JP6215706B2 - 薬物送達デバイスと薬物送達デバイスを組立てる方法 - Google Patents
薬物送達デバイスと薬物送達デバイスを組立てる方法 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M2005/3151—Means for blocking or restricting the movement of the rod or piston by friction
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- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
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- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
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- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31515—Connection of piston with piston rod
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- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
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Description
更に、特許文献2は、1つのエレメントを他方に対して回転させるのに必要なトルクを低減するために2つのエレメントのささえ面の間に潤滑剤が適用されるデバイスを開示する。
ここで一つの実施態様において、薬学的に活性な化合物は、最大で1500Daまでの分子量を有し、及び/又は、ペプチド、蛋白質、多糖類、ワクチン、DNA、RNA、酵素、抗体、ホルモン、若しくはオリゴヌクレオチド、又は上記の薬学的に活性な化合物の混合物であり、
ここで更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病関連の合併症、深部静脈又は肺血栓塞栓症などの血栓塞栓症の治療、急性冠症候群(ACS)、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症、及び/又は、関節リウマチ、及び/又は、予防に有用である。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);又は
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
ここで、基−Lys6−NH2は、エキセンジン−4誘導体のC−末端と連結してもよく;
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28 Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38 エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5,desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
又は前述のいずれかのエキセンジン−4誘導体の薬学的に許容可能な塩若しくは溶媒和物;
から選択される。
Publishing社,Easton, Pa., U.S.A., 1985 及び Encyclopedia of Pharmaceutical Technologyに記載されている。
1:薬物送達デバイス;
2:ハウジング;
3:カートリッジホルダ;
4:カートリッジ;
5:栓;
6:用量ボタン;
7:遠位端;
8:近位端;
9:用量表示エレメント;
10:膜;
11:出口;
12:ピストンロッド;
13:薬物;
14:支持部材;
15:窓;
16:物質;
17:ささえ面;
18:ささえ面;
Claims (9)
- ハウジング(2)、第一の部材(6)と第二の部材(9)を含んでなる薬物送達デバイス(1)であって、
ここで用量の設定及び投与中に第一の部材(6)はハウジング(2)に対して可動であり、
そして、ここで、物質(16)が、第一の部材(6)と第二の部材(9)の少なくとも1つに設けられ、
ここで、物質(16)の内部摩擦が、外部衝撃又はデバイス(1)の振動によって生じる第一及び第二の部材(9)の相対運動を阻止するのに十分大きく、
そしてここで、物質(16)の内部摩擦が、デバイス(1)の意図した操作に必要な第一の部材(6)と第二の部材(9)の相対運動を可能にするには十分小さく、
そしてここで、第一の及び第二の部材(6、9)の予め決められた互いに対する位置が物質(16)によって維持され、
ここで、第一の部材(6)は、薬物(13)の用量を設定し、そしてそれをデバイス(1)から投薬することの少なくとも1つを行うためにユーザーによって作動されるように構成されるデバイス(1)の用量ボタン(6)を含み、
ここで、第二の部材(9)は、デバイス(1)から投薬された薬物(13)の用量の数を表示するように構成されるデバイス(1)の用量表示エレメント(9)を含む、あるいは、第二の部材(9)は、デバイス(1)の少なくとも2つの異なる操作条件を示すように構成されるデバイス(1)の用量表示エレメント(9)を含む、
上記薬物送達デバイス(1)。 - 物質(16)の内部摩擦が、第一の部材(6)と第二の部材(9)の少なくとも1つの製造公差から生じる及び/又はデバイス(1)の組立て中に生じる第一と第二の部材(9)の相対運動を阻止するのに十分に大きい、請求項1に記載の薬物送達デバイス(1)。
- 上記デバイス(1)の意図した操作中に第一の部材(6)と第二の部材(9)の少なくとも1つにかけられた力が、物質(16)の内部摩擦を上回るのに十分に大きい、請求項1又は2に記載の薬物送達デバイス(1)。
- 第一の部材(6)と第二の部材(9)の間の相対運動が、相対的な回転運動及び軸方向運動の少なくとも1つを含む、請求項1〜3のいずれか1項に薬物送達デバイス(1)。
- 第一の部材(6)と第二の部材(9)が、デバイス(1)の駆動機構の部分であって、ここで、第一と第二の部材(6,9)の相対運動が、駆動機構の操作に必要である限り許容される、請求項1〜4のいずれか1項に記載の薬物送達デバイス(1)。
- 第一の部材(6)と第二の部材(9)の外形が、デバイス(1)の意図した操作によって予め決められる、請求項1〜5のいずれか1項に記載の薬物送達デバイス(1)。
- 物質(16)が、第一の部材(6)と第二の部材(9)の少なくとも1つのささえ面(17,18)に接着連結される、請求項1〜6のいずれか1項に記載の薬物送達デバイス(1)。
- 物質(16)が粘性流体を含む、請求項1〜7のいずれか1項に記載の薬物送達デバイス(1)。
- 用量ボタン(6)が管形状を含み、用量表示エレメント(9)がリング形状を含み、ここで、用量表示エレメント(9)が用量ボタン(6)内に配置される、請求項1〜8のいずれか1項に記載の薬物送達デバイス(1)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10188657 | 2010-10-25 | ||
EP10188657.0 | 2010-10-25 | ||
PCT/EP2011/068603 WO2012055845A1 (en) | 2010-10-25 | 2011-10-25 | Drug delivery device and method for assembling a drug delivery device |
Publications (2)
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JP2013540541A JP2013540541A (ja) | 2013-11-07 |
JP6215706B2 true JP6215706B2 (ja) | 2017-10-18 |
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EP (1) | EP2632512B1 (ja) |
JP (1) | JP6215706B2 (ja) |
KR (1) | KR101838467B1 (ja) |
CN (1) | CN103180000B (ja) |
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CA (1) | CA2815717A1 (ja) |
DK (1) | DK2632512T3 (ja) |
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RU (1) | RU2586307C2 (ja) |
SG (1) | SG189209A1 (ja) |
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ZA (1) | ZA201301926B (ja) |
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CA2937811A1 (en) * | 2014-02-17 | 2015-08-20 | Carebay Europe Ltd | Medicament delivery device with delivery finish signal delay |
AU2017237925B2 (en) * | 2016-03-25 | 2019-04-04 | Eli Lilly And Company | Determination of a dose set and delivered in a medication delivery device |
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Publication number | Priority date | Publication date | Assignee | Title |
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US5226896A (en) * | 1990-04-04 | 1993-07-13 | Eli Lilly And Company | Dose indicating injection pen |
JP3568959B2 (ja) * | 1995-03-07 | 2004-09-22 | イーライ・リリー・アンド・カンパニー | 再利用可能な投薬装置 |
GB9504878D0 (en) * | 1995-03-10 | 1995-04-26 | Weston Medical Ltd | Viscously coupled actuator |
DE19730999C1 (de) * | 1997-07-18 | 1998-12-10 | Disetronic Licensing Ag | Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts |
US6663602B2 (en) * | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
DE10047637A1 (de) | 2000-09-26 | 2002-04-25 | Disetronic Licensing Ag | Vorrichtung zur Verabreichung eines injizierbaren Produkts |
GB0304824D0 (en) * | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
DE102004063664A1 (de) * | 2004-12-31 | 2006-07-20 | Tecpharma Licensing Ag | Echtzeitanzeige für eine Vorrichtung zur dosierten Verabreichung eines Produkts |
GB2438629B (en) * | 2006-06-01 | 2011-02-23 | Cilag Gmbh Int | Injection device |
CN103122130B (zh) * | 2006-07-31 | 2016-04-06 | 诺沃—诺迪斯克有限公司 | 低摩擦系统和设备 |
JP4910652B2 (ja) | 2006-11-20 | 2012-04-04 | オムロンヘルスケア株式会社 | 低周波治療器 |
ES2657483T3 (es) * | 2007-03-09 | 2018-03-05 | Eli Lilly And Company | Mecanismo de retardo para un dispositivo de inyección automática |
WO2009030975A1 (en) * | 2007-09-03 | 2009-03-12 | Becton Dickinson France | Medical device comprising a siliconized chamber and a coated closure means |
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AU2011322648B2 (en) | 2014-09-18 |
US20130204183A1 (en) | 2013-08-08 |
AU2011322648A1 (en) | 2013-05-02 |
PL2632512T3 (pl) | 2018-02-28 |
RU2013123994A (ru) | 2014-12-10 |
ES2650165T3 (es) | 2018-01-17 |
EP2632512A1 (en) | 2013-09-04 |
RU2586307C2 (ru) | 2016-06-10 |
NO2632512T3 (ja) | 2018-01-27 |
ZA201301926B (en) | 2013-11-27 |
IL225805A0 (en) | 2013-07-31 |
CA2815717A1 (en) | 2012-05-03 |
NZ609718A (en) | 2014-05-30 |
BR112013010144A2 (pt) | 2016-09-06 |
JP2013540541A (ja) | 2013-11-07 |
CN103180000B (zh) | 2015-09-09 |
SG189209A1 (en) | 2013-05-31 |
IL225805B (en) | 2018-06-28 |
EP2632512B1 (en) | 2017-08-30 |
HUE035439T2 (en) | 2018-05-02 |
KR20130131349A (ko) | 2013-12-03 |
DK2632512T3 (en) | 2017-12-11 |
MX2013003953A (es) | 2013-06-03 |
US9775952B2 (en) | 2017-10-03 |
CN103180000A (zh) | 2013-06-26 |
KR101838467B1 (ko) | 2018-03-15 |
WO2012055845A1 (en) | 2012-05-03 |
MX349452B (es) | 2017-07-31 |
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