JP6219166B2 - 皮膚、粘膜、毛髪及び/又は爪の処置及び/又はケアのためのエキソ多糖 - Google Patents
皮膚、粘膜、毛髪及び/又は爪の処置及び/又はケアのためのエキソ多糖 Download PDFInfo
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- JP6219166B2 JP6219166B2 JP2013541244A JP2013541244A JP6219166B2 JP 6219166 B2 JP6219166 B2 JP 6219166B2 JP 2013541244 A JP2013541244 A JP 2013541244A JP 2013541244 A JP2013541244 A JP 2013541244A JP 6219166 B2 JP6219166 B2 JP 6219166B2
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Description
本発明の理解を容易にするために、本発明の文脈で使用されるいくつかの用語及び表現の意味を含める。
本発明の第3の態様は、皮膚、粘膜、毛髪及び/又は爪の処置及び/又はケアのための美容又は皮膚医薬組成物の調製における本発明のエキソ多糖の使用を指す。
a)シュードアルテロモナス(Pseudoalteromonas)種に対応する菌株CNCM I−4150の培養方法。
菌株CNCM I−4150を発酵槽内にて29℃及びpH7.5で培養し、そのブロスは、ブドウ糖(20g/l)で補強した2216E培地(ZoBell C.E. J. Mar. Res., 1941, 4:42.)を含んでいた。10%(v/v)の以前の収穫物を用いて接種材料を調製し、発酵の継続時間を72時間に延長した。通気及び撹拌の速度は、各々、2vvm及び250rpm、であった。
12,000gで45分間遠心分離することにより、細菌をブロスから分離した。多糖を、蒸留水によるポリエーテルスルホン膜を使用した限外濾過により、100KDaの分子量を超える多糖に関して精製した。精製後、多糖をラジカル脱重合により脱重合し(Volpi N. et al. Anal. Biochem., 1992, 200:100−107)、3,000〜40,000Daの分子量を有するポリマーを得た。
a)化学分析
得られたエキソ多糖類の中性及び酸性単糖類の含有率を、実施例1に記載したように、Kamerling et al. Biochem. J.,1975 151:491−495により記載され、Montreuil et al.により1986に修正された方法、Glycoproteins In Carbohydrate analysis: a practical approach. Eds Chaplin et Kennedy, I.R.L Pres、Oxford, Washington D.C., pp143−204に従って、加水分解及びガスのクロマトグラフィーにより決定した。得られた糖の百分率関係は、マンノース7.25%、ブドウ糖24.64%、グルクロン酸23.19%、ガラクツロン酸11.59%、ガラクトース24.64%及びN−アセチルグルコサミン8.70%であった。
好適な容器内に、以下の成分をこの順序で加えた:水[INCI:水(Aqua)]、Phenonip[INCI:フェノキシエタノール、メチルパラベン、エチルパラベン、ブチルパラベン、プロピルパラベン、イソブチルパラベン]、Abiol[INCI:イミダゾリジニル尿素]及びプロピレングリコールUSP/EP[INCI:プロピレングリコール](相A成分)。相A中の成分の混合物を一定の撹拌に供した後、Carbopol ETD 2020[INCI:アクリレート/C10〜30アルキルアクリレートクロスポリマー]を加えた(相B)。得られた混合物をマイクロ波中で65℃に加熱した。
本実施例の美容組成物は、実施例3の組成物の調製に関する教示に従って、同一の成分を用いたが表2の量を使用して調製された。
本実施例は、ヒアルロン酸と比較した、CNCM I−4150の菌株のエキソ多糖のサンプルの相対湿度0〜95%の任意のレベルにおける、ある時間にわたる重量変化を試験する。
実施例4の美容組成物と、菌株CNCM I−4150のエキソ多糖を水で置き換えたことを除いて、実施例4の組成物と同一の成分を同一の百分率で含有するそのプラセボ組成物との、インビボでの皮膚水和力の比較試験。
実施例3の美容組成物と、菌株CNCM I−4150のエキソ多糖を水で置き換えたことを除いて、実施例3の組成物と同一の成分及び同一の百分率を含有するそのプラセボ組成物との、皮膚粗さを低下させる能力、即ち抗皺効果のインビボでの比較試験。
本実施例の美容組成物は、実施例3の組成物の調製に関する教示に従って、表5の成分及び量を用いて調製された。相Dの調製には、サリチル酸ナトリウム[INCI:サリチル酸ナトリウム]と共にAntarcticine(登録商標)[INCI:シュードアルテロモナス発酵抽出物]も加えた。
本実施例の美容組成物は、実施例3の組成物の調製に関する教示に従って、表6の成分及び量を用いて調製された。相Dの調製には、Serilesine(登録商標)[INCI:ヘキサペプチド−10]も加えた。
好適な容器内に、水[INCI:水(Aqua)]中の、実施例1に従って得られたエキソ多糖をサリチル酸ナトリウム[INCI:サリチル酸ナトリウム]と共に加え、相Aを得た。水、Zemea(商標) Propanediol[INCI:プロパンジオール]及びフェノキシエタノールをこの相に加えた(相B〜D)。前述の構成成分全部が溶解した際、Leciflor 100 IP[INCI:レシチン]を、完全に溶解するまで、激しい撹拌下で少量ずつ加えた(相E)。その後、Labrasol[INCI:PEG−8カプリル/カプリングリコシド]を加え(相F)、10〜15分間、撹拌した状態にしておいて、エマルションを形成させた。
ドクサートナトリウムUSP[INCI:ジエチルヘキシルスルホコハク酸ナトリウム]とPrisorine 3505[INCI:イソステアリン酸]とを、好適な容器内で一緒に混合した(相A)。別の容器内で、実施例1に従って得られたエキソ多糖を、フタレート−Bitrex[INCI:アルコールDenat.]で部分的に変性させたエタノールに溶解した。溶解後、水を加えた(相B)。
Claims (13)
- 寄託番号CNCM I−4150を有するシュードアルテロモナス属(Pseudoalteromonas sp.)の菌株から単離され、ラジカル脱重合によって100〜800,000ダルトンの分子量を有するポリマーに変更されたエキソ多糖であって、マンノース、ブドウ糖、グルクロン酸、ガラクツロン酸、ガラクトース及びN−アセチルグルコサミンを含み、皮膚、粘膜、毛髪及び/又は爪の処置及び/又はケア用であることを特徴とするエキソ多糖。
- 請求項1に記載のエキソ多糖において、前記処置及び/又はケアが、前記皮膚、粘膜、毛髪及び/又は爪の老化の処置及び/又は予防であることを特徴とするエキソ多糖。
- 請求項2に記載のエキソ多糖において、前記皮膚の老化の処置及び/又は予防が、前記皮膚上の皺の処置及び/又は予防であることを特徴とするエキソ多糖。
- 請求項1に記載のエキソ多糖において、前記処置及び/又はケアが、前記皮膚、粘膜、毛髪及び/又は爪の水和の不足又は低下の結果である疾患、状態及び/又は疾病の処置及び/又はケアであることを特徴とするエキソ多糖。
- 請求項4に記載のエキソ多糖において、前記状態、疾患及び/又は疾病が、乾燥肌、乾燥症、角化症、反応性角化症、手掌及び足底角化症、鶏眼及びカルス、日光角化症、非−日光角化症、アトピー性皮膚炎、接触性湿疹、脂漏性皮膚炎、フケ、乳児上の乳痂、ざ瘡、酒さ、母斑、魚鱗癬、乾癬、不全角化、粃糠疹、扁平苔癬、掌蹠角化症、唇あれ、膣乾燥症、眼球乾燥症、乾燥毛髪、脆弱な毛髪及び爪により形成される群から選択されることを特徴とするエキソ多糖。
- 請求項1乃至5の何れか1項に記載のエキソ多糖において、化学修飾を含むことを特徴とするエキソ多糖。
- 請求項1に記載のエキソ多糖において、百分率の合計が100%を超えない条件にて、重量で3%〜12%のマンノース、12%〜34%のブドウ糖、12%〜34%のグルクロン酸、2%〜20%のガラクツロン酸、12%〜34%のガラクトース及び2%〜18%のN−アセチルグルコサミンを含むことを特徴とするエキソ多糖。
- 請求項1及び7の何れか1項に記載のエキソ多糖において、更にラムノースを含むことを特徴とするエキソ多糖。
- 有効な美容又は皮膚医薬量の請求項1乃至8の何れか1項に記載のエキソ多糖と、少なくとも1種の美容的又は皮膚医薬的に許容し得る賦形剤、補助剤及び/又は成分とを含有することを特徴とする美容又は皮膚医薬組成物。
- 請求項9に記載の美容又は皮膚医薬組成物において、前記エキソ多糖が、美容的又は皮膚医薬的に許容し得る送達システム又は徐放システムに組み込まれることを特徴とする美容又は皮膚医薬組成物。
- 請求項9及び10の何れか1項に記載の美容又は皮膚医薬組成物において、タルク、ベントナイト、シリカ、澱粉及びマルトデキストリンにより形成される群から選択される固体有機ポリマー又は固体無機物担体上に吸収されることを特徴とする美容又は皮膚医薬組成物。
- 請求項9及び10の何れか1項に記載の美容又は皮膚医薬組成物において、前記組成物が、多層乳剤、水中油及び/又はシリコーンの乳剤、油及び/又はシリコーン中水の乳剤、水/油/水又は水/シリコーン/水タイプの乳剤、及び油/水/油又はシリコーン/水/シリコーンタイプの乳剤、マイクロエマルション、乳剤及び/又は溶液、液晶、無水組成物、無水分散物、油、乳液、バルサム、フォーム、水性又は油性ローション、水性又は油性ジェル、クリーム、水性アルコール溶液、水性グリコール溶液、ヒドロゲル、リニメント、美容液(sera)、石鹸、シャンプー、コンディショナー、フェースマスク、毛髪スプレー、美容液(serums)、多糖フィルム、軟膏、ムース、ポマード、ペースト、パウダー、バー、ペンシル、スプレー又はエアゾルにより形成される群から選択される調製物中に、またはカプセル剤、ゼラチンカプセル剤、軟カプセル剤、硬カプセル剤、錠剤、散剤、顆粒、チューインガム、液剤、縣濁剤、乳剤、シロップ剤、多糖フィルム、ゼリー又はゼラチンにより形成される群から選択される経口投与用の調製物中に存在することを特徴とする美容又は皮膚医薬組成物。
- 請求項9乃至12の何れか1項に記載の美容又は皮膚医薬組成物において、前記賦形剤、補助剤及び/又は成分が、アセチルコリン受容体クラスタリングを阻害する薬剤、筋収縮阻害剤、抗コリン剤、エラスターゼ阻害剤、マトリックスメタロプロテアーゼ阻害剤、メラニン合成刺激又は阻害剤、ホワイトニング剤又は脱色剤、着色促進剤、自己日焼け剤、抗老化剤、NO−シンターゼ阻害剤、5α−レダクターゼ阻害剤、リジル−及び/又はプロリルヒドロキシラーゼ阻害剤、酸化防止剤、フリーラジカルスカベンジャー及び/又は大気汚染に対抗する薬剤、反応性カルボニル種スカベンジャー、抗糖化剤、抗ヒスタミン剤、抗ウィルス剤、抗寄生虫剤、乳化剤、皮膚軟化剤、有機溶媒、液体噴射剤、皮膚コンディショナー、湿潤剤、水分を保持する物質、αヒドロキシ酸、βヒドロキシ酸、保湿剤、上皮加水分解酵素、ビタミン、アミノ酸、タンパク質、ピグメント又は着色剤、色素、ゲル化ポリマー、増粘剤、界面活性剤、柔軟剤、抗皺/抗老化剤、眼下の腫れを低減又は処置することが可能な薬剤、剥脱剤、剥離剤、角質溶解剤、抗菌剤、抗真菌剤、静真菌剤、殺菌剤、静菌剤、真皮若しくは上皮巨大分子の合成を刺激し、及び/又は、真皮若しくは上皮巨大分子の分解を阻害若しくは予防することが可能な薬剤、コラーゲン合成刺激剤、エラスチン合成刺激剤、デコリン合成刺激剤、ラミニン合成刺激剤、デフェンシン合成刺激剤、アクアポリン合成刺激剤、ヒアルロン酸合成刺激剤、フィブロネクチン合成刺激剤、サーチュイン合成刺激剤、シャペロン合成刺激剤、脂質及び角質層の構成成分の合成を刺激する薬剤、セラミド、脂肪酸、コラーゲン分解を阻害する薬剤、エラスチン分解を阻害する薬剤、セリンプロテアーゼを阻害する薬剤、カテプシンG、線維芽細胞増殖を刺激する薬剤、角化細胞増殖を刺激する薬剤、脂肪細胞増殖を刺激する薬剤、メラニン細胞増殖を刺激する薬剤、角化細胞分化を刺激する薬剤、脂肪細胞分化を刺激する薬剤、アセチルコリンエステラーゼを阻害する薬剤、皮膚弛緩剤、グリコサミノグリカン合成刺激剤、抗角化症剤、コメド溶解剤、抗乾癬剤、DNA修復剤、DNA保護剤、安定剤、痒み止め剤、感受性皮膚の処置及び/又はケアのための薬剤、固化剤、密度向上剤、再構築剤、抗皮膚線条剤、結合剤、皮脂生成を調節する薬剤、脂肪分解剤又は脂肪分解を刺激する薬剤、抗セルライト剤、制汗剤、治癒を刺激する薬剤、コアジュバント治癒剤、再上皮化を刺激する薬剤、コアジュバント再上皮化剤、サイトカイン増殖因子、鎮静剤、抗炎症剤及び/又は鎮痛剤、麻酔剤、毛細血管循環及び/又は微小循環に作用する薬剤、血管新生を刺激する薬剤、血管透過性を阻害する薬剤、静脈治療剤、細胞代謝に作用する薬剤、真皮−表皮接合を改善する薬剤、毛髪成長を誘導する薬剤、毛髪成長阻害又は遅延剤、毛髪損失を遅延させる薬剤、芳香剤、キレート化剤、野菜抽出物、エッセンシャルオイル、海産物抽出物、生物発酵工程から得られた薬剤、無機塩、細胞抽出物及び日焼け止め、紫外A及び/又はB光線に対して活性な有機又は無機光保護剤により形成される群から選択されることを特徴とする美容又は皮膚医薬組成物。
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CA2818723A1 (en) | 2012-06-07 |
US20130302261A1 (en) | 2013-11-14 |
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EP2646115A2 (en) | 2013-10-09 |
ES2390033B1 (es) | 2013-10-31 |
ES2390033A1 (es) | 2012-11-06 |
MX2013006023A (es) | 2013-12-02 |
JP2013544309A (ja) | 2013-12-12 |
WO2012072245A3 (en) | 2013-04-11 |
CN103619415B (zh) | 2017-09-22 |
BR112013013110B1 (pt) | 2018-05-08 |
KR101912478B1 (ko) | 2018-10-26 |
AU2011335404A1 (en) | 2013-06-06 |
MX358978B (es) | 2018-09-11 |
WO2012072245A2 (en) | 2012-06-07 |
CO6791607A2 (es) | 2013-11-14 |
AU2011335404B2 (en) | 2017-02-02 |
CN103619415A (zh) | 2014-03-05 |
US9770400B2 (en) | 2017-09-26 |
BR112013013110A2 (pt) | 2016-07-12 |
CA2818723C (en) | 2020-01-21 |
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