko) 염증유발 사이토카인에 의한 혈관평활근세포의 증식 및 이동을 조절하는 ｍｉｃｒｏＲＮＡ２９―ｂ
Markowitz et al. 1028. Invivofectamine™-New Non-Viral Delivery Reagent for In Vivo Delivery of Stealth™ RNAi

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140310

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140310

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150210

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150427

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150602

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20151124

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160324

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20160517

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20160722

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170629

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170802

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20171005

R150 Certificate of patent or registration of utility model

Ref document number: 6224455

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250