JP6214657B2 - ヒト免疫不全ウイルス複製阻害剤 - Google Patents
ヒト免疫不全ウイルス複製阻害剤 Download PDFInfo
- Publication number
- JP6214657B2 JP6214657B2 JP2015527515A JP2015527515A JP6214657B2 JP 6214657 B2 JP6214657 B2 JP 6214657B2 JP 2015527515 A JP2015527515 A JP 2015527515A JP 2015527515 A JP2015527515 A JP 2015527515A JP 6214657 B2 JP6214657 B2 JP 6214657B2
- Authority
- JP
- Japan
- Prior art keywords
- tert
- butoxy
- acetic acid
- dioxa
- tetraazahexacyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- SCSKQHGHSGOQOS-PSDZNPJRSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)/C=C/C=C\CCc1ccccc1-c1cccc-2c1 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)/C=C/C=C\CCc1ccccc1-c1cccc-2c1 SCSKQHGHSGOQOS-PSDZNPJRSA-N 0.000 description 1
- HANFDNAKFLXLSV-XIFFEERXSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)CCCCCCc1ccccc1-c1cccc-2c1 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)CCCCCCc1ccccc1-c1cccc-2c1 HANFDNAKFLXLSV-XIFFEERXSA-N 0.000 description 1
- QNHCUEYHMKHFHZ-WRAWZCCESA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1c2)c(-c(cc3)cc4c3OCC[C@H]4CCCCOc3c-4cccc3)[n]1nc2-c1cccc-4c1 Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1c2)c(-c(cc3)cc4c3OCC[C@H]4CCCCOc3c-4cccc3)[n]1nc2-c1cccc-4c1 QNHCUEYHMKHFHZ-WRAWZCCESA-N 0.000 description 1
- GAWSZJCLDKAJAW-ZZMOXNGHSA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1c2)c(-c(ccc(OCC3)c4N3C/C=C/CCc3cccc-5c3)c4Cl)[n]1nc2-c1cc-5ccc1 Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1c2)c(-c(ccc(OCC3)c4N3C/C=C/CCc3cccc-5c3)c4Cl)[n]1nc2-c1cc-5ccc1 GAWSZJCLDKAJAW-ZZMOXNGHSA-N 0.000 description 1
- CXAIOJIHWSUYRD-HKBQPEDESA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cc(-c3cc(C(F)(F)F)ccc3O)ccc2)n[n]11)c1N(CC1)CCC1(C)OCC=C Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cc(-c3cc(C(F)(F)F)ccc3O)ccc2)n[n]11)c1N(CC1)CCC1(C)OCC=C CXAIOJIHWSUYRD-HKBQPEDESA-N 0.000 description 1
- DLNWMDLPJPGRIH-VWLOTQADSA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cc(Br)ccc2)n[n]11)c1N(CC1)CCC1(C)OCC=C Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cc(Br)ccc2)n[n]11)c1N(CC1)CCC1(C)OCC=C DLNWMDLPJPGRIH-VWLOTQADSA-N 0.000 description 1
- XDCADFBGVBKALR-HKBQPEDESA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cccc(-c(c(O)c3)ccc3F)c2)n[n]11)c1N(CC1)CCC1(C)OCC=C Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cccc(-c(c(O)c3)ccc3F)c2)n[n]11)c1N(CC1)CCC1(C)OCC=C XDCADFBGVBKALR-HKBQPEDESA-N 0.000 description 1
- VPLPWULVNFGHGO-MZNKCQHYSA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)COC/C=C/CCc1ccccc1-c1cccc-2c1 Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)COC/C=C/CCc1ccccc1-c1cccc-2c1 VPLPWULVNFGHGO-MZNKCQHYSA-N 0.000 description 1
- LZQMKLLEWNOCCA-UHFFFAOYSA-N CC(C)(C)[O-4]C(C(O)=O)c(c(C)nc1c2)c(-c(cc3F)cc4c3OCCN4CCCCCc3c-4cccc3)[n]1nc2-c1cc-4ccc1 Chemical compound CC(C)(C)[O-4]C(C(O)=O)c(c(C)nc1c2)c(-c(cc3F)cc4c3OCCN4CCCCCc3c-4cccc3)[n]1nc2-c1cc-4ccc1 LZQMKLLEWNOCCA-UHFFFAOYSA-N 0.000 description 1
- XJGLKZJLIXOCRB-UHFFFAOYSA-N CC(C)(C)[O-4]C(C(OC)=O)c(c(C)nc1c2)c(-c(cc3F)cc4c3OCCN4CC=C)[n]1nc2-c1cc(-c2ccccc2CCC=C)ccc1 Chemical compound CC(C)(C)[O-4]C(C(OC)=O)c(c(C)nc1c2)c(-c(cc3F)cc4c3OCCN4CC=C)[n]1nc2-c1cc(-c2ccccc2CCC=C)ccc1 XJGLKZJLIXOCRB-UHFFFAOYSA-N 0.000 description 1
- KSNOFMBHCAGULO-UHFFFAOYSA-N CC1(C)OB(c(cc2F)cc3c2OCCN3CC=C)OC1(C)C Chemical compound CC1(C)OB(c(cc2F)cc3c2OCCN3CC=C)OC1(C)C KSNOFMBHCAGULO-UHFFFAOYSA-N 0.000 description 1
- SDSSOFXNNKFCPE-UHFFFAOYSA-N CN(CC(OB(c1ccccc1CCC=C)O1)=O)CC1=O Chemical compound CN(CC(OB(c1ccccc1CCC=C)O1)=O)CC1=O SDSSOFXNNKFCPE-UHFFFAOYSA-N 0.000 description 1
- LIDHCSXTMSQAQK-QIIIRZTJSA-N C[C@@H](/C=N/CCOC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccncc1-c1cccc-3c1 Chemical compound C[C@@H](/C=N/CCOC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccncc1-c1cccc-3c1 LIDHCSXTMSQAQK-QIIIRZTJSA-N 0.000 description 1
- WRJYLABXLMJHFV-SPFKFGNLSA-N C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc(ccc(C)c1)c1-c1cccc-3c1 Chemical compound C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc(ccc(C)c1)c1-c1cccc-3c1 WRJYLABXLMJHFV-SPFKFGNLSA-N 0.000 description 1
- RPBJAKCLYAXHCN-GGOOWQFJSA-N C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)c(F)c1-c1cccc-3c1 Chemical compound C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)c(F)c1-c1cccc-3c1 RPBJAKCLYAXHCN-GGOOWQFJSA-N 0.000 description 1
- PGELZYLOKZTIHE-DCUOSEHISA-N C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc(-c(cc3)c4)n[n]12)Oc1cccc(F)c1-c4c3F Chemical compound C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc(-c(cc3)c4)n[n]12)Oc1cccc(F)c1-c4c3F PGELZYLOKZTIHE-DCUOSEHISA-N 0.000 description 1
- OQKOWQJBXNXVAL-VIYHJVHISA-N C[C@@H](C/C=C\COC(C)(CC1)CCN1c1c(C(C(O)=O)[O-4]C(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(F)ccc1-c1cccc-3c1 Chemical compound C[C@@H](C/C=C\COC(C)(CC1)CCN1c1c(C(C(O)=O)[O-4]C(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(F)ccc1-c1cccc-3c1 OQKOWQJBXNXVAL-VIYHJVHISA-N 0.000 description 1
- OGYNPJIREZDYQI-CRFKOJLDSA-N C[C@@H](C/C=C\COC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)cc1-c1cccc-3c1 Chemical compound C[C@@H](C/C=C\COC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)cc1-c1cccc-3c1 OGYNPJIREZDYQI-CRFKOJLDSA-N 0.000 description 1
- CVKULBDZZYFAPG-NSHDSACASA-N C[C@@H](CC=C)Oc1cccc(Cl)c1-c1cc(Br)ccc1F Chemical compound C[C@@H](CC=C)Oc1cccc(Cl)c1-c1cc(Br)ccc1F CVKULBDZZYFAPG-NSHDSACASA-N 0.000 description 1
- QYTGNHIUXQXHRC-FDLYHPRCSA-N C[C@@H](CC=C)Oc1cccc(Cl)c1-c1cccc(-c2n[n]3c(N(CC4)CCC4(C)OCC=C)c(C(C(OC)=O)[O-4]C(C)(C)C)c(C)nc3c2)c1 Chemical compound C[C@@H](CC=C)Oc1cccc(Cl)c1-c1cccc(-c2n[n]3c(N(CC4)CCC4(C)OCC=C)c(C(C(OC)=O)[O-4]C(C)(C)C)c(C)nc3c2)c1 QYTGNHIUXQXHRC-FDLYHPRCSA-N 0.000 description 1
- BJUFYBQDPVNSLS-LHAPQZOASA-N C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(F)c(C)cc1-c1cccc-3c1 Chemical compound C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(F)c(C)cc1-c1cccc-3c1 BJUFYBQDPVNSLS-LHAPQZOASA-N 0.000 description 1
- WQVKIUDQOPILAN-LHAPQZOASA-N C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)c(F)c1-c1cc-3ccc1 Chemical compound C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)c(F)c1-c1cc-3ccc1 WQVKIUDQOPILAN-LHAPQZOASA-N 0.000 description 1
- KCBOBIHKIHLPSV-CYFIQEHSSA-N C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)cc1-c1cccc-3c1 Chemical compound C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)cc1-c1cccc-3c1 KCBOBIHKIHLPSV-CYFIQEHSSA-N 0.000 description 1
- 0 C[C@@](C(C1)[*@@]1C=CCOC(C)(CC1)CCN1c1c([C@@](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(C)ccc1-c1cccc-3c1 Chemical compound C[C@@](C(C1)[*@@]1C=CCOC(C)(CC1)CCN1c1c([C@@](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(C)ccc1-c1cccc-3c1 0.000 description 1
- LXLAYZCOPUSIAB-AWEZNQCLSA-N Cc1nc2cc(-c3cc(Br)ccc3)n[n]2c(I)c1[C@@H](C(OC)=O)O Chemical compound Cc1nc2cc(-c3cc(Br)ccc3)n[n]2c(I)c1[C@@H](C(OC)=O)O LXLAYZCOPUSIAB-AWEZNQCLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261683772P | 2012-08-16 | 2012-08-16 | |
| US61/683,772 | 2012-08-16 | ||
| US201361818572P | 2013-05-02 | 2013-05-02 | |
| US61/818,572 | 2013-05-02 | ||
| US13/959,268 | 2013-08-05 | ||
| US13/959,268 US8906929B2 (en) | 2012-08-16 | 2013-08-05 | Inhibitors of human immunodeficiency virus replication |
| PCT/US2013/054532 WO2014028384A1 (en) | 2012-08-16 | 2013-08-12 | Inhibitors of human immunodeficiency virus replication |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524841A JP2015524841A (ja) | 2015-08-27 |
| JP2015524841A5 JP2015524841A5 (OSRAM) | 2016-09-15 |
| JP6214657B2 true JP6214657B2 (ja) | 2017-10-18 |
Family
ID=50100460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527515A Expired - Fee Related JP6214657B2 (ja) | 2012-08-16 | 2013-08-12 | ヒト免疫不全ウイルス複製阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8906929B2 (OSRAM) |
| EP (1) | EP2888266B1 (OSRAM) |
| JP (1) | JP6214657B2 (OSRAM) |
| KR (1) | KR20150042830A (OSRAM) |
| CN (1) | CN104583214B (OSRAM) |
| AU (1) | AU2013302873B2 (OSRAM) |
| BR (1) | BR112015003175A2 (OSRAM) |
| CA (1) | CA2882077A1 (OSRAM) |
| EA (1) | EA201590358A1 (OSRAM) |
| ES (1) | ES2619960T3 (OSRAM) |
| IL (1) | IL237154A (OSRAM) |
| MX (1) | MX2015001899A (OSRAM) |
| SG (1) | SG11201500887QA (OSRAM) |
| TW (1) | TW201412750A (OSRAM) |
| WO (1) | WO2014028384A1 (OSRAM) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG186820A1 (en) | 2010-07-02 | 2013-02-28 | Gilead Sciences Inc | Napht- 2 -ylacetic acid derivatives to treat aids |
| BR112012033689A2 (pt) | 2010-07-02 | 2019-09-24 | Gilead Sciences Inc | derivados de ácido 2-quinolinil-acético como compostos de hiv antivirais |
| ES2615734T3 (es) | 2011-04-21 | 2017-06-08 | Gilead Sciences, Inc. | Compuestos de benzotiazol y su uso farmacéutico |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| MX2014005002A (es) | 2012-04-20 | 2014-07-09 | Gilead Sciences Inc | Derivados de acido benzotiazol-6-il acetico y su uso para tratar una infeccion por vih. |
| US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| CN105189510B (zh) * | 2013-03-13 | 2017-05-17 | 百时美施贵宝公司 | 人免疫缺陷病毒复制的抑制剂 |
| WO2014159076A1 (en) * | 2013-03-14 | 2014-10-02 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| WO2015123182A1 (en) * | 2014-02-12 | 2015-08-20 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| ES2654242T3 (es) | 2014-02-12 | 2018-02-12 | Viiv Healthcare (No.5) Limited | Macrociclos de benzotiazol como inhibidores de la réplica del virus de la inmunodeficiencia humana |
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| IL237154A0 (en) | 2015-04-30 |
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